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https://www.readbyqxmd.com/read/28944992/ginsenoside-rb1-enhances-atherosclerotic-plaque-stability-by-skewing-macrophages-to-the-m2-phenotype
#1
Xue Zhang, Ming-Hao Liu, Lei Qiao, Xin-Yu Zhang, Xiao-Ling Liu, Mei Dong, Hong-Yan Dai, Mei Ni, Xiao-Rong Luan, Jun Guan, Hui-Xia Lu
Atherosclerosis (AS) is characterized as progressive arterial plaque, which is easy to rupture under low stability. Macrophage polarization and inflammation response plays an important role in regulating plaque stability. Ginsenoside Rb1 (Rb1), one of the main active principles of Panax Ginseng, has been found powerful potential in alleviating inflammatory response. However, whether Rb1 could exert protective effects on AS plaque stability remains unclear. This study investigated the role of Rb1 on macrophage polarization and atherosclerotic plaque stability using primary peritoneal macrophages isolated from C57BL/6 mice and AS model in ApoE(-/-) mice...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944890/paeonol-exerts-potential-activities-to-inhibit-the-growth-migration-and-invasion-of-human-gastric-cancer-bgc823-cells-via-downregulating-mmp%C3%A2-2-and-mmp%C3%A2-9
#2
Zhong-Kuan Lyu, Chang-Ling Li, Yan Jin, Yu-Zhao Liu, Xi Zhang, Fang Zhang, Lu-Ning Ning, Er-Shun Liang, Min Ma, Wei Gao, Ming-Xiang Zhang, De-Shan Liu
Paeonol (Pae) is an herbal extract that has attracted extensive attention for its anti‑cancer effects demonstrated by a number of studies, which have predominantly demonstrated inhibition of cell proliferation and induction of apoptosis. The influence of Pae on cancer cell metastasis has been less widely reported. The present study aimed to investigate the under‑reported effects of Pae on the growth, invasion and migration of poorly differentiated BGC823 gastric cancer cells with strong invasive and metastatic abilities...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944880/edoxaban-improves-venous-thrombosis-via-increasing-hydrogen-sulfide-and-homocysteine-in-rat-model
#3
Wei Song, Hongbo Ci, Guanglei Tian, Yanjun Zhang, Xiaohu Ge
Anticoagulant therapy is prescribed to millions of patients worldwide for the prevention and treatment of venous thrombosis. Evidence has indicated that edoxaban is a potential drug of oral anticoagulant in the acute treatment of venous thromboembolism. Hydrogen sulfide and homocysteine plasma concentration are indicators of cardiovascular and neurovascular disease risk factors that have attracted considerable attention for regulation of vascular health and homeostasis. However, the molecular mechanism of edoxaban‑mediated differences of hydrogen sulfide and homocysteine has not been investigated in the progression of venous thrombosis...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28943961/the-roles-of-arhgap10-in-the-proliferation-migration-and-invasion-of-lung-cancer-cells
#4
Ji-Ping Teng, Zhi-Ying Yang, Yu-Ming Zhu, Da Ni, Zhi-Jun Zhu, Xiao-Qiang Li
Lung cancer is a leading cause of cancer-related mortalities worldwide. In the present study, a comparison of To determine the roles of ARHGAP10 in the proliferation, migration and invasion of lung cancer cells expression levels between normal lung tissues and lung cancer tissues were compared using immunoblotting, and CCK-8 and Transwell assays. Lung cancer tissues had a decreased ARHGAP10 mRNA expression level compared to the adjacent normal tissues. The ectopic expression of ARHGAP10 significantly suppressed the migration, invasion and proliferation of lung cancer cells...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943944/andrographolide-suppresses-proliferation-of-human-colon-cancer-sw620-cells-through-the-tlr4-nf-%C3%AE%C2%BAb-mmp-9-signaling-pathway
#5
Rui Zhang, Jian Zhao, Jian Xu, De-Xin Jiao, Jian Wang, Zhi-Qiang Gong, Jian-Hui Jia
Modern pharmacological research has revealed that andrographolide has various functions, including anti-bacterial, anti-inflammatory and anti-viral effects, immunoregulation, treating cardiovascular and cerebrovascular diseases, and prevention and treatment of alcoholic liver injury. The present study investigated whether andrographolide suppresses the proliferation of human colon cancer cell through the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB/matrix metalloproteinase-9 (MMP-9) signaling pathway...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943290/anti-inflammatory-and-anti-arthritic-properties-of-naringenin-via-attenuation-of-nf-%C3%AE%C2%BAb-and-activation-of-the-heme-oxygenase-%C3%AF-ho%C3%AF-1-related-factor-2-pathway
#6
Rong Fan, Tong Pan, An-Li Zhu, Mei-Hong Zhang
BACKGROUND: Naringenin, a bioflavonoid present in various species of citrus fruit, tomatoes and grapes, has been shown to have various pharmacological effects. We evaluated the anti-arthritic potential of naringenin in formaldehyde-induced inflammation and complete Freund's adjuvant (CFA)-induced arthritis. METHODS: For both evaluations, rats were divided into groups of six. Different doses of naringenin (5, 10 and 20mg/kg) were used in the models. Body weight and the arthritic index were assessed...
