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https://www.readbyqxmd.com/read/28531112/effects-of-polyphenols-on-oxidative-stress-mediated-injury-in-cardiomyocytes
#1
REVIEW
Rosanna Mattera, Monica Benvenuto, Maria Gabriella Giganti, Ilaria Tresoldi, Francesca Romana Pluchinotta, Sonia Bergante, Guido Tettamanti, Laura Masuelli, Vittorio Manzari, Andrea Modesti, Roberto Bei
Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes nuclear and mitochondrial DNA damage, denaturation of intracellular proteins, lipid peroxidation and inflammation. Oxidative or nitrosative stress-mediated injury lead to cardiomyocytes apoptosis or necrosis. The reactive oxygen (ROS) and nitrogen species (RNS) concentration is dependent on their production and on the expression and activity of anti-oxidant enzymes...
May 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28529917/current-guidelines-on-prevention-with-a-focus-on-dyslipidemias
#2
REVIEW
Ian M Graham, Alberico L Catapano, Nathan D Wong
Examination of the current the American College of Cardiology/American Heart Association (ACC/AHA) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines on the prevention of cardiovascular disease and the management of dyslipidemias finds much common ground. Both note that Atherosclerotic cardiovascular disease (ASCVD) is, in most people, the product of a number of risk factors, notably tobacco exposure, hyperlipidemia, hypertension, inactivity, overweight and diabetes. They stress that risk calculators can help in the assessment of risk in apparently healthy persons...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28526936/fingerprint-of-long-non-coding-rna-regulated-by-cyclic-mechanical-stretch-in-human-aortic-smooth-muscle-cells-implications-for-hypertension
#3
Laura-Eve Mantella, Krishna K Singh, Paul Sandhu, Crystal Kantores, Azza Ramadan, Nadiya Khyzha, Adrian Quan, Mohammed Al-Omran, Jason E Fish, Robert P Jankov, Subodh Verma
Emerging evidence suggests that long non-coding RNAs (lncRNAs) represent a cellular hub coordinating various cellular processes that are critical in health and disease. Mechanical stress triggers changes in vascular smooth muscle cells (VSMCs) that in turn contribute to pathophysiological changes within the vasculature. We sought to evaluate the role that lncRNAs play in mechanical stretch-induced alterations of human aortic smooth muscle cells (HASMCs). RNA (lncRNA and mRNA) samples isolated from HASMCs that had been subjected to 10 or 20% elongation (1 Hz) for 24 h were profiled with the Arraystar Human LncRNA Microarray V3...
May 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28525444/cardiovascular-disease-risk-profile-and-readiness-to-change-in-blue-and-white-collar-workers
#4
Kerith D Aginsky, Demitri Constantinou, Maretha Delport, Estelle D Watson
This study provides a health and risk profile of blue- (BCWs) and white-collar workers (WCWs). Health screening data (n = 603; age 38.2 ± 9.7 years) included cholesterol and glucose finger-prick test, blood pressure, body mass index, and self-reported stress levels and readiness to change. Blue-collar workers were significantly older and had higher blood pressure readings and were more likely to develop hypertension (odds ratio [OR]: 1.72; 95% confidence interval [CI]: 1.05-2.81; P = .03), but less likely to present with hypercholesterolemia (OR: 0...
July 2017: Family & Community Health
https://www.readbyqxmd.com/read/28525406/blood-pressure-among-australian-aboriginal-children
#5
Nicholas Larkins, Armando Teixeira-Pinto, Emily Banks, Hasantha Gunasekera, Alan Cass, Jane Kearnes, Jonathan C Craig
OBJECTIVES: To determine the prevalence of elevated blood pressure (BP) and potential predictors of SBP and DBP in urban Australian aboriginal children. METHODS: The Study of Environment on Aboriginal Resilience and Child Health is a prospective cohort study of urban Aboriginal children attending four Aboriginal Community Controlled Health Services in New South Wales, Australia. Clinical measures included a manual BP measured by research officers using standardized protocols...
May 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28522248/adverse-effects-in-kidney-function-antioxidant-systems-and-histopathology-in-rats-receiving-monosodium-glutamate-diet
#6
María Del Carmen Contini, Ana Fabro, Néstor Millen, Adriana Benmelej, Stella Mahieu
We investigated the effects of adding of monosodium glutamate (MSG) to a standard diet on oxidative stress in kidney, nitric oxide excretion, renal ions handling and blood pressure. We examined the association of these changes with the effects on renal histology. The study was performed on male Wistar rats (5 weeks old) divided into 3 groups: 1) MSG group were fed a diet supplemented with 3g of MSG/kg b.w./day, five days a week, and spontaneous ingestion of a 1% MSG solution during 16 weeks; 2) NaCl group were fed a diet with NaCl (1g/kg b...
May 15, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28515952/potential-role-of-high-stress-employment-in-hypertension
#7
Eric J Buenz, Brent A Bauer
We report a patient with a reduction in blood pressure through cessation of high-stress employment.
