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https://www.readbyqxmd.com/read/29929989/intestinal-mineralocorticoid-receptor-contributes-to-epithelial-sodium-channel-mediated-intestinal-sodium-absorption-and-blood-pressure-regulation
#1
Toshifumi Nakamura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Yuko Mitsuishi, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Yukiko Minami, Hirotaka Shibata, Hiroshi Itoh
BACKGROUND: Mineralocorticoid receptor (MR) has pathological roles in various cell types, including renal tubule cells, myocytes, and smooth muscle cells; however, the role of MR in intestinal epithelial cells (IECs) has not been sufficiently evaluated. The intestine is the sensing organ of ingested sodium; accordingly, intestinal MR is expected to have essential roles in blood pressure (BP) regulation. METHODS AND RESULTS: We generated IEC-specific MR knockout (IEC-MR-KO) mice...
June 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29924288/dietary-intake-of-non-dialysis-chronic-kidney-disease-patients-the-progredir-study-a-cross-sectional-study
#2
Alisson Diego Machado, Fernanda Silva Nogueira Dos Anjos, Maria Alice Muniz Domingos, Maria Del Carmen Bisi Molina, Dirce Maria Lobo Marchioni, Isabela Judith Martins Benseñor, Silvia Maria de Oliveira Titan
BACKGROUND: Despite evidence that diet is very important in relation to chronic kidney disease (CKD) progression, studies in this field are scarce and have focused only on some specific nutrients. We evaluated the energy, macronutrient and micronutrient intakes and dietary patterns of non-dialysis CKD participants in the PROGREDIR study. DESIGN AND SETTING: Cross-sectional study; CKD cohort, São Paulo, Brazil. METHODS: Baseline data on 454 participants in the PROGREDIR study were analyzed...
June 18, 2018: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29924275/-prevalence-of-risk-factors-for-metabolic-syndrome-and-its-components-in-community-kitchen-users-in-a-district-in-lima-peru
#3
Karen J Adams, Jesús L Chirinos
OBJECTIVES: . To estimate the prevalence of risk factors for metabolic syndrome in adults who are community kitchen-users in a district in Lima. MATERIALS AND METHODS: . An observational, cross-sectional study was carried out with 20 to 59-year-old users of community kitchens selected from a two-stage cluster sampling. The metabolic syndrome was measured according to the International Diabetes Federation (IDF). Risk factors proposed by the WHO and the IDF were assessed, as well as the diet needs and intake average and its components at lunch...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29917038/serum-untargeted-metabolomic-profile-of-the-dietary-approaches-to-stop-hypertension-dash-dietary-pattern
#4
Casey M Rebholz, Alice H Lichtenstein, Zihe Zheng, Lawrence J Appel, Josef Coresh
Background: The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is recommended for cardiovascular disease risk reduction. Assessment of dietary intake has been limited to subjective measures and a few biomarkers from 24-h urine collections. Objective: The aim of the study was to use metabolomics to identify serum compounds that are associated with adherence to the DASH dietary pattern. Design: We conducted untargeted metabolomic profiling in serum specimens collected at the end of 8 wk following the DASH diet (n = 110), the fruit and vegetables diet (n = 111), or a control diet (n = 108) in a multicenter, randomized clinical feeding study (n = 329)...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29916993/effects-of-dual-angiotensin-type-1-receptor-neprilysin-inhibition-vs-angiotensin-type-1-receptor-inhibition-on-target-organ-injury-in-the-stroke-prone-spontaneously-hypertensive-rat
#5
Speranza Rubattu, Maria Cotugno, Maurizio Forte, Rosita Stanzione, Franca Bianchi, Michele Madonna, Simona Marchitti, Massimo Volpe
OBJECTIVES: The combination of AT1 blocker/neutroendopeptidase neprilysin inhibition (ARNi) represents an interesting approach to reduce cardiovascular risk in hypertension. We assessed the efficacy of ARNi, compared with angiotensin II type 1 receptor blockade alone, on blood pressure (BP) and on protection from target organ damage development in the stroke-prone spontaneously hypertensive rat (SHRSP). METHODS: In high-salt fed SHRSP, we assessed plasma and tissue natriuretic peptides, urinary volume, BP and body weight over a short-term treatment (6 weeks) with either ARNi (sacubitril/valsartan 68 mg/kg per day) or valsartan (30 mg/kg per day), protection from stroke and renal damage (as documented by proteinuria) over 4 months of treatment with either sacubitril/valsartan or valsartan; the ability of either treatment to reduce progression of cerebrovascular and renal damage after 2 weeks of high-salt diet...
