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https://www.readbyqxmd.com/read/28645087/ep2-receptor-agonist-ono-ae1-259-01-attenuates-pentylenetetrazole-and-pilocarpine-induced-seizures-but-causes-hippocampal-neurotoxicity
#1
Aline Carré Santos, Fernanda Rossatto Temp, Joseane Righes Marafiga, Micheli Mainardi Pillat, Amanda Titzel Hessel, Leandro Rodrigo Ribeiro, Lígia Gomes Miyazato, Mauro Schneider Oliveira, Carlos Fernando Mello
Epilepsy is a common and devastating neurological disease affecting more than 50 million people worldwide. Accumulating experimental and clinical evidence suggests that inflammatory pathways contribute to the development of seizures in various forms of epilepsy. In this context, while the activation of the PGE2 EP2 receptor causes early neuroprotective and late neurotoxic effects, the role of EP2 receptor in seizures remains unclear. We investigated whether the systemic administration of the highly selective EP2 agonist ONO-AE1-259-01 prevented acute pentylenetetrazole (PTZ)- and pilocarpine-induced seizures...
June 20, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28641116/mechanisms-for-selective-single-cell-reactivation-during-offline-sharp-wave-ripples-and-their-distortion-by-fast-ripples
#2
Manuel Valero, Robert G Averkin, Ivan Fernandez-Lamo, Juan Aguilar, Diego Lopez-Pigozzi, Jorge R Brotons-Mas, Elena Cid, Gabor Tamas, Liset Menendez de la Prida
Memory traces are reactivated selectively during sharp-wave ripples. The mechanisms of selective reactivation, and how degraded reactivation affects memory, are poorly understood. We evaluated hippocampal single-cell activity during physiological and pathological sharp-wave ripples using juxtacellular and intracellular recordings in normal and epileptic rats with different memory abilities. CA1 pyramidal cells participate selectively during physiological events but fired together during epileptic fast ripples...
June 21, 2017: Neuron
https://www.readbyqxmd.com/read/28639431/decrease-in-oxidative-stress-parameters-after-post-ischaemic-recombinant-human-erythropoietin-administration-in-the-hippocampus-of-rats-exposed-to-focal-cerebral-ischaemia
#3
Jasenka Mršić-Pelčić, Kristina Pilipović, Goran Pelčić, Dinko Vitezić, Gordana Župan
Recombinant human erythropoietin (rhEpo) is a multifunctional drug with antioxidant potential. However, the underlying molecular mechanisms of its action are still unclear. The purpose of this study was to investigate the effects of rhEpo on the brain infarct volume as well as on the levels of the neuronal damage, oxidative stress parameters and active caspase-3, nuclear factor erythroid 2-related factor 2 (Nrf2) and hemeoxygenase-1 (HO-1) expressions in the hippocampi of rats exposed to the right middle cerebral artery occlusion (MCAO) for 1 hr...
June 21, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28638710/nicotine-prevented-learning-and-memory-impairment-in-rem-sleep-deprived-rat-is-modulated-by-dream-protein-in-the-hippocampus
#4
Norlinda Abd Rashid, Hermizi Hapidin, Hasmah Abdullah, Zalina Ismail, Idris Long
INTRODUCTION: REM sleep deprivation is associated with impairment in learning and memory, and nicotine treatment has been shown to attenuate this effect. Recent studies have demonstrated the importance of DREAM protein in learning and memory processes. This study investigates the association of DREAM protein in REM sleep-deprived rats hippocampus upon nicotine treatment. METHODS: Male Sprague Dawley rats were subjected to normal condition, REM sleep deprivation and control wide platform condition for 72 hr...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638322/neural-signals-related-to-outcome-evaluation-are-stronger-in-ca1-than-ca3
#5
Sung-Hyun Lee, Namjung Huh, Jong Won Lee, Jeong-Wook Ghim, Inah Lee, Min W Jung
We have shown previously that CA1 conveys significant neural signals necessary to update value of the chosen target, namely chosen value and reward signals. To better understand hippocampal neural processes related to valuation, we compared chosen value- and reward-related neural activity between the CA3 and CA1 regions. Single units were recorded with tetrodes from the dorsal CA3 and CA1 regions of rats performing a dynamic foraging task, and chosen value- and reward-related neural activity was estimated using a reinforcement learning model and multiple regression analyses...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28638149/hsp90-inhibitor-induces-nuclear-translocation-of-hsf1-predominantly-in-hippocampal-ca1-region
#6
B Wang, Y Liu, L Huang, J Chen, J J Li, R Wang, E Kim, Y Chen, C Justicia, K Sakata, H Chen, A Planas, R S Ostrom, W Li, G Yang, M P McDonald, R Chen, D H Heck, F-F Liao
No abstract text is available yet for this article.
