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Brain Derived Growth Factor

Imdad Ullah Khan, Yongseok Yoon, Ahyoung Kim, Kwang Rae Jo, Kyeung Uk Choi, Taeseong Jung, Namyul Kim, YeonSung Son, Wan Hee Kim, Oh-Kyeong Kweon
Abundant expression of proinflammatory cytokines after a spinal cord injury (SCI) creates an inhibitory microenvironment for neuroregeneration. The mesenchymal stem cells help to mitigate the inflammation and improve neural growth and survival. For this purpose, we potentiated the function of adipose-derived mesenchymal stem cells (Ad-MSCs) by transfecting them with brain-derived neurotrophic factor (BDNF) and heme oxygenase-1 (HO-1), through a lentivirus, to produce BDNF overexpressed Ad-MSCs (BDNF-MSCs), and HO-1 overexpressed Ad-MSCs (HO-1-MSCs)...
January 1, 2018: Cell Transplantation
Lauren R Brink, Bo Lönnerdal
Milk fat globule membranes (MFGM) surround droplets delivering lipids to the breast-fed infant and are enriched with glycoproteins upon exocytosis out of the mammary cell. MFGM is typically removed during processing of cow milk for the manufacture of infant formula. Recent clinical trials have found that formula supplemented with bovine MFGM improved cognition. Here, we aimed to explore the mechanisms behind this improved developmental outcome. Sprague-Dawley rats were bred, and their litters were manipulated to either 10 pups to represent normal growth (N) or 16 pups to represent restricted growth (R) per dam...
May 21, 2018: Journal of Nutritional Biochemistry
Che-Sheng Chu, Dian-Jeng Li, Chin-Liang Chu, Chih-Ching Wu, Ti Lu
Objective: Schizophrenia (SZ) has been associated with the inflammatory-related and immunological pathogenesis. This study investigates the aberration of cytokines in patients with SZ. Methods: Thirty patients with SZ without antipsychotic treatment for at least two weeks participated. We measured the serum levels of fourteen cytokines at hospital admission and after 8-week antipsychotic treatment. Severity was measured by expanded version of 24-items brief psychiatric rating scale (BPRS-E)...
June 15, 2018: Psychiatry Investigation
Sally K da Silva, Carolina Wiener, Gabriele Ghisleni, Jean P Oses, Karen Jansen, Mariane L Molina, Ricardo Silva, Luciano D Souza
OBJECTIVE: To correlate neurotrophic factors - brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and beta-nerve growth factor (beta-NGF) - and severity of depressive symptoms in patients diagnosed with major depressive disorder (MDD) undergoing cognitive-behavioral therapy (CBT). METHODS: In this quasi-experimental study, participants were selected by convenience and received 16 sessions of CBT. The outcomes of interest were severity of depressive symptoms and changes in neurotrophic factor levels after CBT...
June 11, 2018: Revista Brasileira de Psiquiatria
Natalia Pessoa Rocha, João Paulo Sampaio Ferreira, Paula Luciana Scalzo, Izabela Guimarães Barbosa, Mariana Soares de Souza, Paulo Pereira Christo, Helton José Reis, Antonio Lucio Teixeira
There is great evidence linking neurotrophic factor (NF) dysfunction with Parkinson's disease (PD) pathophysiology. This study was conducted to evaluate plasma levels of NFs and their possible associations with clinical symptoms in PD. For this purpose, 40 PD patients and 25 controls were subjected to a clinical evaluation and peripheral blood draw. Plasma levels of brain-derived neurotrophic factor (BDNF), pro-BDNF, neurotrophin 3, neurotrophin 4, nerve growth, glial cell line-derived neurotrophic factor and ciliary neurotrophic factor were measured by enzyme-linked immunosorbent assay...
May 2018: Arquivos de Neuro-psiquiatria
Bowen Liu, Cheng Luo, Zhaoguang Zheng, Zhenyan Xia, Qian Zhang, Chienchih Ke, Renshyan Liu, Yonghua Zhao
BACKGROUND: As a traditional Chinese herbal formula, Shengui Sansheng San (SSS) has been employed for stroke treatment more than 300 years. PURPOSE: We hypothesize that SSS extraction is an angiogenic switch in penumbra post-stroke, and corresponding mechanisms are investigated. METHODS: In present study, rats were subjected to permanent middle cerebral artery occlusion model (MCAo) and were treated with low, middle and high doses of SSS extraction...
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
André R Brunoni, Frank Padberg, Erica Leandro Marciano Vieira, Antônio Lucio Teixeira, André F Carvalho, Paulo Andrade Lotufo, Wagner F Gattaz, Isabela Martins Benseñor
BACKGROUND: Transcranial direct current stimulation (tDCS) holds promise as a therapeutic intervention for major depressive disorder (MDD). A more precise understanding of its underlying mechanisms may aid in the identification of subsets of patients responsive to tDCS within the context of precision psychiatry. OBJECTIVE: In this ancillary investigation of the Escitalopram vs. Electrical Current Therapy for Treating Depression Clinical Study (ELECT-TDCS), we investigated whether plasma levels of several cytokines and neurotrophic factors associated with major depression or antidepressant response predicted tDCS effects...
