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Angiogenin

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https://www.readbyqxmd.com/read/29431851/stress-induced-trna-cleavage-and-tirna-generation-in-rat-neuronal-pc12-cells
#1
Elkordy Alaa, Eikan Mishima, Kuniyasu Niizuma, Yasutoshi Akiyama, Miki Fujimura, Teiji Tominaga, Takaaki Abe
Transfer RNA (tRNA) plays a role in stress response programs involved in various pathological conditions including neurological diseases. Under cell stress conditions, intracellular tRNA is cleaved by a specific ribonuclease, angiogenin, generating tRNA-derived fragments or tRNA-derived stress-induced RNA (tiRNA). Generated tiRNA contributes to the cell stress response and has potential cell protective effects. However, tiRNA generation under stress conditions in neuronal cells has not been fully elucidated...
February 12, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29396049/increased-expression-of-angiogenic-cytokines-in-cd56-uterine-natural-killer-cells-from-women-with-recurrent-miscarriage
#2
Xiaoyan Chen, Yingyu Liu, Wing Ching Cheung, Yiwei Zhao, Jin Huang, Jacqueline Pui Wah Chung, Chi Chiu Wang, Tin Chiu Li
OBJECTIVE: To compare the expression pattern of angiogenic cytokines in CD56+ uNK cells from peri-implantation endometrium in women with a history of recurrent miscarriage and fertile controls. METHODS: 28 women were recruited, from which 18 women were diagnosed as recurrent miscarriage and 10 women were of proven fertility. Endometrial biopsy samples were obtained precisely 7 days after luteinization hormone surge in a natural cycle. The angiogenic profile of isolated CD56+ uNK cells was determined by RayBio human angiogenesis antibody array G Series 1000...
January 30, 2018: Cytokine
https://www.readbyqxmd.com/read/29369908/predominance-of-cd14-cells-in-burn-blister-fluids
#3
Szu-Han Chen, Tak-Wah Wong, Chou-Hwei Lee, Chung-Lin Chen, Li-Wha Wu, Shin-Chen Pan
BACKGROUND: Burn blister fluid contains several angiogenic factors to promote wound neovascularization. In our previous study, we found that deep partial-thickness burn (DPTB) wounds showed higher expression levels of angiogenin to enhance vascularization compared with superficial partial-thickness burn wounds. Neovascularization is a complex process that involves an interaction between circulating angiogenic cells and mediators. We hypothesized that in addition to angiogenic factors burn blisters may contain specific cell types...
January 25, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29369907/angiogenin-attenuates-scar-formation-in-burn-patients-by-reducing-fibroblast-proliferation-and-transforming-growth-factor-%C3%AE-1-secretion
#4
Shin-Chen Pan, Chou-Hwei Lee, Chung-Lin Chen, Wei-Yu Fang, Li-Wha Wu
BACKGROUND: Deep burn wounds have a high tendency to form hypertrophic scars. Previously, we found that angiogenin promoted neovascularization during deep burn wound healing. However, the association between angiogenin and scar formation is unclear. METHODS: We obtained human burn scar tissues from patients who underwent scar surgery and examined the role of angiogenin in scar tissues and determined its effects in scar fibroblasts and on transforming growth factor β1 (TGF-β1) secretion...
January 25, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29353019/induction-by-innate-defence-regulator-peptide-1018-of-pro-angiogenic-molecules-and-endothelial-cell-migration-in-a-high-glucose-environment
#5
Paulina Marin-Luevano, Valentin Trujillo, Adrian Rodriguez-Carlos, Irma González-Curiel, Jose A Enciso-Moreno, Robert E W Hancock, Bruno Rivas-Santiago
Synthetic innate defence regulator (IDR) peptides such as IDR-1018 modulate immunity to promote key protective functions including chemotaxis, wound healing, and anti-infective activity, while suppressing pro-inflammatory responses to non-pathological levels. Here we demonstrated that IDR-1018 induced, by up to 75-fold, pro-angiogenic VEGF-165 in keratinocytes but suppressed this isoform in endothelial cells. It also induced early angiogenin and prolonged anti-inflammatory TGFβ expression on endothelial cells, while suppressing early pro-inflammatory IL-1β expression levels...
