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https://www.readbyqxmd.com/read/28819632/detection-of-islet-cell-immune-reactivity-with-low-glycemic-index-foods-is-this-a-concern-for-type-1-diabetes
#1
Datis Kharrazian, Martha Herbert, Aristo Vojdani
Dietary management of autoimmune diabetes includes low glycemic foods classified from the glycemic index, but it does not consider the role that immunoreactive foods may play with the immunological etiology of the disease. We measured the reactivity of either monoclonal or polyclonal affinity-purified antibodies to insulin, insulin receptor alpha, insulin receptor beta, zinc transporter 8 (ZnT8), tyrosine phosphatase-based islet antigen 2 (IA2), and glutamic acid decarboxylase (GAD) 65 and 67 against 204 dietary proteins that are commonly consumed...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28818810/evaluating-quality-of-life-in-epilepsy-the-role-of-screening-for-adverse-drug-effects-depression-and-anxiety
#2
Jean-Arthur Micoulaud-Franchi, Fabrice Bartolomei, Roderick Duncan, Aileen McGonigal
OBJECTIVE: The objective of this study was to evaluate the contribution of validated screening tools for antiepileptic drug (AED) adverse effects, depression, and anxiety to measure the quality of life (QoL) in people with epilepsy (PWE). METHODS: Patients in a tertiary epilepsy service were screened for quality of life (using QOLIE-31), major depressive disorder (MDD) (NDDI-E), generalized anxiety disorder (GAD) (GAD-7), and AED effects (AEP). Mini International Neuropsychiatric Interview (MINI) generalized anxiety disorder module was also performed...
August 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28818699/apathy-in-people-with-epilepsy-and-its-clinical-significance-a-case-control-study
#3
Jong-Geun Seo, Gun-Hee Lee, Sung-Pa Park
PURPOSE: Apathy as a state of decreased motivation has not been highlighted in people with epilepsy (PWE). We investigated its clinical significance in PWE. METHODS: We invited adult PWE who had been administered antiepileptic drugs (AEDs) for at least 1year and compared them with age- and gender-matched healthy controls. Eligible participants completed several questionnaires including the Apathy Evaluation Scale-Self (AES-S), the Korean version of the Neurological Disorders Depression Inventory for Epilepsy (K-NDDI-E), the Generalized Anxiety Disorder-7 (GAD-7), the Epworth Sleepiness Scale (ESS), and the Insomnia Severity Index (ISI), and the Quality of Life in Epilepsy-10 (QOLIE-10)...
August 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28818145/protective-effects-of-emotional-intelligence-and-proactive-coping-on-civil-pilots-mental-health
#4
Yaning Guo, Ming Ji, Xuqun You, Jie Huang
INTRODUCTION: Pilots' mental health is an issue of crucial importance that may endanger flight safety. As such, it is of profound significance to address the question of what characteristics are protective of mental health among pilots. The present study aimed to explore the indirect effects of emotional intelligence (EI) on depression and anxiety via proactive coping, and examine the moderating role of previous flight experience (PFE) in the conditional indirect effect of EI on depression through proactive coping...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28815865/bone-marrow-and-adipose-mesenchymal-stem-cells-attenuate-cardiac-fibrosis-induced-by-methotrexate-in-rats
#5
Ebtehal Mohammad Fikry, Wedad A Hassan, Amany M Gad
Mesenchymal stem cells (MSCs) are an ideal adult stem cell with capacity for self-renewal and differentiation with an extensive tissue distribution. The present study evaluates the therapeutic effects of bone marrow mesenchymal stem cells (BM-MSCs) or adipose-derived mesenchymal stem cells (AD-MSCs) against the development of methotrexate (MTX)-induced cardiac fibrosis versus dexamethasone (DEX). Rats were allocated into five groups; group 1, received normal saline orally; group 2, received MTX (14 mg/kg/week for 2 weeks); groups 3 and 4, treated once with 2 × 10(6) cells of MTX + BM-MSCs and MTX + AD-MSCs, respectively; and group 5, MTX + DEX (0...