April 13, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28942456/staphylococcus-aureus-induces-osteoclastogenesis-via-the-nf-%C3%AE%C2%BAb-signaling-pathway
#7
Li-Rong Ren, Zhi-Hua Wang, Hai Wang, Xiao-Qing He, Mu-Guo Song, Yong-Qing Xu
BACKGROUND Osteomyelitis is one of the refractory diseases encountered in orthopedics, while Staphylococcus aureus (S. aureus) is the most common causative organism in osteomyelitis. However, the precise mechanisms underlying the bone loss caused by S. aureus infection have not been well defined. Here, we investigated the effect of S. aureus on osteoclast differentiation and the probable molecular mechanism. MATERIAL AND METHODS RAW 264.7 cells were treated for 5 days with live S. aureus, inactivated S. aureus, and S...
September 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28942445/effect-of-biodegradable-scleral-plugs-containing-curcumin-on-proliferative-vitreoretinopathy
#8
Jun Zhang, Nalei Zhou, Bin Zhang, Jingxue Ma
BACKGROUND: This study aimed to explore the inhibitory effect of biodegradable scleral plugs containing curcumin on rabbits with proliferative vitreoretinopathy (PVR). MATERIALS AND METHODS: The biodegradable scleral plugs containing curcumin were prepared by dissolving PLGA [poly(lactide-co-glycolide)] and curcumin. In total, 30 rabbits were divided into 2 groups: the model group received a vitreous injection of self-blood, and the treatment group received a vitreous injection of self-blood plus biodegradable scleral implants containing 1...
September 23, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28942298/immunohistochemical-expression-profiles-of-cell-adhesion-molecules-matrix-metalloproteinases-and-their-tissue-inhibitors-in-central-and-peripheral-neoplastic-foci-of-feline-mammary-carcinoma
#9
S Pisamai, A Rungsipipat, N Kunnasut, G Suriyaphol
Feline mammary carcinoma (FMC) is a common cancer with high metastatic potential and high mortality rate. Loss of cell-cell interactions and degradation of the extracellular matrix by proteinases enhances tumour invasion and metastasis. Peripheral neoplastic foci (PNF) are defined as the presence of discrete tumour cell clusters, splitting off from central neoplastic foci (CNF) and lodging around these CNF. PNF therefore locate at the tumour-host interface at the site of invasion. The aim of this study was to evaluate immunohistochemically the expression of cell adhesion molecules (e-cadherin [CDH-1], syndecan 1 [SDC-1] and nectin-2), matrix metalloproteinases (matrix metalloproteinase [MMP]-2, MMP-7 and MMP-9) and their tissue inhibitors (tissue inhibitor of matrix metalloproteinase [TIMP]-1 and TIMP-2) together with the cellular proliferation marker, Ki67, in CNF and PNF of FMCs of different clinical stages and histological grades...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28940965/epirubicin-suppresses-proliferative-and-metastatic-potential-by-down-regulating-tgfbi-expression-in-urothelial-carcinoma
#10
Donghao Shang, Bo Song, Yuting Liu
Transforming growth factor-β-induced (TGFΒI) is considered to be a vital gene in several carcinomas. In this study we determined the effect of TGFBI on the proliferative and metastatic potential of human urothelial carcinoma (UC) cells as well as its mRNA and protein expression, which were detected by RT-PCR and Western blot, respectively. UC cell proliferation was analyzed by WST-1 assay and Hoechst 33258 staining. The effect of TGFBI on UC cell metastasis was analyzed using adhesion, migration, and invasion assays...