January 15, 2018: Peptides
https://www.readbyqxmd.com/read/29314771/evidence-for-novel-action-at-the-cell-binding-site-of-human-angiogenin-revealed-by-heteronuclear-nmr-spectroscopy-in-silico-and-in-vivo-studies
#6
Demetra Sm Chatzileontiadou, Aikaterini C Tsika, Zoi Diamantopoulou, Jean Delbé, Josette Badet, José Courty, Vassiliki T Skamnaki, Vanessa Parmenopoulou, Dimitri Komiotis, Joseph M Hayes, Georgios A Spyroulias, Demetres D Leonidas
A member of Ribonuclease A superfamily, human Angiogenin (hAng) is a potent angiogenic factor. Heteronuclear NMR spectroscopy combined with induced-fit docking revealed a dual binding mode for the most antiangiogenic compound of a series of ribofuranosyl pyrimidine nucleosides that strongly inhibit hAng's angiogenic activity in vivo. While modelling suggests the potential of a simultaneous binding of the inhibitors at the active and cell binding sites, NMR indicates greater affinity for the cell binding site than for the active site...
January 4, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29247834/the-kl-vs-polymorphism-of-klotho-gene-is-protective-against-retinopathy-incidence-in-patients-with-type-1-diabetes
#7
Bartosz Słomiński, Monika Ryba-Stanisławowska, Maria Skrzypkowska, Jolanta Myśliwska, Małgorzata Myśliwiec
BACKGROUND AND AIMS: KLOTHO is an anti-ageing circulating hormone involved in insulin signaling, inflammation and vascular homeostasis through its protective effects on the endothelium and antioxidant actions. The common functional "KL-VS" variant of the KLOTHO gene is reproducibly associated with longevity in humans. Large number of studies have evaluated close relationship between KLOTHO protein and diabetes but the association between KL-VS variant and retinopathy in type 1 diabetes mellitus (T1D) is unknown...
December 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29245935/association-of-mmp-2-rb-and-pai-1-with-decreased-recurrence-free-survival-and-overall-survival-in-bladder-cancer-patients
#8
Owen T M Chan, Hideki Furuya, Ian Pagano, Yoshiko Shimizu, Kanani Hokutan, Lars Dyrskjøt, Jørgen Bjerggaard Jensen, Per-Uno Malmstrom, Ulrika Segersten, Filip Janku, Charles J Rosser
Background: We previously reported an accurate urine-based bladder cancer (BCa)-associated diagnostic signature that can be used to non-invasively detect BCa. In this study, we investigated whether a component of this signature could risk stratify patients with BCa. Methods: Utilizing immunohistochemistry, we investigated angiogenin, MMP-2, p53, RB and PAI-1 expression from 939 patients with BCa. The expression levels were scored by assigning a proportion score and an intensity score to yield a total staining score for each protein...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29243036/mediators-of-angiogenesis-and-fibrosis-in-igg4-related-disease
#9
Ilaria Puxeddu, Riccardo Capecchi, Federico Pratesi, Silvana Cianchetti, Antonio Tavoni, Paola Migliorini
IgG4-related disease (IgG4-RD) is a rare fibro-inflammatory condition that can affect almost any organ, characterized by tumefactive lesions and often by eosinophilia and elevated serum IgG4 concentrations. The aim of the study is to analyze in IgG4-RD patients the serum levels of a group of cytokines and growth factors potentially involved in the regulation of fibrotic processes. In the sera of 12 patients affected by IgG4-RD and of 15 normal healthy subjects (NHS), pro-fibrogenic mediators (TGF-β1 and periostin) and pro- (VEGF and angiogenin-1) and anti- (endostatin and thrombospondin-1) angiogenic mediators were measured by sandwich enzyme immunoassay...
December 14, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29191392/cold-atmospheric-plasma-cap-activates-angiogenesis-related-molecules-in-skin-keratinocytes-fibroblasts-and-endothelial-cells-and-improves-wound-angiogenesis-in-an-autocrine-and-paracrine-mode
#10
Stephanie Arndt, Petra Unger, Mark Berneburg, Anja-Katrin Bosserhoff, Sigrid Karrer
BACKGROUND: Cold atmospheric plasma (CAP) emerged as a novel therapeutic field with applications developed for bacterial sterilization, wound healing and cancer treatment. For clinical implementation it is important to know how CAP works and which molecular changes occur after the CAP treatment. Vascularization is an important step during wound healing, however, the effects of CAP on wound angiogenesis are not well examined so far. Furthermore, it has not been investigated, whether CAP primarily affects endothelial cells directly or via paracrine mechanisms to modulate the vasculature...
