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bechet's disease

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https://www.readbyqxmd.com/read/29719359/-neuro-psycho-bs-a-case-report-of-rare-association-with-bipolar-disorder
#1
Mustafa Ali, Soumitra DAS
Bechet's Disease is an inflammatory disease characterized by recurrent oral ulcers (OU), genital ulcers (GU) and uveitis which can develop a neurobehavioral syndrome, also defined as 'neuro-psycho- BS'. Depending on vascular or parenchymal lesions, the presentations could be varied. Due to sparse literature, there is no consensus on management of psychiatric illness comorbid with Bechet's disease. Bipolar disorder in Bechet's disease is extremely rare. Here, we are presenting a case of episodic exaggeration of Bipolar disorder along with Bechet's disease which imposed both clinical and management challenges...
February 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29370234/febrile-urinary-tract-infection-due-to-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-children-a-french-prospective-multicenter-study
#2
MULTICENTER STUDY
Fouad Madhi, Camille Jung, Sandra Timsit, Corinne Levy, Sandra Biscardi, Mathie Lorrot, Emmanuel Grimprel, Laure Hees, Irina Craiu, Aurelien Galerne, François Dubos, Emmanuel Cixous, Véronique Hentgen, Stéphane Béchet, Stéphane Bonacorsi, Robert Cohen
OBJECTIVES: To assess the management of febrile urinary-tract infection (FUTIs) due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) in children, the Pediatric Infectious Diseases Group of the French Pediatric Society set up an active surveillance network in pediatric centers across France in 2014. MATERIALS AND METHODS: We prospectively analysed data from 2014 to 2016 for all children < 18 years old who received antibiotic treatment for FUTI due to ESBL-E in 24 pediatric centers...
2018: PloS One
https://www.readbyqxmd.com/read/29093413/effects-of-the-concomitant-use-of-low-dose-clarithromycin-with-an-anti-tnf%C3%AE-antibody-in-a-patient-with-intestinal-beh%C3%A3-et-disease
#3
Junichi Iwamoto, Masashi Murakami, Naoki Konishi, Tadakuni Monma, Hajime Ueda, Shoichiro Yara, Takeshi Hirayama, Tadashi Ikegami, Akira Honda, Yasushi Matsuzaki
A 66-year-old Japanese male with a history of Behçet disease exhibited oral and genital ulcers, and a round deep ileocecal ulcer. He was treated with a combination of mesalazine and 20 mg/day of prednisolone (PSL), but was only partially responsive to PSL and we were not able to reduce the steroid dosage. Adalimumab was also administered. However, the ulcer was not completely responsive, and weaning the patient off PSL remained impossible. In contrast, additional treatment with clarithromycin completely healed the refractory active ulcer and left only a scar...
February 1, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29045606/clinical-and-laboratory-features-of-group-b-streptococcus-meningitis-in-infants-and-newborns-study-of-848-cases-in-france-2001-2014
#4
Anne-Sophie Romain, Robert Cohen, Céline Plainvert, Caroline Joubrel, Stéphane Béchet, Amélie Perret, Asmaa Tazi, Claire Poyart, Corinne Levy
Background: Group B Streptococcus (GBS) disease is the leading cause of neonatal bacterial meningitis despite women receiving an intravenous antibiotic prophylaxis during labor. We aimed to describe GBS meningitis in children <1 year old in France. Methods: Clinical and biological data of GBS meningitis gathered by the Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV) were analyzed. The cases were classified by age: 0-6 days old (early-onset disease [EOD]), newborns and infants 7-89 days old (late-onset disease [LOD]: LOD1, 7-26 days; LOD2, 27-89 days), and infants aged 3 months to 1 year (infant disease)...