July 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28637953/synapse-specific-effects-of-il-1%C3%AE-on-long-term-potentiation-in-the-mouse-hippocampus
#7
Koji Hoshino, Kan Hasegawa, Haruyuki Kamiya, Yuji Morimoto
Interleukin-1β (IL-1β) is a key molecule in the inflammatory responses elicited during infection and injury. It exerts local effects on synaptic plasticity by binding to IL-1 receptors that are expressed at high levels in the hippocampus. We examined the effects of IL-1β on synaptic plasticity in different hippocampal regions in acute mouse brain slices by measuring long-term potentiation (LTP). IL-1β (1 ng/mL) was applied for 30 min before LTP was induced with high-frequency stimulation (HFS). LTP was significantly impaired by either IL-1β application to the Schaffer collateral-CA1 synapses or the associational/commissural (A/C) fiber-CA3 synapses, which are both dependent on N-methyl-D-aspartate (NMDA) receptor activation...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28636875/effects-of-prenatal-binge-like-ethanol-exposure-and-maternal-stress-on-postnatal-morphological-development-of-hippocampal-neurons-in-rats
#8
Ewa Jakubowska-Dogru, Birsen Elibol, Ilknur Dursun, Sinan Yürüker
BACKGROUND: Alcohol is one of the most commonly used drugs of abuse negatively affecting human health and it is known as a potent teratogen responsible for fetal alcohol syndrome (FAS), which is characterized by cognitive deficits especially pronounced in juveniles but ameliorating in adults. Searching for the potential morphological correlates of these effects, in this study, we compared the course of developmental changes in the morphology of principal hippocampal neurons in fetal-alcohol (A group), intubated control (IC group), and intact control male rats (C group) over a protracted period of the first two postnatal months...
June 18, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28634464/anti-inflammatory-and-neuroprotective-effects-of-co-ultrapealut-in-a-mouse-model-of-vascular-dementia
#9
Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Rosalia Crupi, Emanuela Esposito, Stefania Petrosino, Salvatore Cuzzocrea
Vascular dementia (VaD), the second most common cause of cognitive impairment in the population, is a disease that results from reduction in regional cerebral blood flow and involves oxidative stress and inflammation. Co-ultramicronized PEALut (co-ultra PEALut) is a new compound with beneficial effects, which include anti-inflammatory and antioxidant properties. Recently, co-ultraPEALut has been shown to exhibit neuroprotective effects in models of Parkinson's disease, cerebral ischemia and Alzheimer's disease...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28629541/stress-and-loss-of-adult-neurogenesis-differentially-reduce-hippocampal-volume
#10
Timothy J Schoenfeld, Hayley C McCausland, H Douglas Morris, Varun Padmanaban, Heather A Cameron
BACKGROUND: Hippocampal volume loss is a hallmark of clinical depression. Chronic stress produces volume loss in the hippocampus in humans and atrophy of CA3 pyramidal cells and suppression of adult neurogenesis in rodents. METHODS: To investigate the relationship between decreased adult neurogenesis and stress-induced changes in hippocampal structure and volume, we compared the effects of chronic unpredictable restraint stress and inhibition of neurogenesis in a rat pharmacogenetic model...
May 22, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28629384/involvement-of-the-glutamate-glutamine-cycle-and-glutamate-transporter-glt-1-in-antidepressant-like-effects-of-xiao-yao-san-on-chronically-stressed-mice
#11
Xiu-Fang Ding, Yue-Hua Li, Jia-Xu Chen, Long-Ji Sun, Hai-Yan Jiao, Xin-Xin Wang, Yan Zhou
BACKGROUND: Xiao Yao San (XYS) is an herbal prescription which is used in the treatment of depression for thousands of years from Song dynasty in China (960-1127 A.D.), and is the bestselling and most popular herb formula for treating major depression. This study aimed to assess the chronic antidepressant effects of XYS and fluoxetine in depressed mice induced by chronic unpredictable mild stress (CUMS) and its association with  alterations in glutamate/glutamine cycle and glutamate transporters...