September 22, 2017: Cancer Science
https://www.readbyqxmd.com/read/28938623/mifepristone-inhibits-ovarian-cancer-metastasis-by-intervening-in-sdf-1-cxcr4-chemokine-axis
#11
Ning Zheng, Jiahang Chen, Weiqun Liu, Jian Liu, Tao Li, Hongning Chen, Jichuang Wang, Lee Jia
SDF-1/CXCR4 signaling axis determines the proliferative potential and site-specific cancer metastasis. Recent studies suggest involvement of the axis and steroidal hormone in ovarian cancer metastasis. Here we hypothesize that mifepristone (RU486), a well-known progesterone-based abortifacient, might interfere this axis and inhibit ovarian cancer metastasis. Mifepristone at concentrations < IC50 inhibited expression of CXCR4 on cell surface of ovarian cancer SKOV-3 and IGROV-1, and reduced expression of the intracellular CXCR4 protein and its related mRNA activated by SDF-1...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28933726/mollugin-has-an-anti-cancer-therapeutic-effect-by-inhibiting-tnf-%C3%AE-induced-nf-%C3%AE%C2%BAb-activation
#12
Zhe Wang, Ming Yue Li, Chunliu Mi, Ke Si Wang, Juan Ma, Xuejun Jin
The NF-κB signaling pathway plays a pivotal role in regulating the immune response and inflammation. However, it has been shown that NF-κB also has a major role in oncogenesis. Therefore, NF-κB inhibitors have been considered as potential drugs against cancer. Herein, we searched for NF-κB inhibitors from natural sources and identified mollugin from the roots of Rubia cordifolia L. as an inhibitor of NF-κB activation. We found that mollugin significantly inhibited the expression of an NF-κB reporter gene induced by tumor necrosis factor (TNF)-α in a dose-dependent manner...
July 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28933425/carnosine-suppresses-oxygen-glucose-deprivation-recovery-induced-proliferation-and-migration-of-reactive-astrocytes-of-rats-in-vitro
#13
Li Ou-Yang, Yuan Liu, Bing-Yu Wang, Pei Cao, Jing-Jing Zhang, Yu-Yan Huang, Yao Shen, Jian-Xin Lyu
Glial scar formation resulted from excessive astrogliosis limits axonal regeneration and impairs recovery of function, thus an intervention to ameliorate excessive astrogliosis is crucial for the recovery of neurological function after cerebral ischemia. In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro. Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h...
September 21, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28932707/neisseria-gonorrhoeae-challenge-increases-matrix-metalloproteinase-8-expression-in-fallopian-tube-explants
#14
Natalia E Juica, Paula I Rodas, Paula Solar, Paula Borda, Renato Vargas, Cristobal Muñoz, Rodolfo Paredes, Myron Christodoulides, Luis A Velasquez
Background:Neisseria gonorrhoeae (Ngo) is the etiological agent of gonorrhea, a sexually transmitted infection that initially infects the female lower genital tract. In untreated women, the bacteria can ascend to the upper genital reproductive tract and infect the fallopian tube (FTs), which is associated with salpingitis and can lead to impaired FT function and infertility. The extracellular matrix (ECM) plays an important role in cell migration and differentiation in the female genital tract, and some pathogens modify the ECM to establish successful infections...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28931592/ubiquitin-ligase-spsb4-diminishes-cell-repulsive-responses-mediated-by-ephb2
#15
Fumihiko Okumura, Akiko Joo-Okumura, Keisuke Obara, Alexander Petersen, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura
Eph receptor tyrosine kinases and their ephrin ligands are overexpressed in various human cancers, including colorectal malignancies, suggesting important roles in many aspects of cancer development and progression as well as in cellular repulsive responses. The ectodomain of EphB2 receptor is cleaved by metalloproteinases (MMPs) MMP-2/MMP-9 and released into the extracellular space after stimulation by its ligand. The remaining membrane-associated fragment is further cleaved by the presenilin-dependent γ-secretase and releases an intracellular peptide that has tyrosine kinase activity...
