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https://www.readbyqxmd.com/read/29141340/-survival-time-of-hiv-aids-death-cases-after-antiretroviral-therapy-and-related-factors-in-henan-province-2003-2015
#1
Z Y Chen, Q X Zhao, C F Li, C L Liu, X Yang, X Zhang, Y Sun
Objective: To analyze and investigate the survival time of dead HIV/AIDS patients after antiretroviral therapy (ART) and related factors in Henan province. Methods: The database of national integrated management system of HIV/AIDS was used to collect the information of dead patients who received ART between January 2003 and December 2015. Software SPSS 23.0 was used to analyze the survival time of dead patients and related factors. Result: A total of 6 267 AIDS patients died after ART and the average survival time was 23...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141339/-survival-time-of-hiv-aids-cases-and-related-factors-in-beijing-1995-2015
#2
Y Li, J Wang, S F He, J Chen, H Y Lu
Objective: To analyze the survival time of HIV/AIDS cases and related factors in Beijing from 1995 to 2015. Methods: A retrospective cohort study was conducted to analyze the data of 12 874 HIV/AIDS cases. The data were collected from Chinese HIV/AIDS Comprehensive Information Management System. Life table method was applied to calculate the survival proportion, and Cox proportion hazard regression model were used to identify the factors related with survival time. Results: Among 12 874 HIV/AIDS cases, 303 (2...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29140942/minority-pediatric-patients-with-inflammatory-bowel-disease-demonstrate-an-increased-length-of-stay
#3
Edward L Barnes, Bharati Kochar, Millie D Long, Christopher F Martin, Michael D Kappelman
BACKGROUND: Genetic and other biological factors may lead to differences in disease behavior among children with inflammatory bowel disease of different races, which may be further modified by disparities in care delivery. Using the Kids' Inpatient Database, we aimed to evaluate differences in the management of pediatric patients with inflammatory bowel disease by race, focusing on length of stay (LOS). METHODS: We performed a cross-sectional analysis using 2000 to 2012 data from the Kids' Inpatient Database, a nationally representative database...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29140578/alleviation-of-cadmium-induced-oxidative-stress-by-trehalose-via-inhibiting-the-nrf2-keap1-signaling-pathway-in-primary-rat-proximal-tubular-cells
#4
Xin-Yu Wang, Zhen-Yong Wang, Yi-Song Zhu, Si-Ming Zhu, Rui-Feng Fan, Lin Wang
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates a cluster of oxidative stress-inducible genes in cells. Here, we aimed to investigate whether trehalose (Tre) protects primary rat proximal tubular (rPT) cells against cadmium (Cd)-induced oxidative stress via Nrf2 antioxidant pathway. Data showed that Tre treatment inhibited Nrf2 nuclear translocation and restored the decline in Kelch-like ECH-associated protein 1 (Keap1) protein level in Cd-exposed rPT cells. Moreover, Cd-activated Nrf2 target genes, including phase II detoxifying enzymes, that is, NAD(P)H quinone oxidoreductase 1 and heme oxygenase-1, direct antioxidant proteins, that is, glutathione peroxidase, superoxide dismutase, catalase, and glutathione biosynthesis-related proteins, that is, glutamatecysteine ligase catalytic subunit, glutamate cysteine ligase modifier subunit, and glutathione reductase, were all downregulated by co-treatment with Tre...
