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Angiopoetin-2

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https://www.readbyqxmd.com/read/27617438/angiopoetin-2-signals-do-not-mediate-the-hypervascularization-of-islets-in-type-2-diabetes
#1
Payal Shah, Navina Lueschen, Amin Ardestani, Jose Oberholzer, Johan Olerud, Per-Ola Carlsson, Kathrin Maedler
AIMS: Changes in the islet vasculature have been implicated in the regulation of β-cell survival and function during the progression to type 2 diabetes (T2D). Failure of the β-cell to compensate for the increased insulin demand in obesity eventually leads to diabetes; as a result of the complex interplay of genetic and environmental factors (e.g. ongoing inflammation within the islets) and impaired vascular function. The Angiopoietin/Tie (Ang/Tie) angiogenic system maintains vasculature and is closely related to organ inflammation and angiogenesis...
2016: PloS One
https://www.readbyqxmd.com/read/25982018/effect-of-different-enamel-matrix-derivative-proteins-on-behavior-and-differentiation-of-endothelial-cells
#2
Oleh Andrukhov, Anja C Gemperli, Yan Tang, Nadia Howald, Michel Dard, Frank Falkensammer, Andreas Moritz, Xiaohui Rausch-Fan
OBJECTIVES: Enamel matrix derivative (EMD) is an effective biomaterial for periodontal tissue regeneration and might stimulate angiogenesis. In order to clarify mechanisms underlying its biological activity, we separated two EMD fractions with different molecular weight protein components and investigated their effects on human umbilical vein endothelial cells (HUVECs) in vitro. METHODS: Fraction Low-Molecular Weight (LMW) included proteins with a molecular weight (M...
July 2015: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/25909285/foretinib-inhibits-angiogenesis-lymphangiogenesis-and-tumor-growth-of-pancreatic-cancer-in-vivo-by-decreasing-vegfr-2-3-and-tie-2-signaling
#3
Hsiu-Mei Chen, Chia-Hua Tsai, Wen-Chun Hung
Foretinib, a multiple kinase inhibitor undergoing clinical trials, could suppress the activity of hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor-2 (VEGFR-2). In addition, Foretinib may inhibit two critical lymphangiogenic signaling receptors VEGFR-3 and TIE-2. However, the effect of Foretinib on lymphatic endothelial cells (LECs) in vitro and lymphangiogenesis in vivo is still unknown. We found Foretinib decreased basal- and HGF-induced c-MET activity at low concentrations...
June 20, 2015: Oncotarget
https://www.readbyqxmd.com/read/25562438/dual-targeting-of-angiopoetin-2-and-vegf-potentiates-effective-vascular-normalisation-without-inducing-empty-basement-membrane-sleeves-in-xenograft-tumours
#4
O Coutelle, L M Schiffmann, M Liwschitz, M Brunold, V Goede, M Hallek, H Kashkar, U T Hacker
BACKGROUND: Effective vascular normalisation following vascular endothelial growth factor (VEGF) inhibition is associated with endothelial cell regression leaving empty basement membrane sleeves (BMS). These long-lived BMS permit the rapid regrowth of tumour vasculature upon treatment cessation and promote resistance to VEGF-targeting drugs. Previous attempts at removing BMS have failed. Angiopoietin-2 (Ang2) is a vascular destabilizing factor that antagonises normalisation. We hypothesised that Ang2 inhibition could permit vascular normalisation at significantly reduced doses of VEGF inhibition, avoiding excessive vessel regression and the formation of empty BMS...
February 3, 2015: British Journal of Cancer
https://www.readbyqxmd.com/read/25172169/impaired-cerebral-angiogenesis-in-the-fetal-lamb-model-of-persistent-pulmonary-hypertension
#5
Susan S Cohen, Bethany R Powers, Alexandra Lerch-Gaggl, Ru-Jeng Teng, Girija Ganesh Konduri
BACKGROUND: Persistent pulmonary hypertension of the newborn (PPHN) is associated with increased risk of neuro-developmental impairments. Whether relative fetal hypoxia during evolution of PPHN renders the fetal brain vulnerable to perinatal brain injury remains unclear. We hypothesized that in utero ductal constriction, which induces PPHN also impairs cerebral angiogenesis. METHODS: Fetal lambs with PPHN induced by prenatal ligation of the ductus arteriosus were compared to gestation matched twin controls...
