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https://www.readbyqxmd.com/read/28913713/ethnic-groups-differ-in-how-poor-self-rated-mental-health-reflects-psychiatric-disorders
#1
Shervin Assari
AIM: This study aimed to explore cross-ethnic variation in the pattern of the associations between psychiatric disorders and self-rated mental health (SRMH) in the USA. METHODS: This cross-sectional study used data from the Collaborative Psychiatric Epidemiology Surveys (CPES), 2001-2003, a national household probability sample. The study enrolled 18,237 individuals who were either Non-Hispanic White (n = 7587), African American (n = 4746), Mexican (n = 1442), Cuban (n = 577), Puerto Rican (n = 495), Other Hispanic (n = 1106), Vietnamese (n = 520), Filipino (n = 508), Chinese (n = 600) or Other Asian (n = 656)...
September 14, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28904912/assessment-of-anxiety-level-of-emergency-health-care-workers-by-generalized-anxiety-disorder-7-tool
#2
Nesrin Alharthy, Osama Abdulrahman Alrajeh, Mohammed Almutairi, Ahmed Alhajri
BACKGROUND: Dealing with emergency patients is considered to be a stressful situation to all health-care workers in the emergency department (ED). Prolonged stress predispose to physical and inconsequential psychiatric disturbances. Anxiety and depressive mode were found to be the most commonly experienced psychiatric manifestation among emergency health-care workers. The aim of this study is to screen and assess the severity of anxiety among health professionals working in ED. METHODS: Cross-sectional study design was used...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28903165/association-of-panic-disorder-generalized-anxiety-disorder-and-benzodiazepine-treatment-during-pregnancy-with-risk-of-adverse-birth-outcomes
#3
Kimberly Ann Yonkers, Kathryn Gilstad-Hayden, Ariadna Forray, Heather S Lipkind
Importance: Registry data show that maternal panic disorder, or anxiety disorders in general, increase the risk for adverse pregnancy outcomes. However, diagnoses from registries may be imprecise and may not consider potential confounding factors, such as treatment with medication and maternal substance use. Objective: To determine whether panic disorder or generalized anxiety disorder (GAD) in pregnancy, or medications used to treat these conditions, are associated with adverse maternal or neonatal pregnancy outcomes...
September 13, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28902463/renoprotective-effects-of-montelukast-in-an-experimental-model-of-cisplatin-nephrotoxicity-in-rats
#4
Amany M Gad, Ola M Abd El-Raouf, Bahia M El-Sayeh, Hala M Fawzy, Dalaal M Abdallah
Renal toxicity is one of the most severe complications that can occur with cisplatin (CIS) administration in cancer patients. Montelukast (ML) renoprotective outcome contrary to CIS-drawn nephrotoxicity remains obscure. Therefore, adult male Sprague-Dawley rats were orally given ML (10 and 20 mg/kg/day) 5 days before and after single CIS (5 mg/kg; i.p.) treatment. ML returned blood urea nitrogen, as well as serum creatinine and gamma glutamyl transferase that were elevated by CIS to normal level. The improved kidney function tests corroborated the attenuation of CIS renal injury at the microscopical level...
September 13, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28899639/prevalence-of-double-diabetes-in-youth-onset-diabetes-patients-from-east-delhi-and-neighboring-ncr-region
#5
B K Mishra, P Shukla, M Aslam, A A Siddiqui, S V Madhu
BACKGROUND: It is being increasingly reported that some of the youth onset diabetes patients cannot be classified clearly as type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) based on usual criteria and the term double diabetes (DD) coined for these cases. AIM: The objective of the study was to find out the prevalence of DD in youth onset diabetes patients from east Delhi and neighboring NCR region. METHODS: A total of 200 patients with youth onset diabetes below 25 years of age were recruited from a tertiary care hospital in East Delhi...
