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https://www.readbyqxmd.com/read/27911486/extended-mortality-results-for-prostate-cancer-screening-in-the-plco-trial-with-median-follow-up-of-15-years
#1
Paul F Pinsky, Philip C Prorok, Kelly Yu, Barnett S Kramer, Amanda Black, John K Gohagan, E David Crawford, Robert L Grubb, Gerald L Andriole
BACKGROUND: Two large-scale prostate cancer screening trials using prostate-specific antigen (PSA) have given conflicting results in terms of the efficacy of such screening. One of those trials, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, previously reported outcomes with 13 years of follow-up. This study presents updated findings from the PLCO trial. METHODS: The PLCO trial randomized subjects from 1993 to 2001 to an intervention or control arm...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27909906/obesity-and-prostate-cancer
#2
Yin Cao, Edward Giovannucci
Prostate cancer is a complex, heterogeneous disease. Factors related to detection, particularly PSA screening, further increase heterogeneity in the manifestation of the disease. It is thus not possible to provide a simple summary of the relationship between obesity and prostate cancer. Findings on obesity, often defined using body mass index (BMI), and total prostate cancer risk have been mixed; however, obesity is relatively consistently associated with a higher risk of aggressive prostate cancer, with aggressiveness defined in various ways (e...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27906455/insights-from-the-plco-trial-about-prostate-cancer-screening
#3
EDITORIAL
Roman Gulati, Peter C Albertsen
No abstract text is available yet for this article.
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27903809/the-bimanual-ovarian-palpation-examination-in-the-prostate-lung-colorectal-and-ovarian-cancer-screening-trial-performance-and-complications
#4
Maryam Doroudi, Barnett S Kramer, Paul F Pinsky
OBJECTIVE: To provide evidence about the performance characteristics and consequences of bimanual ovarian palpation. SETTING AND METHODS: The Prostate, Lung, Colorectal and Ovarian cancer screening trial randomized 154,900 individuals to either an intervention or control arm. Enrolled eligible participants were aged 55-74, had no history of trial cancers, and no current treatment for cancer. Intervention arm women received CA-125 tests and transvaginal ultrasound...
November 30, 2016: Journal of Medical Screening
https://www.readbyqxmd.com/read/27899381/castration-resistance-in-prostate-cancer-is-mediated-by-the-kinase-nek6
#5
Atish D Choudhury, Anna C Schinzel, Maura B Cotter, Rosina T Lis, Katherine Labella, Ying Jie Lock, Francesca Izzo, Isil Guney, Michaela Bowden, Yvonne Y Li, Jinal Patel, Emily Hartman, Steven A Carr, Monica Schenone, Jacob D Jaffe, Philip W Kantoff, Peter S Hammerman, William C Hahn
In prostate cancer, the development of castration resistance is pivotal in progression to aggressive disease. However, understanding of the pathways involved remains incomplete. In this study, we performed a high-throughput genetic screen to identify kinases that enable tumor formation by androgen-dependent prostate epithelial (LHSR-AR) cells under androgen-deprived conditions. In addition to the identification of known mediators of castration resistance, which served to validate the screen, we identified a mitotic-related serine/threonine kinase, NEK6, as a mediator of androgen-independent tumor growth...
November 29, 2016: Cancer Research
https://www.readbyqxmd.com/read/27899188/familial-prostate-cancer
#6
Veda N Giri, Jennifer L Beebe-Dimmer
Prostate cancer is the most commonly diagnosed cancer among men in the United States as well as most Western countries. A significant proportion of men report having a positive family history of prostate cancer in a first-degree relative (father, brother, son), which is important in that family history is one of the only established risk factors for the disease and plays a role in decision-making for prostate cancer screening. Familial aggregation of prostate cancer is considered a surrogate marker of genetic susceptibility to developing the disease, but shared environment cannot be excluded as an explanation for clustering of cases among family members...
October 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27897172/adaptation-and-external-validation-of-the-european-randomised-study-of-screening-for-prostate-cancer-risk-calculator-for-the-chinese-population
#7
P K Chiu, M J Roobol, D Nieboer, J Y Teoh, S K Yuen, S M Hou, M K Yiu, C F Ng
BACKGROUND: To adapt the well-performing European Randomized Study of Screening for Prostate Cancer (ERSPC) risk calculator to the Chinese setting and perform an external validation. METHODS: The original ERSPC risk calculator 3 (RC3) for prostate cancer (PCa) and high-grade PCa (HGPCa) was applied to a development cohort of 3006 previously unscreened Hong Kong Chinese men with initial transrectal biopsies performed from 1997 to 2015, age 50-80 years, PSA 0.4-50 ng ml(-1) and prostate volume 10-150 ml...
