Marco A Obregón-Mendoza, William Meza-Morales, Karla Daniela Rodríguez-Hernández, M Mirian Estévez-Carmona, Leidys L Pérez-González, Rosario Tavera-Hernández, María Teresa Ramírez-Apan, David Barrera-Hernández, Mitzi García-Olivares, Brian Monroy-Torres, Antonio Nieto-Camacho, María Isabel Chávez, Rubén Sánchez-Obregón, Raúl G Enríquez
Breast cancer is one of the leading causes of death in the female population because of the resistance of cancer cells to many anticancer drugs used. Curcumin has cytotoxic activities against breast cancer cells, although it has limited use due to its poor bioavailability and rapid metabolic elimination. The synthesis of metal complexes of curcumin and curcuminoids is a relevant topic in the search for more active and selective derivatives of these molecular scaffolds. However, solubility and bioavailability are concomitant disadvantages of these types of molecules...
April 16, 2024: International Journal of Molecular Sciences