keyword
MENU ▼
Read by QxMD icon Read
search

DC Factors

keyword
https://www.readbyqxmd.com/read/28527949/microproteome-of-dentoalveolar-tissues
#1
Cristiane R Salmon, Ana Paula O Giorgetti, Adriana F Paes Leme, Romênia R Domingues, Tamara N Kolli, Brian L Foster, Francisco H Nociti
Proteomic analysis of extracellular matrices (ECM) of dentoalveolar tissues can provide insights into developmental, pathological, and reparative processes. However, targeted dissection of mineralized tissues, dental cementum (DC), alveolar bone (AB), and dentin (DE), presents technical difficulties. We demonstrate an approach combining EDTA decalcification and laser capture microdissection (LCM), followed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), to analyze proteome profiles of these tissues...
May 17, 2017: Bone
https://www.readbyqxmd.com/read/28526431/measurement-of-apt-using-a-combined-cert-arex-approach-with-varying-duty-cycles
#2
Zhongliang Zu, Hua Li, Junzhong Xu, Xiao-Yong Zhang, Moritz Zaiss, Ke Li, Mark D Does, John C Gore, Daniel F Gochberg
The goal is to develop an imaging method where contrast reflects amide-water magnetization exchange, with minimal signal contributions from other sources. Conventional chemical exchange saturation transfer (CEST) imaging of amides (often called amide proton transfer, or APT, and quantified by the metric MTRasym) is confounded by several factors unrelated to amides, such as aliphatic protons, water relaxation, and macromolecular magnetization transfer. In this work, we examined the effects of combining our previous chemical exchange rotation (CERT) approach with the non-linear AREX method while using different duty cycles (DC) for the label and reference scans...
May 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28522600/frontline-science-nasal-epithelial-gm-csf-contributes-to-tlr5-mediated-modulation-of-airway-dendritic-cells-and-subsequent-iga-response
#3
Yuan Cao, Ejuan Zhang, Jingyi Yang, Yi Yang, Jie Yu, Yang Xiao, Wei Li, Dihan Zhou, Yaoming Li, Bali Zhao, Hu Yan, Mengji Lu, Maohua Zhong, Huimin Yan
Flagellin, as a TLR5 agonist, is an established mucosal adjuvant for enhancing mucosal IgA responses by i.n. immunization. Nasal epithelial cells (NECs) are the first sentinel cells to be exposed to antigen and adjuvant in i.n. immunization, and it is suggested that they play an important role in the mucosal adjuvant activity of flagellin. However, the molecular mechanism leading to modulation and the response by flagellin-activated NECs remain unknown. We aimed to identify the soluble mediator(s) from flagellin-activated NECs that modulate the functions of airway dendritic cells (DCs) and enhance subsequent IgA response...
May 18, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28515782/ecotypic-differentiation-under-farmers-selection-molecular-insights-into-the-domestication-of-pachyrhizus-rich-ex-dc-fabaceae-in-the-peruvian-andes
#4
Marc Delêtre, Beatriz Soengas, Prem Jai Vidaurre, Rosa Isela Meneses, Octavio Delgado Vásquez, Isabel Oré Balbín, Monica Santayana, Bettina Heider, Marten Sørensen
Understanding the distribution of crop genetic diversity in relation to environmental factors can give insights into the eco-evolutionary processes involved in plant domestication. Yam beans (Pachyrhizus Rich. ex DC.) are leguminous crops native to South and Central America that are grown for their tuberous roots but are seed-propagated. Using a landscape genetic approach, we examined correlations between environmental factors and phylogeographic patterns of genetic diversity in Pachyrhizus landrace populations...
June 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28512613/comparison-of-complications-following-cranioplasty-using-a-sterilized-autologous-bone-flap-or-polymethyl-methacrylate
#5
Sung Hoon Kim, Dong Soo Kang, Jin Hwan Cheong, Jung Hee Kim, Kwan Young Song, Min Ho Kong
OBJECTIVE: The aims of current study are to compare complications following cranioplasty (CP) using either sterilized autologous bone or polymethyl methacrylate (PMMA), and to identify the risk factors for two of the most common complications: bone flap resorption (BFR) and surgical site infection (SSI). METHODS: Between January 2004 and December 2013, 127 patients underwent CP and were followed at least 12 months. Variables, including sex, age, initial diagnosis, time interval between decompressive craniectomy (DC) and CP, operation time, size of bone flap, and presence of ventriculo-peritoneal shunt, were analyzed to identify the risk factors for BFR and SSI...