November 15, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29138816/protective-effects-of-fucoidan-against-hyperoxic-lung-injury-via-the-erk-signaling-pathway
#5
Minghao Nie, Yan Wang, Yanhong Lu, Ying Yuan, Yingying Liu, Xiurong Li
High oxygen mechanical ventilation is widely used to treat various lung diseases; however, it may result in hyperoxia, which induces inflammation and lung injury. Fucoidan is an extract of the seaweed Fucus vesiculosus, which has previously been reported to exert effects against diabetic nephropathy. The present study is the first, to the best of our knowledge, to investigate the protective effects of fucoidan against hyperoxic lung injury. Balb/c mice were ventilated with 100% oxygen, with or without the atomization inhalation of fucoidan, for 36 h...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29138095/kinetics-and-thermodynamics-of-the-thermal-inactivation-and-chaperone-assisted-folding-of-zebrafish-dihydrofolate-reductase
#6
Charu Thapliyal, Neha Jain, Naira Rashid, Pratima Chaudhuri
The maintenance of thermal stability is a major issue in protein engineering as many proteins tend to form inactive aggregates at higher temperatures. Zebrafish DHFR, an essential protein for the survival of cells, shows irreversible thermal unfolding transition. The protein exhibits complete unfolding and loss of activity at 50 °C as monitored by UV-Visible, fluorescence and far UV-CD spectroscopy. The heat induced inactivation of zDHFR follows first-order kinetics and Arrhenius law. The variation in the value of inactivation rate constant, k with increasing temperatures depicts faster inactivation at elevated temperatures...
November 11, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29136606/heavy-metals-in-soils-of-hechuan-county-in-the-upper-yangtze-sw-china-comparative-pollution-assessment-using-multiple-indices-with-high-spatial-resolution-sampling
#7
Maofei Ni, Rong Mao, Zhongmin Jia, Ruozhu Dong, Siyue Li
In order to assess heavy metals (HMs) in soils of the upper Yangtze Basin, a very high-spatial-resolution sampling (582 soil samples) was conducted from Hechuan County, an important agricultural practice area in the Southwest China. Multiple indices including geoaccumulation index (Igeo), enrichment factor (EF), sediment pollution index (SPI) and risk index (RI), as well as multivariate statistics were employed for pollution assessment and source identification of HMs in soils. Our results demonstrated that the averages of eight HMs decreased in the following order: Zn (82...
November 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29136460/graphitic-nitrogen-triggers-red-fluorescence-in-carbon-dots
#8
Katerina Hola, Mária Sudolská, Sergii Kalytchuk, Dana Nachtigallova, Andrey L Rogach, Michal Otyepka, Radek Zbořil
Carbon dots (CDs) are a stable and highly biocompatible fluorescent material offering great application potential in cell labeling, optical imaging, LED diodes, and optoelectronic technologies. Because their emission wavelengths provide the best tissue penetration, red-emitting CDs are of a particular interest for applications in biomedical technologies. Current synthetic strategies enabling red-shifted emission include increasing the CD particle size (sp2 domain) by a proper synthetic strategy and tuning the surface chemistry of CDs with suitable functional groups (e...
November 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/29135043/a-framework-for-ecological-risk-assessment-of-metal-mixtures-in-aquatic-systems
#9
Charlotte Nys, Tina Van Regenmortel, Colin R Janssen, Koen Oorts, Erik Smolders, Karel A C DE Schamphelaere
Although metal mixture toxicity has been studied relatively intensely, there is no general consensus yet on how to incorporate metal mixture toxicity into aquatic risk assessment. Here, we combined existing data on chronic metal mixture toxicity at the species level with species-sensitivity-distribution (SSD)-based in-silico metal mixture risk predictions at the community-level for mixtures of Ni, Zn, Cu, Cd and Pb, in order to develop a tiered risk assessment scheme for metal mixtures in freshwater. Generally, independent action (IA) predicts chronic metal mixture toxicity at the species level most accurately, while concentration addition (CA) is the most conservative model...
November 14, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29134530/a-review-of-heavy-metal-pollution-levels-and-health-risk-assessment-of-urban-soils-in-chinese-cities
#10
Libo Pan, Yue Wang, Jin Ma, Yu Hu, Benying Su, Guangling Fang, Lei Wang, Bao Xiang
This study assessed literature-based data for the period 2006-2016 regarding heavy metal (As, Cd, Cr, Cu, Pb, Ni, Zn, and Hg) concentrations in soils from 32 Chinese cities and the associated human health risks. The mean concentrations of the eight metals were lower than the soil environmental quality standards in China, but were much higher than the background values for most cities. The enrichment factor (EF) and geoaccumulation index (I geo) values showed moderate pollution levels, possibly influenced by anthropogenic activity for Cd, Hg, Pb, and Zn...