November 29, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27897049/using-text-messages-to-promote-health-in-african-americans-hearthealthyandcancerfree
#8
Allison R Jones, Debra K Moser, Jennifer Hatcher
OBJECTIVES: African-Americans are vulnerable to both cancer and cardiovascular disease (CVD) due to intricately connected risk factors. Use of text messages is an innovative method to provide health information to reduce these risks. The aim of this study was to test the feasibility and acceptability of a text messaging intervention to reduce CVD and cancer risk factors in African-Americans. DESIGN: We developed an intervention using text messages culturally tailored for African-Americans over age 50 who were at risk (one or more modifiable risk factors) for CVD and/or cancer...
November 29, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27891324/high-throughput-cell-based-compound-screen-identifies-pinosylvin-methyl-ether-and-tanshinone-iia-as-inhibitors-of-castration-resistant-prostate-cancer
#9
Kirsi Ketola, Miro Viitala, Pekka Kohonen, Vidal Fey, Zoran Culig, Olli Kallioniemi, Kristiina Iljin
Current treatment options for castration-resistant prostate cancer (CRPC) are limited. In this study, a high-throughput screen of 4910 drugs and drug-like molecules was performed to identify antiproliferative compounds in androgen ablated prostate cancer cells. The effect of compounds on cell viability was compared in androgen ablated LNCaP prostate cancer cells and in LNCaP cells grown in presence of androgens as well as in two non-malignant prostate epithelial cells (RWPE-1 and EP156T). Validation experiments of cancer specific anti-proliferative compounds indicated pinosylvin methyl ether (PSME) and tanshinone IIA as potent inhibitors of androgen ablated LNCaP cell proliferation...
March 30, 2016: Journal of Molecular Biochemistry
https://www.readbyqxmd.com/read/27889661/what-explains-the-differences-between-centres-in-the-european-screening-trial-a-simulation-study
#10
Jaakko Nevalainen, Ulf-Håkan Stenman, Teuvo L Tammela, Monique Roobol, Sigrid Carlsson, Kirsi Talala, Fritz H Schröder, Anssi Auvinen
BACKGROUND: The European Randomised study of Screening for Prostate Cancer (ERSPC) is a multicentre, randomised screening trial on men aged 55-69 years at baseline without known prostate cancer (PrCa) at randomisation to an intervention arm invited to screening or to a control arm. The ERSPC has shown a significant 21% reduction in PrCa mortality at 13 years of follow-up. The effect of screening appears to vary across centres, for which several explanations are possible. We set to assess if the apparent differences in PrCa mortality reduction between the centres can be explained by differences in screening protocols...
November 24, 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27883257/determining-the-binding-affinities-of-prostate-specific-antigen-to-lectins-spr-and-microarray-approaches
#11
Pavel Damborský, Martina Zámorová, Jaroslav Katrlík
Prostate cancer (PCa) is one of the most common newly diagnosed cancer among men and we focused on its traditional biomarker, prostate-specific antigen (PSA), using targeted glycomics-based strategies. The aberrant glycosylation pattern of PSA may serve as valuable tool for improving PCa diagnosis including its early-stage. In the present work we evaluated the usability of two techniques, surface plasmon resonance and protein microarray assay, for the study and characterization of interactions of PSA (both free and complexed) with 6 lectins (SNA, ConA, RCA, AAL, WGA and MAA II)...
November 24, 2016: Proteomics
https://www.readbyqxmd.com/read/27882638/anxiety-symptoms-prior-to-a-prostate-cancer-diagnosis-associations-with-knowledge-and-openness-to-treatment
#12
Amanda J Dillard, Laura D Scherer, Peter A Ubel, Stewart Alexander, Angela Fagerlin
AIM: Research suggests that anxiety may be a common response to a cancer diagnosis, but research is needed to examine anxiety before diagnosis. Anxiety before diagnosis may relate to the comprehension of relevant health information or openness to potential treatments. This study examined anxiety and these outcomes in men who were waiting to learn of a prostate cancer diagnosis. OBJECTIVES: One goal of this study was to determine whether anxiety would increase as men came closer to learning the results of their prostate cancer biopsy...
