keyword
MENU ▼
Read by QxMD icon Read
search

MMP-9

keyword
https://www.readbyqxmd.com/read/29329315/role-of-n-glycosylation-in-activation-of-prommp-9-a-molecular-dynamics-simulations-study
#1
Sonu Kumar, Piotr Cieplak
Human matrix metalloproteinase proMMP-9 is secreted as latent zymogen, which requires two-steps proteolytic activation. The secreted proMMP-9 is glycosylated at two positions: Asn38 and Asn120 located in the prodomain and catalytic domain, respectively. It has been demonstrated that glycosylation at Asn120 is required for secretion of the enzyme, while the role of Asn38 glycosylation is not well understood, but is usually linked to the activation process. One hypothesis stated that the Asn38 glycosylation might protect against proteolytic activation...
2018: PloS One
https://www.readbyqxmd.com/read/29329251/pharmacological-investigation-of-the-anti-inflammation-and-anti-oxidation-activities-of-diallyl-disulfide-in-a-rat-emphysema-model-induced-by-cigarette-smoke-extract
#2
Yan Liu, Ang Li, Xiuli Feng, Xiao Sun, Xiaosong Zhu, Zhongxi Zhao
Diallyl disulfide (DADS) is the main organosulfur ingredient in garlic, with known antioxidant and anti-inflammatory activities. The aim of the present study was to investigate the effect of DADS on reducing the inflammation and redox imbalance in a rat emphysema model that was induced by intraperitoneal injection of cigarette smoke extract (CSE). Briefly, DADS exerted an anti-inflammation effect on emphysema rats through decreasing cell influx in the bronchoalveolar lavage fluid (BALF) and suppressing pro-inflammation cytokine production including tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) via inhibiting the NF-κB pathway...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29328525/a-role-of-sialic-acid-containing-glycans-of-matrix-metalloproteinase-9-mmp-9-in-the-interaction-between-mmp-9-and-staphylococcal-superantigen-like-protein-5-ssl5
#3
Chisato Kurisaka, Teruaki Oku, Saotomo Itoh, Tsutomu Tsuji
The staphylococcal superantigen-like proteins (SSLs) exhibit no superantigenic activity but have recently been considered to act as immune suppressors. It was previously reported that SSL5 bound to P-selectin glycoprotein ligand-1 (PSGL-1) and matrix metalloproteinase (MMP)-9, leading to inhibition of leukocyte adhesion and invasion. These interactions were suggested to depend on sialic acid-containing glycans of MMP-9, but the roles of sialic acids in the interaction between SSL5 and MMP-9 are still controversial...
January 12, 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/29328471/prostaglandin-e2-receptor-ep4-is-involved-in-the-cell-growth-and-invasion-of-prostate-cancer-via-the-camp%C3%A2-pka-pi3k%C3%A2-akt-signaling-pathway
#4
Song Xu, Wenquan Zhou, Jingping Ge, Zhengyu Zhang
Prostate cancer (PCa) is one of the most prevalent diagnosed malignancies globally. Previous studies have demonstrated that prostaglandin E2 (PGE2) is closely associated with the tumorigenesis and progression of PCa. However, the underlying molecular mechanisms remain unclear and require further investigation. Matrix metalloproteinases (MMPs), receptor activator of nuclear factor‑κB ligand (RANKL) and runt‑related transcription factor 2 (RUNX2), which are involved in cell growth and bone metastasis, are frequently activated or overexpressed in various types of cancer, including PCa...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328461/anti%C3%A2-inflammatory-effects-of-gambogic-acid-in-murine-collagen%C3%A2-induced-arthritis-through-pi3k-akt-signaling-pathway
#5
Qing Lai Wang, Dong Zhen Yang, Cunxian Lv
Garcinia angustifolia is a dry resin secreted by Garcinia cambogia, which has the functions of breaking blood, detoxifying, stopping bleeding and killing insects. It is used for the treatment of cancer and brain edema. Gambogic acid is the primary active ingredient. The present study aimed to investigate the anti‑inflammatory and antiproliferative effects of gambogic acid on arthritis and the possible mechanisms. It was demonstrated that gambogic acid decreased arthritic scores in murine collagen‑induced arthritic mice...