August 16, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28815738/the-effect-of-depression-generalized-anxiety-and-selective-serotonin-reuptake-inhibitors-on-change-in-bone-metabolism-in-adolescents-and-emerging-adults
#6
Chadi A Calarge, James A Mills, Kathleen F Janz, Trudy L Burns, Janet A Schlechte, William H Coryell, Babette S Zemel
OBJECTIVES: To prospectively examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) use to changes in bone metabolism in older adolescents and emerging adults. METHODS: Medically-healthy 15 to 20 year-olds who were unmedicated or within one month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly...
August 16, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28814859/inhibitory-effect-of-zirconium-oxide-nanoparticles-on-candida-albicans-adhesion-to-repaired-polymethyl-methacrylate-denture-bases-and-interim-removable-prostheses-a-new-approach-for-denture-stomatitis-prevention
#7
Mohammed M Gad, Ahmad M Al-Thobity, Suliman Y Shahin, Badar T Alsaqer, Aiman A Ali
BACKGROUND: Despite drawbacks, cold-cured acrylic resin is still the most common material used in denture repair. Zirconia nanoparticles were among the reinforcements added to increase the strength of the resin. The effect on Candida due to the addition of zirconia nanoparticles to the resin has not been investigated. PURPOSE: The aim of this study was to evaluate the effect of zirconia nanoparticles added to cold-cured acrylic resin on Candida albicans adhesion...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28811200/globular-adiponectin-reverses-osteo-sarcopenia-and-altered-body-composition-in-ovariectomized-rats
#8
Shyamsundar Pal China, Subhashis Pal, Sourav Chattopadhyay, Konica Porwal, Sapana Kushwaha, Sharmishtha Bhattacharyya, Monika Mittal, Anagha A Gurjar, Tarun Barbhuyan, Abhishek K Singh, Arun K Trivedi, Jiaur R Gayen, Sabyasachi Sanyal, Naibedya Chattopadhyay
Adiponectin regulates various metabolic processes including glucose flux, lipid breakdown and insulin response. We recently reported that adiponectin receptor1 (adipoR1) activation by a small molecule reverses osteopenia in leptin receptor deficient db/db (diabetic) mice. However, the role of adiponectin in bone metabolism under the setting of post-menopausal (estrogen-deficiency) osteopenia and associated metabolic derangements has not been studied. Here, we studied the therapeutic effect of the globular form of adiponectin (gAd), which is predominantly an adipoR1 agonist, in aged ovariectomized (OVX) rats and compared it with standard-of-care anti-osteoporosis drugs...
August 12, 2017: Bone
https://www.readbyqxmd.com/read/28809854/in-the-grip-of-worry-cerebral-blood-flow-changes-during-worry-induction-and-reappraisal-in-late-life-generalized-anxiety-disorder
#9
H T Karim, D L Tudorascu, M A Butters, S Walker, H J Aizenstein, C Andreescu
Severe worry includes a complex blend of maladaptive affective and cognitive processes. Contrary to other forms of anxiety, there is no consensus in the field regarding the neural basis of worry. To date, no study has looked at neural patterns associated specifically with in-scanner induction and reappraisal of worry. In this study, we attempt to describe distinct components of the 'neural phenomenology' of worry: induction, maintenance, severity and reappraisal, by using a personalized, in-scanner worry script...
