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Brain Derived Growth Factor

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https://www.readbyqxmd.com/read/29054324/protective-role-of-chrysin-on-6-hydroxydopamine-induced-neurodegeneration-a-mouse-model-of-parkinson-s-disease-involvement-of-neuroinflammation-and-neurotrophins
#1
André T R Goes, Cristiano R Jesse, Michelle S Antunes, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Cristiane Luchese, Natalia Paroul, Silvana Peterini Boeira
Chrysin is a natural flavonoid which is found in bee propolis, honey and various plants, and neuroprotective effect of chrysin in mice was previously demonstrated by our group. Neuroinflammation, neurotrophic factors and neuronal recovery factors associated with the neuroprotective effect of this flavonoid require further investigations. Thus, now we investigated the possible involvement of inflammatory cytokines, neurotrophic factors and neuronal recovery in the effect of chrysin in 6-hydroxidopamine (6-OHDA), a well-established model of Parkinson's disease, in striatum of mice...
October 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29053791/pharmacological-targeting-of-apelin-impairs-glioblastoma-growth
#2
Elizabeth Harford-Wright, Gwennan Andre-Gregoire, Kathryn A Jacobs, Lucas Treps, Sophie Le Gonidec, Heloise M Leclair, Sara Gonzalez-Diest, Quentin Roux, François Guillonneau, Delphine Loussouarn, Lisa Oliver, François M Vallette, Fabienne Foufelle, Philippe Valet, Anthony P Davenport, Robert C Glen, Nicolas Bidere, Julie Gavard
Glioblastoma are highly aggressive brain tumours that are associated with an extremely poor prognosis. Within these tumours exists a subpopulation of highly plastic self-renewing cancer cells that retain the ability to expand ex vivo as tumourspheres, induce tumour growth in mice, and have been implicated in radio- and chemo-resistance. Although their identity and fate are regulated by external cues emanating from endothelial cells, the nature of such signals remains unknown. Here, we used a mass spectrometry proteomic approach to characterize the factors released by brain endothelial cells...
October 3, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29034461/the-migraine-attack-as-a-homeostatic-neuroprotective-response-to-brain-oxidative-stress-preliminary-evidence-for-a-theory
#3
Jonathan M Borkum
BACKGROUND: Previous research has suggested that migraineurs show higher levels of oxidative stress (lipid peroxides) between migraine attacks and that migraine triggers may further increase brain oxidative stress. Oxidative stress is transduced into a neural signal by the TRPA1 ion channel on meningeal pain receptors, eliciting neurogenic inflammation, a key event in migraine. Thus, migraines may be a response to brain oxidative stress. RESULTS: In this article, a number of migraine components are considered: cortical spreading depression, platelet activation, plasma protein extravasation, endothelial nitric oxide synthesis, and the release of serotonin, substance P, calcitonin gene-related peptide, and brain-derived neurotrophic factor...
October 16, 2017: Headache
https://www.readbyqxmd.com/read/29031771/a-nonrandomized-controlled-clinical-pilot-trial-on-8%C3%A2-wk-of%C3%A2-intermittent-fasting-24%C3%A2-h-wk
#4
Christian S Kessler, Rainer Stange, Maike Schlenkermann, Michael Jeitler, Andreas Michalsen, Antonia Selle, Franca Raucci, Nico Steckhan
OBJECTIVE: The aim of the study was to evaluate whether intermittent fasting (IF) is an effective preventive measure, and whether it is feasible for healthy volunteers under every day conditions. METHODS: A nonrandomized controlled clinical trial on IF was performed with healthy volunteers over a period of 8 wk, and a subsequent 4-mo follow-up. Outcomes were assessed at baseline, after 8 wk, and after 6 mo. Volunteers who were not interested in fasting served as a control group...
August 12, 2017: Nutrition
https://www.readbyqxmd.com/read/29030174/growth-hormone-protects-against-kainate-excitotoxicity-and-induces-bdnf-and-nt3-expression-in-chicken-neuroretinal-cells
#5
C G Martinez-Moreno, T Fleming, M Carranza, J Ávila-Mendoza, M Luna, S Harvey, C Arámburo
There is increasing evidence to suggest a beneficial neuroprotective effect of growth hormone (GH) in the nervous system. While our previous studies have largely focused on retinal ganglion cells (RGCs), we have also found conclusive evidence of a pro-survival effect of GH in cells of the inner nuclear layer (INL) as well as a protective effect on the dendritic trees of the inner plexiform layer (IPL) in the retina. The administration of GH in primary neuroretinal cell cultures protected and induced neural outgrowths...