June 18, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29912268/diet-quality-indices-and-leukocyte-telomere-length-among-healthy-us-adults-data-from-the-national-health-and-nutrition-examination-surveys-nhanes-1999-2002
#6
Cindy W Leung, Teresa T Fung, Claire T McEvoy, Jue Lin, Elissa S Epel
Aging is the biggest risk factor for the development of chronic diseases. Telomere length may represent one important mechanism by which dietary intake influences age-related diseases; however, it is unknown which diet pattern is most strongly related to telomere length. We compared the relations between four evidence-based diet quality indices and leukocyte telomere length in a nationally representative sample of healthy adults, and the extent to which these associations differ between men and women. Data came from 4,758 adults, aged 20-65 years, with no prior diagnosis of major chronic disease, from the 1999-2002 National Health and Nutrition Examination Surveys (NHANES)...
June 15, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29909933/community-pharmacist-led-employer-based-wellness-services-a-pilot-study
#7
Justin Gatwood, Rhonda Hanley, Joe S Moore, Kenneth Hohmeier
The emphasis that United States employers are placing on employee wellness continues to grow; however, most attention has been paid to larger firms to gauge return-on-investment from a larger pool of enrollees. With fewer resources available to fund expansive wellness programs, smaller businesses need a cost-effective mechanism to provide such benefits. As the most accessible healthcare provider, community pharmacists are in an ideal position to support certain wellness programs for smaller businesses. This research piloted a community pharmacist-led, employer-sponsored wellness program for a self-insured financial services company in Tennessee...
June 12, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29909161/-host-microbiota-crosstalk-and-cardiovascular-diseases
#8
Jacques Amar
When analyzing the microbiota-host crosstalk, we have to consider three participants in this dialogue: the gut microbiota, the intestinal barrier and bacterial translocation. Experimental data demonstrate that host microbiota crosstalk plays a causal on the regulation of blood pressure, glucose metabolism and the development of atherosclerosis. Host microbiota crosstalk is associated in humans with main cardiovascular risk factors notably hypertension and type 2 diabetes. Host microbiota crosstalk is associated in humans with the onset of cardiovascular diseases...
June 13, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29909116/altered-microrna-regulation-of-short-chain-fatty-acid-receptors-in-the-hypertensive-kidney-is-normalized-with-hydrogen-sulfide-supplementation
#9
Gregory J Weber, Jaleyea Foster, Sathnur B Pushpakumar, Utpal Sen
Hypertension affects nearly one third of the adult US population and is a significant risk factor for chronic kidney disease (CKD). An expanding body of recent studies indicates that gut microbiome has crucial roles in regulating physiological processes through, among other mechanisms, one mode of short chain fatty acids (SCFA) and their target receptors. In addition, these SCFA receptors are potential targets of regulation by host miRNAs, however, the mechanisms through which this occurs is not clearly defined...
June 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29907155/green-leafy-vegetables-in-diets-with-a-25-1-omega-6-omega-3-fatty-acid-ratio-modify-the-erythrocyte-fatty-acid-profile-of-spontaneously-hypertensive-rats
#10
Melissa Johnson, Ralphenia D Pace, Wendell H McElhenney
BACKGROUND: In addition to the actual composition of the diet (i.e. nutrient composition, food groups), the omega-6/omega-3 fatty acid ratio has been demonstrated to influence the tissue fatty acid profile and subsequently the risk for cardiovascular and other diseases. Likewise, the consumption of green leafy vegetables (GLVs) may favorably reduce the risks associated with disease. Although an ~ 3:1 omega-6/omega-3 fatty acid ratio (ω-6/ω-3 FAR) is recommended, the typical American diet has an ~ 25:1 ω-6/ω-3 FAR...