January 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328460/terrein-inhibits-migration-of-human-breast-cancer-cells-via-inhibition-of-the-rho-and-rac-signaling-pathways
#6
Anongnard Kasorn, Fabien Loison, Thaned Kangsamaksin, Suchada Jongrungruangchok, Mathurose Ponglikitmongkol
Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal metabolite, terrein, isolated from the Aspergillus terreus has been revealed to exhibit selective anticancer activity; although this molecule has a variety of biological activities. The inhibitory effect on cell proliferation in hepatoma, keratinocytes, and lung cancer cells was due to cell cycle arrest without induction of apoptosis...
January 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29328406/mir-141-inhibits-prostatic-cancer-cell-proliferation-and-migration-and-induces-cell-apoptosis-via-targeting-of-runx1
#7
Song Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou
Prostate cancer (PCa) is the most commonly diagnosed male malignancy and the second leading cause of male cancer-related deaths. miR-141 has been demonstrated to be inversely correlated with tumorigenicity. In the present study, we investigated the effect of miR-141 and runt-related transcription factor 1 (RUNX1) on PCa cells. We determined that miR-141 was expressed at a low level and RUNX1 was expressed at a high level in PCa tissues in comparison to that in adjacent normal tissues. Upregulation of miR-141 significantly inhibited cell growth, migration and invasion, and promoted cell apoptosis in PCa cells...
January 11, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29326045/ing5-inhibits-cell-proliferation-and-invasion-in-esophageal-squamous-cell-carcinoma-through-regulation-of-the-akt-nf-%C3%AE%C2%BAb-mmp-9-signaling-pathway
#8
Guang-Jing Zhang, Jing Zhao, Mei-Ling Jiang, Lu-Chang Zhang
The inhibitor of growth 5 (ING5) is a new candidate tumor suppressor gene (TSG) of the ING family. So far, there have been many reports about its functions related to cancer development. However, the biological roles of ING5 in esophageal squamous cell carcinoma (ESCC) remain unclear. In the present study, we demonstrated that ING5 was lowly expressed in ESCC tissues and cell lines. Overexpression of ING5 inhibited ESCC cell proliferation and invasion in vitro as well as suppressed tumor growth and metastasis in vivo...
January 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29325936/carotid-atherosclerotic-plaque-features-in-patients-with-acute-ischemic-stroke
#9
Runming Sun, Lixia Wang, Cuiling Guan, Wenyuan Cao, Bing Tian
OBJECTIVE: To investigate the carotid atherosclerotic plaque features in patients with acute ischemic stroke (AIS). METHODS: A total of 288 patients meeting the included criteria were enrolled and divided into ulcer plaque group (n = 139) and none ulcer plaque group (n = 149). Patients in ulcer plaque group were further subdivided into < and ≥ 50% stenosis group. Carotid plaque components characteristics including luminal stenosis, carotid plaque volume, hypoechoic plaque volume and hyperechoic plaque volume were analyzed by color Doppler ultrasound measurement...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325849/coagonist-of-glp-1-and-glucagon-decreases-liver-inflammation-and-atherosclerosis-in-dyslipidemic-condition
#10
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Brijesh Sutariya, Maulik Patel, Dhreerendra Pandey, Hiren Patel, Ramchandra Ranvir, Shekhar Kadam, Dipam Patel, Rajesh Bahekar, Mukul Jain
Dyslipidemia enhances progression of atherosclerosis. Coagonist of GLP-1 and glucagon are under clinical investigation for the treatment of obesity and diabetes. Earlier, we have observed that coagonist reduced circulating and hepatic lipids, independent of its anorexic effects. Here, we investigated the role of coagonist of GLP-1 and glucagon receptors in complications of diet-induced dyslipidemia in hamsters and humanized double transgenic mice. Hamsters fed on high fat high cholesterol diet were treated for 8 weeks with coagonist of GLP-1 and glucagon receptors (75 and 150 μg/kg)...