April 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/28510691/nf-%C3%AE%C2%BAb-upregulation-through-epigenetic-silencing-of-ldoc1-drives-tumor-biology-and-specific-immunophenotype-in-group-a-ependymoma
#6
Andrea M Griesinger, Davis A Witt, Sydney T Grob, Sabrina R Georgio Westover, Andrew M Donson, Bridget Sanford, Jean M Mulcahy Levy, Randall Wong, Daniel C Moreira, John A DeSisto, Ilango Balakrishnan, Lindsey M Hoffman, Michael H Handler, Kenneth L Jones, Rajeev Vibhakar, Sujatha Venkataraman, Nicholas K Foreman
Background.: Inflammation has been identified as a hallmark of high-risk Group A (GpA) ependymoma (EPN). Chronic interleukin (IL)-6 secretion from GpA tumors drives an immune suppressive phenotype by polarizing infiltrating monocytes. This study determines the mechanism by which IL-6 is dysregulated in GpA EPN. Methods.: Twenty pediatric GpA and 21 pediatric Group B (GpB) EPN had gene set enrichment analysis for MSigDB Hallmark gene sets performed. Protein and RNA from patients and cell lines were used to validate transcriptomic findings...
May 16, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28508528/competing-risks-model-in-screening-for-preeclampsia-in-twin-pregnancies-by-maternal-characteristics-and-medical-history
#7
Carla Francisco, David Wright, Zsófia Benkő, Argyro Syngelaki, Kypros H Nicolaides
OBJECTIVE: A survival-time regression model for the gestational age at delivery with preeclampsia (PE) in singleton pregnancies using maternal demographic characteristics and medical history was previously reported. The objective of this paper is to extend this model for dichorionic (DC) and monochorionic (MC) twin pregnancies. METHODS: The study population included 1,789 DC and 430 MC twin pregnancies and 93,297 singleton pregnancies. A survival-time model for the gestational age at delivery with PE was developed from variables of maternal characteristics and history...
May 15, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28507805/generation-and-functional-characterization-of-mdsc-like-cells
#8
Annkristin Heine, Stefanie Andrea Erika Held, Jonas Schulte-Schrepping, Julia Friederike Andrea Wolff, Kathrin Klee, Thomas Ulas, Niklas Arndt Schmacke, Solveig Nora Daecke, Kati Riethausen, Joachim L Schultze, Peter Brossart
Myeloid-derived suppressor cells (MDSC) are critical in regulating immune responses by suppressing antigen presenting cells (APC) and T cells. We previously observed that incubation of peripheral blood monocytes with interleukin (IL)-10 during their differentiation to monocyte-derived dendritic cells (moDCs) results in the generation of an APC population with a CD14(+)HLA-DR(low)phenotype (IL-10-APC) with reduced stimulatory capacity similar to human MDSC. Co-incubation experiments now revealed that the addition of IL-10-APC to moDC caused a reduction of DC-induced T-cell proliferation, of the expression of maturation markers, and of secreted cytokines and chemokines such as TNF-α, IL-6, MIP-1α and Rantes...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28507788/adaptive-t-cell-responses-induced-by-oncolytic-herpes-simplex-virus-granulocyte-macrophage-colony-stimulating-factor-therapy-expanded-by-dendritic-cell-and-cytokine-induced-killer-cell-adoptive-therapy
#9
Jun Ren, William R Gwin, Xinna Zhou, Xiaoli Wang, Hongyan Huang, Ni Jiang, Lei Zhou, Pankaj Agarwal, Amy Hobeika, Erika Crosby, Zachary C Hartman, Michael A Morse, Kevin H Eng, H Kim Lyerly
Purpose: Although local oncolytic viral therapy (OVT) may enhance tumor lysis, antigen release, and adaptive immune responses, systemic antitumor responses post-therapy are limited. Adoptive immunotherapy with autologous dendritic cells (DC) and cytokine-induced killer cells (DC-CIK) synergizes with systemic therapies. We hypothesized that OVT with Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor (HSV-GM-CSF) would induce adaptive T cell responses that could be expanded systemically with sequential DC-CIK therapy...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28507543/long-term-monocyte-dysfunction-after-sepsis-in-humanized-mice-is-related-to-persisted-activation-of-macrophage-colony-stimulation-factor-m-csf-and-demethylation-of-pu-1-and-it-can-be-reversed-by-blocking-m-csf-in-vitro-or-by-transplanting-na%C3%A3-ve-autologous