June 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Marieli Araujo Rossoni Marcioli, José Luis da Conceição Silva, Lucinéia de Fátima Chasko Ribeiro, Rose Meire Costa Brancalhão, Gladson Ricardo Flor Bertolini
Objective: To evaluate the neurotrophin mRNA expression and axon count in the median nerve of Wistar rats submitted to neural mobilization (NM) after nerve compression. Methods: Eighteen animals were randomly divided into G1 (nerve compression only), G2 (NM for 1 min), and G3 (NM for 3 min). For NM, the animals were anesthetized and the right scapula received the mobilization, adapted as indicated for humans, on alternate days, from the third to the 13th postoperative (PO) day, totaling six days of therapy...
May 2018: Revista Brasileira de Ortopedia
Kang Song, Ye Yuan, Yong Lin, Yan-Xia Wang, Jie Zhou, Qu-Jing Gai, Lin Zhang, Min Mao, Xiao-Xue Yao, Yan Qin, Hui-Min Lu, Xiang Zhang, You-Hong Cui, Xiu-Wu Bian, Xia Zhang, Yan Wang
Glioma, the most prevalent malignancy in brain, is classified into four grades (I, II, III, and IV), and grade IV glioma is also known as glioblastoma multiforme (GBM). Aberrant activation of receptor tyrosine kinases (RTKs), including platelet-derived growth factor receptor (PDGFR), are frequently observed in glioma. Accumulating evidence suggests that PDGFR plays critical roles during glioma development and progression and is a promising drug target for GBM therapy. However, PDGFR inhibitor (PDGFRi) has failed in clinical trials, at least partially, due to the activation of other RTKs, which compensates for PDGFR inhibition and renders tumor cells resistance to PDGFRi...
2018: American Journal of Cancer Research
Leon C D Smyth, Justin Rustenhoven, Emma L Scotter, Patrick Schweder, Richard L M Faull, Thomas I H Park, Mike Dragunow
Brain pericytes and vascular smooth muscle cells (vSMCs) are a critical component of the neurovascular unit and are important in regulating cerebral blood flow and blood-brain barrier integrity. Identification of subtypes of mural cells in tissue and in vitro is important to any study of their function, therefore we identified distinct mural cell morphologies in neurologically normal post-mortem human brain. Further, the distribution of mural cell markers platelet-derived growth factor receptor-β (PDGFRβ), α-smooth muscle actin (αSMA), CD13, neural/glial antigen-2 (NG2), CD146 and desmin was examined...
June 7, 2018: Journal of Chemical Neuroanatomy
Huan Wang, Xiaoyi Wang, Cao Xie, Mingfei Zhang, Huitong Ruan, Songli Wang, Kuan Jiang, Fei Wang, Changyou Zhan, Weiyue Lu, Hao Wang
Heptapeptide ATWLPPR (A7R) binds specifically to vascular endothelial growth factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1) overexpressed in glioma cells, exhibiting high potential to achieve glioma targeted drug delivery. However, in vivo application of A7R peptide remains challenging due to the poor proteolytic stability and inaccessibility of A7R to the brain. To tackle these problems, we identified a glycosylated A7R derivative to enhance in vivo stability and brain transport efficacy. Our results showed that glycosylation of peptide could efficiently improve stability in serum, traverse the blood-brain barrier (BBB) and be uptaken by glioma cells...
June 6, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Akram Zamani, Junhua Xiao, Ann M Turnley, Simon S Murray
Brain-derived neurotrophic factor (BDNF) is highly expressed in the hippocampus, where it can initiate signalling pathways leading to neurite outgrowth, neuron survival, spine maturation and increased synapse strength. Although suppressor of cytokine signalling 2 (SOCS2) is primarily known to negatively regulate cytokine signalling, it is also highly expressed in the hippocampus and exerts neuron-specific functions in the brain, effecting the length and architecture of neurons. However, little is known about the role of SOCS2 in the hippocampus...
June 7, 2018: Molecular Neurobiology
Motahare Mokhtarzade, Robert Motl, Raoof Negaresh, Philipp Zimmer, Mostafa Khodadoost, Julien S Baker, Darpan Patel, Nastaran Majdinasab, Rouholah Ranjbar
Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15)...
May 31, 2018: Neuropeptides
Fang Xu, Jing Yang, Fan Lu, Rongjun Liu, Jinwei Zheng, Junfang Zhang, Wei Cui, Chuang Wang, Wenhua Zhou, Qinwen Wang, Xiaowei Chen, Junping Chen
Fast Green FCF (FGF), a biocompatible dye, recently drew attention as a potential drug to treat amyloid-deposit diseases due to its effects against amyloid fibrillogenesis in vitro and a high degree of safety. However, its role in inflammatory pain is unknown. Our study aimed to investigate the effect of FGF in the inflammatory pain model induced by complete Freund's adjuvant (CFA) and to identify the associated mechanisms. We found that systemic administration of FGF reversed mechanical and thermal pain hypersensitivity evoked by CFA in a dose-dependent manner...