January 8, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29324263/the-role-of-pro-fibrotic-biomarkers-in-paroxysmal-and-persistent-atrial-fibrillation
#11
Adina Elena Stanciu, Radu Gabriel Vatasescu, Marcel Marian Stanciu, Nafija Serdarevic, Maria Dorobantu
PURPOSE: Signaling pathways involved in electrical, structural and contractile remodeling processes behind development and progression of atrial fibrillation (AF) have not been completely elucidated, but it seems to be related to complex interactions among neurohormonal and cellular mediators. We aimed to investigate interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-β1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), as biomarkers of atrial remodeling, in patients with paroxysmal and persistent AF, and their correlation with N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and left atrial (LA) diameter...
January 8, 2018: Cytokine
https://www.readbyqxmd.com/read/29323792/the-retinamide-vnlg-152-inhibits-ar-ar-v7-and-mnk-eif4esignaling-pathways-to-suppress-emt-and-castration-resistant-prostate-cancer-xenograft-growth
#12
Vidya P Ramamurthy, Senthilmurugan Ramalingam, Lalji K Gediya, Vincent C O Njar
VNLG-152, a lead novel retinamide (NR) shown to suppress growth and progression in genetically diverse PCa cells via inhibition of AR signaling and eIF4E translational machinery. Herein, we report therapeutic effects of VNLG-152 on castration resistant prostate cancer (CRPC) growth and metastatic phenotype in CRPC tumor xenograft model. Administration of VNLG-152 significantly and dose-dependently suppressed the growth of aggressive CWR22Rv1 tumors by 63.4% and 76.3% respectively (P = 0.001), vs. vehicle with no host toxicity...
January 11, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29323709/osteosarcoma-derived-extracellular-vesicles-induce-a-tumour-like-phenotype-in-normal-recipient-cells
#13
Enrica Urciuoli, Ezio Giorda, Marco Scarsella, Stefania Petrini, Barbara Peruzzi
Osteosarcoma is the most common primary bone cancer and the most frequent cause of bone cancer-related deaths in children and adolescents. Osteosarcoma cells are able to establish a crosstalk with resident bone cells leading to the formation of a deleterious vicious cycle. We hypothesized that osteosarcoma cells can release, in the bone microenvironment, transforming Extracellular Vesicles (EVs) involved in regulating bone cell proliferation and differentiation, thereby promoting tumour growth. We assessed EV production by three osteosarcoma cell lines with increasing aggressiveness in order to investigate their roles in the communication between osteosarcoma cells and normal recipient cells...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29322789/rna-interference-mediated-silencing-of-aquaporin-aqp-5-hinders-angiogenesis-of-colorectal-tumor-by-suppressing-the-production-of-vascular-endothelial-growth-factor
#14
W Wang, Q Li, T Yang, D Li, F Ding, H Sun, G Bai
Aquaporin (AQP)-5 is an essential member of AQP family involved in the tumorigenesis of various malignant tumors. However, its role in the angiogenesis of colorectal cancer is unclear and requires further investigation. In this study, a pRNA-H1.1 vector containing the short hairpin RNA (shRNA) targeting AQP5 mRNA was constructed to inhibit the endogenous expression of AQP5 in human umbilical vein endothelial cells (HUVECs). We found that the AQP5-silenced HUVECs acquired decreased proliferation, migration and tube formation ability...
2018: Neoplasma
https://www.readbyqxmd.com/read/29321009/dual-action-of-highbush-blueberry-proanthocyanidins-on-aggregatibacter-actinomycetemcomitans-and-the-host-inflammatory-response
#15
Amel Ben Lagha, Geneviève LeBel, Daniel Grenier
BACKGROUND: The highbush blueberry (Vaccinium corymbosum) has a beneficial effect on several aspects of human health. The present study investigated the effects of highbush blueberry proanthocyanidins (PACs) on the virulence properties of Aggregatibacter actinomycetemcomitans and macrophage-associated inflammatory responses. METHODS: PACs were isolated from frozen highbush blueberries using solid-phase chromatography. A microplate dilution assay was performed to determine the effect of highbush blueberry PACs on A...