#10
Natalia Lapko, Mateusz Zawadka, Jacek Polosak, George S Worthen, Gwenn Danet-Desnoyers, Monika Puzianowska-Kuźnicka, Krzysztof Laudanski
The duration of post-sepsis long-term immune suppression is poorly understood. Here, we focused on the role of monocytes (MO) as the pivotal cells for long-term regulation of post-sepsis milieu. Lost ability of MO to adapt is seen in several acute conditions, but it is unclear for how long MO aberrancy post-sepsis can persist. Interestingly, the positive feedback loop sustaining secretion of macrophage-colony stimulation factor (M-CSF) can persist even after resolution of sepsis and significantly alters performance of MO...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28504575/alleviation-of-enterotoxigenic-escherichia-coli-challenge-by-recombinant-lactobacillus-plantarum-expressing-a-faeg-and-dc-targeting-peptide-fusion-protein
#11
G Yang, Y Jiang, P Tong, C Li, W Yang, J Hu, L Ye, W Gu, C Shi, B Shan, C Wang
FaeG is the major subunit of K88 fimbriae. These cell surface attachments are considered to be the major virulence factor of enterotoxigenic Escherichia coli (ETEC), which causes diarrhoea in piglets. The use of dendritic cell-targeting peptide (DCpep) has been demonstrated to be an effective approach to enhance the immunity of vaccines. Lactobacillus plantarum is an attractive candidate for oral vaccination owing to its beneficial effects and safety. In this study, L. plantarum was employed to deliver a FaeG-DCpep fusion antigen, and the immune response in mice was evaluated...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28503991/platelet-concentrates-modulate-myeloid-dendritic-cell-immune-responses
#12
Katrina K Ki, Helen M Faddy, Robert L Flower, Melinda M Dean
Platelet transfusion has been reported to modulate the recipients' immune system. To date, the precise mechanism(s) driving poor patient outcomes (e.g., increased rate of mortality, morbidity, infectious complications and prolonged hospital stays) following platelet transfusion are largely undefined. To determine the potential for platelet concentrates (PC) to modulate responses of crucial immune regulatory cells, a human in vitro whole blood model of transfusion was established. Maturation and activation of human myeloid dendritic cells (mDC) and the specialized subset blood DC antigen (BDCA)3(+) DC were assessed following exposure to buffy-coat derived PC at day (D)2 (fresh) and D5 (date-of-expiry)...
May 15, 2017: Platelets
https://www.readbyqxmd.com/read/28502994/depoling-and-fatigue-behavior-of-pb-mg1-3nb2-3-o3-pbtio3-single-crystal-at-megahertz-frequencies-under-bipolar-electric-field
#13
Zhaojiang Chen, Shiyang Li, Yang Zhang, Wenwu Cao
Bipolar electric field induced degradation in [001]c poled Pb(Mg1/3Nb2/3)O3-0.29PbTiO3 (PMN-0.29PT) single crystals was investigated at megahertz frequencies. The electromechanical coupling factor kt , dielectric constant εr , dielectric loss D, and piezoelectric constant d33 were measured as a function of amplitude, frequency, and number of cycles of the applied electric field. Our results showed that samples degrade rapidly when the field amplitude is larger than a critical value due to the onset of domain switching...
May 7, 2017: Journal of Applied Physics
https://www.readbyqxmd.com/read/28501572/quercetin-inhibited-epithelial-mesenchymal-transition-in-diabetic-rats-high-glucose-cultured-lens-and-sra01-04-cells-through-transforming-growth-factor-%C3%AE-2-phosphoinositide-3-kinase-akt-pathway
#14
Lei Du, Meng Hao, Chengcheng Li, Wenya Wu, Wenwen Wang, Zhongxuan Ma, Tingting Yang, Nan Zhang, Adelusi Temitope Isaac, Xia Zhu, Ying Sun, Qian Lu, Xiaoxing Yin
Diabetic cataract (DC), an identified life-threatening secondary complication of diabetes mellitus, has proven to be a dilemma because of its multifactorial caused and progression. An increasing number of studies have shown that in addition to the maillard reaction, enhanced polyol pathway, and oxidative insults, epithelial mesenchymal transition (EMT) is related to the prevalence of DC. Quercetin, a classic flavonoid with multiple pharmacological effects has been reported to possess therapeutic efficacy in the management and treatment of this disease...