October 10, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29021765/enhancing-neuroplasticity-to-augment-cognitive-remediation-in-schizophrenia
#6
REVIEW
Carol Jahshan, Yuri Rassovsky, Michael F Green
There is a burgeoning need for innovative treatment strategies to improve the cognitive deficits in schizophrenia. Cognitive remediation (CR) is effective at the group level, but the variability in treatment response is large. Given that CR may depend on intact neuroplasticity to produce cognitive gains, it is reasonable to combine it with strategies that harness patients' neuroplastic potential. In this review, we discuss two non-pharmacological approaches that can enhance neuroplasticity and possibly augment the effects of CR in schizophrenia: physical exercise and transcranial direct current stimulation (tDCS)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29016934/microrna-7-upregulates-death-receptor-5-and-primes-resistant-brain-tumors-to-caspase-mediated-apoptosis
#7
Deepak Bhere, Kaoru Tamura, Hiroaki Wakimoto, Sung Hugh Choi, Benjamin Purow, Jeremy Debatisse, Khalid Shah
Background: MicroRNAs (miRs) are known to play a pivotal role in tumorigenesis, controlling cell proliferation and apoptosis. In this study, we investigated the potential of miR-7 to prime resistant tumor cells to apoptosis in glioblastoma (GBM). Methods: We created constitutive and regulatable miR-7 expression vectors and utilized pharmacological inhibition of caspases and genetic loss of function to study the effect of forced expression of miR-7 on death receptor (DR) pathways in a cohort of GBM with established resistance to tumor necrosis factor apoptosis inducing ligand (TRAIL) and in patient-derived primary GBM stem cell (GSC) lines...
July 25, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29016822/platelet-derived-growth-factor-as-an-antidepressant-treatment-selection-biomarker-higher-levels-selectively-predict-better-outcomes-with-bupropion-ssri-combination
#8
Manish K Jha, Abu Minhajuddin, Bharathi S Gadad, Madhukar H Trivedi
Background: Platelet derived growth factor is integral to maintenance of blood brain barrier, increases in response to blood brain barrier disruption, and may reflect neuroinflammation. Based on previous reports of better outcomes with dopaminergic antidepressants in depressed patients with elevated inflammatory biomarkers, we hypothesize that elevated peripheral platelet derived growth factor levels can serve as a powerful biomarker for selecting dopaminergic antidepressants. Methods: Platelet derived growth factor, basic fibroblast growth factor, and granulocyte colony stimulating factor were measured as part of Bioplex Pro human cytokine 27-plex kit in participants of the Combining Medications to Enhance Depression Outcomes trial who provided baseline plasma (n=166) and were treated with either bupropion-plus-escitalopram, escitalopram-plus-placebo, or venlafaxine-plus-mirtazapine...
July 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29016807/a-recombinant-lentiviral-pdgf-driven-mouse-model-of-proneural-glioblastoma
#9
Gilbert J Rahme, Bryan W Luikart, Chao Cheng, Mark A Israel
Background: Mouse models of glioblastoma (GBM), the most aggressive primary brain tumor, are critical for understanding GBM pathology and can contribute to the preclinical evaluation of therapeutic agents. Platelet-derived growth factor (PDGF) signaling has been implicated in the development and pathogenesis of GBM, specifically the proneural subtype. Although multiple mouse models of PDGF-driven glioma have been described, they require transgenic mice engineered to activate PDGF signaling and/or impair tumor suppressor genes and typically represent lower-grade glioma...
