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https://www.readbyqxmd.com/read/28727948/a-collaborative-network-based-approach-to-advance-women-s-depression-research-in-the-united-states-preliminary-findings
#1
Heather A Flynn, Catherine Spino, Constance Guille, Kristina M Deligiannidis, Pauline Maki, Jordan Jahnke, Katherine L Rosenblum, C Neill Epperson, Sandra J Weiss
OBJECTIVE: Translation of women's mental health research has yet to impact overall prevalence and burden of Mood Disorders in the United States. The lack of standard measures and methodological coordination across studies has contributed to the slow impact of research on outcomes. The primary aims of this project were to demonstrate the process by which multiple investigators, sites, and settings administered a standard women's mental health questionnaire within a new Women's Depression Network...
July 20, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28727150/generalized-convulsive-seizures-are-associated-with-ketamine-anesthesia-in-a-rhesus-macaque-macaca-mulatta-undergoing-urodynamic-studies-and-transcutaneous-spinal-cord-stimulation
#2
Parag N Gad, Gregory W Salyards, Laura M Garzel, Kari L Christe, V Reggie Edgerton, Leif A Havton
A female rhesus macaque developed two episodes of generalized convulsions during transcutaneous spinal cord stimulation (TSCS) and urodynamic studies under ketamine anesthesia. The seizures took place in the absence of active TSCS and bladder pressure elevation. Ketamine anesthesia remains the primary risk factor for the convulsions during these experimental procedures.
July 20, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28726484/annals-express-experience-with-newer-central-nervous-system-autoantibodies
#3
Abid Karim, Saiju Jacob
In the last decade, a large number of neuronal cell-surface antibodies have been described which are responsible for a range of neuroimmunological central nervous system disorders. Unlike the paraneoplastic antibodies which target intracellular antigens, these antibodies appear to be pathogenic and hence identification and prompt treatment can make a substantial impact on clinical outcomes of these patients. We review the common antibodies against the ionotropic Glutamate receptors (NMDAR, AMPAR), metabotropic Glutamate receptors (mGluR1 and mGluR5), voltage gated potassium channel-complex proteins (LGI1, CASPR2), and other antibodies targeted against Glycine receptor, Glutamic acid decarboxylase (GAD), Gamma Amino Butyric Acid B (GABAB), Dopamine-2-receptor (D2R) and Dipeptidyl-peptidase-like protein 6 (DPPX)...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28722620/case-report-infectious-diseases-in-pilgrims-visiting-the-holy-land
#4
Orna Nitzan, Arnon Blum, Esther Marva, Adina Katz, Bat-Sheva Tzadok, Yaarit Nachum-Biala, Gad Baneth, Avi Peretz
Every year Christian pilgrims from around the world visit the holy sites located around the Sea of Galilee. Some become ill during their stay with infectious diseases that were acquired in their country of origin, and are hospitalized at Poriya Medical Center. They pose a diagnostic challenge due to language barriers, the rarity of these infections in Israel, and the fact that diagnostic tests are not readily available. All patient records from 2015 of Holy Land tourists hospitalized at Poriya Medical Center were screened for the diagnosis of imported zoonotic diseases that are not commonly diagnosed in Israel...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28720552/autoimmune-limbic-encephalitis-associated-with-type-1-diabetes-mellitus
#5
Onur Akın, Aylin Kılınç Uğurlu, Emine Demet Akbaş, Esra Döğer, Yılmaz Akbaş, Aysun Bideci, Özge Yüce, Kıvılcım Gücüyener, Orhun Çamurdan, Neşe Karabacak, Peyami Cinaz
Glutamic acid decarboxylase (GAD) antibodies can participate in the pathogenesis of both type 1 diabetes mellitus (T1DM) and limbic encephalitis (LE). However, an association between T1DM and LE is very rare. We report a patient who was diagnosed with type 1 diabetes mellitus six months after encountering limbic encephalitis. A 16-year-old boy was admitted with behavioral changes, confusion, and headache. He was diagnosed with LE. Anti-GAD levels were high. He was treated with pulse methylprednisolone. During the steroid treatment, neurological symptoms improved but hyperglycemia occurred...