September 9, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28895787/internet-based-acceptance-and-commitment-therapy-for-psychological-distress-experienced-by-people-with-hearing-problems-a-pilot-randomized-controlled-trial
#6
Peter Molander, Hugo Hesser, Sandra Weineland, Kajsa Bergwall, Sonia Buck, Johan Jäder Malmlöf, Henning Lantz, Thomas Lunner, Gerhard Andersson
Psychological distress is common among people with hearing problems, but treatments that specifically target this aspect have been almost non-existent. In this pilot randomized controlled trial, an eight-week long Internet-based treatment, informed by Acceptance and Commitment Therapy, was administered to explore the feasibility and efficacy of such a treatment. Included participants were randomized to either treatment (n = 31) or wait-list control (n = 30) condition. All participants were measured prior to randomization and immediately after treatment ended using standardized self-report instruments measuring hearing-related emotional and social adjustment (Hearing Handicap Inventory for the Elderly - S, HHIE-S), quality of life (Quality of Life Inventory, QOLI), and symptoms of depression and anxiety (Patient health Questionnaire, PHQ-9 and Generalized Anxiety Disorder scale, GAD-7)...
September 12, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/28893153/emotion-focused-perspective-on-generalized-anxiety-disorder-a-qualitative-analysis-of-clients-in-session-presentations
#7
Katie O'Brien, Nora O'Keeffe, Hannah Cullen, Aoife Durcan, Ladislav Timulak, James McElvaney
OBJECTIVE: The classification of generalized anxiety disorder (GAD) is influenced by the tradition of conceptualizing disorders in the context of their clinical presentation and subsequent professional thinking around them. Our qualitative, descriptive-interpretative study uses a theoretical framework drawn from emotion-focused therapy (EFT) as the basis of our interpretation of GAD clients' presentation of their difficulties. METHOD: The current research consists of an investigation into the GAD presentation based on a multiple case study observational qualitative design...
September 11, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28892641/independent-assortment-of-gc-gene-polymorphism-rs2282679-and-25-hydroxyvitamin-d-levels-in-coronary-artery-disease
#8
Nada Sedky, Sally Hassanein, Mohamed Gad
BACKGROUND: Coronary artery disease (CAD) remains a major public health burden. Emerging research has suggested an association between vitamin D insufficiency and CAD. Vitamin D binding protein (VDBP) is the primary vitamin D carrier and many of its genetic polymorphisms are able to induce the expression of proteins with different affinities for the vitamin, which in turn, might affect its serum levels and CAD incidence. SUBJECTS/METHODS: 112 male patients, aged between 35 and 50, with verified CAD and 109 age- and sex-matched controls were recruited...
September 11, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28892476/induction-of-allopurinol-resistance-in-leishmania-infantum-isolated-from-dogs
#9
Daniel Yasur-Landau, Charles L Jaffe, Adi Doron-Faigenboim, Lior David, Gad Baneth
Resistance to allopurinol in zoonotic canine leishmaniasis has been recently shown to be associated with disease relapse in naturally-infected dogs. However, information regarding the formation of resistance and its dynamics is lacking. This study describes the successful in-vitro induction of allopurinol resistance in Leishmania infantum cultured under increasing drug pressure. Allopurinol susceptibility and growth rate of induced parasites were monitored over 23 weeks and parasite clones were tested at selected time points and compared to their parental lines, both as promastigotes and as amastigotes...
September 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28892075/analysis-of-somatic-microsatellite-indels-identifies-driver-events-in-human-tumors
#10
Yosef E Maruvka, Kent W Mouw, Rosa Karlic, Prasanna Parasuraman, Atanas Kamburov, Paz Polak, Nicholas J Haradhvala, Julian M Hess, Esther Rheinbay, Yehuda Brody, Amnon Koren, Lior Z Braunstein, Alan D'Andrea, Michael S Lawrence, Adam Bass, Andre Bernards, Franziska Michor, Gad Getz
Microsatellites (MSs) are tracts of variable-length repeats of short DNA motifs that exhibit high rates of mutation in the form of insertions or deletions (indels) of the repeated motif. Despite their prevalence, the contribution of somatic MS indels to cancer has been largely unexplored, owing to difficulties in detecting them in short-read sequencing data. Here we present two tools: MSMuTect, for accurate detection of somatic MS indels, and MSMutSig, for identification of genes containing MS indels at a higher frequency than expected by chance...