January 10, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29318546/gel-based-gelatin-zymography-to-examine-matrix-metalloproteinase-activity-in-cell-culture
#16
Aastha Chhabra, Vibha Rani
Gelatin zymography, first described by Heussen and Dowdle in the 1980s, is a widely used valuable tool in research and diagnostics. The technique identifies gelatinases by the degradation of their preferential substrate as well as by their molecular weight (kDa). We here describe detailed methodology for the detection of pro- and active- forms of both MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in cells using norepinephrine-stimulated H9c2 cardiomyoblasts as model. An easy to follow step-by-step protocol has been carefully written for reliable results...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29317819/inhibition-of-cancer-cell-migration-with-cus-msio2-peg-nanoparticles-by-repressing-mmp-2-mmp-9-expression
#17
Guoying Deng, Feng Zhou, Zizheng Wu, Fei Zhang, Kerun Niu, Yingjie Kang, Xijian Liu, Qiugen Wang, Yin Wang, Qian Wang
The metastasis of cancer cells is a vital aspect of disease progression and therapy. Although a few nanoparticles (NPs) aimed at controlling metastasis in cancer therapy have been reported, the NPs are normally combined with drugs, yet the direct therapeutic effects of the NPs are not reported. To study the direct influence of NPs on cancer metastasis, the potential suppression capacity of CuS@mSiO2-PEG NPs to tumor cell migration, a kind of typical photothermal NPs, was systemically evaluated in this study...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29317480/mir-205-targets-angiogenesis-and-emt-concurrently-in-anaplastic-thyroid-carcinoma
#18
Haleh Vosgha, Armin Ariana, Robert Smith, Alfred Lam
The current study aims to evaluate for the first time the inhibitory roles of miR-205 in the pathogenesis of anaplastic thyroid carcinoma. In addition, we investigated the mechanisms by which miR-205 regulates angiogenesis and epithelial-to-mesenchymal transition (EMT) in cancer. Two anaplastic thyroid carcinoma cell lines were transfected with the expression vector pCMV-MIR-205. Selected markers of angiogenesis and EMT including vascular endothelial growth factor A (VEGF-A) and zinc-finger E-box-binding homeobox 1 (ZEB1) were investigated by Western blot...
January 9, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29317141/serum-levels-of-osteopontin-predict-major-adverse-cardiovascular-events-in-patients-with-severe-carotid-artery-stenosis
#19
Federico Carbone, Fabio Rigamonti, Fabienne Burger, Aline Roth, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Aldo Pende, Aldo Bonaventura, Luca Liberale, Alessandra Vecchié, Franco Dallegri, François Mach, Fabrizio Montecucco
BACKGROUND: Inflammatory mediators in the blood stream and within plaques are key determinants in atherogenesis. Here, we investigated serum osteopontin (OPN) as a potential predictor of poor outcome in patients with severe carotid atherosclerosis. METHODS: Carotid plaques and serum were collected from patients asymptomatic (n=185) or symptomatic (n=40) for ischemic stroke. Plaques were stained for lipids, smooth muscle cells, neutrophils, M1 and M2 macrophage subsets and matrix metallopropteinase-9 (MMP-9)...
January 5, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29316907/expression-of-mmp-9-decreases-metastatic-potential-of-chondrosarcoma-an-immunohistochemical-study
#20
Dominik Malcherczyk, Thomas J Heyse, Bilal F El-Zayat, Vanessa Kunzke, Roland Moll, Susanne Fuchs-Winkelmann, Jürgen R J Paletta
BACKGROUND: Chondrosarcoma is the second most common primary malignant bone tumor. Because of their heterogeneity, with differences in invasive and metastatic behavior, it is important to identify biological markers that will allow for a more accurate estimation of prognosis in patients with these tumors. Matrix metalloproteinases (MMP) play a crucial role in tumor progression, invasion and metastasis. The mechanism of tumor progression dependent of MMPs is complex and influences malignant transformation, angiogenesis and tumor growth at the primary and metastatic sites...
January 9, 2018: BMC Musculoskeletal Disorders
keyword
keyword
49149
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"