July 17, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28720078/characteristics-of-cardio-cerebrovascular-modulation-in-patients-with-generalized-anxiety-disorder-an-observational-study
#6
Zhen-Ni Guo, Liangshu Feng, Xiuli Yan, Le Yang, Shuo Huang, Yingqi Xing, Yi Yang
BACKGROUND: Generalized anxiety disorder (GAD) has been shown in previous studies to display abnormal cerebral blood flow velocity (CBFV); however, the characteristics of cardio-cerebrovascular modulation are unknown. We aimed to analyze cardio-cerebrovascular modulation using parameters from a supine-to-standing test. METHODS: There are 2 parts to this study; in Part 1, 125 participants with Hamilton Anxiety scale scores ≥14 were enrolled, and 33 age- and sex-matched medically and psychiatrically healthy volunteers were recruited as control participants...
July 18, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28719448/biopsy-proven-diffuse-mediastinal-prostate-cancer-metastases-negative-on-18f-fluorocholine-diagnosed-on-68ga-psma-and-18f-psma-pet-ct
#7
Guillaume Chaussé, Tamim Niazi, Gad Solomon Abikhzer, Stephan Michael Probst
A 72-year-old man with prostate cancer (stage T3b, Gleason score 7) treated by radical prostatectomy was found to have biochemical failure (prostate-specific antigen 8.5 ng/mL) and a suspicious growing nodularity at the left prostate bed on MRI. F-fluorocholine PET/CT failed to demonstrate any site of uptake suggestive of malignancy. A bone scan did exclude bone metastases. Ga-PSMA PET/CT revealed various positive lymph nodes in the supraclavicular, mediastinal, and hilar regions. This was confirmed on F-DCFPyl PET/CT, with the addition of a suspicious right axillary lymph node...
July 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28716999/improving-recognition-of-anxiety-and-depression-in-rheumatoid-arthritis-a-qualitative-study-in-a-community-clinic
#8
Annabelle Machin, Samantha Hider, Nicky Dale, Carolyn Chew-Graham
BACKGROUND: Comorbid anxiety and depression are common in patients with rheumatoid arthritis (RA) but are often under-recognised and treated, contributing to worse outcomes. National Institute for Health and Care Excellence (NICE) recommends that patients with RA should be offered a holistic annual review, including an assessment of mood. AIM: To explore patients' perspectives of anxiety and depression in RA and preferences for disclosure and management of mood problems...
July 17, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28716529/the-pro-inflammatory-cytokines-salivary-cortisol-and-alpha-amylase-are-associated-with-generalized-anxiety-disorder-gad-in-patients-with-asthma
#9
Chang-Jiang Yang, Di Liu, Zhen-Sheng Xu, Shen-Xun Shi, Yi-Jie Du
Generalized anxiety disorder (GAD) is common in patients with asthma. High levels of GAD may lead both to exacerbation of the condition and poor management. However, the physiological mechanisms of GAD in asthma patient is unclear. This study investigated the associations between the diurnal rhythm of sputum cytokines, salivary cortisol, α-amylase and GAD in asthma patients. Patients with co-morbid GAD and asthma showed higher sputum IL-1 AUC, sputum IL-6 AUC and sAA AUC. And there were positive correlations between Hamilton anxiety scale (HAMA) scores and sputum IL-1 AUC concentrations (r=0...
July 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28714987/comparison-of-algorithms-for-the-detection-of-cancer-drivers-at-subgene-resolution
#10
Eduard Porta-Pardo, Atanas Kamburov, David Tamborero, Tirso Pons, Daniela Grases, Alfonso Valencia, Nuria Lopez-Bigas, Gad Getz, Adam Godzik
Understanding genetic events that lead to cancer initiation and progression remains one of the biggest challenges in cancer biology. Traditionally, most algorithms for cancer-driver identification look for genes that have more mutations than expected from the average background mutation rate. However, there is now a wide variety of methods that look for nonrandom distribution of mutations within proteins as a signal for the driving role of mutations in cancer. Here we classify and review such subgene-resolution algorithms, compare their findings on four distinct cancer data sets from The Cancer Genome Atlas and discuss how predictions from these algorithms can be interpreted in the emerging paradigms that challenge the simple dichotomy between driver and passenger genes...
