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https://www.readbyqxmd.com/read/28088111/psychometric-evaluation-of-the-generalized-anxiety-disorder-screener-gad-7-based-on-a-large-german-general-population-sample
#1
Andreas Hinz, Annette M Klein, Elmar Brähler, Heide Glaesmer, Tobias Luck, Steffi G Riedel-Heller, Kerstin Wirkner, Anja Hilbert
BACKGROUND: The Generalized Anxiety Disorder Scales GAD-7 and GAD-2 are instruments for the assessment of anxiety. The aims of this study are to test psychometric properties of these questionnaires, to provide normative values, and to investigate associations with sociodemographic factors, quality of life, psychological variables, and behavioral factors. METHODS: A German community sample (n=9721) with an age range of 18-80 years was surveyed using the GAD-7 and several other questionnaires...
December 18, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28077221/interpersonal-problems-predict-differential-response-to-cognitive-versus-behavioral-treatment-in-a-randomized-controlled-trial
#2
Michelle G Newman, Nicholas C Jacobson, Thane M Erickson, Aaron J Fisher
OBJECTIVE: We examined dimensional interpersonal problems as moderators of cognitive behavioral therapy (CBT) versus its components (cognitive therapy [CT] and behavioral therapy [BT]). We predicted that people with generalized anxiety disorder (GAD) whose interpersonal problems reflected more dominance and intrusiveness would respond best to a relaxation-based BT compared to CT or CBT, based on studies showing that people with personality features associated with a need for autonomy respond best to treatments that are more experiential, concrete, and self-directed compared to therapies involving abstract analysis of one's problems (e...
January 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28075650/pharmacokinetic-evaluation-of-pregabalin-for-the-treatment-of-generalized-anxiety-disorder
#3
Massimiliano Buoli, Alice Caldiroli, Marta Serati
Pregabalin is an alternative compound to SSRIs and SNRIs for the first-line treatment of generalized anxiety disorder (GAD). Areas covered: We describe the pharmacokinetic properties of pregabalin and their implications for the treatment of GAD. A search in the main database sources (Medline, ISI, Web of Knowledge and Medscape) was performed in order to obtain a comprehensive and balanced evaluation about the clinical implications of the pharmacokinetic properties of pregabalin in the treatment of GAD. The word "pregabalin" was associated with "pharmacokinetics", "interactions"', "GAD", "anxiety" and "tolerability"...
January 11, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28068460/side-effects-to-antidepressant-treatment-in-patients-with-depression-and-comorbid-panic-disorder
#4
Stewart A Shankman, Stephanie M Gorka, Andrea C Katz, Daniel N Klein, John C Markowitz, Bruce A Arnow, Rachel Manber, Barbara O Rothbaum, Michael E Thase, Alan F Schatzberg, Martin B Keller, Madhukar H Trivedi, James H Kocsis
OBJECTIVE: Side effects to antidepressant medication can affect the efficacy of treatment, but few predictors foretell who experiences side effects and which side effects they experience. This secondary data analysis examined whether depressed patients with comorbid panic disorder were more likely to experience side effects than those without panic disorder. The study also examined whether greater burden of side effects predicted a poorer treatment course for patients with panic disorder than those without panic disorder...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28067044/a-physiology-oriented-engineering-strategy-to-improve-gamma-aminobutyrate-production-in-lactobacillus-brevis
#5
Changjiang Lyu, Weirui Zhao, Sheng Hu, Jun Huang, Tao Lu, Zhihua Jin, Lehe Mei, Shan-Jing Yao
Gamma-aminobutyrate (GABA) is an important chemical in pharmaceutical field. GABA-producing lactic acid bacteria (LAB) offer the opportunity of developing this health-oriented product. In this study, the gadA, gadB, gadC, gadCB and gadCA gene segments of Lactobacillus brevis were cloned into pMG36e, and strain Lb. brevis/pMG36e-gadA was selected for thorough characterization in terms of GABA production after analysis of GAD activities. Subsequently, a physiology-oriented engineering strategy was adopted to construct an FoF1-ATPase deficient strain NRA6 with higher GAD activity...
