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https://www.readbyqxmd.com/read/28749629/knowledge-attitudes-and-perceptions-of-prostate-cancer-among-male-staff-of-the-university-of-nigeria
#1
Maxwell Ogochukwu Adibe, Deborah Oyine Aluh, Abdulmuminu Isah, Chibueze Anosike
Prostate cancer is the number one cancer in males in Africa, both in terms of incidence and mortality, accounting for 40,000 (13%) male cancers and 28,000 (11.3%) male cancer-associated deaths. In the developed world, the probability of being diagnosed with cancer is more than twice as high as in developing countries. In developing countries, most cancer victims are diagnosed at late stage, with incurable tumors, pointing to the need for education schemes and better detection programs. This study assessed knowledge, attitudes and perceptions of prostate cancer among male staff of the University of Nigeria...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28747566/pten-loss-detection-in-prostate-cancer-comparison-of-pten-immunohistochemistry-and-pten-fish-in-a-large-retrospective-prostatectomy-cohort
#2
Tamara L Lotan, Asmus Heumann, Sebastian Dwertmann Rico, Jessica Hicks, Kristen Lecksell, Christina Koop, Guido Sauter, Thorsten Schlomm, Ronald Simon
PTEN deletion is an established prognostic biomarker in prostate cancer. We compared PTEN immunohistochemistry (IHC) and PTEN fluorescence in situ hybridization (FISH) in the largest existing radical prostatectomy cohort with clinical follow-up data. There was high concordance between IHC and FISH: 93% (3098/3330) of tumors with intact PTEN IHC showed absence of PTEN gene deletion and 66% (720/1087) of cases with PTEN protein loss by IHC showed PTEN gene deletion by FISH. 84% (447/533) of cases with PTEN homozygous gene deletion had PTEN protein loss by IHC...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747187/general-practitioners-views-and-preferences-about-quality-improvement-feedback-in-preventive-care-a-cross-sectional-study-in-switzerland-and-france
#3
Paul Sebo, Hubert Maisonneuve, Jean-Pascal Fournier, Nicolas Senn, Dagmar M Haller
BACKGROUND: Feedback is widely used as a strategy to improve the quality of care in primary care settings. As part of a study conducted to explore the quality of preventive care, we investigated general practitioners' (GPs) views on the usefulness of feedback and their preferences regarding how feedback is provided. METHODS: This cross-sectional study was conducted in 2015 among randomly selected community-based GPs in two regions of Switzerland and France. GPs were asked to complete an anonymous questionnaire about how often they provided 12 measures of preventive care: blood pressure, weight and height measurements, screening for dyslipidemia, at-risk drinking (and advice to reduce for at-risk drinkers), smoking (and advice to stop for smokers), colon and prostate cancer, and influenza immunization for patients >65 years and at-risk patients...
July 26, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28742796/leukocyte-telomere-length-and-renal-cell-carcinoma-survival-in-two-studies
#4
Catherine L Callahan, Kendra Schwartz, Julie J Ruterbusch, Brian Shuch, Barry I Graubard, Qing Lan, Richard Cawthon, Andrea A Baccarelli, Wong-Ho Chow, Nathaniel Rothman, Jonathan N Hofmann, Mark P Purdue
BACKGROUND: Leukocyte telomere length (LTL) is a potential biomarker of cancer prognosis; however, evidence for renal cell carcinoma (RCC) is inconsistent. METHODS: We investigated LTL and RCC-specific survival among 684 cases from the US kidney cancer study (USKC) and 241 cases from the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO). Leukocyte telomere length was measured by quantitative polymerase chain reaction, and hazard ratios (HRs) and 95% confidence intervals (CIs) computed using multivariable Cox models...