March 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29034643/epididymo-orchitis-in-bechet-s-disease-a-review-of-the-wide-spectrum-of-the-disease
#5
Meletios A Kanakis, Aristeides G Vaiopoulos, George A Vaiopoulos, Phaedon G Kaklamanis
 Behçet's disease is a chronic, recurrent, inflammatory disorder characterized by orogenital ulcers and skin lesions; serious manifestations also include ocular, large vessel, gastrointestinal and neurological involvement. Genetic and unknown environmental factors modify the wide clinical spectrum of the disease. During the long clinical course of the disease, testicular and epididymal involvement has been reported, with scrotal pain and swelling being the most common symptoms. In this review, we discuss the various aspects of epididymo-orchitis in Behcet's disease patients, and we evaluate the diagnostic approaches as well as the empirical therapeutic modalities of this entity...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28977551/aagmarker-1-0-a-resource-of-serological-autoantigen-biomarkers-for-clinical-diagnosis-and-prognosis-of-various-human-diseases
#6
Jianbo Pan, Sheng Liu, Heng Zhu, Jiang Qian
Autoantibodies are produced to target an individual's own antigens (e.g. proteins). They can trigger autoimmune responses and inflammation, and thus, cause many types of diseases. Many high-throughput autoantibody profiling projects have been reported for unbiased identification of serological autoantigen-based biomarkers. However, a lack of centralized data portal for these published assays has been a major obstacle to further data mining and cross-evaluate the quality of these datasets generated from different diseases...
January 4, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/28936054/patterns-of-intermediate-uveitis-in-children-presenting-at-a-tertiary-eye-care-center-in-south-india
#7
Radha Annamalai, Jyotirmay Biswas
PURPOSE: To study the patterns of intermediate uveitis in the pediatric age group in a referral eye care center in South India. METHODS: This is a study of twenty consecutive patients under 16 years of age with intermediate uveitis, conducted at a tertiary referral center. Numerous variables were assessed, including age and gender distribution, laboratory data, the presence of systemic diseases, onset and course of ocular inflammation, clinical features, their complications, therapeutic strategies with their outcomes, remission, final visual acuity (VA), and characteristics associated with poor visual outcome...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28933970/the-importance-of-calprotectin-levels-in-obstructive-sleep-apnea-syndrome-severity
#8
Mümtaz Taner Torun, Ethem Ünver, Yusuf Yalçın, Lutfi Kanmaz, Ender Seçkin
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is mostly seen in adult populations. It is known that increased levels of several inflammatory mediators play roles in OSAS and related comorbidities. Calprotectin is an inflammatory mediator that increases in some diseases such as Behçet's syndrome, bowel diseases and cardiovascular and cerebrovascular diseases. AIMS: The purpose of this study was to investigate whether calprotectin can be used as a biomarker in OSAS by determining the relation between serum calprotectin levels and OSAS severity...
March 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28811201/the-unmet-need-in-rheumatology-reports-from-the-targeted-therapies-meeting-2017
#9
Kevin L Winthrop, Vibeke Strand, Désirée van der Heijde, Philip Mease, Mary Crow, Michael Weinblatt, Joan Bathon, Gerd R Burmester, Maxime Dougados, Johnathan Kay, Xavier Mariette, Ronald Van Vollenhoven, Joachim Sieper, Fritz Melchers, Ferdinand C Breedfeld, Joachim Kalden, Josef S Smolen, Daniel E Furst
The 19th annual international Targeted Therapies meeting brought together over 100 leading basic scientists and clinical researchers from around the world in the field of immunology, molecular biology and rheumatology and other specialties. During the meeting, breakout sessions were held consisting of 5 disease-specific groups with 20-40 experts assigned to each group based on clinical or scientific expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematous, connective tissue diseases (e...
January 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28414674/a-clot-possibly-due-to-loss-of-tnf-%C3%AE-supression
#10
J Broussard, M Berlinger, D Lauret
INTRODUCTION: Inflammation and venous thrombosis enjoy a close Relationship. We present a patient who had multiple DVTs following the discontinuation of anti- TNF-α therapy. CASE: A 34 year old African American female with a history of multiple DVT's, miscarriages, and reported Crohn's disease presented with shortness of breath. In the Emergency Department, CTA showed bilateral pulmonary emboli. The patient had been off adalimumab for one year and reported abdominal pain with 6-7 non-bloody bowel movements daily...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27978898/-risk-factors-for-long-term-result-of-endovascular-treatment-for-auto-immune-disease-related-abdominal-aorta-pseudo-aneurysm
#11
W Ye, X Di, Q Liu, Y J Li, Y H Zheng, R Zeng, X J Song, Z L Liu, C W Liu
Objective: To summarize results of endovascular treatment for auto-immune disease related abdominal aorta pseudo-aneurysm(AIPA), and to analysis clinical predictors of long term major adverse clinical events(MACE). Methods: Retrospectively collected endovascular treatment for AIPA cases in Peking Union Medical College Hospital within 2000 to 2015. Twenty-nine cases with AIPA treated by endovascular therapy were enrolled in this study. Twenty five cases were male, range from 23 to 67 years old, mean age was (39...