May 2017: JRSM Open
https://www.readbyqxmd.com/read/28514939/antioxidant-properties-of-drugs-used-in-type-2-diabetes-management-could-they-contribute-to-confound-or-conceal-effects-of-antioxidant-therapy
#8
Siu Wai Choi, Cyrus K Ho
OBJECTIVES: This is a narrative review, investigating the antioxidant properties of drugs used in the management of diabetes, and discusses whether these antioxidant effects contribute to, confound, or conceal the effects of antioxidant therapy. METHODS: A systematic search for articles reporting trials, or observational studies on the antioxidant effect of drugs used in the treatment of diabetes in humans or animals was performed using Web of Science, PubMed, and Ovid...
May 17, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28513228/relationship-between-chop-gadd153-and-unstable-human-carotid-atherosclerotic-plaque
#9
Suping Wang, Meiyan Zhang, Zanhua Liu, Wuyang Yang, Junwei Shi, Victor Dean, Dong Chen
BACKGROUND AND AIMS: The signaling protein C/EBP homologous protein (CHOP) and corresponding growth-arrest-and-DNA-damage-inducible gene 153 (GADD153) is associated with endoplasmic reticulum stress (ERS), which can lead to apoptosis. Our study aims to elucidate the role of CHOP/GADD153 in unstable atherosclerotic (AS) plaque formation isolated from confounding factors such as diabetes mellitus, primary hyperlipidemia, autoimmune deficiencies/abnormalities, essential hypertension, chronic heart failure, chronic kidney disease, and smoking...
May 17, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28511733/similarities-and-interactions-between-the-ageing-process-and-high-chronic-intake-of-added-sugars
#10
Eva Gatineau, Sergio Polakof, Dominique Dardevet, Laurent Mosoni
In our societies, the proportions of elderly people and of obese individuals are increasing. Both factors are associated with high health-related costs. During obesity, many authors suggest that it is a high chronic intake of added sugars (HCIAS) that triggers the shift towards pathology. However, the majority of studies were performed in young subjects and only a few were interested in the interaction with the ageing process. Our purpose was to discuss the metabolic effects of HCIAS, compare with the effects of ageing, and evaluate how deleterious the combined action of HCIAS and ageing could be...
May 17, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28511369/study-of-nitrosative-stress-in-pregnancy-induced-hypertension
#11
Kapila B Gaikwad, Nitin G Joshi, Sohan P Selkar
INTRODUCTION: Hypertension is the most common medical problem encountered during pregnancy. Pregnancy Induced Hypertension (PIH) is also called a disease of maternal endothelium. Nitric-oxide being a potent vasodilator released by endothelial cells, its role has been implicated in PIH. AIM: To study the role of reactive nitrogen species in PIH. MATERIALS AND METHODS: One hundred and twenty samples were selected for the study. Of these, 60 patients had PIH (case) and the rest without PIH (control)...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509114/implicating-the-potential-role-of-orexin-in-hypertension
#12
REVIEW
Monika Rani, Raghuvansh Kumar, Pawan Krishan
Orexins (orexin A and orexin B), neuropeptides of hypothalamic origin also known as hypocretins, have been well documented for regulating the different physiological functions including feeding, sleep wakefulness, stress, and reward. However, from the past few years, orexins have evolved as an emerging biomarker for various endocrine disorders including diabetes mellitus and obesity which ultimately leads to various cardiovascular risk factors. Orexins exist in two isoforms orexin A and orexin B and exert their effect by acting on the G protein-coupled receptors orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R)...
May 16, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28505062/relationships-between-depression-and-anxiety-symptoms-scores-and-blood-pressure-in-young-adults
#13
Sunil K Bhat, Lawrence J Beilin, Monique Robinson, Sally Burrows, Trevor A Mori
BACKGROUND: Depression and anxiety are risk factors for cardiovascular disease, but their relationship to blood pressure (BP) is less clear. Age-related comorbidity and lifestyle factors may confound these relationships. This study aimed to assess the relationships among BP, depression and anxiety symptom scores and self-reported history of depression in young adults. METHOD: Data on 1014 participants aged 20 years from the Western Australian Cohort (Raine) Study were analyzed for cross-sectional associations between clinic BP and Depression, Anxiety, Stress Scale questionnaire scores or a reported history of depression, accounting for relevant confounders...