January 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28064112/ultra-short-screening-instruments-for-major-depressive-episode-and-generalized-anxiety-disorder-in-epilepsy-the-nddie-2-and-the-gad-si
#6
Jean-Arthur Micoulaud-Franchi, Fabrice Bartolomei, Aileen McGonigal
BACKGROUND: Systematic screening is recommended for major depressive episode (MDE) with the Neurological Disorders Depression Inventory for Epilepsy NDDI-E, 6 items and generalized anxiety disorder (GAD) with the GAD 7 items in patients with epilepsy (PWE). Shorter versions of the NDDI-E and the GAD-7 could facilitate increased screening by busy clinicians and be more accessible to patients with mild cognitive and/or language impairments. METHODS: The effectiveness of ultra-short versions of the NDDI-E (2 items) and the GAD-7 (the GAD-2, 2 items, and the GAD-SI with a single item) in comparison with the original versions were statistically tested using ROC analysis...
December 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28063073/suicidal-ideation-persists-among-individuals-engaged-in-hiv-care-in-the-era-of-antiretroviral-therapy
#7
J D López, E Shacham, T Brown
Little research has focused on suicidality in the era of successful antiretroviral therapy among those engaged in HIV care. We performed a study of 648 clinic patients who completed a psychological and behavioral annual assessment in 2012. Depressive symptoms were measured using the Patient Health Questionnaire-9 (PHQ-9), suicidal ideation was measured by the last item of the scale. Anxiety symptoms were measured using the Generalized Anxiety Disorder-7 questionnaire (GAD-7). HIV biomedical markers were abstracted from medical records...
January 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28062647/on-the-effect-of-alkaline-ph-and-cofactor-availability-in-the-conformational-and-oligomeric-state-of-escherichia-coli-glutamate-decarboxylase
#8
F Giovannercole, C Mérigoux, C Zamparelli, D Verzili, G Grassini, M Buckle, P Vachette, D De Biase
Escherichia coli glutamate decarboxylase (EcGad) is a homohexameric pyridoxal 5'-phosphate (PLP)-dependent enzyme. It is the structural component of the major acid resistance system that protects E. coli from strong acid stress (pH < 3), typically encountered in the mammalian gastrointestinal tract. In fact EcGad consumes one proton/catalytic cycle while yielding γ-aminobutyrate and carbon dioxide from the decarboxylation of l-glutamate. Two isoforms of Gad occur in E. coli (GadA and GadB) that are 99% identical in sequence...
January 5, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/28062252/using-neuroimaging-to-individualize-tms-treatment-for-depression-toward-a-new-paradigm-for-imaging-guided-intervention
#9
Bruce M Luber, Simon Davis, Elisabeth Bernhardt, Andrada Neacsiu, Lori Kwapil, Sarah H Lisanby, Timothy J Strauman
The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than state-of-the-science methods which incorporate fMRI-guided neuronavigation based on a specific model of neurocircuit dysfunction. In this review, we examine such a specific model drawn from regulatory focus theory, which postulates two brain/behavior systems, the promotion and prevention systems, underlying goal pursuit...
January 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28058109/engagement-and-outcomes-for-a-computerised-cognitive-behavioural-therapy-intervention-for-anxiety-and-depression-in-african-americans
#10
Charles R Jonassaint, Patrice Gibbs, Bea Herbeck Belnap, Jordan F Karp, Kaleab K Abebe, Bruce L Rollman
BACKGROUND: Computerised cognitive-behavioural therapy (CCBT) helps improve mental health outcomes in White populations. However, no studies have examined whether CCBT is acceptable and beneficial for African Americans. AIMS: We studied differences in CCBT use and self-reported change in depression and anxiety symptoms among 91 African Americans and 499 White primary care patients aged 18-75, enrolled in a randomised clinical trial of collaborative care embedded with an online treatment for depression and anxiety...