July 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28742748/beyond-the-psa-test-how-to-better-stratify-a-patient-s-risk-of-prostate-cancer
#5
Ryan Lewis, Brad Hornberger
The primary method of screening for and detecting prostate cancer is the prostate-specific antigen (PSA) test. Although this test is very prostate-specific, it is not cancer-specific; conditions other than prostate cancer can cause an elevated PSA. Many efforts have been made to discover more specific tests and methods beyond the PSA. This article describes several literature-supported tests and methods to better stratify a man's risk of having prostate cancer.
August 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28739723/immortalized-cancer-associated-fibroblasts-promote-prostate-cancer-carcinogenesis-proliferation-and-invasion
#6
Shengqiang Yu, Yingjuan Jiang, Fengchun Wan, Jitao Wu, Zhenli Gao, Dongfu Liu
BACKGROUND: Cancer-associated fibroblasts (CAFs) are dominant components of the prostate cancer (PCa) stroma. However, the contrasting effects of CAFs and adjacent normal prostate fibroblasts (NPFs) are still poorly defined. The senescence of non-immortalized CAFs after subculture may limit the cell number and influence experimental results of in vitro studies. In this study, we immortalized CAFs to study their role in PCa carcinogenesis, proliferation, and invasion. MATERIALS AND METHODS: We cultured and immortalized CAFs and NPFs, then compared their effect on epithelial malignant transformation by using in vitro co-culture, soft agar assay, and a mouse renal capsule xenograft model...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739176/digital-rectal-examination-for-prostate-cancer-screening-performed-with-colonoscopy-for-colon-cancer-screening-two-for-the-price-of-one
#7
John C Fang, Gary Faerber, Jewel Samadder
No abstract text is available yet for this article.
July 21, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28736250/change-in-prostate-cancer-presentation-coinciding-with-uspstf-screening-recommendations-at-a-community-based-urology-practice
#8
Franklin D Gaylis, Jae E Choi, Zachary Hamilton, Paul Dato, Edward Cohen, Renee Calabrese, Hilary Prime, Aaron Rosenbaum, Andrew Karim Kader
OBJECTIVE: The benefits of prostate-specific antigen (PSA)-based prostate cancer screening are controversial. We sought to determine the change in prostate cancer presentation coinciding with the release of the United States Preventative Services Task Force recommendations against screening in a high-volume community-based urology practice. METHODS: Characteristics of men presenting for an elevated PSA at a community urology practice from August 2011 to August 2015 were queried from a prospectively collected database...
July 20, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28734085/novel-menadione-hybrids-synthesis-anticancer-activity-and-cell-based-studies
#9
Chakka Vara Prasad, Vadithe Lakshma Nayak, Sistla Ramakrishna, Uppuluri Venkata Mallavadhani
A series of novel menadione based triazole hybrids were designed and synthesized by employing copper catalyzed azide-alkyne cycloaddition (CuAAC). All the synthesized hybrids were characterized by their spectral data ((1) H NMR, (13) C NMR, IR and HRMS). The synthesized compounds were evaluated for their anticancer activity against five selected cancer cell lines including lung (A549), prostate (DU-145), cervical (Hela), breast (MCF-7) and mouse melanoma (B-16) by using MTT assay. The screening results showed that majority of the synthesized compounds displayed significant anticancer activity...
July 22, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28731949/cancer-screening-in-the-elderly-a-review-of-breast-colorectal-lung-and-prostate-cancer-screening
#10
Ashwin A Kotwal, Mara A Schonberg
There are relatively limited data on outcomes of screening older adults for cancer; therefore, the decision to screen older adults requires balancing the potential harms of screening and follow-up diagnostic tests with the possibility of benefit. Harms of screening can be amplified in older and frail adults and include discomfort from undergoing the test itself, anxiety, potential complications from diagnostic procedures resulting from a false-positive test, false reassurance from a false-negative test, and overdiagnosis of tumors that are of no threat and may result in overtreatment...