August 15, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28807136/misuse-of-prescription-opioids-among-chronic-pain-patients-suffering-from-anxiety-a-cross-sectional-analysis
#10
Daniel Feingold, Silviu Brill, Itay Goor-Aryeh, Yael Delayahu, Shaul Lev-Ran
OBJECTIVE: In the past two decades, chronic pain has been increasingly treated with prescription opioids, particularly in developed countries. This has drawn public concern of possible risks associated with the potential misuse of prescriptions opioids. Previous research has indicated that this may be particularly true among individuals suffering from co-occurring psychiatric disorders. The present study sought to explore rates of misuse among chronic pain patients prescribed opioids, comparing individuals with and without anxiety...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28806609/sleep-disturbances-in-young-and-middle-aged-adults-empirical-patterns-and-related-factors-from-an-epidemiological-survey
#11
Wulf Rössler, Vladeta AjdacicGross, Nick Glozier, Stephanie Rodgers, Helene Haker, Mario Müller
BACKGROUND: Previous research suggests that sleep disorders are highly associated with other mental health problems. However, sleep problems even below the diagnostic threshold of sleep disorders are very common in the general population, which highly affects wellbeing and functioning. In order to broaden the focus beyond those severe cases we explored empirical patterns across the whole spectrum of sleep problems as well as associated clinical and other factors. METHOD: A representative community sample of N=1274 residents from the canton of Zurich was interviewed for sleep problems and diagnostic criteria for mental disorders as well as was given a number of mental health-related psychometrical checklists...
July 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28805404/mixed-methods-evaluation-of-a-collaborative-care-implementation-using-re-aim
#12
Bethany M Kwan, Sanjay Chadha, Mika K Hamer, David Spagnolo, Sheila Kee
INTRODUCTION: Application of the reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework using mixed methods to evaluate a collaborative care practice implementation can inform the literature on real-world collaborative care experiences. METHOD: Two primary care practices serving Niagara Falls, NY, implemented collaborative care. Adults age 18 and over were screened at least annually for depression, anxiety, and alcohol use using the 9-item Patient Health Questionnaire (PHQ-9), the 7-item Generalized Anxiety Disorder questionnaire (GAD-7), and the AUDIT alcohol consumption questionnaire (AUDIT-C)...
August 14, 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/28803688/demand-withdraw-communication-in-the-context-of-intimate-partner-violence-implications-for-psychological-outcomes
#13
Alison M Pickover, Alexandra J Lipinski, Thomas S Dodson, Han N Tran, Matthew J Woodward, J Gayle Beck
Intimate partner violence (IPV) is associated with symptoms of posttraumatic stress disorder (PTSD) and generalized anxiety disorder (GAD). To clarify the influence of a dyadic conflict pattern that has previously been shown to accompany violence in romantic relationships (partner demand/self withdraw) on these mental health outcomes, we examined the associations between three forms of IPV (physical, emotional-verbal, dominance-isolation), partner demand/self withdraw, and PTSD and GAD symptoms, in a sample of 284 IPV-exposed women...
July 22, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28800174/curcumin-ameliorates-diclofenac-sodium-induced-nephrotoxicity-in-male-albino-rats
#14
Ahmady Y Ahmed, Amany M Gad, Ola M Abd El-Raouf
Exposure to drugs often results in toxicity in the kidney which represents the major control system maintaining homeostasis of the body and thus is especially susceptible to xenobiotics. Nephrotoxicity is a life-threatening side-effect of nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac is one of the most frequently prescribed NSAIDs and have been reported to cause multiple organs damage. Curcumin (CUR) exhibits nephroprotective properties. Therefore, rats were divided into four groups; rats of groups 3 and 4 received diclofenac (100 mg/kg, i...
August 11, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28790831/spontaneous-alterations-of-regional-brain-activity-in-patients-with-adult-generalized-anxiety-disorder
#15
Likun Xia, Shumei Li, Tianyue Wang, Yaping Guo, Lihong Meng, Yunping Feng, Yu Cui, Fan Wang, Jian Ma, Guihua Jiang
OBJECTIVE: We aimed to examine how spontaneous brain activity might be related to the pathophysiology of generalized anxiety disorder (GAD). PATIENTS AND METHODS: Using resting-state functional MRI, we examined spontaneous regional brain activity in 31 GAD patients (mean age, 36.87±9.16 years) and 36 healthy control participants (mean age, 39.53±8.83 years) matched for age, education, and sex from December 2014 to October 2015. We performed a two-sample t-test on the voxel-based analysis of the regional homogeneity (ReHo) maps...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28789715/metabolic-alterations-in-generalised-anxiety-disorder-a-review-of-proton-magnetic-resonance-spectroscopic-studies
#16
G Delvecchio, J A Stanley, A C Altamura, P Brambilla
Generalised anxiety disorder (GAD) is a common psychiatric illness characterised by selective morpho-functional brain alterations. The breath of neuroimaging studies investigating the neural basis of GAD is extensive; however, its pathophysiology is still largely unknown. Specifically for proton Magnetic Resonance Spectroscopy (¹H MRS) investigations, which have the aim of identifying differences in metabolite levels between conditions in key brain areas, often showed contrasting results. Indeed, there are selected ¹H MRS studies reporting deficits of key metabolites in GAD patients; however, collectively the literature remains mixed with respect to consistency of major findings...