January 2017: BJPsych Open
https://www.readbyqxmd.com/read/28057609/intellicare-an-eclectic-skills-based-app-suite-for-the-treatment-of-depression-and-anxiety
#11
David C Mohr, Kathryn Noth Tomasino, Emily G Lattie, Hannah L Palac, Mary J Kwasny, Kenneth Weingardt, Chris J Karr, Susan M Kaiser, Rebecca C Rossom, Leland R Bardsley, Lauren Caccamo, Colleen Stiles-Shields, Stephen M Schueller
BACKGROUND: Digital mental health tools have tended to use psychoeducational strategies based on treatment orientations developed and validated outside of digital health. These features do not map well to the brief but frequent ways that people use mobile phones and mobile phone apps today. To address these challenges, we developed a suite of apps for depression and anxiety called IntelliCare, each developed with a focused goal and interactional style. IntelliCare apps prioritize interactive skills training over education and are designed for frequent but short interactions...
January 5, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28055573/guidelines-for-the-detection-of-babesia-and-theileria-parasites
#12
Laetitia Lempereur, Relja Beck, Isabel Fonseca, Cátia Marques, Ana Duarte, Marcos Santos, Sara Zúquete, Jacinto Gomes, Gernot Walder, Ana Domingos, Sandra Antunes, Gad Baneth, Cornelia Silaghi, Patricia Holman, Annetta Zintl
The genera Babesia and Theileria (phylum Apicomplexa, order Piroplasmida) are mainly transmitted by Ixodid ticks in which the sexual part of their life cycle followed by sporogony takes place. They include protozoan parasites that infect erythrocytes of a variety of vertebrate hosts, including domestic and wild animals, with some Babesia spp. also infecting humans. Babesia sporozoites transmitted in the tick's saliva during the bloodmeal directly infect erythrocytes, where they asexually multiply to produce pear-shaped merozoites in the process of merogony; whereas a pre-erythrocytic schizogonic life stage in leukocytes is found in Theileria and precedes merogony in the erythrocytes...
January 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28055571/a-review-of-methods-for-detection-of-hepatozoon-infection-in-carnivores-and-arthropod-vectors
#13
David Modrý, Relja Beck, Kristýna Hrazdilová, Gad Baneth
Vector-borne protists of the genus Hepatozoon belong to the apicomplexan suborder Adeleorina. The taxonomy of Hepatozoon is unsettled and different phylogenetic clades probably represent evolutionary units deserving the status of separate genera. Throughout our review, we focus on the monophyletic assemblage of Hepatozoon spp. from carnivores, classified as Hepatozoon sensu stricto that includes important pathogens of domestic and free-ranging canine and feline hosts. We provide an overview of diagnostic methods and approaches from classical detection in biological materials, through serological tests to nucleic acid amplification tests (NAATs)...
January 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28055283/crp-velocity-and-short-term-mortality-in-st-segment-elevation-myocardial-infarction
#14
Assi Milwidsky, Tomer Ziv-Baran, Sevan Letourneau-Shesaf, Gad Keren, Philippe Taieb, Shlomo Berliner, Yacov Shacham
CONTEXT: There is a known association between C-reactive protein (CRP) levels and adverse outcomes in patients presenting with ST-elevation myocardial infarction (STEMI). The optimal time frame to measure CRP for risk stratification is not known. OBJECTIVE: The aim of the current study was to evaluate the relation between the change in CRP velocity (CRPv) and 30-day mortality among STEMI patients. MATERIAL AND METHODS: We included consecutive patients with a diagnosis of STEMI who presented to Tel-Aviv Medical Center between 2008 to 2014 and had their CRP measured with a wide range assay (wr-CRP) at least twice during the 24 hours after admission...
January 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28054376/toll-like-receptor-tlr-7-expression-in-mycosis-fungoides-and-psoriasis-a-case-control-study
#15
A M El Tawdy, I M Amin, R M Abdel Hay, A S Hassan, Z S Gad, L A Rashed
BACKGROUND: Toll-like receptors (TLRs) have been implicated in various dermatological diseases. TLR agonists have the capacity to potently activate the innate immune cells of patients with advanced, refractory, cutaneous T-cell lymphoma (CTCL). AIM: To detect TLR7 gene expression in mycosis fungoides (MF) (a neoplastic skin condition) and to compare it with psoriasis (an inflammatory skin condition) in an attempt to clarify the pathogenic role played by TLR7 in both conditions...