September 11, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28890837/why-it-is-not-always-anxiety-a-tough-diagnosis-of-stiff-person-syndrome
#11
Carmen Elena Cervantes, Hsien Lee Lau, Tina Ataian Binazir, Keith O O'Brien, Jonathan S Cross
Anxiety disorder is a commonly used diagnosis that may mask underlying conditions. Stiff person syndrome (SPS) is a rare neuroimmunological disorder characterized by progressive rigidity and painful muscle spasms affecting axial and lower extremity musculature. These episodes can be triggered by sudden movement, noise, or emotional stress, which may present as a psychiatric condition. We report the case of a 30-year-old female who presented with recurrent panic attacks with multiple prior hospital admissions for anxiety, rigidity, and difficulty in walking...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28889839/laser-acupuncture-at-ht7-improves-the-cerebellar-disorders-in-valproic-acid-rat-model-of-autism
#12
Jurairat Khongrum, Jintanaporn Wattanathorn
The novel therapeutic strategy against autism is essential due to the limited therapeutic efficacy. Based on the benefit of laser acupuncture at HT7 acupoint on the neurological disorders related with oxidative stress and inflammation, its benefit on oxidative stress, neuroinflammation, and GABAergic/glutamatergic imbalance in cerebellum of autism have been considered. To elucidate this issue, male rat pups were induced autistic-like conditions by valproic acid (VPA) and treated with laser acupuncture at HT7 acupoint once daily between postnatal Day 14 and Day 40...
August 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28886500/peripheral-proinflammatory-cytokines-in-chinese-patients-with-generalised-anxiety-disorder
#13
Zhen Tang, Gang Ye, Xinyun Chen, Mingzhi Pan, Jialin Fu, Tian Fu, Qichun Liu, Zhenyong Gao, David S Baldwin, Ruihua Hou
BACKGROUND: Inflammatory responses and inflammatory cytokines have been implicated in the pathogenesis of affective disorders, particularly major depression. Given the limited evidence relating to the potential role of proinflammatory cytokines in generalised anxiety disorder (GAD), we aimed to examine peripheral proinflammatory cytokines in Chinese patients with GAD. METHODS: A case-controlled cross-sectional study design, with recruitment of 48 patients with first episode GAD and 48 matched healthy controls...
August 31, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28886420/discriminant-validity-diagnostic-utility-and-parent-child-agreement-on-the-screen-for-child-anxiety-related-emotional-disorders-scared-in-treatment-and-non-treatment-seeking-youth
#14
B I Rappaport, D Pagliaccio, D S Pine, D N Klein, J M Jarcho
The Screen for Child Anxiety and Related Emotional Disorder (SCARED) may be differentially sensitive to detecting specific or comorbid anxiety diagnoses in treatment-seeking and non-treatment-seeking youth. We assessed the SCARED's discriminant validity, diagnostic utility, and informant agreement using parent- and self-report from healthy and treatment-seeking anxious youth (Study 1, N=585) and from non-treatment-seeking anxious youth (Study 2, N=331) diagnosed with generalized anxiety disorder (GAD), social anxiety disorder (SAD), or comorbid GAD+SAD...
August 30, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28881028/specific-rescue-by-ortho-hydroxy-atorvastatin-of-cortical-gabaergic-neurons-from-previous-oxygen-glucose-deprivation-role-of-pcreb
#15
Verónica Guirao, Octavi Martí-Sistac, Nuria DeGregorio-Rocasolano, Jovita Ponce, Antoni Dávalos, Teresa Gasull
The statin atorvastatin (ATV) given as a post-treatment has been reported beneficial in stroke, although the mechanisms involved are not well understood so far. Here we investigated in vitro the effect of post-treatment with ATV and its main bioactive metabolite ortho-hydroxy ATV (o-ATV) on neuroprotection after oxygen and glucose deprivation (OGD), and the role of the pro-survival cAMP response element-binding protein (CREB). Post-OGD treatment of primary cultures of rat cortical neurons with o-ATV, but not ATV, provided neuroprotection to a specific subset of cortical neurons that were large and positive for glutamic acid decarboxylase (large-GAD((+)) neurons, GABAergic)...
