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https://www.readbyqxmd.com/read/29685009/sudden-onset-unilateral-ptosis-induced-by-pituitary-macroadenoma-with-false-positive-jolly-and-neostigmine-tests
#1
G X Shen, K J Wu, Z Chen, Y F Gao, G X Nan
The development of ptosis as a consequence of pituitary tumor is an exceptionally rare occurrence. Here, we describe the case of sudden-onset unilateral ptosis induced by pituitary macroadenoma. The condition was characterized by false-positive Jolly and neostigmine tests. These findings mimic oculomotor nerve palsy and make the correct diagnostics rather challenging. The case points to the fact that patients with acquired ptosis need detailed neuroophthalmological examination.
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29683988/case-report-ocular-myasthenia-gravis-associated-with-in-vitro-fertilization-procedures
#2
Yung Ju Yoo, Sang Beom Han, Hee Kyung Yang, Jeong-Min Hwang
SIGNIFICANCE: Ocular myasthenia gravis is a localized form of myasthenia gravis, which is a postsynaptic disorder of the neuromuscular junction that causes fluctuating weakness of extraocular muscles resulting from autoimmune mechanisms. In women with myasthenia, changes in sex hormone levels and administration of corticosteroids can trigger or worsen symptoms of myasthenia gravis. PURPOSE: To describe a case of seronegative ocular myasthenia gravis whose first symptom appeared a day after in vitro fertilization procedure...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29643637/neostigmine-induced-coronary-spasm-beware-of-kounis-syndrome
#3
Xiaofei Yang, Xiaozhi Feng, Feiru Duan, Zhiyong Wang, Monish S Raut, Baryon Swain
No abstract text is available yet for this article.
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29643557/reversal-agents-do-we-need-to-administer-with-neuromuscular-monitoring-an-observational-study
#4
Shilpa Goyal, Nikhil Kothari, Deepak Chaudhary, Shilpi Verma, Pooja Bihani, Mahaveer Singh Rodha
Background and Aims: In clinical practice, in the majority of patients, recovery from the effect of muscle relaxants is assessed using subjective methods such as head lift, eye-opening, or by sustained hand grip after giving anticholinesterases (neostigmine) at the end of surgery. We planned a prospective observational cohort study to test the hypothesis that objective neuromuscular monitoring can help us in avoiding the use of anticholinesterases for reversal. Methods: The patients posted for surgery of <2 h duration were included in the study...
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29621739/incidence-of-hypersensitivity-and-anaphylaxis-with-sugammadex
#5
K Chris Min, Tiffany Woo, Christopher Assaid, Jacqueline McCrea, Deborah M Gurner, Christine McCrary Sisk, Franklin Adkinson, W Joseph Herring
STUDY OBJECTIVE: To evaluate the incidence of hypersensitivity and anaphylaxis after administration of sugammadex. DESIGN: Retrospective analysis. SETTING: Sugammadex clinical development program and post-marketing experience. PATIENTS: Surgical patients and healthy volunteers who received sugammadex or placebo/comparator with anesthesia and/or neuromuscular blockade (NMB). INTERVENTIONS: Sugammadex administered as 2...
April 2, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29620652/use-of-low-dose-neostigmine-intravenously-in-the-treatment-of-thyroid-storm-induced-severe-tachycardia-in-patient-during-huge-pelvic-mass-resection-a-case-report-and-review-of-literature
#6
Xue Zhang, Hui Jiang, Shiyong Li, Ailin Luo, Yilin Zhao
RATIONALE: Thyroid storm is a rare and life-threatening metabolic crisis because of an emergent release of excess thyroid hormone. Sinus tachycardia induced by excess thyroid hormone may result in congestive heart failure due to decreased diastolic filling time. PATIENT CONCERNS: A controlled hyperthyroidism patient with severe sinus tachycardia. DIAGNOSES: A controlled hyperthyroidism patient was induced thyroid storm during huge pelvic mass resection...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29528806/neostigmine-hyperinflation
#7
Ashlee G Hamel, Mark W Recker
No abstract text is available yet for this article.
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29518833/-clinical-and-genetic-characteristics-of-congenital-myasthenia-syndrome-with-episodic-apnea-caused-by-chat-gene-mutation-a-report-of-2-cases
#8
Z M Liu, F Fang, C H Ding, W H Zhang, J Deng, C H Chen, X Wang, J Liu, Z Li, X L Jia, J S Zeng, S Y Qian
Objective: To investigate the clinical and genetic features of congenital myasthenia syndrome with episodic apnea (CMS-EA) caused by gene mutation of choline acetyltransferase (CHAT) Methods: The clinical data of 2 patients with congenital myasthenia syndrome were collected, and both were diagnosed from 2013 to 2015 in Beijing Children's Hospital, Capital Medical University. The clinical features and gene mutation characteristics were analyzed, and the patients were followed-up for therapeutic efficacy. Results: The two patients (case 1 and case 2) had the onset soon after birth and at 3 months after birth respectively...
