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https://www.readbyqxmd.com/read/28445810/circulating-cadmium-concentration-and-risk-of-aortic-aneurysms-a-nested-case-control-study-within-the-malm%C3%A3-diet-and-cancer-cohort
#1
Björn Fagerberg, Yan Borné, Gerd Sallsten, J Gustav Smith, Stefan Acosta, Margaretha Persson, Olle Melander, Niklas Forsgard, Anders Gottsäter, Bo Hedblad, Lars Barregard, Gunnar Engström
BACKGROUND AND AIMS: Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether blood Cd levels, a valid measure of Cd exposure, are associated with increased risk of abdominal aortic aneurysm (AAA). METHODS: All middle-aged men and women enrolled in the Malmö Diet and Cancer study (n = 30 447) were followed from the baseline examination in 1991-1996 through 2009...
April 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28445259/the-role-of-stat3-and-ahr-in-the-differentiation-of-cd4-t-cells-into-th17-and-treg-cells
#2
Xingxing Liu, Hui Hu, Heng Fan, Dongmei Zuo, Zhexing Shou, Yi Liao, Zhen Nan, Qing Tang
BACKGROUND: This study aimed to investigate the role of aryl hydrocarbon receptor (AhR) and STAT3 gene during the differentiation of cluster of differentiation (CD)4 T cells into T helper (Th)17 and T regulatory (Treg) cells. METHODS: First, CD4 T cells were isolated from the spleen of BALB/c mice. Then, stable CD4 T cells expressing STAT3 shRNA were constructed. CD4 T cells were assigned to one of the following treatments: Th17 group: antibodies against CD3 and CD28, 2...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28442662/possible-involvement-of-mucosal-associated-invariant-t-cells-in-the-progression-of-inflammatory-bowel-diseases
#3
Kentaro Tominaga, Satoshi Yamagiwa, Toru Setsu, Naruhiro Kimura, Hiroki Honda, Hiroteru Kamimura, Yutaka Honda, Masaaki Takamura, Junji Yokoyama, Kenji Suzuki, Toshifumi Wakai, Shuji Terai
Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved in anti-bacterial immunity. Recent studies have demonstrated that MAIT cells might be implicated in inflammatory bowel diseases (IBDs), but their precise function in IBD remains to be elucidated. We investigated the possible involvement of MAIT cells in the immunopathogenesis of IBDs. Heparinized peripheral blood and biopsy specimens of the colon were collected from 25 patients with ulcerative colitis (UC), 15 patients with Crohn's disease (CD), and 19 heathy individuals...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28442372/long-term-release-and-stability-of-pharmaceutical-proteins-delivered-from-solid-lipid-implants
#4
Moritz Vollrath, Julia Engert, Gerhard Winter
Solid lipid implants (SLIs) prepared by twin-screw (tsc) extrusion represent a promising technology platform for the sustained release of pharmaceutical proteins. In this work, we report on two aspects, long-term release and stability of released protein. First, SLIs were produced by tsc-extrusion containing the low melting triglyceride H12 and the high melting triglyceride Dynasan D118. Two different proteins available in a freeze-dried matrix containing hydroxypropyl-β-cyclodextrine (HP-β-CD) were incorporated into the lipid matrix: a monoclonal antibody (mAb) from the IgG1 class and the fab-fragment Ranibizumab (Lucentis(®))...