May 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28500591/a-brief-introduction-into-the-renin-angiotensin-aldosterone-system-new-and-old-techniques
#14
Sean E Thatcher
The renin-angiotensin-aldosterone system (RAAS) is a complex system of enzymes, receptors, and peptides that help to control blood pressure and fluid homeostasis. Techniques in studying the RAAS can be difficult due to such factors as peptide/enzyme stability and receptor localization. This paper gives a brief account of the different components of the RAAS and current methods in measuring each component. There is also a discussion of different methods in measuring stem and immune cells by flow cytometry, hypertension, atherosclerosis, oxidative stress, energy balance, and other RAAS-activated phenotypes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28496494/effect-of-inhalation-of-lavender-essential-oil-on-vital-signs-in-open-heart-surgery-icu
#15
Armaiti Salamati, Soheyla Mashouf, Faraz Mojab
This study evaluated the effects of inhalation of Lavender essential oil on vital signs in open heart surgery ICU. The main complaint of patients after open-heart surgery is dysrhythmia, tachycardia, and hypertension due to stress and pain. Due to the side effects of chemical drugs, such as opioids, use of non-invasive methods such as aromatherapy for relieving stress and pain parallel to chemical agents could be an important way to decrease the dose and side effects of analgesics. In a multicenter, single-blind trial, 40 patients who had open-heart surgery were recruited...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28495910/oxidative-imbalance-and-kidney-damage-in-spontaneously-hypertensive-rats-activation-of-extrinsic-apoptotic-pathway
#16
Daniele La Russa, Elvira Brunelli, Daniela Pellegrino
In both humans and animals, essential hypertension acts as a risk factor for subclinical kidney damage and precedes renal dysfunction. Several lines of evidence indicate that hypertension and oxidative stress are closely related. The increase in vascular oxidative stress plays a key role in the pathophysiological consequences of hypertension, including kidney disease. Our study examined this issue in SHR, a reliable model of essential hypertension. We used SHR 20 weeks-old when hypertension is stably developed, vascular remodeling started, but kidney function is preserved...
May 11, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28494104/prevalence-of-metabolic-syndrome-and-its-association-with-lifestyle-and-cardiovascular-biomarkers-among-postmenopausal-women-in-western-algeria
#17
Ali Khalfa, Amina Tiali, Lakhdar Zemour, Azzedine Fatah, Khedidja Mekki
OBJECTIVE: To evaluate the prevalence of metabolic syndrome (MetS), its components, and their relationship with lifestyle, inflammation, and oxidative stress among postmenopausal Algerian women. METHODS: A prospective cross-sectional survey was conducted among postmenopausal women at a clinic in Oran, Algeria, from March 1 to June 28, 2015. A diagnosis of MetS was made using the National Cholesterol Education Program Adult Treatment Panel III guidelines. Demographic, clinical, metabolic, inflammatory, dietary, and energy variables were assessed...
May 11, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28493736/promoting-mental-health-recovery-and-improving-clinical-assessment-using-video-technology
#18
Daniel W Bradford, Gary Cuddeback, Eric B Elbogen
TOPIC: Although individuals with medical problems (e.g., diabetes, hypertension) can monitor their symptoms using objective measures (e.g., blood glucose, blood pressure), objective measures are not typically used by individuals with psychotic disorders to monitor symptoms of mental illness. PURPOSE: To examine the benefits and limitations of the use of video self-observation for treatment of individuals with psychotic disorders. SOURCES USED: The authors reviewed studies examining video self-observation among individuals with severe mental illnesses...
May 11, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28492872/urinary-isoprostane-levels-and-age-related-macular-degeneration
#19
Charumathi Sabanayagam, Weng Kit Lye, Andrzej Januszewski, Riswana Banu Binte Mohammed Abdul, Gemmy Chui Ming Cheung, Neelam Kumari, Tien Y Wong, Ching-Yu Cheng, Ecosse Lamoureux
Purpose: Oxidative stress, characterized by an excessive production of reactive oxygen intermediates has been suggested to play a role in the pathogenesis of age-related macular degeneration (AMD). We examined the association of urinary F2-isoprostanes (F2-IsoPs), a marker of lipid peroxidation and the most reliable marker of oxidative damage with AMD. Methods: We included 238 adults with AMD and 390 age- and sex-matched controls without AMD who participated in a population-based cross-sectional study in Singapore (Singapore Chinese Eye Study, 2009-2011)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28491105/the-impacts-of-chrysanthemum-indicum-extract-on-oxidative-stress-and-inflammatory-responses-in-adjuvant-induced-arthritic-rats
#20
Mei Dong, Dongsheng Yu, Naif Abdullah Al-Dhabi, Veeramuthu Duraipandiyan
Chrysanthemum indicum has been used as a therapeutic agent against inflammation, hypertension, and respiratory conditions for many years. This research's aim has been to examine the antioxidant impacts that Chrysanthemum indicum extract (CIE) has on the oxidative stress and inflammatory responses in adjuvant-induced arthritic (AA) rats. 40 rats were categorised into 4 groups according to a completely randomized approach: Group I involved normal control rats (CTRL) that received a basal diet; Group II involved arthritic control rats (CTRL-AA) that received the same diet; Group III involved rats that received a basal diet and 30 mg/kg CIE; and Group IV involved arthritic rats with the same diet as Group III rats (CIE-AA)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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