November 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29134519/capability-of-secale-montanum-trusted-for-phytoremediation-of-lead-and-cadmium-in-soils-amended-with-nano-silica-and-municipal-solid-waste-compost
#11
Mehdi Moameri, Masoomeh Abbasi Khalaki
The purpose of this study is to evaluate the capability of Secale montanum trusted for phytoremediation of contaminated soils with lead (Pb) and cadmium (Cd). To conduct this study, soil samples were taken from contaminated rangelands soils around National Lead & Zinc Factory, Zanjan, Iran. In this study, which was performed in a greenhouse, after preparing the pot and treating soils with nano-silica (NS) and municipal solid waste compost (MSWC) amendments, 20 Secale seeds were cultured in each pot. The translocation factor (TF), the bio-concentration factor (BCF), and remediation factor (RF) were calculated to determine the phytoremediation capability of Secale...
November 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29134383/spatial-distribution-and-metal-contamination-in-the-coastal-sediments-of-al-khafji-area-arabian-gulf-saudi-arabia
#12
Talal Alharbi, Hussain Alfaifi, Sattam A Almadani, Abdelbaset El-Sorogy
To document the spatial distribution and metal contamination in the coastal sediments of the Al-Khafji area in the northern part of the Saudi Arabian Gulf, 27 samples were collected for Al, V, Cr, Mn, Cu, Zn, Cd, Pb, Hg, Sr, As, Fe, Co, and Ni analysis using inductively coupled plasma-mass spectrometer (ICP-MS). The results revealed the following descending order of the metal concentrations: Sr > Fe > Al > As > Mn > Ni > V > Zn > Cr > Cu > Pb > Co > Hg > Cd. Average levels of enrichment factor of Sr, As, Hg, Cd, Ni, V, Cu, Co, and Pb were higher than 2 (218...
November 13, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29132002/brassica-napus-has-a-key-role-in-the-recovery-of-the-health-of-soils-contaminated-with-metals-and-diesel-by-rhizoremediation
#13
Rafael G Lacalle, María T Gómez-Sagasti, Unai Artetxe, Carlos Garbisu, José M Becerril
Contaminated soils are frequently characterized by the simultaneous presence of organic and inorganic contaminants, as well as a poor biological and nutritional status. Rhizoremediation, the combined use of phytoremediation and bioremediation, has been proposed as a Gentle Remediation Option to rehabilitate multi-contaminated soils. Recently, newer techniques, such as the application of metallic nanoparticles, are being deployed in an attempt to improve traditional remediation options. In order to implement a phytomanagement strategy on calcareous alkaline peri-urban soils simultaneously contaminated with several metals and diesel, we evaluated the effectiveness of Brassica napus L...
November 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29130664/-prediction-value-of-tweak-fn14-in-crohn-s-disease-with-intestinal-fibrosis
#14
Ting Xu, Yan Yang, Li Zhao, Dan-Dan Zhou, Yan Zhang
OBJECTIVE: To investigate the expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/ fibroblast growth factorinducible 14 (Fn14) in the serum and colon tissue of Crohn's disease (CD) and to elucidate whether the expression of TWEAK/Fn14 can be used as an indicator for intestinal fibrosis. METHODS: Blood samples from 67 CD patients and 33 healthy controls were collected to measure the level of TWEAK by ELISA. Meanwhile,colon samples from 29 CD patients received colectomy and the normal colon tissues from 15 patients with colon cancer were included...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29130308/highly-enhanced-light-outcoupling-efficiency-in-ito-free-organic-light-emitting-diodes-using-surface-nanostructure-embedded-high-refractive-index-polymers
#15
Dong Woo Kim, Joo Won Han, Kwon Taek Lim, Yong Hyun Kim
We develop the internal light outcoupling system (HRLOC) based on the high refractive index polyimide (PI) and metal oxide nanoparticles for organic light-emitting diodes (OLEDs) with silver nanowires (AgNWs). The spontaneously formed nano-bump structures, high refractive index, and light scattering properties of HRLOC significantly enhance the light extraction efficiency of OLEDs. Not only do the outcoupling structures improve the light extraction efficiency, but remarkably enhance the electrical properties of OLEDs...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29129496/runt-related-transcription-factor-2-runx2-inhibits-apoptosis-of-intestinal-epithelial-cells-in-crohn-s-disease
#16
Liugen Gu, Juan Zhao, Shiqing Zhang, Weisong Xu, Runzhou Ni, Xiaojuan Liu
Apoptosis in intestinal epithelial cells (IECs) prevents the development of Crohn's disease (CD), a type of inflammatory bowel disease (IBD). Runt-related transcription factor 2 (Runx2) inhibits apoptosis in osteosarcoma-derived U2OS cells via down-regulating the transcriptional activity of p53. However, the expression and function of Runx2 in CD remain unclear. In this study, Runx2 protein levels were decreased in the intestinal epithelial cells (IECs) of CD patients and in a mouse 2, 4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis model; in contrast, the expression levels of p53 and Bax, a p53-target gene, were increased...