July 7, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28990762/multichanneled-nerve-guidance-conduit-with-spatial-gradients-of-neurotrophic-factors-and-oriented-nanotopography-for-repairing-the-peripheral-nervous-system
#10
Yo-Cheng Chang, Ming-Hong Chen, Shih-Yung Liao, Hsi-Chin Wu, Chen-Hsiang Kuan, Jui-Sheng Sun, Tzu-Wei Wang
Peripheral nerve injuries, causing sensory and motor impairment, affect a great number of patients annually. It is therefore important to incorporate different strategies to promote nerve healing. Among the treatment options, however, the efficacy of nerve conduits is often compromised by their lack of living cells, insufficient growth factors, and absence of the extracellular matrix (ECM)-like structure. To improve the functional recovery, we aimed to develop a natural biodegradable multichanneled scaffold characterized with aligned electrospun nanofibers and neurotrophic gradient (MC/AN/NG) to guide axon outgrowth...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28990414/biomarkers-of-endothelial-renal-and-platelet-dysfunction-in-stage-5-chronic-kidney-disease-hemodialysis-patients-with-heart-failure
#11
Ryan McMillan, Leonidas Skiadopoulos, Debra Hoppensteadt, Nil Guler, Vinod Bansal, Ravipresenna Parasuraman, Jawed Fareed
The aim of this study was to determine the role of endothelial, renal, and inflammatory biomarkers in the pathogenesis of heart failure (HF) in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD). Plasma levels of biomarkers-kidney injury molecule 1 (KIM-1), N-terminal pro brain natriuretic peptide (NT-proBNP), glycated hemoglobin, neutrophil gelatinase-associated lipocalin, interleukin-18,platelet-derived growth factor, platelet factor 4 (PF4), 25-OH vitamin D, parathyroid hormone (PTH), endothelin, and endocan-were measured in CKD5-HD patients at the Loyola University Ambulatory Dialysis facility...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28987031/using-minimalist-self-assembling-peptides-as-hierarchical-scaffolds-to-stabilize-growth-factors-and-promote-stem-cell-integration-in-the-injured-brain
#12
A L Rodriguez, K F Bruggeman, Y Wang, T Y Wang, R J Williams, C L Parish, D R Nisbet
Neurotrophic growth factors are effective in slowing progressive degeneration and/or promoting neural repair through the support of residual host and/or transplanted neurons. However, limitations including short half-life and enzyme susceptibility of growth factors highlight the need for alternative strategies to prolong localised delivery at a site of injury. Here, we establish the utility of minimalist N-fluorenylmethyloxycarbonyl (Fmoc) self-assembling peptides (SAPs) as growth factor delivery vehicle, targeted at supporting neural transplants in an animal model of Parkinson's disease...
October 7, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28986333/protective-effect-of-danhong-injection-combined-with-naoxintong-capsule-on-cerebral-ischemia-reperfusion-injury-in-rats
#13
Jiayang Wan, Haofang Wan, Rongbin Yang, Haitong Wan, Jiehong Yang, Yu He, Huifen Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Danhong Injection (DHI) and Naoxintong Capsule (NXT) are renowned traditional Chinese medicine in China. The drug combination of DHI and NXT is frequently applied for the treatment of cardiovascular and cerebrovascular diseases in clinic. However, there had been no pharmacological experiment studies of interaction between DHI and NXT. Due to the drug interactions, exploring their interaction profile is of great importance. MATERIAL AND METHODS: In this study, focal cerebral I/R injury in adult male Sprague-Dawley rats were induced by transient middle cerebral artery occlusion (tMCAO) for 1h followed by reperfusion...
October 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28983620/implantation-of-bone-mesenchymal-stem-cells-overexpressing-mirna%C3%A2-705-mitigated-ischemic-brain-injury
#14
Meng Ji, Wei Wang, Shujuan Li, Wenli Hu
Ischemic brain damage remains the major cause of death and disability worldwide. Bone mesenchymal stem cell (BMSC) transplantation has been identified to serve important roles in cerebral infarction due to its multi‑directional differentiation and proliferative ability. However, the function of miR‑705 combined with BMSCs on ischemic brain injury remains to be fully elucidated. In the present study, an ischemic brain injury mouse model was constructed, and the mice were injected with BMSCs infected by lentiviral particles expressing miR‑705 (BMSCs‑Ad‑miR‑705) to explore the mechanism by which BMSCs‑Ad‑miR‑705 mitigates neurological deficits in ischemic brain damage...
