keyword
MENU ▼
Read by QxMD icon Read
search

Red Nucleus

keyword
https://www.readbyqxmd.com/read/28424610/characterizing-brain-iron-deposition-in-patients-with-subcortical-vascular-mild-cognitive-impairment-using-quantitative-susceptibility-mapping-a-potential-biomarker
#1
Yawen Sun, Xin Ge, Xu Han, Wenwei Cao, Yao Wang, Weina Ding, Mengqiu Cao, Yong Zhang, Qun Xu, Yan Zhou, Jianrong Xu
The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed to examine brain iron deposition in svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we aimed to investigate the correlation between brain iron deposition and the severity of cognitive impairment as indicated by z-scores. We recruited 20 subcortical ischemic vascular disease (SIVD) patients who fulfilled the criteria for svMCI...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28412365/vaccinia-related-kinase-3-vrk3-sets-the-circadian-period-and-amplitude-by-affecting-the-subcellular-localization-of-clock-proteins-in-mammalian-cells
#2
Nayoung Park, Ji-Eun Song, Seongsu Jeong, Thanh Thi Tran, Hyuk Wan Ko, Eun Young Kim
In the eukaryotic circadian clock machinery, negative feedback repression of CLOCK (CLK) and BMAL1 transcriptional activity by PERIOD (PER) and CRYPTOCHROME (CRY) underlies the basis for 24 h rhythmic gene expression. Thus, precise regulation of the time-dependent nuclear entry of circadian repressors is crucial to generating normal circadian rhythms. Here, we sought to identify novel kinase(s) that regulate nuclear entry of mammalian CRY1 (mCRY1) with an unbiased screening using red fluorescent protein (RFP)-tagged human kinome expression plasmids in mammalian cells...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28398031/a-carbon-nanotube-optical-sensor-reports-nuclear-entry-via-a-noncanonical-pathway
#3
Januka Budhathoki-Uprety, Rachel E Langenbacher, Prakrit V Jena, Daniel Roxbury, Daniel A Heller
Single-walled carbon nanotubes are of interest in biomedicine for imaging and molecular sensing applications and as shuttles for various cargos such as chemotherapeutic drugs, peptides, proteins, and oligonucleotides. Carbon nanotube surface chemistry can be modulated for subcellular targeting while preserving photoluminescence for label-free visualization in complex biological environments, making them attractive materials for such studies. The cell nucleus is a potential target for many pathologies including cancer and infectious diseases...
April 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28391323/genomic-and-transcriptomic-analysis-reveals-spliced-leader-trans-splicing-in-cryptomonads
#4
Scott William Roy
Spliced leader trans-splicing (SLTS) is a poorly understood mechanism that is found in a diversity of eukaryotic lineages. In SLTS, a short RNA sequence is added near the 5' ends of the transcripts of protein-coding genes by a modified spliceosomal reaction. Available data suggest that SLTS has evolved many times, and might be more likely to evolve in animals. That SLTS might be more likely to evolve in the context of the generally complex transcriptomes characteristic of animals suggests the possibility that SLTS functions in gene regulation or transcriptome diversification, however no general novel function for SLTS is known...
March 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28388867/are-friends-really-the-family-we-choose-local-variations-of-hypothalamus-activity-when-viewing-personally-known-faces
#5
Farah H Wolfe, Christine Deruelle, Thierry Chaminade
Sibling and friend relationships have significant impact on socio-emotional development. Hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN) are viable candidates in the formation and maintenance of these relationships through the synthesis and secretion of neuropeptides associated with attachment behaviors, including oxytocin. Here, using fMRI, we investigate the implication of these two hypothalamic nuclei in the processing of personally known faces. Faces of same-sex sibling, best friend, celebrity and unknown person appear in the middle of the screen while participants perform a task requiring a button click each time a central white dot turns red...