March 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29509554/methylnaltrexone-for-neostigmine-resistant-ogilvie-syndrome
#9
Muhammad Tahir, Amanapal Singh, Waseem Amjad
No abstract text is available yet for this article.
February 20, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29491752/preliminary-indications-for-the-use-of-sugammadex-after-its-addition-to-a-formulary-at-a-tertiary-care-children-s-hospital
#10
N'Diris Barry, Joshua C Uffman, Dmitry Tumin, Joseph D Tobias
OBJECTIVES: Neuromuscular blocking agents (NMBAs) are administered to facilitate endotracheal intubation and provide skeletal muscle relaxation in surgical procedures. Sugammadex (Bridion) recently received approval by the United States Food and Drug Administration for reversal of rocuronium and vecuronium-induced neuromuscular blockade thereby providing an alternative to acetylcholinesterase inhibitors such as neostigmine. This quality improvement analysis sought to investigate the clinical reasons and common clinical perceptions for choosing sugammadex over neostigmine to reverse NMBAs...
January 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29479387/use-of-sugammadex-in-a-patient-with-myotonic-dystrophy
#11
Samira Ahmed, Aymen Naguib, Dmitry Tumin, Joseph D Tobias
One of the challenges during the perioperative care of patients with myotonic dystrophy is the reversal of neuromuscular blocking agents. Agents that inhibit acetylcholinesterase, such as neostigmine, may precipitate myotonia, and are therefore relatively contraindicated. Sugammadex is a novel pharmacologic agent, which encapsulates rocuronium or vecuronium, thereby reversing their effect. We report anecdotal experience with the use of sugammadex to reverse neuromuscular blockade in a patient with myotonic dystrophy...
February 2018: Cardiology Research
https://www.readbyqxmd.com/read/29467022/recovery-of-muscle-function-after-deep-neuromuscular-block-by-means-of-diaphragm-ultrasonography-and-adductor-of-pollicis-acceleromyography-with-comparison-of-neostigmine-vs-sugammadex-as-reversal-drugs-study-protocol-for-a-randomized-controlled-trial
#12
Iacopo Cappellini, Fabio Picciafuochi, Daniele Ostento, Ginevra Danti, Angelo Raffaele De Gaudio, Chiara Adembri
BACKGROUND: The extensive use of neuromuscular blocking agents (NMBAs) during surgical procedures still leads to potential residual paralyzing effects in the postoperative period. Indeed, neuromuscular monitoring in an intra-operative setting is strongly advocated. Acetylcholinesterase inhibitors can reverse muscle block, but their short half-life may lead to residual curarization in the ward, especially when intermediate or long-acting NMBAs have been administered. Sugammadex is the first selective reversal drug for steroidal NMBAs; it has been shown to give full and rapid recovery of muscle strength, thus minimizing the occurrence of residual curarization...
February 21, 2018: Trials
https://www.readbyqxmd.com/read/29430647/the-cells-and-conductance-mediating-cholinergic-neurotransmission-in-the-murine-proximal-stomach
#13
Tae Sik Sung, Sung Jin Hwang, Sang Don Koh, Yulia Bayguinov, Lauen E Peri, Peter J Blair, Timothy I Webb, David M Pardo, Jason R Rock, Kenton M Sanders, Sean M Ward
Enteric motor neurotransmission is essential for normal gastrointestinal (GI) motility. Controversy exists regarding the cells and ionic conductance(s) that mediate post-junctional neuroeffector responses to motor neurotransmitters. Isolated intramuscular ICC (ICC-IM) and smooth muscle cells (SMCs) from murine fundus muscles were used to determine the conductances activated by carbachol (CCh) in each cell-type. The calcium-activated chloride conductance (CaCC), Ano1 is expressed by ICC-IM but not resolved in SMCs, and CCh activated a Cl- conductance in ICC-IM and a non-selective cation conductance (NSCC) in SMCs...
February 12, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29405667/sugammadex-antagonism-of-rocuronium-induced-neuromuscular-blockade-in-patients-with-liver-cirrhosis-undergoing-liver-resection-a-randomized-controlled-study
#14
Mohamed Abdulatif, Maha Lotfy, Mahmoud Mousa, Mohamed H Afifi, Khaled Yassen
BACKGROUND: This randomized controlled study compared the recovery times of sugammadex and neostigmine as antagonists of moderate rocuroniuminduced neuromuscular block in patients with liver cirrhosis and controls undergoing liver resection. METHODS: The study enrolled 27 adult patients with Child class "A" liver cirrhosis and 28 patients with normal liver functions. Normal patients and patients with liver cirrhosis were randomized according to the type of antagonist (sugammadex 2mg/kg or neostigmine 50μg/kg)...