July 2017: Cancer Journal
https://www.readbyqxmd.com/read/28731947/early-stage-cancer-in-older-adults-prostate-avoiding-overtreatment-and-undertreatment
#11
Vikram Narayan, Song Jiang, Christopher A Warlick
The diagnosis of prostate cancer in elderly men is likely to increase over the next several decades, owing to changing demographics and a rising population of men older than 65 years. Given the heterogeneity and well-documented challenges in screening, diagnosing, and managing indolent versus aggressive prostate cancer, the geriatric patient population is particularly vulnerable to prostate cancer treatment nuances. Clinicians must become familiar with geriatric assessment tools to better answer life-expectancy questions prior to counseling patients on treatment options...
July 2017: Cancer Journal
https://www.readbyqxmd.com/read/28728212/men-s-information-seeking-behaviour-regarding-cancer-risk-and-screening-a-meta-narrative-systematic-review
#12
REVIEW
Mohamad M Saab, Mary Reidy, Josephine Hegarty, Mairin O'Mahony, Mike Murphy, Christian Von Wagner, Frances J Drummond
OBJECTIVE: Preventive strategies are known to reduce cancer risk and incidence and improve prognosis. Men seldom seek medical information about cancer prevention and risk reduction. The aim of this meta-narrative systematic review was to critically appraise evidence from qualitative, quantitative, and mixed-methods studies that explored men's information-seeking behaviours in relation to cancer prevention and risk reduction. METHODS: MEDLINE, CINAHL Plus with Full Text, PsycINFO, PsycARTICLES, Psychology and Behavioral Sciences Collection, Education Full Text, and ERIC were systematically searched for studies published in English between January 1(st) 2006 and May 30(th) 2016...
July 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28725588/role-of-mpmri-of-the-prostate-in-screening-for-prostate-cancer
#13
REVIEW
Christopher J D Wallis, Masoom A Haider, Robert K Nam
Prostate cancer screening offers the opportunity to significantly reduce morbidity and mortality from this disease. Currently, serum prostate-specific antigen (PSA) testing is the most widely used screening modality. However, PSA testing continues to have low positive and negative predictive value leading to unnecessary invasive prostate biopsy while missing patients with aggressive forms of the disease. Magnetic resonance imaging (MRI) has been gaining an increasingly large role in the management of patients with early stage prostate cancer including diagnosis in patients with abnormal PSA levels, monitoring of patients on active surveillance, and staging prior to definitive interventions...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725580/pre-biopsy-mri-as-an-adjunct-for-cancer-detection-in-men-with-elevated-psa-and-no-previous-biopsy
#14
REVIEW
Facundo Uriburu-Pizarro, Veeru Kasivisvanathan, Philippe Puech, Arnauld Villers
The role of magnetic resonance imaging (MRI) prior to biopsy in the diagnosis of prostate cancer in biopsy-naïve patients has been strengthened by recent developments such as the PIRADS V2 criteria, which cover acquisition, interpretation, and reporting for clinical practice and data collection for research. Important questions on the role of prostate MRI remain: can MRI be used as a triage test before first biopsy series? Can it be used to avoid the use of systematic biopsies (SB) and instead use only targeted biopsies (TB) to MRI-suspicious lesions? Studies to evaluate image guided TB compared to SB have started to accumulate...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725579/multiparametric-magnetic-resonance-imaging-of-the-prostate-a-basic-tutorial
#15
REVIEW
Miguel C Cabarrus, Antonio C Westphalen
Prostate cancer is the second most common cause of cancer related death in the United States and the most commonly diagnosed malignancy in men. In general, prostate cancer is slow growing, though there is a broad spectrum of disease that may be indolent, or aggressive and rapidly progressive. Screening for prostate is controversial and complicated by lack of specificity and over diagnosis of clinically insignificant cancer. Imaging has played a role in diagnosis of prostate cancer, primarily through systemic transrectal ultrasound (TRUS) guided biopsy...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725576/cost-consideration-in-utilization-of-multiparametric-magnetic-resonance-imaging-in-prostate-cancer