April 7, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28367713/src-syk-targeted-anti-inflammatory-actions-of-triterpenoidal-saponins-from-gac-momordica-cochinchinensis-seeds
#6
Jae Sik Yu, Jun Ho Kim, Seulah Lee, Kiwon Jung, Ki Hyun Kim, Jae Youl Cho
Momordica cochinchinensis Spreng (family Cucurbitaceae), also known as gac, or red melon, is an edible Southeast Asian fruit valued for its nutritional and medicinal properties. Specifically, Momordicae Semen, the seeds of the gac fruit, is used in traditional Chinese medicine to treat boils, rheumatic pain, muscle spasm, hemorrhoids, and hemangiomas. In this study, a chemical investigation into a gac seed ethanol (EtOH) extract resulted in the identification of three triterpenoidal saponins (1-3), which were investigated for their anti-inflammatory effects...
April 2, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28364007/combined-diffusion-tensor-imaging-and-apparent-transverse-relaxation-rate-differentiate-parkinson-disease-and-atypical-parkinsonism
#7
G Du, M M Lewis, S Kanekar, N W Sterling, L He, L Kong, R Li, X Huang
BACKGROUND AND PURPOSE: Both diffusion tensor imaging and the apparent transverse relaxation rate have shown promise in differentiating Parkinson disease from atypical parkinsonism (particularly multiple system atrophy and progressive supranuclear palsy). The objective of the study was to assess the ability of DTI, the apparent transverse relaxation rate, and their combination for differentiating Parkinson disease, multiple system atrophy, progressive supranuclear palsy, and controls...
March 31, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28345262/purebreeding-of-red-maasai-and-crossbreeding-with-dorper-sheep-in-different-environments-in-kenya
#8
E Zonabend König, E Strandberg, J M K Ojango, T Mirkena, A M Okeyo, J Philipsson
The aim of this article was to study opportunities for improvement of the indigenous and threatened Red Maasai sheep (RM) in Kenya, by comparing purebreeding with crossbreeding with Dorper sheep (D) as a terminal breed, in two different environments (Env. A and a harsher Env. B), assuming different levels of genotype-by-environment interaction (G × E). Breeding goals differed between environments and breeds. Four scenarios of nucleus breeding schemes were stochastically simulated, with the nucleus in Env...
March 27, 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/28345164/comparing-functional-mri-protocols-for-small-iron-rich-basal-ganglia-nuclei-such-as-the-subthalamic-nucleus-at-7-t-and-3-t
#9
Gilles de Hollander, Max C Keuken, Wietske van der Zwaag, Birte U Forstmann, Robert Trampel
The basal ganglia (BG) form a network of subcortical nuclei. Functional magnetic resonance imaging (fMRI) in the BG could provide insight in its functioning and the underlying mechanisms of Deep Brain Stimulation (DBS). However, fMRI of the BG with high specificity is challenging, because the nuclei are small and variable in their anatomical location. High resolution fMRI at field strengths of 7 Tesla (T) could help resolve these challenges to some extent. A set of MR protocols was developed for functional imaging of the BG nuclei at 3 T and 7 T...
March 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28339754/expression-of-deep-brain-photoreceptors-in-the-pekin-drake-a-possible-role-in-the-maintenance-of-testicular-function
#10
R Haas, E Alenciks, S Meddle, G S Fraley
Several putative deep brain photoreceptors (DBPs) have been identified, such as melanopsin, opsin 5, and vertebrate ancient opsin. The aim of this study was to elucidate the role of DBPs in gonadal regulation in the Pekin drake. As previously reported, we observed opsin-like immunoreactivity (-ir) in the lateral septum (LS), melanopsin-ir in the premammillary nucleus (PMM), and opsin 5-ir in the periventricular organ. To determine the sensitivity of the DBPs to specific wavelengths of light, drakes were given an acute exposure to red, blue, or white light...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28338525/orexin-action-on-oxytocin-neurons-in-the-paraventricular-nucleus-of-the-hypothalamus
#11
Yuko Maejima, Shinichi Takahashi, Katsuya Takasu, Seiichi Takenoshita, Yoichi Ueta, Kenju Shimomura
Oxytocin neurons in the paraventricular nucleus (PVN) of the hypothalamus play an important role in food intake regulation. It has been shown that the secretion of oxytocin from the hypothalamus shows a diurnal circadian rhythmic pattern and disturbance of this pattern leads to the development of obesity. However, whether oxytocin secretion from the PVN has a diurnal pattern remains unknown. Here, we show that oxytocin secretion from the PVN does have a diurnal pattern and that the terminals of orexin neurons, the neuropeptide responsible for regulating the sleep-wake rhythm, are synapsed with PVN oxytocin neurons...
