Hong Xu, Qi Qiu, Peng Hu, Kevt'her Hoxha, Elliot Jang, Mia O'Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D Schellenberg, Brian Kraemer, Kelvin C Luk, Edward B Lee, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Lee
Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include Alzheimer's disease (AD). The spreading of misfolded tau "seeds" along neuronal networks is thought to play a crucial role in the progression of tau pathology. Consequently, restricting the release or uptake of tau seeds may inhibit the spread of tau pathology and potentially halt the advancement of the disease. Previous studies have demonstrated that the Mammalian Suppressor of Tauopathy 2 (MSUT2), an RNA binding protein, modulates tau pathogenesis in a transgenic mouse model...
March 12, 2024: Acta Neuropathologica