September 7, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28878667/adaptive-pathways-possible-next-steps-for-payers-in-preparation-for-their-potential-implementation
#16
REVIEW
Patricia Vella Bonanno, Michael Ermisch, Brian Godman, Antony P Martin, Jesper Van Den Bergh, Liudmila Bezmelnitsyna, Anna Bucsics, Francis Arickx, Alexander Bybau, Tomasz Bochenek, Marc van de Casteele, Eduardo Diogene, Irene Eriksson, Jurij Fürst, Mohamed Gad, Ieva Greičiūtė-Kuprijanov, Martin van der Graaff, Jolanta Gulbinovic, Jan Jones, Roberta Joppi, Marija Kalaba, Ott Laius, Irene Langner, Ileana Mardare, Vanda Markovic-Pekovic, Einar Magnusson, Oyvind Melien, Dmitry O Meshkov, Guenka I Petrova, Gisbert Selke, Catherine Sermet, Steven Simoens, Ad Schuurman, Ricardo Ramos, Jorge Rodrigues, Corinne Zara, Eva Zebedin-Brandl, Alan Haycox
Medicines receiving a conditional marketing authorization through Medicines Adaptive Pathways to Patients (MAPPs) will be a challenge for payers. The "introduction" of MAPPs is already seen by the European Medicines Agency (EMA) as a fait accompli, with payers not consulted or involved. However, once medicines are approved through MAPPs, they will be evaluated for funding by payers through different activities. These include Health Technology Assessment (HTA) with often immature clinical data and high uncertainty, financial considerations, and negotiations through different types of agreements, which can require monitoring post launch...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28877358/utility-of-transfacial-dental-ultrasonography-in-evaluation-of-cystic-jaw-lesions
#17
Khaled Gad, Mohamed Ellabban, James Sciubba
OBJECTIVES: Plain radiography has been widely used in dentistry. Because of the variability of the quality of equipment, radiographic technique, accuracy of interpretation, and radiation risk to the patients, the field is ripe for the introduction of other newer diagnostic modalities. In this report, we demonstrate the utility of ultrasonography in the diagnostic workup of cystic or cystlike lesions of the jaw. METHODS: We used a transfacial ultrasonographic scanning approach to examine 32 patients with clinical or radiographic presentation of a jaw cyst...
September 6, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28875469/a-panel-of-autoantibodies-against-neural-proteins-as-peripheral-biomarker-for-pesticide-induced-neurotoxicity
#18
Heba Allah Abd El Rahman, Mohamed Salama, Seham A Gad El-Hak, Mona A El-Harouny, Passent ElKafrawy, Mohamed B Abou-Donia
In the present study, we screened the sera of subjects chronically exposed to mixtures of pesticides (composed mainly of organophosphorus compounds (OPs) and others) and developed neurological symptoms for the presence of autoantibodies against cytoskeletal neural proteins. OPs have a well-characterized clinical profile resulting from acute cholinergic crisis. However, some of these compounds cause neuronal degeneration and demyelination known as organophosphorus compound-induced delayed neurotoxicity (OPIDN) and/or organophosphorus compound-induced chronic neurotoxicity (OPICN)...
September 5, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28873232/liver-size-waning-by-day-waxing-by-night
#19
Hans Reinke, Gad Asher
No abstract text is available yet for this article.
September 5, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28871621/systolic-blood-pressure-reduction-during-the-first-24%C3%A2-h-in-acute-heart-failure-admission-friend-or-foe
#20
Gad Cotter, Marco Metra, Beth A Davison, Guillaume Jondeau, John G F Cleland, Robert C Bourge, Olga Milo, Christopher M O'Connor, John D Parker, Guillermo Torre-Amione, Dirk J van Veldhuisen, Isaac Kobrin, Maurizio Rainisio, Stefanie Senger, Christopher Edwards, John J V McMurray, John R Teerlink
AIMS: Changes in systolic blood pressure (SBP) during an admission for acute heart failure (AHF), especially those leading to hypotension, have been suggested to increase the risk for adverse outcomes. METHODS AND RESULTS: We analysed associations of SBP decrease during the first 24 h from randomization with serum creatinine changes at the last time-point available (72 h), using linear regression, and with 30- and 180-day outcomes, using Cox regression, in 1257 patients in the VERITAS study...
September 4, 2017: European Journal of Heart Failure
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