May 10, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28496337/immunogenicity-of-oncolytic-vaccinia-viruses-jx-gfp-and-tg6002-in-a-human-melanoma-in-vitro-model-studying-immunogenic-cell-death-dendritic-cell-maturation-and-interaction-with-cytotoxic-t-lymphocytes
#15
B Heinrich, J Klein, M Delic, K Goepfert, V Engel, L Geberzahn, M Lusky, P Erbs, X Preville, M Moehler
Oncolytic virotherapy is an emerging immunotherapeutic modality for cancer treatment. Oncolytic viruses with genetic modifications can further enhance the oncolytic effects on tumor cells and stimulate antitumor immunity. The oncolytic vaccinia viruses JX-594-GFP+/hGM-CSF (JX-GFP) and TG6002 are genetically modified by secreting granulocyte-macrophage colony-stimulating factor (GM-CSF) or transforming 5-fluorocytosine (5-FC) into 5-fluorouracil (5-FU). We compared their properties to kill tumor cells and induce an immunogenic type of cell death in a human melanoma cell model using SK29-MEL melanoma cells...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28479516/risk-model-for-predicting-complications-in-patients-undergoing-atrial-fibrillation-ablation-short-title-risk-score-for-predicting-atrial-fibrillation-ablation-complications
#16
Santosh K Padala, Sampath Gunda, Parikshit S Sharma, Le Kang, Jayanthi N Koneru, Kenneth A Ellenbogen
BACKGROUND: Predictors of complications from AF ablation have been identified in small studies. The combination of risk factors to predict complications after ablation has not yet been explored. OBJECTIVE: To develop a risk score model that predicts complications after AF ablation. METHODS: The National Inpatient Sample database was utilized to identify 106,105 patients who underwent AF ablation. The study population was split into derivation cohort (DC, 2007-2010, n= 56,658) and validation cohort (VC, 2011-2013, n= 49,447)...
May 4, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28479366/cholesterol-accumulation-in-dendritic-cells-links-the-inflammasome-to-acquired-immunity
#17
Marit Westerterp, Emmanuel L Gautier, Anjali Ganda, Matthew M Molusky, Wei Wang, Panagiotis Fotakis, Nan Wang, Gwendalyn J Randolph, Vivette D D'Agati, Laurent Yvan-Charvet, Alan R Tall
Autoimmune diseases such as systemic lupus erythematosus (SLE) are associated with increased cardiovascular disease and reduced plasma high-density lipoprotein (HDL) levels. HDL mediates cholesterol efflux from immune cells via the ATP binding cassette transporters A1 and G1 (ABCA1/G1). The significance of impaired cholesterol efflux pathways in autoimmunity is unknown. We observed that Abca1/g1-deficient mice develop enlarged lymph nodes (LNs) and glomerulonephritis suggestive of SLE. This lupus-like phenotype was recapitulated in mice with knockouts of Abca1/g1 in dendritic cells (DCs), but not in macrophages or T cells...
May 4, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28475545/effects-of-stimulus-duration-on-event-related-potentials-recorded-from-cochlear-implant-users
#18
Alessandro Presacco, Hamish Innes-Brown, Matthew J Goupell, Samira Anderson
OBJECTIVES: Several studies have investigated the feasibility of using electrophysiology as an objective tool to efficiently map cochlear implants. A pervasive problem when measuring event-related potentials is the need to remove the direct-current (DC) artifact produced by the cochlear implant. Here, we describe how DC artifact removal can corrupt the response waveform and how the appropriate choice of stimulus duration may minimize this corruption. DESIGN: Event-related potentials were recorded to a synthesized vowel /a/ with a 170- or 400-ms duration...
May 4, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28463991/selective-effect-of-phosphatidylcholine-on-the-lysis-of-adipocytes
#19
Ji-Young Kim, Min-Seo Kwon, Junghyun Son, Sang-Wook Kang, Youngsup Song
Obesity, a serious health risk factor, is often associated with depression and negatively affects many aspects of life. Injection of a formula comprising phosphatidylcholine (PPC) and deoxycholate (DC) has emerged as an alternative to liposuction in the reduction of local fat deposits. However, the formula component mainly responsible for this effect and the mechanism behind the actions of the components with respect to fat reduction are unknown. Here, we investigate the specific effects of PPC and DC on adipocyte viability...
2017: PloS One
https://www.readbyqxmd.com/read/28463985/palmitic-acid-is-a-toll-like-receptor-4-ligand-that-induces-human-dendritic-cell-secretion-of-il-1%C3%AE
#20
Dequina A Nicholas, Kangling Zhang, Christopher Hung, Shane Glasgow, Aruni Wilson Aruni, Juli Unternaehrer, Kimberly J Payne, William H R Langridge, Marino De Leon
Palmitic acid (PA) and other saturated fatty acids are known to stimulate pro-inflammatory responses in human immune cells via Toll-like receptor 4 (TLR4). However, the molecular mechanism responsible for fatty acid stimulation of TLR4 remains unknown. Here, we demonstrate that PA functions as a ligand for TLR4 on human monocyte derived dendritic cells (MoDCs). Hydrophobicity protein modeling indicated PA can associate with the hydrophobic binding pocket of TLR4 adaptor protein MD-2. Isothermal titration calorimetry quantified heat absorption that occurred during PA titration into TLR4/MD2, indicating that PA binds to TLR4/MD2...
2017: PloS One
keyword
keyword
49163
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"