August 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28783004/sorption-behavior-of-eu-iii-from-an-aqueous-solution-onto-modified-hydroxyapatite-kinetics-modeling-and-thermodynamics
#17
H M H Gad, M A Youssef
Nano-pore hydroxyapatite (HAP) was prepared using physical activation of raw and chemically modified [using Acid; HNO3 (HAPA) or Base; NaOH (HAPB)] bone char (BC) by heating at 900°C for 1 hr to obtain HAP9, HAPA9 and HAPB9, respectively. Investigation the effects of thermal and chemical treatment of prepared nano-hydroxyapatite on elemental analysis, FTIR, scanning electron microscopy, surface area and consequently, the sorption behavior of Eu (III) ions onto the prepared nano-pore hydroxyapatite. Batch adsorption technique was used and the obtained results revealed that the optimum pH = 5...
August 16, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28777984/comorbid-sleep-disorders-and-suicide-risk-among-children-and-adolescents-with-bipolar-disorder
#18
Ian H Stanley, Melanie A Hom, Joan L Luby, Paramjit T Joshi, Karen D Wagner, Graham J Emslie, John T Walkup, David A Axelson, Thomas E Joiner
Children and adolescents with bipolar disorder are at increased risk for suicide. Sleep disturbances are common among youth with bipolar disorder and are also independently implicated in suicide risk; thus, comorbid sleep disorders may amplify suicide risk in this clinical population. This study examined the effects of comorbid sleep disorders on suicide risk among youth with bipolar disorder. We conducted secondary analyses of baseline data from the Treatment of Early Age Mania (TEAM) study, a randomized controlled trial of individuals aged 6-15 years (mean ± SD = 10...
July 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28777828/depression-anxiety-and-smartphone-addiction-in-university-students-a-cross-sectional-study
#19
Jocelyne Matar Boumosleh, Doris Jaalouk
OBJECTIVES: The study aims to assess prevalence of smartphone addiction symptoms, and to ascertain whether depression or anxiety, independently, contributes to smartphone addiction level among a sample of Lebanese university students, while adjusting simultaneously for important sociodemographic, academic, lifestyle, personality trait, and smartphone-related variables. METHODS: A random sample of 688 undergraduate university students (mean age = 20.64 ±1.88 years; 53% men) completed a survey composed of a) questions about socio-demographics, academics, lifestyle behaviors, personality type, and smartphone use-related variables; b) 26-item Smartphone Addiction Inventory (SPAI) Scale; and c) brief screeners of depression and anxiety (PHQ-2 and GAD-2), which constitute the two core DSM-IV items for major depressive disorder and generalized anxiety disorder, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28777032/suicidal-ideation-in-an-egyptian-sample-of-hospitalized-patients-with-acute-psychosis
#20
Maha Ftouh, El-Sayed Gad, Mohammad A Seleem, Sameh Saada, Ahmed A Mubarak
BACKGROUND: Suicide mortality is 12 times higher in psychotic patients compared to the general population. Identifying characteristic of suicidal patients among this group might help in preventing such behavior. AIMS: To assess the predictors of suicidal risk in patients hospitalized due to acute psychosis. METHODS: One hundred and fifty patients (age 18 - 60 years) admitted with acute psychotic features were recruited. Patients were evaluated clinically by The Arabic version of Mini International Neuropsychiatric Interview (M...
August 4, 2017: Clinical Schizophrenia & related Psychoses
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