April 22, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28441892/changes-in-blood-and-urinary-cadmium-levels-and-bone-mineral-density-according-to-osteoporosis-medication-in-individuals-with-an-increased-cadmium-body-burden
#5
S-Y Eom, D-H Yim, S-M Hong, Y-D Kim, H Kim, B-S Choi, J-D Park, C-H Park, G-B Kim, S-D Yu
The aim of this study was to assess changes in bone mineral density (BMD) and cadmium (Cd) levels in blood and urine in individuals living in a Cd-contaminated area according to the type of osteoporosis medication over a three-year period. This follow-up study included 204 residents living in the vicinity of a closed copper refinery, who had been found to have elevated urinary or blood Cd levels. Cd levels in the blood and urine, as well as BMD, were measured every 6 months. After the first BMD measurement, individuals were prescribed antiresorptives such as alendronate or vitamin D and calcium, according to their BMD...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28441144/highly-efficient-inverted-organic-light-emitting-diodes-by-inserting-zinc-oxide-polyethyleneimine-zno-pei-nano-composite-interfacial-layer
#6
Rifat Kaçar, Selin Mucur, Fikret Yildiz, Salih Dabak, Emine Tekin
The electrode/organic interface is one of the crucial key factor to attain superior device performance in organic electronics, and inserting a tailor-made layer can dramatically modify its properties. Using of nano-composite (NC) materials lead to many advantages by combining the materials with the objective of getting desirable combination of properties. In this context, zinc oxide/polyethyleneimine (ZnO:PEI) NC film was incorporated as the interfacial layer into the inverted bottom-emission organic light emitting diodes (IBOLEDs) and fully optimized...
April 25, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28440046/attenuated-low-grade-inflammation-following-long-term-dietary-intervention-in-postmenopausal-women-with-obesity
#7
Caroline Blomquist, Malin Alvehus, Jonas Burén, Mats Ryberg, Christel Larsson, Bernt Lindahl, Caroline Mellberg, Ingegerd Söderström, Elin Chorell, Tommy Olsson
OBJECTIVE: Abdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment is therefore needed. METHODS: Seventy healthy postmenopausal women (age 60 ± 5.6 years) with BMI 32.5 ± 5.5 were randomized to a Paleolithic-type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation-related parameters...
May 2017: Obesity
https://www.readbyqxmd.com/read/28439421/factors-associated-with-cesarean-delivery-rates-a-single-institution-experience
#8
Spencer McClelland, Naomi Gorfinkle, Alan A Arslan, Maria Teresa Benedetto-Anzai, Teresa Cheon, Yuzuru Anzai
BACKGROUND: The aim of this study was to identify factors associated with variability in Cesarean delivery (CD) rates amongst providers at a single institution. METHODS: A retrospective cohort analysis was carried out on all births at NYU Langone Medical Center from 2005-2013. Data was collected for subjects and linked to diagnosis codes for singleton and twin deliveries. Descriptive characteristics were generated for all deliveries, and inferential analysis was performed including multiple covariates for singleton deliveries in the 2010-2013 cohort, including both univariate and multivariate regression analyses to identify factors associated with higher CD rates...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28438174/exercise-attenuates-neurological-deficits-by-stimulating-a-critical-hsp70-nf-%C3%AE%C2%BAb-il-6-synapsin-i-axis-in-traumatic-brain-injury-rats
#9
Chung-Ching Chio, Hung-Jung Lin, Yu-Feng Tian, Yu-Chieh Chen, Mao-Tsun Lin, Cheng-Hsien Lin, Ching-Ping Chang, Chien-Chin Hsu
BACKGROUND: Despite previous evidence for a potent inflammatory response after a traumatic brain injury (TBI), it is unknown whether exercise preconditioning (EP) improves outcomes after a TBI by modulating inflammatory responses. METHODS: We performed quantitative real-time PCR (qPCR) to quantify the genes encoding 84 cytokines and chemokines in the peripheral blood and used ELISA to determine both the cerebral and blood levels of interleukin-6 (IL-6). We also performed the chromatin immunoprecipitation (ChIP) assay to evaluate the extent of nuclear factor kappa-B (NF-κB) binding to the DNA elements in the IL-6 promoter regions...
April 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28437770/historical-and-contemporary-metal-budgets-for-a-boreal-shield-lake
#10
Shaun A Watmough
Metal concentrations in sediment cores are widely used to reconstruct metal deposition histories, but rarely have metal budgets based on measured inputs (atmospheric deposition and inflows) and lake outflows been compared with metal fluxes estimated from lake sediment cores. In this study, budgets for six metals (As, Cd, Co, Cu, Ni and Pb) were estimated by measuring inputs in bulk deposition, inputs in the major inflow and export in the lake outflow for one hydrologic year (2002-2003) at Plastic Lake, Ontario, Canada...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28437479/conformational-dynamics-of-bacterial-trigger-factor-in-apo-and-ribosome-bound-states
#11
Mehmet Tarik Can, Zeynep Kurkcuoglu, Gokce Ezeroglu, Arzu Uyar, Ozge Kurkcuoglu, Pemra Doruker
The chaperone trigger factor (TF) binds to the ribosome exit tunnel and helps cotranslational folding of nascent chains (NC) in bacterial cells and chloroplasts. In this study, we aim to investigate the functional dynamics of fully-atomistic apo TF and its complex with 50S. As TF accomodates a high percentage of charged residues on its surface, the effect of ionic strength on TF dynamics is assessed here by performing five independent molecular dynamics (MD) simulations (total of 1.3 micro-second duration) at 29 mM and 150 mM ionic strengths...