December 6, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27938463/effectiveness-of-endoscopic-cricopharyngeal-myotomy-in-adults-with-neurological-disease-systematic-review
#12
REVIEW
Ó Gilheaney, P Kerr, S Béchet, M Walshe
OBJECTIVE: To determine the effectiveness of endoscopic cricopharyngeal myotomy on upper oesophageal sphincter dysfunction in adults with upper oesophageal sphincter dysfunction and neurological disease. DATA SOURCES: Published and unpublished studies with a quasi-experimental design investigating endoscopic cricopharyngeal myotomy effects on upper oesophageal sphincter dysfunction in humans were considered eligible. Electronic databases, grey literature and reference lists of included studies were systematically searched...
December 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27595445/comparative-impact-of-pneumococcal-conjugate-vaccines-on-pneumococcal-meningitis-according-to-underlying-conditions
#13
MULTICENTER STUDY
Robert Cohen, Emmanuelle Varon, Stéphane Béchet, Stéphane Bonacorsi, Corinne Levy
BACKGROUND: Several underlying conditions increase the risk of pneumococcal meningitis (PM) in childhood. Patients with these diseases are initially considered as an important target of pneumococcal conjugate vaccines (PCVs). Limited data are available for PM in children with underlying conditions. To understand the benefits of PCV7 followed by PCV13 in this vulnerable population, we analyzed the data for a large cohort of pediatric patients with PM in France from 2001 to 2014. METHODS: We conducted hospital-based active surveillance with 227 pediatric wards working with 168 microbiology departments throughout France...
September 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27239420/docosahexaenoic-acid-supplementation-prior-to-fasting-prevents-muscle-atrophy-in-mice
#14
Christiane Deval, Frédéric Capel, Brigitte Laillet, Cécile Polge, Daniel Béchet, Daniel Taillandier, Didier Attaix, Lydie Combaret
BACKGROUND: Muscle wasting prevails in numerous diseases (e.g. diabetes, cardiovascular and kidney diseases, COPD,…) and increases healthcare costs. A major clinical issue is to devise new strategies preventing muscle wasting. We hypothesized that 8-week docosahexaenoic acid (DHA) supplementation prior to fasting may preserve muscle mass in vivo . METHODS: Six-week-old C57BL/6 mice were fed a DHA-enriched or a control diet for 8 weeks and then fasted for 48 h...
December 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27102410/upregulation-of-murf1-and-mafbx-participates-to-muscle-wasting-upon-gentamicin-induced-acute-kidney-injury
#15
Julien Aniort, Cécile Polge, Agnès Claustre, Lydie Combaret, Daniel Béchet, Didier Attaix, Anne-Elisabeth Heng, Daniel Taillandier
Acute Kidney Injury (AKI) is frequently encountered in hospitalized patients where it is associated with increased mortality and morbidity notably affecting muscle wasting. Increased protein degradation has been shown to be the main actor of AKI-induced muscle atrophy, but the proteolytic pathways involved are poorly known. The Ubiquitin Proteasome System (UPS) is almost systematically activated in various catabolic situations, and the E3 ligases MuRF1 and MAFbx are generally up regulated in atrophying muscles...