July 17, 2017: Nature Methods
https://www.readbyqxmd.com/read/28712429/the-association-between-multiple-chemical-sensitivity-and-mental-illness-evidence-from-a-nationally-representative-sample-of-canadians
#11
Dylan Johnson, Ian Colman
OBJECTIVE: The goal of the present study was to investigate the association between multiple chemical sensitivity (MCS) and major depressive disorder (MDD), generalized anxiety disorder (GAD), MDD and GAD comorbidity (MDD+GAD), severe distress, and positive mental wellbeing. METHODS: This cross-sectional investigation was carried out using the 2012 Canadian Community Health Survey - Mental Health Component. The study population consisted of 21,977 individuals aged 20 and older, from Canada's ten provinces...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28711797/symptom-severity-and-disability-in-psychiatric-disorders-the-u-s-collaborative-psychiatric-epidemiology-survey
#12
R García-Velázquez, M Jokela, T H Rosenström
BACKGROUND: While most psychiatric diagnoses are based on simple counts of symptoms, some symptoms may be sign of a more severe mental syndrome than others. This calls for validated estimates of the relative severity specific symptoms imply within a disorder. We focused on four diagnostic disorders: Manic Episode (ME), Major Depressive Episode (MDE), Post-traumatic Stress Disorder (PTSD) and Generalized Anxiety Disorder (GAD). Symptom-specific severity parameters were estimated, and validated by examining their association with levels of self-reported disability in daily activities over and above the number of symptoms...
July 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28711111/to-do-or-not-to-do-task-control-deficit-in-obsessive-compulsive-disorder
#13
Eyal Kalanthroff, Avishai Henik, Helen Blair Simpson, Doron Todder, Gideon E Anholt
Task control is an executive control mechanism that facilitates goal-directed task selection by suppressing irrelevant automatic "stimulus-driven" behaviors. In the current study, we test the hypothesis that less efficient task control in individuals diagnosed with obsessive-compulsive disorder (OCD) is associated with OCD symptoms, and specifically, with the inability to inhibit unwanted behaviors in OCD. Thirty-five healthy controls, 30 participants with OCD, and 26 participants with generalized anxiety disorder (GAD) completed the object-interference (OI) task to measure task control, the stop-signal task to measure response inhibition, and the arrow-flanker task to evaluate executive abilities not contingent upon task control...
September 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28704828/extremely-high-prevalence-of-maternal-and-neonatal-vitamin-d-deficiency-in-the-arab-population
#14
Mona A Fouda, Iqbal Z Turkestani, Sara Almusharraf, Abdulrahman Al-Ajlan, Fatima F Angkaya-Bagayawa, Shaun Sabico, Ashry Gad Mohammed, Rana Hassanato, Amal Al-Serehi, Naemah M Alshingetti, Nasser M Al-Daghri
BACKGROUND: Vitamin D deficiency is a global public health problem. The published literature on vitamin D deficiency is limited among Arab pregnant women and its association with different metabolic markers. OBJECTIVE: To determine the prevalence of vitamin D deficiency in Arab pregnant women and neonates and its association with various biomarker profiles. METHODS: This is a multicenter study taken from a large prospective project in Riyadh, the capital city of Saudi Arabia...
July 14, 2017: Neonatology
https://www.readbyqxmd.com/read/28701371/population-based-assessment-of-a-biomarker-based-screening-pathway-to-aid-diagnosis-of-monogenic-diabetes-in-young-onset-patients
#15
Beverley M Shields, Maggie Shepherd, Michelle Hudson, Timothy J McDonald, Kevin Colclough, Jaime Peters, Bridget Knight, Chris Hyde, Sian Ellard, Ewan R Pearson, Andrew T Hattersley
OBJECTIVE: Monogenic diabetes, a young-onset form of diabetes, is often misdiagnosed as type 1 diabetes, resulting in unnecessary treatment with insulin. A screening approach for monogenic diabetes is needed to accurately select suitable patients for expensive diagnostic genetic testing. We used C-peptide and islet autoantibodies, highly sensitive and specific biomarkers for discriminating type 1 from non-type 1 diabetes, in a biomarker screening pathway for monogenic diabetes. RESEARCH DESIGN AND METHODS: We studied patients diagnosed aged 30 years or younger, currently younger than 50 years, in two U...