2017: PloS One
https://www.readbyqxmd.com/read/28436856/task-based-modeling-of-an-5k-ultra-high-resolution-medical-imaging-system-for-digital-breast-tomosynthesis
#12
Chumin Zhao, Jerzy Kanicki
High-resolution, low noise x-ray detectors based on CMOS active pixel sensor (APS) technology have demonstrated superior imaging performance for digital breast tomosynthesis (DBT). This paper presents a task-based model for a high resolution medical imaging system to evaluate its ability to detect simulated microcalcifications and masses as lesions for breast cancer. Three-dimensional (3D) cascaded system analysis for a 50 μm pixel pitch CMOS APS x-ray detector was integrated with an object task function, a medical imaging display model, and the human eye contrast sensitivity function to calculate the detectability index and area under the ROC curve (AUC)...
April 19, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28435068/metal-metal-interaction-mediates-the-iron-induction-of-drosophila-mtnb
#13
Wenjia Qiang, Yunpeng Huang, Zhihui Wan, Bing Zhou
Metallothionein (MT) protein families are a class of small and universal proteins rich in cysteine residues. They are synthesized in response to heavy metal stresses to sequester the toxic ions by metal-thiolate bridges. Five MT family members, namely MtnA, MtnB, MtnC, MtnD and MtnE, have been discovered and identified in Drosophila. These five isoforms of MTs are regulated by metal responsive transcription factor dMTF-1 and play differentiated but overlapping roles in detoxification of metal ions. Previous researches have shown that Drosophila MtnB responds to copper (Cu), cadmium (Cd) and zinc (Zn)...
April 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28434820/interrelationships-of-metal-transfer-factor-under-wastewater-reuse-and-soil-pollution
#14
D Papaioannou, I K Kalavrouziotis, P H Koukoulakis, F Papadopoulos, P Psoma
The transfer of heavy metals under soil pollution wastewater reuse was studied in a Greenhouse experiment using a randomized block design, including 6 treatments of heavy metals mixtures composed of Zn, Mn, Cd, Co, Cu, Cr, Ni, and Pb, where each metal was taking part in the mixture with 0, 10, 20, 30, 40, 50 mg/kg respectively, in four replications. The Beta vulgaris L (beet) was used as a test plant. It was found that the metal transfer factors were statistically significantly related to the: (i) DTPA extractable soil metals, (ii) the soil pollution level as assessed by the pollution indices, (iii) the soil pH, (iv) the beet dry matter yield and (v) the interactions between the heavy metals in the soil...
April 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28434666/heavy-metal-distribution-and-contamination-status-in-the-sedimentary-environment-of-cochin-estuary
#15
P M Salas, C H Sujatha, C S Ratheesh Kumar, Eldhose Cheriyan
Heavy metals (Fe, Mn, Cr, Zn, Ni, Pb, Cu, Co and Cd) in the surface sediments of Cochin estuary, Southwest coast of India were analyzed to understand the spatio-temporal variation and contamination status via six sampling campaigns. Pollution indices like enrichment factor, geoaccumulation index and pollution load index inferred that the sediments of the northern arm of the estuary exhibited severe trace metal accumulation. Numerical sediment quality guidelines were applied to assess adverse biological effects of the trace metals, suggesting that occasional biological effect may occur due to Cr, Cu, Ni and Pb...