September 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28974767/the-neurotrophic-effects-of-different-human-dental-mesenchymal-stem-cells
#15
Mallappa K Kolar, Vinay N Itte, Paul J Kingham, Lev N Novikov, Mikael Wiberg, Peyman Kelk
The current gold standard treatment for peripheral nerve injury is nerve grafting but this has disadvantages such as donor site morbidity. New techniques focus on replacing these grafts with nerve conduits enhanced with growth factors and/or various cell types such as mesenchymal stem cells (MSCs). Dental-MSCs (D-MSCs) including stem cells obtained from apical papilla (SCAP), dental pulp stem cells (DPSC), and periodontal ligament stem cells (PDLSC) are potential sources of MSCs for nerve repair. Here we present the characterization of various D-MSCs from the same human donors for peripheral nerve regeneration...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28974731/alternative-promoter-usage-generates-novel-shorter-mapt-mrna-transcripts-in-alzheimer-s-disease-and-progressive-supranuclear-palsy-brains
#16
Vincent Huin, Luc Buée, Hélène Behal, Julien Labreuche, Bernard Sablonnière, Claire-Marie Dhaenens
Alternative promoter usage is an important mechanism for transcriptome diversity and the regulation of gene expression. Indeed, this alternative usage may influence tissue/subcellular specificity, protein translation and function of the proteins. The existence of an alternative promoter for MAPT gene was considered for a long time to explain differential tissue specificity and differential response to transcription and growth factors between mRNA transcripts. The alternative promoter usage could explain partly the different tau proteins expression patterns observed in tauopathies...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28971775/beyond-the-therapeutic-effect-of-rtms-in-alzheimer-s-disease-a-possible-neuroprotective-role-of-hippocampal-bdnf-a-minireview
#17
Burak Yulug, Lütfü Hanoglu, Elmir Ksanmemmedov, Ozge Arıcı Düz, Burcu Polat, Taha Hanoglu, Mehmet Yalçin Günal, Ertugrul Kilic
There are limited studies in the literature evaluating region specific neuroprotective effects of repetitive transcranial magnetic stimulation (rTMS) in Alzheimer's Disease. Here, we aimed to review the neurochemical correlates of the hippocampal neuroprotective effect of rTMS in various preclinical and clinical studies. Our findings indicate that rTMS may exert a significant neuroprotective effect through acting on the hippocampal Brain Derived Growth Factor (BDNF) levels which may, in turn, slow the progression of Alzheimer's Disease...
September 27, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28966935/brain-derived-neutrophic-factor-bdnf-coordinates-lympho-vascular-metastasis-through-a-fibroblast-governed-paracrine-axis-in-the-tumor-microenvironment
#18
Tilahun Jiffar, Turker Yilmaz, Junegoo Lee, Yair Miller, Lei Feng, Adel El-Naggar, Michael E Kupferman
It has long been known that the tumor microenvironment contributes to the proliferation and survival of neoplasms through the constant interaction with the stromal and immune compartments. In this investigation, we explored the role of cancer-associated fibroblasts (CAFs) in the regulation of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) though a complex intercellular BDNF-TrkB signaling system. Our studies show that conditioned media derived from patient-derived CAFs promoted HNSCC cell proliferation, in vitro cell migration, cell invasion and chemotherapy resistance, compared to normal fibroblasts...
2017: Cancer Cell & Microenvironment
https://www.readbyqxmd.com/read/28966643/extract-of-ginkgo-biloba-promotes-neuronal-regeneration-in-the-hippocampus-after-exposure-to-acrylamide
#19
Wei-Ling Huang, Yu-Xin Ma, Yu-Bao Fan, Sheng-Min Lai, Hong-Qing Liu, Jing Liu, Li Luo, Guo-Ying Li, Su-Min Tian
Previous studies have demonstrated a neuroprotective effect of extract of Ginkgo biloba against neuronal damage, but have mainly focused on antioxidation of extract of Ginkgo biloba. To date, limited studies have determined whether extrasct of Ginkgo biloba has a protective effect on neuronal damage. In the present study, acrylamide and 30, 60, and 120 mg/kg extract of Ginkgo biloba were administered for 4 weeks by gavage to establish mouse models. Our results showed that 30, 60, and 120 mg/kg extract of Ginkgo biloba effectively alleviated the abnormal gait of poisoned mice, and up-regulated protein expression levels of doublecortin (DCX), brain-derived neurotrophic factor, and growth associated protein-43 (GAP-43) in the hippocampus...
August 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28966265/the-endothelin-etb-receptor-antagonist-bq788-protects-against-brain-edema-after-fluid-percussion-injury-by-decreasing-vascular-endothelial-growth-factor-a-expression-in-mice
#20
Shotaro Michinaga
 Brain edema is a severe morbid complication of brain injury, characterized by excessive fluid accumulation and an elevation of intracranial pressure. However, effective anti-brain edema drugs are lacking. One of the causes of brain edema is disruption of blood-brain barrier (BBB) function, which results in extravasation of intravascular fluid. After brain damage, astrocytes are activated, and astrocyte-derived vascular endothelial growth factor-A (VEGF-A) is known to induce BBB dysfunction. Therefore maintaining BBB integrity by regulating astrocyte function is a potentially effective strategy for treating brain edema...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
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