November 2014: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/25159192/vasculotide-an-angiopoietin-1-mimetic-reduces-acute-skin-ionizing-radiation-damage-in-a-preclinical-mouse-model
#6
Elina Korpela, Darren Yohan, Lee Cl Chin, Anthony Kim, Xiaoyong Huang, Shachar Sade, Paul Van Slyke, Daniel J Dumont, Stanley K Liu
BACKGROUND: Most cancer patients are treated with radiotherapy, but the treatment can also damage the surrounding normal tissue. Acute skin damage from cancer radiotherapy diminishes patients' quality of life, yet effective biological interventions for this damage are lacking. Protecting microvascular endothelial cells from irradiation-induced perturbations is emerging as a targeted damage-reduction strategy. Since Angiopoetin-1 signaling through the Tie2 receptor on endothelial cells opposes microvascular perturbations in other disease contexts, we used a preclinical Angiopoietin-1 mimic called Vasculotide to investigate its effect on skin radiation toxicity using a preclinical model...
2014: BMC Cancer
https://www.readbyqxmd.com/read/24857153/for-the-next-trick-new-discoveries-in-radiobiology-applied-to-glioblastoma
#7
REVIEW
Juergen Debus, Amir Abdollahi
Glioblastoma (GBM) is the most common malignant brain tumor. Radiotherapy post surgical resection remained the mainstay of the management of GBM for decades until the addition of temozolomide was shown to prolong the median overall survival (OS) by 2.5 months to 14.6 months in 2005. Infiltrative growth to surrounding normal brain tissue and cooption of vascular niches, peripheral microvasuclar hyperplasia, and central hypoxic regions with pseudopalisading necrosis are characteristics of GBM and are causally linked to their exceptional radio- and chemo-resistant phenotype...
2014: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/24807599/minimally-invasive-colorectal-resection-for-benign-pathology-is-associated-with-persistent-proangiogenic-plasma-compositional-changes
#8
H M C Shantha Kumara, Elizabeth A Myers, Sonali A C Herath, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Nadav Dujovny, Richard L Whelan
BACKGROUND: Minimally invasive colorectal resection for cancer is associated with increased plasma levels of numerous proangiogenic proteins for 3 to 4 weeks postoperatively, and plasma from postoperative weeks 2 and 3 stimulates proangiogenic endothelial cell behavior in vitro. It is unknown if similar plasma changes occur after minimally invasive colorectal resection for benign pathology. OBJECTIVE: The aim of this study is to assess 1) plasma levels of angiopoetin-2, placental growth factor, and soluble vascular cell adhesion molecule-1 after minimally invasive colorectal resection for benign pathology and 2) postoperative plasma's effects on in vitro endothelial cell proliferation (branch point formation), migration, and invasion...
June 2014: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/24353175/adipose-derived-mesenchymal-stromal-cells-from-aged-patients-with-coronary-artery-disease-keep-mesenchymal-stromal-cell-properties-but-exhibit-characteristics-of-aging-and-have-impaired-angiogenic-potential
#9
Anastasia Efimenko, Nina Dzhoyashvili, Natalia Kalinina, Tatiana Kochegura, Renat Akchurin, Vsevolod Tkachuk, Yelena Parfyonova
Tissue regeneration is impaired in aged individuals. Adipose-derived mesenchymal stromal cells (ADSCs), a promising source for cell therapy, were shown to secrete various angiogenic factors and improve vascularization of ischemic tissues. We analyzed how patient age affected the angiogenic properties of ADSCs. ADSCs were isolated from subcutaneous fat tissue of patients with coronary artery disease (CAD; n = 64, 43-77 years old) and without CAD (n = 31, 2-82 years old). ADSC phenotype characterized by flow cytometry was CD90(+)/CD73(+)/CD105(+)/CD45(-)/CD31(-) for all samples, and these cells were capable of adipogenic and osteogenic differentiation...
January 2014: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/24048963/persistent-endothelial-activation-and-inflammation-after-plasmodium-falciparum-infection-in-malawian-children
#10
Christopher A Moxon, Ngawina V Chisala, Samuel C Wassmer, Terrie E Taylor, Karl B Seydel, Malcolm E Molyneux, Brian Faragher, Neil Kennedy, Cheng-Hock Toh, Alister G Craig, Robert S Heyderman
Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits...
February 15, 2014: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/23984546/-the-concentration-of-growth-factors-in-patients-with-inherent-and-acquired-shortenings-of-limbs-bones
#11
M V Strogov, S N Luneva, K I Novikov
The article deals with the results of study of level of growth factors in blood serum of patients with inherent and post-traumatic shortenings of limbs' bones. The detection in blood serum the level of epidermal growth factor insulin-like growth factor I and angiopoetins is proposed to monitor in given patients the reparative bone formation.