October 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27073159/when-should-clinicians-suspect-group-a-streptococcus-empyema-in-children-a-multicentre-case-control-study-in-french-tertiary-care-centres
#16
MULTICENTER STUDY
Sophia Bellulo, Julie Sommet, Corinne Lévy, Yves Gillet, Laure Hees, Mathie Lorrot, Christèle Gras-Le-Guen, Irina Craiu, François Dubos, Philippe Minodier, Sandra Biscardi, Marie-Aliette Dommergues, Stéphane Béchet, Philippe Bidet, Corinne Alberti, Robert Cohen, Albert Faye
BACKGROUND: The incidence of invasive group A streptococcus (GAS) infections is increasing worldwide, whereas there has been a dramatic decrease in pneumococcal invasive diseases. Few data describing GAS pleural empyema in children are available. OBJECTIVE: To describe the clinical and microbiological features, management and outcome of GAS pleural empyema in children and compare them with those of pneumococcal empyema. DESIGN, SETTING AND PATIENTS: Fifty children admitted for GAS pleural empyema between January 2006 and May 2013 to 8 hospitals participating in a national pneumonia survey were included in a descriptive study and matched by age and centre with 50 children with pneumococcal empyema...
August 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27048880/spatial-and-temporal-homogeneity-of-driver-mutations-in-diffuse-intrinsic-pontine-glioma
#17
Hamid Nikbakht, Eshini Panditharatna, Leonie G Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L Ligon, Benjamin Ellezam, Wendy J Ingram, Caedyn Stinson, Andrew S Moore, Katherine E Warren, Jason Karamchandani, Roger J Packer, Nada Jabado, Jacek Majewski, Javad Nazarian
Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, here we analyse 134 specimens from various neuroanatomical structures of whole autopsy brains from nine DIPG patients. Evolutionary reconstruction indicates histone 3 (H3) K27M--including H3.2K27M--mutations potentially arise first and are invariably associated with specific, high-fidelity obligate partners throughout the tumour and its spread, from diagnosis to end-stage disease, suggesting mutual need for tumorigenesis...
April 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27020729/outcomes-of-bacterial-meningitis-in-children
#18
C Briand, C Levy, F Baumie, L Joao, S Béchet, E Carbonnelle, E Grimprel, R Cohen, J Gaudelus, L de Pontual
OBJECTIVE: Pediatricians are well aware of the immediate risks of bacterial meningitis in children. However, the long-term outcome of the disease has not been extensively studied. We aimed: (i) to evaluate the duration and quality of the long-term follow-up of children diagnosed with bacterial meningitis in a general pediatric department, (ii) to estimate the incidence of sequelae at the various stages of follow-up, and (iii) to compare our data with that of other studies. METHODS: We conducted a retrospective study and included 34 children (3 months-15 years) who had been hospitalized for bacterial meningitis in the pediatric department of a University Hospital between January 1st, 2001 and December 31st, 2013...
June 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/26709995/-manic-episode-in-a-patient-with-be%C3%A3-het-s-disease
#19
V Bozikas, A Ramnalis, J Dittopoulos, J Iakovou, G Garyfallos, K Fokas
Beçhet's disease (BD) is a chronic, heterogeneous, multisystem disease that affects young males and females around the Mediterranean region, as well as from Far and Middle East. Its etiology is vague with vasculitis being its main pathological feature. International diagnostic criteria have been established and they require the presence of recurrent oral ulcerations plus two of the following: Recurrent genital ulceration, eye lesions, skin lesions and positive pathergy test. A significant number of patients with Beçhet's disease suffers from symptoms from the central nervous system (CNS), while the most common clinical symptoms are pyramidal signs, mental-behavioral changes, hemiparesis and brain stem syndrome...
October 2015: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/26603630/-implementation-of-meningococcal-b-vaccination-bexsero%C3%A2-in-france-physicians-perceptions-and-experiences-of-a-few-months-after-marketing-approval
#20
C Levy, S Bechet, R Cohen
BACKGROUND: In December 2013, the French public health authorities recommended the use of Bexsero® (meningococcus B vaccine) in areas with endemic risk and for patients at risk for invasive meningococcal B disease. In this context, InfoVac-France performed a national survey a few months after the implementation of the vaccine to evaluate physicians' perceptions and experiences with this new vaccine. METHODS: This survey was proposed by email in April 2014 to the InfoVac network...
January 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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