April 12, 2017: Neuroreport
https://www.readbyqxmd.com/read/28326454/quercetin-and-ascorbic-acid-suppress-fructose-induced-nlrp3-inflammasome-activation-by-blocking-intracellular-shuttling-of-txnip-in-human-macrophage-cell-lines
#12
Jung-Yoon Choe, Seong-Kyu Kim
The aim of this study was to identify the role of thioredoxin-interacting protein (TXNIP) and its interaction with antioxidants in the activation of the fructose-induced NOD-like receptor protein 3 (NLRP3) inflammasome in human macrophages. The study was performed with U937 and THP-1 macrophage cell lines. Total reactive oxygen species (ROS) were measured by flow cytometry. Interleukin-1β (IL-1β), IL-18, NLRP3, TXNIP, and caspase-1 protein expression was detected using western blotting. Quantitative real-time polymerase chain reaction was used to detect IL-1β, IL-18, and caspase-1 gene expression...
March 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28325844/the-sole-lsm-complex-in-cyanidioschyzon-merolae-associates-with-pre-mrna-splicing-and-mrna-degradation-factors
#13
Kirsten A Reimer, Martha R Stark, Lisbeth Carolina Aguilar, Sierra R Stark, Robert D Burke, Jack Moore, Richard P Fahlman, Calvin K Yip, Haruko Kuroiwa, Marlene Oeffinger, Stephen D Rader
Proteins of the Sm and Sm-like (LSm) families, referred to collectively as (L)Sm proteins, are found in all three domains of life, and are known to promote a variety of RNA processes such as base-pair formation, unwinding, RNA degradation, and RNA stabilization. In eukaryotes, (L)Sm proteins have been studied, inter alia, for their role in pre-mRNA splicing. In many organisms, the LSm proteins form two distinct complexes, one consisting of LSm1-7 that is involved in mRNA degradation in the cytoplasm, and the other consisting of LSm2-8 that binds spliceosomal U6 snRNA in the nucleus...
March 21, 2017: RNA
https://www.readbyqxmd.com/read/28316289/post-stapedectomy-granuloma-a-devastating-complication
#14
E Watts, H R F Powell, S R Saeed, R M Irving
OBJECTIVES: This paper reports three cases of severe post-stapedectomy granuloma, emphasising the variable presentation of this devastating complication and the challenges of its management. METHODS: A retrospective review was conducted of three cases of post-stapedectomy granuloma requiring surgical debulking between 2010 and 2015. Clinical symptoms, serial imaging, histopathology and post-operative outcomes were considered. RESULTS: Intra-operatively, extensive granulation tissue with erosion of the otic capsule was found...
March 20, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28303377/the-differences-of-the-precommissural-and-postcommissural-fornix-in-the-hippocampal-location-a-diffusion-tensor-tractography-study
#15
Sung Ho Jang, Sang Seok Yeo
PURPOSE: The precommissural fornix and postcommissural fornix have different connections to the basal forebrain and septal region, and mammillary body, respectively. However, little is known about the differences of the precommissural fornix and postcommissural fornix in the hippocampal location. In this study, using diffusion tensor tractography, we investigated the differences of the precommissural fornix and postcommissural fornix in the hippocampal location. METHODS: We recruited 25 healthy volunteers for this study...
