Abhimanyu, Mridula Bose, Astha Giri, Mandira Varma-Basil
BACKGROUND: Tuberculosis (TB) manifests itself primarily in the lungs as pulmonary disease (PTB) and sometimes disseminates to other organs to cause extra-pulmonary TB, such as lymph node TB (LNTB). This study aimed to investigate the role of host genetic polymorphism in immunity related genes to find a genetic basis for such differences. METHODS: Sixty-three, Single nucleotide polymorphisms (SNPs) in twenty-three, TB-immunity related genes including eleven innate immunity ( SLCA11 , VDR , TLR2 , TLR4 , TLR8 , IRGM , P2RX7 , LTA4H , SP110 , DCSIGN and NOS2A ) and twelve cytokine (TNFA, IFNG , IL2 , Il12 , IL18 , IL1B , IL10 , IL6 , IL4 , rs1794068 , IL8 and TNFB ) genes were investigated to find genetic associations in both PTB and LNTB as compared to healthy community controls...
January 13, 2023: Genes