February 5, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29402603/monosodium-glutamate-impairs-the-contraction-of-uterine-visceral-smooth-muscle-ex-vivo-of-rat-through-augmentation-of-acetylcholine-and-nitric-oxide-signaling-pathways
#15
Mukti Mondal, Kaushik Sarkar, Partha Pratim Nath, Ashma Khatun, Sanghamitra Pal, Goutam Paul
The aim of the study was to examine the toxic effects of Monosodium glutamate (MSG), an extensively used food additive, on the contraction of uterine visceral smooth muscle (UVSM) in rat and to elucidate the probable neurocrine mechanism involved in it. MSG produced significant potentiation of the force and inhibition of frequency of uterus recorded ex vivo in chronic MSG exposure and in single dose acute experiments. MSG also produced significant potentiation of force of acetylcholine induced contraction and no alterations in atropine induced contraction of uterus...
February 2, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29385292/advanced-continuous-flow-platform-for-on-demand-pharmaceutical-manufacturing
#16
Ping Zhang, Nopphon Weeranoppanant, Dale A Thomas, Kohei Tahara, Torsten Stelzer, Mary Grace Russell, Marcus O'Mahony, Allan S Myerson, Hongkun Lin, Liam P Kelly, Klavs F Jensen, Timothy F Jamison, Chunhui Dai, Yuqing Cui, Naomi Briggs, Rachel L Beingessner, Andrea Adamo
As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technology, herein we report a second-generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0...
January 31, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29363292/acute-intoxications-among-turkish-children
#17
Baran S Kizilyildiz, Kamuran Karaman, Selvi Özen, Abdurrahman Üner
BACKGROUND: The aim of this study was to investigate characteristics, outcomes and clinical features of acute intoxications among children in Van region of Turkey. METHODS: All cases with a diagnosis of acute intoxication admitted to the Pediatric Emergency Department of the Yüzüncü Yıl University of Van from June 1, 2010 to November 30, 2011 were evaluated. We retrospectively examined the medical records for demographical and etiological characteristics of patients below 17 years of age...
February 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29359574/efficacy-and-safety-of-subcutaneous-neostigmine-for-ileus-acute-colonic-pseudo-obstruction-or-refractory-constipation
#18
Bridgette Kram, Maegan Greenland, Mollie Grant, Michael E Campbell, Charlotte Wells, Courtney Sommer
BACKGROUND: Neostigmine is traditionally administered intravenously for treatment of acute colonic pseudo-obstruction (ACPO), though use is associated with administration constraints and adverse effects. OBJECTIVE: To evaluate whether an alternative route of administration for neostigmine via subcutaneous (SQ) delivery is safe and effective in a broad cohort of medical and surgical patients. METHODS: This multicenter, retrospective observational study included adult patients administered SQ neostigmine for ileus, ACPO, or refractory constipation...
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29332816/comparative-enzymatic-studies-using-ion-selective-electrodes-the-case-of-cholinesterases
#19
Maria Cuartero, Soraya Pérez, Maria S García, Francisco García-Cánovas, Joaquín A Ortuño
The application of traditional ion-selective electrodes for comparative enzymatic analysis was demonstrated for the first time in this study. A kinetic-potentiometric method based on the monitoring of the concentration of the ionic substrate involved in the enzymatic reaction catalyzed by different cholinesterases is used for this purpose. A comparative study was performed comprising both enzymatic assays using different ionic substrates and the corresponding inhibited reactions in presence of neostigmine (a synthetic anticholinesterase)...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29330628/clinical-and-cn-sfemg-evaluation-of-neostigmine-test-in-myasthenia-gravis
#20
Giorgia Sciacca, Ester Reggio, Giovanni Mostile, Alessandra Nicoletti, Filippo Drago, Salvatore Salomone, Mario Zappia
Neostigmine test (NT) is a pharmacological test, demonstrating a clinical improvement in patients affected by myasthenia gravis (MG). We aim to compare clinical evaluation and neurophysiological recordings by concentric-needle single-fiber electromyography (CN-SFEMG) in response to acute administration of neostigmine in ocular and generalized MG patients. Twenty-three MG patients (10 with ocular MG and 13 with generalized MG) were evaluated before and after 90 min neostigmine 0.5-mg administration. Clinical responsiveness was assessed by MG composite (MGC) scale...
February 2018: Neurological Sciences
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