November 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29190616/apatinib-inhibits-angiogenesis-via-suppressing-akt-gsk3%C3%AE-ang-signaling-pathway-in-anaplastic-thyroid-cancer
#11
Zhijian Jin, Xi Cheng, Haoran Feng, Jie Kuang, Weiping Yang, Chenghong Peng, Baiyong Shen, Weihua Qiu
BACKGROUND/AIMS: Anaplastic thyroid carcinoma (ATC) is one of the most lethal human malignancies, and there is no efficient method to slow its process. Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma patients. However, the effects of Apatinib in ATC are still unknown. METHODS: In this study, we explored the effects and mechanisms of Apatinib on tumor growth and angiogenesis in vitro and in vitro in ATC cells...
December 1, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29180963/spinal-cord-molecular-and-cellular-changes-induced-by-adenoviral-vector-and-cell-mediated-triple-gene-therapy-after-severe-contusion
#12
Andrei A Izmailov, Tatyana V Povysheva, Farid V Bashirov, Mikhail E Sokolov, Filip O Fadeev, Ravil R Garifulin, Boris S Naroditsky, Denis Y Logunov, Ilnur I Salafutdinov, Yuri A Chelyshev, Rustem R Islamov, Igor A Lavrov
The gene therapy has been successful in treatment of spinal cord injury (SCI) in several animal models, although it still remains unavailable for clinical practice. Surprisingly, regardless the fact that multiple reports showed motor recovery with gene therapy, little is known about molecular and cellular changes in the post-traumatic spinal cord following viral vector- or cell-mediated gene therapy. In this study we evaluated the therapeutic efficacy and changes in spinal cord after treatment with the genes encoding vascular endothelial growth factor (VEGF), glial cell-derived neurotrophic factor (GDNF), angiogenin (ANG), and neuronal cell adhesion molecule (NCAM) applied using both approaches...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29158675/transplantation-of-bone-mesenchymal-stem-cells-promotes-angiogenesis-and-improves-neurological-function-after-traumatic-brain-injury-in-mouse
#13
Shewei Guo, Yingwei Zhen, Anran Wang
Traumatic brain injury (TBI) has emerged as a leading cause of mortality and morbidity worldwide. Transplantation of bone mesenchymal stem cells (BMSCs) has emerged as a promising treatment for various central nervous system diseases. This study aims to evaluate the effect of BMSCs transplantation by intravenous injection on neurological function and angiogenesis of the TBI mice. C57BL/6 male mice were randomly divided into four groups: control, sham, TBI, and BMSC. Functional neurological evaluation was performed 1, 4, 7, 14, and 21 days after TBI using neurological severity scores...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29152123/msc-derived-cytokines-repair-radiation-induced-intra-villi-microvascular-injury
#14
Peng-Yu Chang, Bo-Yin Zhang, Shuang Cui, Chao Qu, Li-Hong Shao, Tian-Kai Xu, Ya-Qin Qu, Li-Hua Dong, Jin Wang
Microvascular injury initiates the pathogenesis of radiation enteropathy. As previously demonstrated, the secretome from mesenchymal stem cells contains various angiogenic cytokines that exhibited therapeutic potential for ischemic lesions. As such, the present study aimed to investigate whether cytokines derived from mesenchymal stem cells can repair endothelial injuries from irradiated intestine. Here, serum-free medium was conditioned by human adipose-derived mesenchymal stem cells, and we found that there were several angiogenic cytokines in the medium, including IL-8, angiogenin, HGF and VEGF...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29110608/the-profile-of-angiogenic-factors-in-vitreous-humor-of-the-patients-with-proliferative-diabetic-retinopathy
#15
Y Yu, J Zhang, R Zhu, R Zhao, J Chen, J Jin, Y Tian, S B Su
OBJECTIVE: To explore the expression profile of angiogenic factors associated with proliferative diabetic retinopathy (PDR). METHODS: Undiluted vitreous humor samples were obtained from 10 diabetic patients with PDR (10 eyes) and 9 non-diabtic patients (9 eyes). The concentrations of 60 angiogenic factors in the vitreous humor samples were measured by RayBio Angiogenic Cytokine Antibody Array. Some differentially expressed factors were further confirmed in vitreous humor by enzyme-linked immunosorbent assay (ELISA)...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29100074/plexin-b2-mediates-physiologic-and-pathologic-functions-of-angiogenin
#16
Wenhao Yu, Kevin A Goncalves, Shuping Li, Hiroko Kishikawa, Guangjie Sun, Hailing Yang, Nil Vanli, Yunxia Wu, Yuxiang Jiang, Miaofen G Hu, Roland H Friedel, Guo-Fu Hu
Angiogenin (ANG) is a secreted ribonuclease (RNase) with cell-type- and context-specific roles in growth, survival, and regeneration. Although these functions require receptor-mediated endocytosis and appropriate subcellular localization, the identity of the cell surface receptor remains undefined. Here, we show that plexin-B2 (PLXNB2) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells. Mechanistically, PLXNB2 mediates intracellular RNA processing that contribute to cell growth, survival, and regenerative capabilities of ANG...