November 8, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29128772/intrinsic-and-extrinsic-factors-which-influence-metal-adsorption-to-road-dust
#17
Ayomi Jayarathne, Prasanna Egodawatta, Godwin A Ayoko, Ashantha Goonetilleke
The adsorption behaviour of metals deposited on road surfaces is a complex process and influenced by a range of factors common to the urban environment. However, all factors do not have the same level of importance. It is therefore important to identify the most crucial factors for accurate stormwater quality predictions and to implement effective stormwater pollution mitigation measures. Accordingly, this study investigated the extrinsic and intrinsic factors in terms of their degree of influence on the adsorption of individual metal cations to particulates...
November 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29127815/distribution-of-metal-and-metalloid-elements-in-human-scalp-hair-in-taiyuan-china
#18
Yuen Zhu, Yuzhe Wang, Fanjian Meng, Lifen Li, Shan Wu, Xiaohui Mei, Hua Li, Guixiang Zhang, Daishe Wu
This study investigated the levels of metal and metalloid elements (As, Ca, Cd, Cr, Cu, Fe, Hg, Mg, Ni, Pb, and Zn) in scalp hair samples collected from 161 people of different age and gender groups living in the six districts of Taiyuan, an industrial city with rich coal reserve in Shanxi province in China. Levels of most elements in the hair were high in the 26-40 age groups and increased with the length of residence. Calcium, Cr, Mg, Ni and Zn levels in the females' hair were significantly higher than those in the males' (p < 0...
November 7, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29127640/single-and-combined-metal-contamination-in-coastal-environments-in-china-current-status-and-potential-ecological-risk-evaluation
#19
Romana Manzoor, Tingwan Zhang, Xuejiao Zhang, Min Wang, Jin-Fen Pan, Zhumei Wang, Bo Zhang
With the development of industrialization and urbanization, metal and metalloid pollution is one of the most serious environmental problems in China. Current contamination status of metals and metalloid and their potential ecological risks along China's coasts were reviewed in the present paper by a comprehensive study on metal contents in marine waters and sediments in the past few decades. The priority metals/metalloid cadmium (Cd), mercury (Hg), chromium (Cr), lead (Pb), and arsenic (As), which were the target elements of the designated project "Comprehensive Prevention and Control of Heavy Metal Pollution" issued by the Chinese government in 2011, were selected considering their high toxicity, persistence, and prevalent existence in coastal environment...
November 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29127572/strong-surface-enhanced-florescence-of-carbon-dot-labeled-bacteria-cells-observed-with-high-contrast-on-gold-film
#20
Rostislav Bukasov, Olena Filchakova, Kristina Gudun, Mohamed Bouhrara
Strong surface (metal) enhanced fluorescence (SEF or MEF) is observed from clusters and single E coli bacteria cells labeled with Carbon nanodots (CDs), which were synthesized from date pits. The enhancement factor (EF) for SEF of the cell clusters were close to 50 for both 533 and 633 nm laser excitation wavelength. Those EFs are ratios of emission peak areas from CD labeled cell clusters on gold film to the peak areas of the same batch cell clusters on glass substrate. SEF with 633 nm excitation performed better than SEF with 532 nm excitation, achieving higher fluorescence intensity and much higher contrast...
November 10, 2017: Journal of Fluorescence
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