April 20, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28434139/neurological-manifestations-of-atypical-celiac-disease-in-childhood
#16
Çiğdem Genç Sel, Erhan Aksoy, Ayşe Aksoy, Deniz Yüksel, Ferda Özbay
Various typical and atypical neurological manifestations can be seen as the initial symptoms of celiac disease (CD). We suggest that gluten toxicity is the most suspicious triggering risk factor for probable pathophysiological pathways of neurological involvement in atypical CD. The medical charts of 117 patients diagnosed with atypical CD were retrieved from a tertiary center in Ankara, Turkey. Eight patients reported as having neurologic manifestations as initiating symptoms were evaluated in detail. The initial neurological manifestations of CD in our study included atypical absence, which was reported first in this study, generalized tonic-clonic seizures, complex partial seizures, severe axial hypotonia and down phenotype, multifocal leukoencephalopathy, mild optic neuritis, attention deficit hyperactivity disorder, and short duration headaches...
April 22, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28434067/sediment-metal-contamination-in-the-kafue-river-of-zambia-and-ecological-risk-assessment
#17
Ethel M'kandawire, Kennedy Choongo, John Yabe, Maxwell Mwase, Ngonda Saasa, Shouta M M Nakayama, Nesta Bortey-Sam, Claudia A Blindauer
Zambia's Kafue River receives wastes from various sources, resulting in metal pollution. This study determined the degree of contamination of 13 metals (Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, Hg and Pb) in Kafue River sediment and the associated ecological risks at six sites in three different seasons. The level of contamination for most metals showed significant site and seasonal differences. The contamination factor and pollution load index indicated that concentrations of most metals particularly copper (Cu), cobalt (Co), manganese (Mn) and arsenic (As) were very high at sites within the Copperbelt mining area...
April 22, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28433395/distribution-enrichment-and-source-of-heavy-metals-in-rizhao-offshore-area-southeast-shandong-province
#18
Hongying Song, Jinqing Liu, Ping Yin, Yong Zhang
50 surface sediments were collected from Rizhao offshore area to determine heavy metals (Cu, Pb, Zn, Cr, Cd, As, Hg) pollution. High heavy metal values were located near the two ports in the north and south study areas, which was consistent with the distribution of fine-grained sediments. According to threshold effect level (TEL) and probable effect level (PEL), Cu and As had occasionally adverse biological effects on the aquatic ecosystems. The enrichment factor (EF) values showed that most of the study area was moderate or moderately severe enrichment for As, and minor enrichment for Pb, but Hg was only moderately enriched in the river estuaries...
April 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28433060/enhanced-photoresponsive-polyethyleneimine-citric-acid-co-carbonized-dots-for-facile-and-selective-sensing-and-intracellular-imaging-of-cobalt-ions-at-physiologic-ph
#19
Wen-Sheng Zou, Qing-Chun Zhao, Jun Zhang, Xiao-Ming Chen, Xiu-Fang Wang, Lin Zhao, Shao-Hua Chen, Ya-Qin Wang
Whether as an important biological element or as a radioactive source/medicine, the monitoring of trace levels of cobalt ions (Co) has become a non-negligible factor for human health and green environment. Current technologies for the detection of Co are cost-expensive and time-consuming, and require cumbersome sample pretreatment process. Herein a novel sensing platform has been developed for Co detection based on the quenching of the enhanced fluorescence signal of polyamine functionalized C-dots. Amine groups at the surface of the C-dots can capture Zn(2+)/Cd(2+) to form coordination compound, which can inhibit the photoinduced electron transfer pathways of C-dots and then induce the fluorescence enhancement of the C-dots by ∼80% margin...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28432963/health-hazards-of-child-labor-in-the-leather-products-and-surgical-instrument-manufacturing-industries-of-sialkot-pakistan
#20
Muhammad Junaid, Riffat Naseem Malik, De-Sheng Pei
Child labor is a major challenge in the developing countries and comprehensive health hazard identification studies on this issue are still lacking. Therefore, the current study is an effort to highlight the health concerns of child labor exposed in the key small scale industries of Sialkot, Pakistan. Our findings revealed jolting levels of heavy metals in the urine, blood, serum, saliva, and hair samples collected from the exposed children. For example, in the urine samples, Cd, Cr, Ni, and Pb were measured at the respective concentrations of 39...
April 19, 2017: Environmental Pollution
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