January 5, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28051028/influence-of-marital-status-on-the-quality-of-life-of-chinese-adult-patients-with-epilepsy
#16
Fu-Li Wang, Xiang-Min Gu, Bao-Yun Hao, Shan Wang, Ze-Jie Chen, Cheng-Yun Ding
BACKGROUND: Epilepsy is a chronic disorder characterized by recurrent seizures and has significant psychological and social consequence for everyday living. Epilepsy affects various aspects of ones' social life. The present study aimed to investigate the influence of marital status on the quality of life of adult Chinese patients with epilepsy. METHODS: This study surveyed 805 Chinese adults who have been clinically diagnosed with epilepsy for longer than 1 year in 11 hospitals in Beijing...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28048325/th-cd-202-07-a-methodology-for-generating-numerical-phantoms-for-radiation-therapy-using-geometric-attribute-distribution-models
#17
S Dolly, H Chen, S Mutic, M Anastasio, H Li
PURPOSE: A persistent challenge for the quality assessment of radiation therapy treatments (e.g. contouring accuracy) is the absence of the known, ground truth for patient data. Moreover, assessment results are often patient-dependent. Computer simulation studies utilizing numerical phantoms can be performed for quality assessment with a known ground truth. However, previously reported numerical phantoms do not include the statistical properties of inter-patient variations, as their models are based on only one patient...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043063/investigation-of-neuronal-auto-antibodies-in-systemic-lupus-erythematosus-patients-with-epilepsy
#18
Zerrin Karaaslan, Esme Ekizoğlu, Pınar Tektürk, Ece Erdağ, Erdem Tüzün, Nerses Bebek, Candan Gürses, Betül Baykan
PURPOSE: Epilepsy is an important feature for neuropsychiatric involvement in systemic lupus erythematosus (SLE) with unknown mechanism. Our aim was to investigate the presence of neuronal auto-antibodies (NAbs) in neuropsychiatric SLE (NPSLE). METHODS: Eighteen SLE patients (17 females, 1 male) experiencing recurrent seizures were enrolled to this study. Their clinical characteristics, EEG and MRI findings and follow-up information were evaluated from their files...
December 14, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28043058/epilepsy-surgery-in-drug-resistant-temporal-lobe-epilepsy-associated-with-neuronal-antibodies
#19
Mar Carreño, Christian G Bien, Ali A Asadi-Pooya, Michael Sperling, Petr Marusic, Martin Elisak, Jose Pimentel, Tim Wehner, Rajiv Mohanraj, Juan Uranga, Asier Gómez-Ibáñez, Vicente Villanueva, Francisco Gil, Antonio Donaire, Nuria Bargalló, Jordi Rumià, Pedro Roldán, Xavier Setoain, Luis Pintor, Teresa Boget, Eva Bailles, Mercè Falip, Javier Aparicio, Josep Dalmau, Francesc Graus
We assessed the outcome of patients with drug resistant epilepsy and neuronal antibodies who underwent epilepsy surgery. Retrospective study, information collected with a questionnaire sent to epilepsy surgery centers. Thirteen patients identified, with antibodies to GAD (8), Ma2 (2), Hu (1), LGI1 (1) or CASPR2 (1). Mean age at seizure onset: 23 years. Five patients had an encephalitic phase. Three had testicular tumors and five had autoimmune diseases. All had drug resistant temporal lobe epilepsy (median: 20 seizures/month)...
December 15, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28042613/targeting-cancer-using-polymeric-nanoparticle-mediated-combination-chemotherapy
#20
Aniket Gad, Janel Kydd, Brandon Piel, Prakash Rai
Cancer forms exhibiting poor prognosis have been extensively researched for therapeutic solutions. One of the conventional modes of treatment, chemotherapy shows inadequacy in its methodology due to imminent side-effects and acquired drug-resistance by cancer cells. However, advancements in nanotechnology have opened new frontiers to significantly alleviate collateral damage caused by current treatments via innovative delivery techniques, eliminating pitfalls encountered in conventional treatments. Properties like reduced drug-clearance and increased dose efficacy by the enhanced permeability and retention effect deem nanoparticles suitable for this application...
September 2016: Int J Nanomed Nanosurg
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