September 20, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28931365/predictive-value-of-matrix-metalloproteinases-and-their-inhibitors-for-mortality-in-septic-patients-a-cohort-study
#16
Sergio Serrano-Gomez, Gabriel Burgos-Angulo, Daniela Camila Niño-Vargas, María Eugenia Niño, María Eugenia Cárdenas, Estephania Chacón-Valenzuela, Diana Margarita McCosham, Juan Sebastián Peinado-Acevedo, M Marcos Lopez, Fernando Cunha, Antonio Pazin-Filho, Ramses Ilarraza, Richard Schulz, Diego Torres-Dueñas
PURPOSE: Over 170 biomarkers are being investigated regarding their prognostic and diagnostic accuracy in sepsis in order to find new tools to reduce morbidity and mortality. Matrix metalloproteinases (MMPs) and their inhibitors have been recently studied as promising new prognostic biomarkers in patients with sepsis. This study is aimed at determining the utility of several cutoff points of these biomarkers to predict mortality in patients with sepsis. MATERIALS AND METHODS: A multicenter, prospective, analytic cohort study was performed in the metropolitan area of Bucaramanga, Colombia...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28929659/-effects-and-mechanisms-of-shenkang-injection-promoting-extracellular-matrix-degradation-via-regulating-erk1-2-mmps-signaling-pathway-in-renal-failure-rats
#17
Jing-Jing Yang, Zhi-Min Mao, Yi-Gang Wan, Wei Wu, Yan-Ru Huang, Ge Shi, Wen-Bei Han, Jian Yao
This study aimed to clarify preliminarily the effects and mechanisms of Shenkang injection (SKI) promoting extracellular matrix(ECM)degradation via regulating extracellular-signal regulated protein kinase(ERK)1/2/matrix metalloproteinases(MMPs)signaling pathway in renal failure rats. Twenty rats were randomly divided into 4 groups:the Sham group,the Model group,the SKI group and the Enalapril maleate(EM)group. The model rats with renal failure were induced by intragastric administration of adenine and unilateral ureteral obstruction(UUO)...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929560/minocycline-and-matrix-metalloproteinase-inhibition-in-acute-intracerebral-hemorrhage-a-pilot-study
#18
J J Chang, M Kim-Tenser, B A Emanuel, G M Jones, K Chapple, A Alikhani, N Sanossian, W J Mack, G Tsivgoulis, A V Alexandrov, T Pourmotabbed
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disorder with high morbidity and mortality. Minocycline is a matrix metalloproteinase-9 (MMP-9) inhibitor that may attenuate secondary mechanisms of injury in ICH. The feasibility and safety of minocycline in ICH patients were evaluated in a pilot, double-blinded, placebo-controlled randomized clinical trial. METHODS: Patients with acute onset (<12 h from symptom onset) ICH and small initial hematoma volume (<30 ml) were randomized to high-dose (10 mg/kg) intravenous minocycline or placebo...
September 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28928847/anti-angiogenic-effect-of-arsenic-trioxide-in-lung-cancer-via-inhibition-of-endothelial-cell-migration-proliferation-and-tube-formation
#19
Meng-Hang Yang, Ke-Jie Chang, Jin-Cheng Zheng, Hai Huang, Guang-Yuan Sun, Xue-Wei Zhao, Bing Li, Qing-Yu Xiu
Arsenic trioxide (As2O3) exhibits a remarkable effect on leukemia treatment; however, its effect on solid tumors remains poorly explored. The present study demonstrated the inhibitory effect of As2O3 on lung cancer and explored its possible mechanism. It was observed that As2O3 significantly inhibited the growth of lung cancer xenografts and tumor angiogenesis in vivo. The inhibitory effect of As2O3 on cell proliferation in vitro was more remarkable in vascular endothelial cells than in lung cancer cells. It was also observed that As2O3 inhibited the migration of vascular endothelial cells and disrupted vascular tube formation on Matrigel assays...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928824/isobavachalcone-inhibits-the-proliferation-and-invasion-of-tongue-squamous-cell-carcinoma-cells
#20
Yi Shi, Wei-Zhong Wu, An Huo, Wei Zhou, Xiao-Hong Jin
Isobavachalcone (2',4',4-trihydroxy-3'-[3'-methylbut-3'-ethyl] chalcone or IBC) exhibits anticancer activities in a number of types of cancer cell. However, its role in tongue squamous cell carcinoma (TSCC) cells remains unclear. The aim of the present study was to investigate the biological effect of IBC in TSCC Tca8113 cells. The function of IBC on Tca8113 cell apoptosis and apoptosis-associated signaling pathways was determined using an MTT assay, morphological staining, annexin V-propidium iodide (PI) staining and Western blot analysis...
September 2017: Oncology Letters
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