June 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28628945/precise-spike-timing-dynamics-of-hippocampal-place-cell-activity-sensitive-to-cholinergic-disruption
#12
Ehren L Newman, Sarah Jo C Venditto, Jason R Climer, Elijah A Petter, Shea N Gillet, Sam Levy
New memory formation depends upon both the hippocampus and modulatory effects of acetylcholine. The mechanism by which acetylcholine levels in the hippocampus enable new encoding remains poorly understood. Here, we tested the hypothesis that cholinergic modulation supports memory formation by leading to structured spike timing in the hippocampus. Specifically, we tested if phase precession in dorsal CA1 was reduced under the influence of a systemic cholinergic antagonist. Unit and field potential was recorded from the dorsal CA1 of rats as they completed laps on a circular track for food rewards before and during the influence of the systemically administered acetylcholine muscarinic receptor antagonist scopolamine...
June 19, 2017: Hippocampus
https://www.readbyqxmd.com/read/28627606/effects-of-ischemic-preconditioning-on-pdgf-bb-expression-in-the-gerbil-hippocampal-ca1-region-following-transient-cerebral-ischemia
#13
Jae-Chul Lee, Yang Hee Kim, Tae-Kyeong Lee, In Hye Kim, Jeong Hwi Cho, Geum-Sil Cho, Bich-Na Shin, Joon Ha Park, Ji Hyeon Ahn, Myoung Cheol Shin, Jun Hwi Cho, Il Jun Kang, Moo-Ho Won, Jeong Yeol Seo
Ischemic preconditioning (IPC) is induced by exposure to brief durations of transient ischemia, which results in ischemic tolerance to a subsequent longer or lethal period of ischemia. In the present study, the effects of IPC (2 min of transient cerebral ischemia) were examined on immunoreactivity of platelet‑derived growth factor (PDGF)‑BB and on neuroprotection in the gerbil hippocampal CA1 region following lethal transient cerebral ischemia (LTCI; 5 min of transient cerebral ischemia). IPC was subjected to a 2‑min sublethal ischemia and a LTCI was given 5‑min transient ischemia...
June 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28626015/reciprocal-interaction-of-dendrite-geometry-and-nuclear-calcium-vegfd-signaling-gates-memory-consolidation-and-extinction
#14
Thekla J Hemstedt, C Peter Bengtson, Omar Ramírez, Ana Mm Oliveira, Hilmar Bading
Nuclear calcium is an important signaling end-point in synaptic excitation-transcription coupling that is critical for long-term neuroadaptations. Here we show that nuclear calcium acting via a target gene VEGFD is required for hippocampus-dependent fear memory consolidation and extinction in mice. Nuclear calcium-VEGFD signaling upholds structural integrity and complexity of the dendritic arbor of CA1 neurons that renders those cells permissive for the efficient generation of synaptic input-evoked nuclear calcium transients driving the expression of plasticity-related genes...
June 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28625390/dopamine-protects-cerebral-autoregulation-and-prevents-hippocampal-necrosis-after-traumatic-brain-injury-via-block-of-erk-mapk-in-juvenile-pigs
#15
Victor Curvello, Hugh Hekierski, Philip Pastor, Monica S Vavilala, William M Armstead
Traumatic brain injury (TBI) contributes to morbidity in children, and more boys experience TBI. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Cerebral Perfusion Pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of newborn and juvenile pigs, vasoactive agent choice influenced outcome after TBI as a function of age and sex, with none protecting cerebral autoregulation in both ages and sexes. Dopamine (DA) prevents impairment of cerebral autoregulation in male and female newborn pigs via inhibition of upregulation of ERK mitogen activated protein kinase (MAPK) after fluid percussion injury (FPI)...