November 24, 2016: British Journal of Health Psychology
https://www.readbyqxmd.com/read/27878855/the-personal-cancer-screening-behaviours-of-nurses-and-midwives
#13
Rachel Nicholls, Lin Perry, Robyn Gallagher, Christine Duffield, David Sibbritt, Xiaoyue Xu
AIM: To identify the personal cancer screening behaviours of nurses and midwives in New South Wales, Australia, and identify factors predictive of cancer screening uptake. BACKGROUND: The nursing workforce may have a higher risk for some cancers and is ageing. In Australia, more than 40 percent are over 50 years - an age where cancer incidence rises rapidly, but when screening may reduce cancer mortality. Nurses and midwives are important health role models for the population, but their engagement in cancer screening is unknown...
November 23, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27874064/prostate-cancer-screening-and-treatment-where-do-we-go-from-here
#14
Fred Saad
No abstract text is available yet for this article.
November 22, 2016: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/27873211/screening-mammalian-cells-on-a-hydrogel-functionalized-small-molecule-microarray
#15
Biwei Zhu, Bo Jiang, Zhenkun Na, Shao Q Yao
Mammalian cell-based microarray technology has gained wide attention, for its plethora of promising applications. The platform is able to provide simultaneous information on multiple parameters for a given target, or even multiple target proteins, in a complex biological system. Here we describe the preparation of mammalian cell-based microarrays using selectively captured of human prostate cancer cells (PC-3). This platform was then used in controlled drug release and measuring the associated drug effects on these cancer cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27867909/prostate-cancer-screening-a-brief-tool-to-incorporate-patient-preferences-in-a-clinical-encounter
#16
Anita D Misra-Hebert, Michael W Kattan
No abstract text is available yet for this article.
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27865297/cancer-screening-2016
#17
REVIEW
S Calvin Thigpen, Stephen A Geraci
The primary goal of cancer screening is to reduce cancer-related mortality without incurring significant harm. Screening efforts for solid tumors, therefore, have targeted the precursors of the most common and the most deadly cancers-breast, cervical, colorectal, lung and prostate cancer. Balancing risk and benefit has led to controversy regarding the timing of cancer screening-when to begin, how often to screen and when to stop-and the nature of the modality of cancer screening-invasive or noninvasive, laboratory-centered or imaging-centered...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27865106/high-speed-biosensing-strategy-for-non-invasive-profiling-of-multiple-cancer-fusion-genes-in-urine
#18
Kevin M Koo, Eugene J H Wee, Matt Trau
Aberrant chromosal rearrangements, such as the multiple variants of TMPRSS2:ERG fusion gene mutations in prostate cancer (PCa), are promising diagnostic and prognostic biomarkers due to their specific expression in cancerous tissue only. Additionally, TMPRSS2:ERG variants are detectable in urine to provide non-invasive PCa diagnostic sampling as an attractive surrogate for needle biopsies. Therefore, rapid and simplistic assays for identifying multiple urinary TMPRSS2:ERG variants are potentially useful to aid in early cancer detection, immediate patient risk stratification, and prompt personalized treatment...
November 12, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27864809/determinants-of-prostate-cancer-screening-intentions-of-young-black-men-aged-18-to-40%C3%A2-years
#19
Motolani E Ogunsanya, Carolyn M Brown, Folakemi T Odedina, Jamie C Barner, Taiwo Adedipe
INTRODUCTION: Black men are more likely to be diagnosed with prostate cancer, with higher stage and higher grade at presentation. Evidence suggests that for education in health promotion behaviors (such as screenings) in early adult years, young Black men can be better equipped to make informed decisions in later years. OBJECTIVE: Using the theory of reasoned action (TRA), we assessed the intention of young Black men to screen for prostate cancer when it is recommended and determined its correlates...
November 18, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27864107/should-hypoechoic-lesions-on-trus-be-sampled-during-mri-targeted-prostate-biopsy
#20
Nabeel A Shakir, M Minhaj Siddiqui, Arvin K George, Michael Kongnyuy, Richard Ho, Michele Fascelli, Maria J Merino, Baris Turkbey, Peter L Choyke, Bradford J Wood, Peter A Pinto
OBJECTIVES: To determine whether supplemental biopsy of hypoechoic ultrasound lesions (HUL) incidentally found during MRI-transrectal ultrasound (TRUS) fusion-targeted prostate biopsy results in improved prostate cancer (PCa) detection. METHODS: Patients underwent MRI-TRUS targeted biopsy as part of an ongoing prospective trial from August 2007 to February 2015. For men with HUL, the biopsy pathology of HUL and MRI lesions was classified according to the updated 2014 International Society of Urological Pathology (ISUP) grading system...
November 15, 2016: Urology
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