June 15, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29903846/dietary-patterns-over-time-and-microalbuminuria-in-youth-and-young-adults-with-type-1-diabetes-the-search-nutrition-ancillary-study
#11
Tina Costacou, Jamie Crandell, Anna R Kahkoska, Angela D Liese, Dana Dabelea, Jean M Lawrence, David J Pettitt, Kristi Reynolds, Elizabeth J Mayer-Davis, Amy K Mottl
OBJECTIVE: We assessed the association between diet quality and microalbuminuria in youth-onset type 1 diabetes using three indices: a modified Mediterranean diet score for children and adolescents (mKIDMED), the Dietary Approaches to Stop Hypertension (DASH), and the Healthy Eating Index-2010 (HEI). RESEARCH DESIGN AND METHODS: Youth and young adults from the SEARCH (Search for Diabetes in Youth) Nutrition Ancillary Study diagnosed with type 1 diabetes in 2002-2008, who had repeated dietary assessments at baseline and follow-up visits and urine albumin-to-creatinine ratio (UACR) measured at the outcome visit (2012-2015) ( n = 461), were selected for study...
June 14, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29903789/prevalence-and-clustering-of-cardiovascular-risk-factors-a-cross-sectional-survey-among-nanjing-adults-in-china
#12
Xin Hong, Qing Ye, Jing He, Zhiyong Wang, Huafeng Yang, Shengxiang Qi, Xupeng Chen, Chenchen Wang, Hairong Zhou, Chao Li, Zhenzhen Qin, Fei Xu
OBJECTIVES: To estimate prevalence and clustering of cardiovascular risk factors (CRFs), and investigate the association between relevant characteristics and CRF clustering among adults in eastern China. DESIGN: Community-based cross-sectional study. SETTING: Data were collected by interview survey, physical measurements and laboratory examinations from the 2011 Nanjing Chronic Disease and Risk Factor Surveillance. PARTICIPANTS: A representative sample of 41 072 residents aged ≥18 years volunteered to participate in the survey, with a response rate of 91...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29903198/-relationships-among-long-noncoding-rna-environmental-factors-and-hypertension
#13
Rong Chen, Shiying Chen, Tingxing Zhang, Jiabing Lin, Chunyu Wan, Zhou Chen, Huangyuan Li, Yan Ding, Siying Wu
OBJECTIVE: To understand the main environmental factors of hypertension, and to explore the relationship between hypertension and leukocyte long noncoding RNA. METHODS: A case-control study was conducted in a hospital in Fuzhou City by using stratified random sampling method between Nov. 2014 and Jun. 2015 including 382 essential hypertension patients and 382 control subjects. The related surveys included questionnaire investigation, physical examination and laboratory detection...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29903193/-prevalence-and-change-of-type-2-diabetes-mellitus-among-rural-adults-in-deqing-county-zhejiang-province-in-china-during-2006-2014
#14
Xiaoying Chen, Zhaofan Wu, Xuecai Wang, Yue Chen, Xiaolian Dong, Jianfu Zhu, Tian Xiao, Qingwu Jiang, Chaowei Fu
OBJECTIVE: To describe the prevalence of type 2 diabetes mellitus( T2 DM) in rural Deqing County, Zhejiang Province, and explore its risk factors. METHODS: Random cluster sampling was used to select 8 rural communities in Deqing County, Zhejiang Province, and a cross-sectional survey was conducted in 2006-2008, 2011-2012 and 2013-2014, respectively. Totally, 6562 eligible subjects were investigated in 2006-2008, 11 763 eligible subjects in 2011-2012, and 10 904 eligible subjects in 2013-2014...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902079/hydrogen-gas-improves-left-ventricular-hypertrophy-in-dahl-rat-of-salt-sensitive-hypertension
#15
Hiroki Matsuoka, Seiko Miyata, Nozomi Okumura, Takuya Watanabe, Katsunori Hashimoto, Miki Nagahara, Kazuko Kato, Sayaka Sobue, Kozue Takeda, Masatoshi Ichihara, Takashi Iwamoto, Akiko Noda
PURPOSE: Hypertension is an important risk factor for death resulting from stroke, myocardial infarction, and end-stage renal failure. Hydrogen (H2 ) gas protects against many diseases, including ischemia-reperfusion injury and stroke. The effects of H2 on hypertension and its related left ventricular (LV) function have not been fully elucidated. The purpose of this study was to investigate the effects of H2 gas on hypertension and LV hypertrophy using echocardiography. METHODS: Dahl salt-sensitive (DS) rats were randomly divided into three groups: those fed an 8% NaCl diet until 12 weeks of age (8% NaCl group), those additionally treated with H2 gas (8% NaCl + H2 group), and control rats maintained on a diet containing 0...