April 2013: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/23742074/transplantation-of-modified-human-adipose-derived-stromal-cells-expressing-vegf165-results-in-more-efficient-angiogenic-response-in-ischemic-skeletal-muscle
#12
Evgeny K Shevchenko, Pavel I Makarevich, Zoya I Tsokolaeva, Maria A Boldyreva, Veronika Yu Sysoeva, Vsevolod A Tkachuk, Yelena V Parfyonova
BACKGROUND: Modified cell-based angiogenic therapy has become a promising novel strategy for ischemic heart and limb diseases. Most studies focused on myoblast, endothelial cell progenitors or bone marrow mesenchymal stromal cells transplantation. Yet adipose-derived stromal cells (in contrast to bone marrow) are abundantly available and can be easily harvested during surgery or liposuction. Due to high paracrine activity and availability ADSCs appear to be a preferable cell type for cardiovascular therapy...
2013: Journal of Translational Medicine
https://www.readbyqxmd.com/read/23660186/platelet-rich-plasma-extract-promotes-angiogenesis-through-the-angiopoietin1-tie2-pathway
#13
Tadanori Mammoto, Amanda Jiang, Elisabeth Jiang, Akiko Mammoto
Development and regeneration of tissues and organs require precise coordination among endothelial, epithelial and mesenchymal morphogenesis. Angiogenesis plays key roles in normal development, wound healing, recovery from ischemic disease, and organ regeneration. It has been recognized that the combination of various angiogenic factors in an appropriate physiological ratio is critical for long-term functional blood vessel formation. Here we show that mouse soluble platelet-rich-plasma (PRP) extract, which includes abundant angiopoetin-1 (Ang1) and other angiogenic factors, stimulates endothelial cell growth, migration and differentiation in cultured human dermal microvascular endothelial cells in vitro and neonatal mouse retinal angiogenesis in vivo...
September 2013: Microvascular Research
https://www.readbyqxmd.com/read/23371031/suppression-of-the-proliferation-of-human-u-87-mg-glioblastoma-cells-by-new-antagonists-of-growth-hormone-releasing-hormone-in-vivo-and-in-vitro
#14
Miklos Jaszberenyi, Andrew V Schally, Norman L Block, Marta Zarandi, Ren-Zhi Cai, Irving Vidaurre, Luca Szalontay, Arumugam R Jayakumar, Ferenc G Rick
Five-year survival of patients afflicted with glioblastoma multiforme (GBM) is rare, making this cancer one of the most feared malignancies. Previously, we reported that growth hormone-releasing hormone (GHRH) is a potent growth factor in cancers. The present work evaluated the effects of two antagonistic analogs of GHRH (MIA-604 and MIA-690) on the proliferation of U-87 MG GBM tumors, in vivo as well as in vitro. Both analogs were administered subcutaneously and dose-dependently inhibited the growth of tumors transplanted into nude mice (127 animals in seven groups)...
December 2013: Targeted Oncology
https://www.readbyqxmd.com/read/23218573/amniotic-mesenchymal-stem-cells-with-robust-chemotactic-properties-are-effective-in-the-treatment-of-a-myocardial-infarction-model
#15
Sung-Whan Kim, Hong-Zhe Zhang, Chae-Eun Kim, Jong-Min Kim, Moo Hyun Kim
BACKGROUND: We previously reported that amniotic mesenchymal stem cells (AMMs) possess high angio-vasulogenic properties. In this study, we investigated the chemotactic abilities of AMMs for improved cardiac function and regenerative angiogenesis. METHODS: The expressions of chemotactic and angiogenic genes were determined by qRT-PCR. Myocardial infarction (MI) was induced in NOD/SCID mice and cells were directly transplanted into the border regions of ischemic heart tissue...
September 30, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/23041600/endothelial-vulnerability-and-endothelial-damage-are-associated-with-risk-of-graft-versus-host-disease-and-response-to-steroid-treatment
#16
Sascha Dietrich, Christine S Falk, Axel Benner, Suzan Karamustafa, Esther Hahn, Mindaugas Andrulis, Ute Hegenbart, Anthony D Ho, Peter Dreger, Thomas Luft
There is accumulating evidence indicating that endothelial factors are involved in the pathogenesis of GVHD. We have recently shown that steroid-refractory, but not sensitive, GVHD is characterized by higher pretransplantation serum levels of angiopoetin-2 (ANG2), a hormone mediating endothelial vulnerability. To evaluate whether endothelial vulnerability is a risk factor for GVHD per se or becomes important only when noticeable GVHD is established, we measured ANG2 along with additional serum markers of endothelial stress, including soluble thrombomodulin (sTM), IL-8 (CXCL8), and hepatocyte growth factor (HGF), in patients with no, low-grade, or severe GVHD...