2018: Frontiers in Pharmacology
Kimberly T Meyers, Ketan K Marballi, Samuel J Brunwasser, Briana Renda, Milad Charbel, Diano F Marrone, Amelia L Gallitano
Early growth response 3 ( Egr3 ) is an immediate early gene (IEG) that is regulated downstream of a cascade of genes associated with risk for psychiatric disorders, and dysfunction of Egr3 itself has been implicated in schizophrenia, bipolar disorder, and depression. As an activity-dependent transcription factor, EGR3 is poised to regulate the neuronal expression of target genes in response to environmental events. In the current study, we sought to identify a downstream target of EGR3 with the goal of further elucidating genes in this biological pathway relevant for psychiatric illness risk...
2018: Frontiers in Behavioral Neuroscience
Kazumasa Moriwaki, Yusuke Ayani, Hiroko Kuwabara, Tetsuya Terada, Ryo Kawata, Michio Asahi
It has been reported that one of the neurotrophin receptors, tropomyosin receptor kinase B (TRKB), is frequently overexpressed in various tumor tissues including oral squamous cell carcinoma (OSCC), and that its upregulation promotes tumor progression in human cancers. However, the correlation between TRKB overexpression and clinicopathological characteristics is not fully elucidated. Here, we present the correlation between the expression levels of TRKB and/or its secreted ligand, brain-derived neurotrophic factor (BDNF), and clinicopathological characteristics, especially regarding tumor differentiation, tissue invasion, and disease-free survival in patients with OSCC...
May 18, 2018: Oncotarget
Siddharth Sarkar, Raka Jain, Shanti M Kethawat, Rishi Gupta, Mukesh Kumar
BACKGROUND AND AIMS: Brain-Derived Neurotrophic Factor (BDNF), a neuropeptide important for neural growth and differentiation has been explored in patients with opioid dependence. We aimed to compare the serum BDNF levels in patients with opioid dependence with age and gender matched controls, and to assess change in BDNF levels during initial withdrawal period. METHODS: Thirty cases with a diagnosis of opioid dependence were compared to forty healthy controls. BDNF levels were measured at inclusion for all participants...
May 31, 2018: Neuroscience Letters
YinZhong Ma, Li Li, LingLei Kong, ZhiMei Zhu, Wen Zhang, JunKe Song, Junlei Chang, GuanHua Du
Tissue-type plasminogen activator (t-PA) remains the only approved therapy for acute ischemic stroke but has a restrictive treatment time window of 4.5 hr. Prolonged ischemia causes blood-brain barrier (BBB) damage and increases the incidence of hemorrhagic transformation (HT) secondary to reperfusion. In this study, we sought to determine the effect of pinocembrin (PCB; a pleiotropic neuroprotective agent) on t-PA administration-induced BBB damage in a novel rat thromboembolic stroke model. By assessing the leakage of Evans blue into the ischemic hemisphere, we demonstrated that PCB pretreatment 5 min before t-PA administration significantly reduced BBB damage following 2 hr, 4 hr, 6 hr, and even 8 hr ischemia...
2018: BioMed Research International
Changhui Qian, Dandan Tan, Xianghai Wang, Lixia Li, Jinkun Wen, Mengjie Pan, Yuanyuan Li, Wutian Wu, Jiasong Guo
Accumulating evidences suggest that peripheral nerve injury (PNI) may initiate astrocytic responses in the central nervous system (CNS). However, the response of astrocytes in the spinal ventral horn and its potential role in nerve regeneration after PNI remain unclear. Herein, we firstly illustrated that astrocytes in the spinal ventral horn were dramatically activated in the early stage following sciatic nerve injury, and these profiles were eliminated in the chronic stage. Additionally, we found that the expression of neurotrophins, including brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin-3 (NT-3), also accompanied with astrocyte activation...
2018: Neural Plasticity
Yasuhiro Ogawa, Masahiro Irisa, Takafumi Sano, Yusuke Yanagi, Eiri Furusawa, Takahiro Saito, Shoji Yamanaka, Kohji Itoh, Hitoshi Sakuraba, Kazuhiko Oishi
Sandhoff disease (SD) is a genetic disorder caused by a mutation of the β-subunit gene β-hexosaminidase B (HexB) in humans, which results in the massive accumulation of the ganglioside GM2 and related glycosphingolipids in the nervous system. SD causes progressive neurodegeneration and changes in white matter in human infants. An animal model of SD has been established, Hexb-deficient (Hexb) mice, which shows abnormalities resembling the severe phenotype found in human infants. Previously, we reported that the activation state of microglia caused astrogliosis in the early stage of Hexb mouse development...
May 29, 2018: Neuroreport
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