July 12, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28701370/twenty-year-progression-rate-to-clinical-onset-according-to-autoantibody-profile-age-and-hla-dq-genotype-in-a-registry-based-group-of-children-and-adults-with-a-first-degree-relative-with-type-1-diabetes
#16
Frans K Gorus, Eric V Balti, Anissa Messaaoui, Simke Demeester, Annelien Van Dalem, Olivier Costa, Harry Dorchy, Chantal Mathieu, Luc Van Gaal, Bart Keymeulen, Daniël G Pipeleers, Ilse Weets
OBJECTIVE: We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a 20-year progression to diabetes from first autoantibody positivity (autoAb(+)) in first-degree relatives of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: Persistently islet autoAb(+) siblings and offspring (n = 462) under 40 years of age were followed by the Belgian Diabetes Registry. AutoAbs against insulin (IAA), GAD (GADA), IA-2 antigen (IA-2A), and zinc transporter 8 (ZnT8A) were determined by radiobinding assay...
July 12, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28699640/lfa-1-activates-focal-adhesion-kinases-fak1-pyk2-to-generate-lat-grb2-skap1-complexes-that-terminate-t-cell-conjugate-formation
#17
Monika Raab, Yuning Lu, Karsten Kohler, Xin Smith, Klaus Strebhardt, Christopher E Rudd
Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell adaptor protein linker for the activation of T cells (LAT) couples the TCR to downstream events. Here, we show that LFA-1 can mediate both adhesion and de-adhesion, dependent on receptor clustering. Although increased affinity mediates adhesion, LFA-1 cross-linking induced the association and activation of the protein-tyrosine kinases FAK1/PYK1 that phosphorylated LAT selectively on a single Y-171 site for the binding to adaptor complex GRB-2-SKAP1...
July 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28698481/plasma-neutrophil-gelatinase-associated-lipocalin-and-predicting-clinically-relevant-worsening-renal-function-in-acute-heart-failure
#18
Kevin Damman, Mattia A E Valente, Dirk J van Veldhuisen, John G F Cleland, Christopher M O'Connor, Marco Metra, Piotr Ponikowski, Gad Cotter, Beth Davison, Michael M Givertz, Daniel M Bloomfield, Hans L Hillege, Adriaan A Voors
The aim of this study was to evaluate the ability of Neutrophil Gelatinase-Associated Lipocalin (NGAL) to predict clinically relevant worsening renal function (WRF) in acute heart failure (AHF). Plasma NGAL and serum creatinine changes during the first 4 days of admission were investigated in 1447 patients hospitalized for AHF and enrolled in the Placebo-Controlled Randomized Study of the Selective A₁Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized with Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function (PROTECT) study...
July 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28698449/in-vitro-evaluation-of-the-inhibitory-activity-of-thymoquinone-in-combatting-candida-albicans-in-denture-stomatitis-prevention
#19
Ahmad M Al-Thobity, Khalifa S Al-Khalifa, Mohammed M Gad, Mohammed Al-Hariri, Aiman A Ali, Talal Alnassar
Candida albicans adhesion and proliferation on denture bases may lead to denture stomatitis, which is a common and recurrent problem in denture wearers. The goal of this study was to assess the inhibitory effect of thymoquinone incorporated in the polymethyl methacrylate denture base material against Candida albicans. Eighty acrylic resin specimens were fabricated and divided into eight groups (n = 10) according to thymoquinone concentrations of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, and 5% of acrylic powder. Two methods were used to evaluate the effect of thymoquinone on Candida albicans: the slide count and the serial dilution test...
July 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28697559/depressive-symptoms-and-tau-accumulation-in-the-inferior-temporal-lobe-and-entorhinal-cortex-in-cognitively-normal-older-adults-a-pilot-study
#20
Jennifer R Gatchel, Nancy J Donovan, Joseph J Locascio, Aaron P Schultz, J Alex Becker, Jasmeer Chhatwal, Kathryn V Papp, Rebecca E Amariglio, Dorene M Rentz, Deborah Blacker, Reisa A Sperling, Keith A Johnson, Gad A Marshall
BACKGROUND: Depressive symptoms are common in older adults and associated with increased morbidity and cognitive decline. These symptoms occur during preclinical and prodromal stages of Alzheimer's disease (AD), but their relationship to tau, one of the main AD proteinopathies, is poorly understood. OBJECTIVE: The objective of this study was to investigate the cross-sectional association between depressive symptoms and cerebral tau [18F T807 (also known as 18F-AV-1451) tau positron emission tomography (PET) imaging] in cognitively normal (CN) older adults...
July 4, 2017: Journal of Alzheimer's Disease: JAD
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