June 14, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29901484/the-efficacy-of-a-comprehensive-reminder-system-to-improve-health-behaviors-and-blood-pressure-control-in-hypertensive-ischemic-stroke-patients-a-randomized-controlled-trial
#16
Li-Hong Wan, Xiao-Pei Zhang, Li-Ming You, Heng-Fang Ruan, Shao-Xian Chen
BACKGROUND AND OBJECTIVE: The health behaviors of hypertensive stroke patients in China are not satisfactory. In this study, we tested the effect of a Health Belief Model Comprehensive Reminder System on health behaviors and blood pressure control in hypertensive ischemic stroke patients after occurrence and hospital discharge. METHODS: A randomized, parallel-group, assessor-blinded experimental design yielded participation of 174 hospitalized hypertensive ischemic stroke patients...
June 12, 2018: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29899851/association-of-mrna-expression-of-iron-metabolism-associated-genes-and-progression-of-non-alcoholic-steatohepatitis-in-rats
#17
Teruhisa Higuchi, Mitsuhiko Moriyama, Akiko Fukushima, Hiroshi Matsumura, Shunichi Matsuoka, Tatsuo Kanda, Masahiko Sugitani, Akiko Tsunemi, Takahiro Ueno, Noboru Fukuda
Background: Excess iron is associated with non-alcoholic steatohepatitis (NASH). Results: mRNA expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, hepcidin, hephaestin and transferrin receptor 1 in liver were higher in high fat, high cholesterol-containing diet (HFCD) group than in normal diet (ND) group. mRNA levels of divalent metal transporter 1 and transferrin receptor 1, which stimulate iron absorption and excretion, were enhanced in small intestine...
May 25, 2018: Oncotarget
https://www.readbyqxmd.com/read/29898457/effects-of-amlodipine-on-bone-metabolism-in-orchidectomised-spontaneously-hypertensive-rats
#18
Helena Zivna, Iveta Gradošová, Pavel Zivny, Eva Cermakova, Vladimir Palicka
Spontaneously hypertensive rats (SHR) represent a model of essential hypertension. We studied the effect of amlodipine (AML) on bone markers, bone mineral density (BMD), and biomechanical properties of osteopenic bone induced by orchidectomy in male SHR. Rats were allocated to 3 groups and were sacrificed after 12 weeks: sham-operated control; orchidectomised control; and orchidectomised receiving a diet supplemented with AML. Indicators of bone turnover were assessed in bone homogenate, BMD was measured by dual energy X-ray absorptiometry, and the femurs were subjected to biomechanical testing...
June 13, 2018: Pharmacology
https://www.readbyqxmd.com/read/29897819/lesion-of-the-ovlt-markedly-attenuates-chronic-deoxycorticosterone-acetate-doca-salt-hypertension-in-the-rat
#19
John P Collister, David B Nahey, Rochelle Hartson, Charles E Wiedmeyer, Christopher T Banek, John W Osborn
Lesions of the anteroventral third ventricle (AV3V region) are known to prevent many forms of experimental hypertension, including mineralocorticoid (DOCA-salt) hypertension in the rat. However, AV3V lesions include the organum vasculosum of the lamina terminalis (OVLT), portions of the median preoptic nucleus, as well as efferent fibers from the subfornical organ (SFO), thereby limiting the ability to define the individual contribution of these structures to the prevention of experimental hypertension. Having previously reported that the SFO does not play a significant role in the development of DOCA-salt hypertension, the present study was designed to test the hypothesis that the OVLT is necessary for DOCA-salt hypertension in the rat...
June 13, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29897288/intermittent-hypoxia-exacerbates-increased-blood-pressure-in-rats-with-chronic-kidney-disease
#20
Jennifer L Riggs, Carolyn E Pace, Heather H Ward, Laura V Gonzalez Bosc, Lynnette Rios, Adleaeda Barrera, Nancy L Kanagy
Kidney injury and sleep apnea (SA) are independent risk factors for hypertension. Exposing rats to intermittent hypoxia (IH) to simulate SA increases blood pressure while adenine feeding causes persistent kidney damage to model chronic kidney disease (CKD). We hypothesized that exposing CKD rats to IH would exacerbate the development of hypertension and renal failure. Male Sprague-Dawley rats were fed a 0.2% adenine or control diet until blood urea nitrogen (BUN) was > 120 mg/dL in adenine fed rats (14 {plus minus} 4 days)...
June 13, 2018: American Journal of Physiology. Renal Physiology
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