June 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28624573/plasticity-of-intrinsic-firing-response-gain-in-principal-hippocampal-neurons-following-pilocarpine-induced-status-epilepticus
#16
Idit Tamir, Moshe Daninos, Yoel Yaari
OBJECTIVE: In experimental models of temporal lobe epilepsy (TLE), brain neurons manifest multiple changes in intrinsic excitability that contribute to neuronal network hyperexcitability. We have investigated whether the intrinsic firing response gain, quantified by the slope of the function relating the number of evoked spikes (Ns) to input excitatory current intensity (I), is modified in principal rat hippocampal neurons in the pilocarpine-status epilepticus (SE) model of TLE. METHODS: Intracellular recordings were made in CA3 and CA1 pyramidal cells (PCs) and dentate granule cells (GCs) in acute hippocampal slices obtained 7-36days after pilocarpine-SE...
June 15, 2017: Neuroscience
https://www.readbyqxmd.com/read/28624183/the-neuroprotective-effect-of-perampanel-in-lithium-pilocarpine-rat-seizure-model
#17
Ting Wu, Katsutoshi Ido, Yoshihide Osada, Sadaharu Kotani, Akira Tamaoka, Takahisa Hanada
PURPOSE: Status epilepticus (SE) causes irreversible neurodegeneration if not terminated quickly. Perampanel (PER), a potent AMPA receptor antagonist, has previously been shown to terminate seizures in the lithium-pilocarpine SE model. In the present study, we assessed whether PER would also prevent neuronal damage in this model. METHODS: SE was induced in rats using lithium chloride and pilocarpine. Initiation of SE was defined as continuous seizures that exhibited as rearing accompanied by bilateral forelimb clonus (Racine score 4)...
June 14, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28620824/l-3-n-butylphthalide-activates-akt-mtor-signaling-inhibits-neuronal-apoptosis-and-autophagy-and-improves-cognitive-impairment-in-mice-with-repeated-cerebral-ischemia-reperfusion-injury
#18
Jing Xu, Yaping Huai, Nan Meng, Yanhong Dong, Zhijuan Liu, Qianqian Qi, Ming Hu, Mingyue Fan, Wei Jin, Peiyuan Lv
L-3-n-Butylphthalide (L-NBP) exerts neuroprotective effects in animal models of cerebral ischemia, but its potential benefits in repeated cerebral ischemia-reperfusion (RCIR) injury remain unknown. We investigated the effect of L-NBP on cognitive impairment induced by RCIR in mice. Male C57Bl/6 mice received sham surgery or bilateral common carotid artery occlusion (3 times, 20 min each) and were orally administered preoperative L-NBP (30 mg/kg/day, 7 days), postoperative L-NBP (30 or 60 mg/kg/day, 28 days) or postoperative vehicle (28 days)...
June 15, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28620075/experience-dependent-epigenomic-reorganization-in-the-hippocampus
#19
Corey G Duke, Andrew J Kennedy, Cristin F Gavin, Jeremy J Day, J David Sweatt
Using a hippocampus-dependent contextual threat learning and memory task, we report widespread, coordinated DNA methylation changes in CA1 hippocampus of Sprague-Dawley rats specific to threat learning at genes involved in synaptic transmission. Experience-dependent alternations in gene expression and DNA methylation were observed as early as 1 h following memory acquisition and became more pronounced after 24 h. Gene ontology analysis revealed significant enrichment of functional categories related to synaptic transmission in genes that were hypomethylated at 24 h following threat learning...
July 2017: Learning & Memory
https://www.readbyqxmd.com/read/28615451/molecular-mechanisms-of-signaling-via-the-docosanoid-neuroprotectin-d1-for-cellular-homeostasis-and-neuroprotection
#20
Aram Asatryan, Nicolas G Bazan
Docosahexaenoic acid (DHA), an omega-3 essential fatty acid family member that is enriched in the nervous system, generates bioactive docosanoids that can counteract disruptions of cellular homeostasis. Docosanoids include neuroprotectin D1 (NPD1), which is decreased in the CA1 hippocampal area of patients with early-stage Alzheimers disease (AD). We summarize here how NPD1 elicits neuroprotection by up-regulating c-REL, a nuclear factor (NF)-kappaB subtype that, in turn, enhances expression of BIRC3 (baculoviral IAP repeat-containing protein 3, or cIAP2) in retinal cells...
June 14, 2017: Journal of Biological Chemistry
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