January 2013: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/22949515/imbalance-of-angiopoietin-1-and-angiopoetin-2-in-severe-dengue-and-relationship-with-thrombocytopenia-endothelial-activation-and-vascular-stability
#17
Meta Michels, André J A M van der Ven, Kis Djamiatun, Rob Fijnheer, Philip G de Groot, Arjan W Griffioen, Silvie Sebastian, Sultana M H Faradz, Quirijn de Mast
The pathogenesis of plasma leakage during dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) is largely unknown. Angiopoietins are key regulators of vascular integrity: Angiopoietin-1 is stored in platelets and maintains vascular integrity, and endothelium-derived angiopoietin-2 promotes vascular leakage. We determined angiopoietin-1 and angiopoietin-2 levels in a cohort of children in Indonesia with DHF/DSS and related them to plasma leakage markers. Patients with DHF/DSS had reduced angiopoietin-1 and increased angiopoietin-2 plasma levels on the day of admission when compared with levels at discharge and in healthy controls...
November 2012: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/22539968/ang-1-tie-2-and-bmpr-signalling-defects-are-not-seen-in-the-nitrofen-model-of-pulmonary-hypertension-and-congenital-diaphragmatic-hernia
#18
Harriet Jane Corbett, Marilyn Gwen Connell, David Garth Fernig, Paul Damion Losty, Edwin Chitran Jesudason
BACKGROUND: Pulmonary hypertension (PH) is a lethal disease that is associated with characteristic histological abnormalities of the lung vasculature and defects of angiopoetin-1 (ANG-1), TIE-2 and bone morphogenetic protein receptor (BMPR)-related signalling. We hypothesized that if these signalling defects cause PH generically, they will be readily identifiable perinatally in congenital diaphragmatic hernia (CDH), where the typical pulmonary vascular changes are present before birth and are accompanied by PH after birth...
2012: PloS One
https://www.readbyqxmd.com/read/22468712/proteomic-screen-identifies-igfbp7-as-a-novel-component-of-endothelial-cell-specific-weibel-palade-bodies
#19
Dorothee van Breevoort, Ellen L van Agtmaal, Bieuwke S Dragt, Jacqueline Klein Gebbinck, Ilze Dienava-Verdoold, Astrid Kragt, Ruben Bierings, Anton J G Horrevoets, Karine M Valentijn, Jeroen C Eikenboom, Mar Fernandez-Borja, Alexander B Meijer, Jan Voorberg
Vascular endothelial cells contain unique storage organelles, designated Weibel-Palade bodies (WPBs), that deliver inflammatory and hemostatic mediators to the vascular lumen in response to agonists like thrombin and vasopressin. The main component of WPBs is von Willebrand factor (VWF), a multimeric glycoprotein crucial for platelet plug formation. In addition to VWF, several other components are known to be stored in WPBs, like osteoprotegerin, monocyte chemoattractant protein-1 and angiopoetin-2 (Ang-2)...
May 4, 2012: Journal of Proteome Research
https://www.readbyqxmd.com/read/22343839/angiopoietin-2-levels-are-associated-with-retinopathy-and-predict-mortality-in-malawian-children-with-cerebral-malaria-a-retrospective-case-control-study
#20
Andrea L Conroy, Simon J Glover, Michael Hawkes, Laura K Erdman, Karl B Seydel, Terrie E Taylor, Malcolm E Molyneux, Kevin C Kain
OBJECTIVE: To investigate the relationship among the angiopoietin-Tie-2 system, retinopathy, and mortality in children with cerebral malaria. DESIGN: A case-control study of retinopathy-positive vs. retinopathy-negative children with clinically defined cerebral malaria. SETTING: Queen Elizabeth Central Hospital in Blantyre, Malawi. SUBJECTS: One hundred fifty-five children presenting with severe malaria and meeting a strict definition of clinical cerebral malaria (Blantyre Coma Score ≤ 2, Plasmodium falciparum parasitemia, no other identifiable cause for coma) were included in the study...
March 2012: Critical Care Medicine
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