November 2, 2017: Cell
https://www.readbyqxmd.com/read/29096624/blue-light-filtering-alters-angiogenic-signaling-in-human-retinal-pigmented-epithelial-cells-culture-model
#17
Natalia Vila, Aya Siblini, Evangelina Esposito, Vasco Bravo-Filho, Pablo Zoroquiain, Sultan Aldrees, Patrick Logan, Lluis Arias, Miguel N Burnier
BACKGROUND: Light exposure and more specifically the spectrum of blue light contribute to the oxidative stress in Age-related macular degeneration (AMD). The purpose of the study was to establish whether blue light filtering could modify proangiogenic signaling produced by retinal pigmented epithelial (RPE) cells under different conditions simulating risk factors for AMD. METHODS: Three experiments were carried out in order to expose ARPE-19 cells to white light for 48 h with and without blue light-blocking filters (BLF) in different conditions...
November 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29042175/calcitriol-promotes-proangiogenic-molecules-in-keratinocytes-in-a-diabetic-foot-ulcer-model
#18
Valentin Trujillo, Paulina Marín-Luevano, Irma González-Curiel, Adrián Rodríguez-Carlos, Maira Ramírez-Reyes, Esther Layseca-Espinosa, José A Enciso-Moreno, Lorenza Díaz, Bruno Rivas-Santiago
Foot ulceration is one of the most common and complex sequelae of diabetes mellitus, generally posing a therapeutic challenge due to poor healing responses and high rates of complications, including peripheral vascular disease, ischemia and infections. Calcitriol, the most active vitamin D metabolite, induces antimicrobial peptides production in keratinocytes from diabetic foot ulcers (DFU); however, little is known about its effects on angiogenic factors in this pathology. Herein we aimed at studying whether calcitriol induces angiogenic molecules in keratinocytes under normoxic and hypoxic conditions, and if these molecules are able to improve cell migration in vitro...
November 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28986333/protective-effect-of-danhong-injection-combined-with-naoxintong-capsule-on-cerebral-ischemia-reperfusion-injury-in-rats
#19
Jiayang Wan, Haofang Wan, Rongbin Yang, Haitong Wan, Jiehong Yang, Yu He, Huifen Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Danhong Injection (DHI) and Naoxintong Capsule (NXT) are renowned traditional Chinese medicine in China. The drug combination of DHI and NXT is frequently applied for the treatment of cardiovascular and cerebrovascular diseases in clinic. However, there had been no pharmacological experiment studies of interaction between DHI and NXT. Due to the drug interactions, exploring their interaction profile is of great importance. MATERIAL AND METHODS: In this study, focal cerebral I/R injury in adult male Sprague-Dawley rats were induced by transient middle cerebral artery occlusion (tMCAO) for 1h followed by reperfusion...
October 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28979926/a-comparative-study-of-the-predictive-values-of-urinary-acute-kidney-injury-markers-angiogenin-and-kidney-injury-molecule-1-for-the-outcomes-of-kidney-allografts
#20
Quentin Tavernier, Claire Tinel, Marion Rabant, Lise Morin, Dany Anglicheau, Nicolas Pallet
BACKGROUND: Whether injury-related molecules in urines of individuals with ischemia-reperfusion injury (IRI) are independent predictors of graft outcomes and provide additional information compared with usual risk factors remains to be established. METHODS: We explored a cohort of 244 kidney transplant recipients who systematically had a urine collection 10 days after transplantation. The injury-related markers kidney injury molecule-1 (KIM-1) and angiogenin (ANG) levels in urines were measured...
September 2017: Transplantation Direct
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