#16
REVIEW
Ryan Hutchinson, Yair Lotan
The screening, evaluation and management of prostate cancer changed significantly in the last decade. The recommendations regarding prostate cancer screening continue to evolve with new revelations about existing data sets and longer followup of landmark trials. Robotics has gained the vast majority of the marketplace for surgically managed prostate cancer in rapid fashion. The need for intervention in low risk prostate cancer has been closely examined and more men are being expectantly managed than ever before...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725242/focal-application-of-low-dose-rate-brachytherapy-for-prostate-cancer-a-pilot-study
#17
S Sara Mahdavi, Ingrid T Spadinger, Septimiu E Salcudean, Piotr Kozlowski, Silvia D Chang, Tony Ng, Julio Lobo, Guy Nir, Hamid Moradi, Michael Peacock, W James Morris
PURPOSE: To evaluate the feasibility and to report the early outcomes of focal treatment of prostate cancer using low-dose-rate brachytherapy (LDR-PB). MATERIAL AND METHODS: Seventeen patients were screened with multi-parametric magnetic resonance imaging (mpMRI), 14 of whom proceeded to receive trans-perineal template mapping biopsy (TTMB). Focal LDR-PB was performed on five eligible patients using dual air kerma strength treatment plans based on planning target volumes derived from cancer locations and determined by TTMB...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28721280/increasing-detection-of-significant-prostate-cancer-in-younger-men-ten-year-trends-in-prostate-cancer-risk-profile-in-the-mid-west-of-ireland
#18
Nikita R Bhatt, Tetyana Kelly, Kasia Domanska, Colette Fogarty, Garrett Durkan, Hugh D Flood, Subhasis K Giri
INTRODUCTION: Although PSA (prostate specific antigen) based screening for prostate cancer (PCa) is controversial, an increasing number of men are undergoing Transrectal Ultrasound Guided prostate biopsy (TRUSPB) through primary care-based PSA testing and referral to hospitals. The aim of our study was to investigate presenting risk profiles of PCa over the last decade in a cohort of men in Ireland and to examine any change in the same over this time period. MATERIAL AND METHODS: The hospital patient administration system was analysed for patients who underwent TRUSPB from January 2005 to December 2015...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28717736/cardiovascular-disease-risk-factors-how-relevant-in-african-men-with-prostate-cancer-receiving-androgen-deprivation-therapy
#19
Okon Ekwere Essien, Iya Eze Bassey, Rebecca Mtaku Gali, Alphonsus Ekpe Udoh, Uwem Okon Akpan, Enakirerhi E Glen
PURPOSE: Cardiovascular disease risk factors have been associated with androgen-deprivation therapy (ADT) in white and Hispanic populations. It is therefore relevant to determine if there exists a relationship between these parameters in the African population. PATIENTS AND METHODS: The design of the study was cross sectional. Prostate-specific antigen concentration, waist circumference, body mass index (BMI), lipid profile, glucose level, and insulin level were determined in 153 patients with prostate cancer and 80 controls...
February 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28716650/the-use-of-prostate-specific-antigen-screening-in-purchased-versus-direct-care-settings-data-from-the-tricare-military-database
#20
Alexander P Cole, Wei Jiang, Stuart R Lipsitz, Peter A Learn, Maxine Sun, Toni K Choueiri, Paul L Nguyen, Adam S Kibel, Mani Menon, Jesse D Sammon, Tracey Koehlmoos, Adil Haider, Quoc-Dien Trinh
PURPOSE: Fee for service (FFS) reimbursement incentives may affect care. We sought to compare odds of PSA screening among former and active duty United States (US) military service members based on receipt of primary care from integrated military health facilities versus community providers reimbursed via FFS. MATERIALS AND METHODS: We performed a retrospective study of all active duty and retired male service members (40-64) covered by the TRICARE military health benefit in 2010...
July 14, 2017: Journal of Urology
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