March 16, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28298310/atypical-centrioles-are-present-in-tribolium-sperm
#16
E L Fishman, Kyoung Jo, Andrew Ha, Rachel Royfman, Ashtyn Zinn, Malathi Krishnamurthy, Tomer Avidor-Reiss
Typical centrioles are made of microtubules organized in ninefold symmetry. Most animal somatic cells have two centrioles for normal cell division and function. These centrioles originate from the zygote, but because the oocyte does not provide any centrioles, it is surprising that the zygotes of many animals are thought to inherit only one centriole from the sperm. Recently, in the sperm of Drosophila melanogaster, we discovered a second centriolar structure, the proximal centriole-like structure (PCL), which functions in the zygote...
March 2017: Open Biology
https://www.readbyqxmd.com/read/28295740/green-light-inhibits-gnrh-i-expression-by-stimulating-the-melatonin-gnih-pathway-in-the-chick-brain
#17
Liwei Zhang, Funing Chen, Jing Cao, Yulan Dong, Zixu Wang, Man Hu, Yaoxing Chen
To study the mechanism by which monochromatic light affects gonadotropin-releasing hormone (GnRH) expression in chicken hypothalamus, a total of 192 newly hatched chicks were divided into intact, sham-operated and pinealectomy groups and exposed to white (WL), red (RL), green (GL) and blue (BL) lights using a light-emitting diode (LED) system for 2 wk. In the GL intact group, the mRNA and protein levels of GnRH-I in the hypothalamus, the mean cell area and mean cell optical density (OD) of the GnRH-I-ir cells of the nucleus commissurae pallii (nCPa) were decreased by 13...
March 14, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28270752/neuronal-correlates-of-functional-coupling-between-reach-and-grasp-related-components-of-muscle-activity
#18
Shashwati Geed, Martha L McCurdy, Peter L E van Kan
Coordinated reach-to-grasp movements require precise spatiotemporal synchrony between proximal forelimb muscles (shoulder, elbow) that transport the hand toward a target during reach, and distal muscles (wrist, digit) that simultaneously preshape and orient the hand for grasp. The precise mechanisms through which the redundant neuromuscular circuitry coordinates reach with grasp, however, remain unclear. Recently, Geed and Van Kan (2016) demonstrated, using exploratory factor analysis (EFA), that limited numbers of global, template-like transport/preshape- and grasp-related muscle components underlie the complexity and variability of intramuscular electromyograms (EMGs) of up to 21 distal and proximal muscles recorded while monkeys performed reach-to-grasp tasks...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28266688/the-bmp2-variant-l51p-restores-the-osteogenic-differentiation-of-human-mesenchymal-stromal-cells-in-the-presence-of-intervertebral-disc-cells
#19
A Tekari, R D May, D A Frauchiger, S C Chan, L M Benneker, B Gantenbein
Spinal fusion is hampered by the presence of remaining intervertebral disc (IVD) tissue and leads to spinal non-union. While the exact mechanism remains unknown, we hypothesise that factors preventing disc ossification, such as antagonists of the bone morphogenetic proteins (BMP), could be responsible for this process. The objective of this study was to investigate spinal non-union using an in vitro human model with a focus on the BMP signalling components and to identify factors contributing to the incomplete and delayed ossification...
February 23, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28263830/repeated-corticosterone-injections-in-adult-mice-alter-stress-hormonal-receptor-expression-in-the-cerebellum-and-motor-coordination-without-affecting-spatial-learning
#20
Guillaume Harlé, Robert Lalonde, Coralie Fonte, Armelle Ropars, Jean-Pol Frippiat, Catherine Strazielle
Receptors for glucocorticoid (GR) and corticotropin-releasing hormone (CRH) are largely found in brain sensorimotor structures, particularly in cerebellum, underlining a potential role of stress hormones in the regulation of motor function. Since CRH is involved in neuroplasticity, known for its trophic effect on synapses, we investigated how manipulations in corticosterone serum levels can modulate the CRH system in the cerebellum and affect motor coordination. Corticosterone at doses of either 15 or 30mg/kg was injected in mice and the status of hormonal expression evaluated in cerebellum, hippocampus, and hypothalamus in undisturbed housing conditions or after different behavioral tests...
March 2, 2017: Behavioural Brain Research
keyword
keyword
49158
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"