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https://www.readbyqxmd.com/read/29312604/serum-amyloid-a-induces-m2b-like-macrophage-polarization-during-liver-inflammation
#1
Yibin Wang, Haijun Huang, Renhua Sun, Bingyu Chen, Fang Han, Qian Li, Yin Ni, Xi Li, Jingquan Liu, Xiaozhou Mou, Yuexing Tu
Hepatitis causes hepatic cell injury, regeneration and different levels of fibrogenesis, and severe liver fibrogenesis progresses into cirrhosis with liver dysfunction. Serum amyloid A (SAA) is an acute phase protein that is predominantly secreted by hepatocytes during early injury or infection. Nevertheless, the relationship of SAA and development of cirrhosis as well as the underlying molecular mechanisms is largely unknown. Here, we found that macrophages are the major SAA-binding cells in the injured liver...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298134/the-synergistic-effect-of-tnfa-and-il10-promoter-polymorphisms-on-genetic-predisposition-to-systemic-lupus-erythematosus
#2
Irena Manolova, Lyuba Miteva, Mariana Ivanova, Todor Kundurzhiev, Rumen Stoilov, Spaska Stanilova
AIMS: We investigated the individual and combined effect of functional TNFA -308G/A and IL10 -1082G/A single nucleotide polymorphisms (SNPs) and their genotypes on the susceptibility to systemic lupus erythematosus (SLE) in a Bulgarian population. MATERIALS AND METHODS: Genotyping for -1082A/G IL10 (rs1800896) and -308G/A TNFA (rs1800629) polymorphisms was performed for 154 SLE patients and 224 healthy controls. RESULTS: An association between SLE and the rs1800629 polymorphism was established under the allelic model (allele A vs...
January 3, 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29297547/tlr2-signaling-pathway-in-alveolar-bone-osteogenesis-induced-by-aloe-vera-and-xenograft-xcb
#3
Utari Kresnoadi, Retno Pudji Rahayu, M Rubianto, Subijanto Marto Sudarmo, Hendrik Setia Budi
The aim of this study was to find the role of TLR2 signaling pathway in reducing osteoclast activity and promoting osteoblast growth by inducing a combination of Aloe vera and cancellous bovine xenograft (XCB) into dental extraction socket. Forty-eight Cavia cobayas were used. They were divided into eight groups (n=6). For control group, their mandibular incisors were extracted and filled with PEG. For treatment groups, they were extracted and filled with XCB, Aloe vera and the combination of Aloe vera and XCB...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29291526/assessment-of-lung-cell-toxicity-of-various-gasoline-engine-exhausts-using-a-versatile-in%C3%A2-vitro-exposure-system
#4
Christoph Bisig, Pierre Comte, Martin Güdel, Jan Czerwinski, Andreas Mayer, Loretta Müller, Alke Petri-Fink, Barbara Rothen-Rutishauser
Adverse effect studies of gasoline exhaust are scarce, even though gasoline direct injection (GDI) vehicles can emit a high number of particles. The aim of this study was to conduct an in vitro hazard assessment of different GDI exhausts using two different cell culture models mimicking the human airway. In addition to gasoline particle filters (GPF), the effects of two lubrication oils with low and high ash content were assessed, since it is known that oils are important contributors to exhaust emissions...
December 29, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29290424/changes-in-gene-expression-in-the-rumen-and-colon-epithelia-during-the-dry-period-through-lactation-of-dairy-cows-and-effects-of-live-yeast-supplementation
#5
A Bach, I Guasch, G Elcoso, F Chaucheyras-Durand, M Castex, F Fàbregas, E Garcia-Fruitos, A Aris
The objectives of this study were (1) to use endoscopy to collect biopsies from the rumen and colon epithelia to describe changes in gene expression in these 2 tissues as cows move from a dry to a lactation ration and (2) to evaluate the potential influence that supplementation of live yeast could exert on these 2 epithelia. Twenty-one Holstein cows were split into 2 treatments and received either 300 g/d of corn containing 1 × 1010 cfu/d of live yeast (LY; n = 10) or 300 g/d of corn with no supplementation (control; n = 11) starting 21 ± 2...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29288802/increasing-extracellular-cgmp-in-cerebellum-in-vivo-reduces-neuroinflammation-gabaergic-tone-and-motor-in-coordination-in-hyperammonemic-rats
#6
Andrea Cabrera-Pastor, Tiziano Balzano, Vicente Hernández-Rabaza, Michele Malaguarnera, Marta Llansola, Vicente Felipo
Hyperammonemia is a main contributor to cognitive impairment and motor in-coordination in patients with hepatic encephalopathy. Hyperammonemia-induced neuroinflammation mediates the neurological alterations in hepatic encephalopathy. Intracerebral administration of extracellular cGMP restores some but not all types of cognitive impairment. Motor in-coordination, is mainly due to increased GABAergic tone in cerebellum. We hypothesized that extracellular cGMP would restore motor coordination in hyperammonemic rats by normalizing GABAergic tone in cerebellum and that this would be mediated by reduction of neuroinflammation...
December 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29288696/cytokine-gene-polymorphisms-in-iraqi-arabs
#7
Ali H Ad'hiah, Zahra'a A Ahmed, Milad A Al-Naseri, Ehab D Salman, Osama B Al-Saffar, Hiba S Ahmed, Talib A Hussain, Ekhlass M Idan, Ibtesam B Hassan, Batool A Shihab, Lateef O Mohammed, Fatima S Al-Nasiri
In this report, 224 unrelated healthy Iraqi Arabs (102 males and 122 females) were genotyped for 22 SNPs (single nucleotide polymorphisms) belong to 13 cytokine genes (IL1A, IL1B, IL1RA, IL1R, IL2, IL4, IL4R, IL6, IL10, IL12, IFNG, TNFA and TGFB1). The method of detection was PCR-SSP (polymerase chain reaction-sequence specific primer). The data were presented in terms of allele and genotype frequencies. Two-locus haplotype frequencies were also estimated for some SNPs. Genotype frequencies of detected cytokine gene polymorphisms are available in the Database of Allele Frequencies Net under the AFND number 3422 and the population name "Iraq Arab Cytokine"...
December 27, 2017: Human Immunology
https://www.readbyqxmd.com/read/29285134/sicyos-angulatus-ameliorates-atherosclerosis-through-downregulation-of-aortic-inflammatory-responses-in-apolipoprotein-e-deficient-mice
#8
Yong-Hoon Kim, Jung-Ran Noh, Jung Hwan Hwang, Kyoung-Shim Kim, Dong-Hee Choi, Jin-Pyo An, Won-Keun Oh, Chul-Ho Lee
Sicyos angulatus (SA), a summer annual vine originating from Northeastern USA, is a widely distributed noxious invasive plant. However, the clinical application of SA has not been investigated previously. The purpose of present study was to determine the effects of SA on atherosclerosis and its underlying mechanism. Atherosclerosis was induced by feeding apolipoprotein E-deficient (apoE-/-) mice with an atherogenic diet for 8 weeks. SA was administered daily by oral gavage during induction of atherosclerosis...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29282687/metabolic-changes-during-cancer-cachexia-pathogenesis
#9
Ng Shyh-Chang
Wasting of adipose tissue and skeletal muscle is a hallmark of metastatic cancer and a major cause of death. Like patients with cachexia caused by other chronic infections or inflammatory diseases, the cancer subject manifests both malnutrition and metabolic stress. Both carbohydrate utilization and amino acid incorporation are decreased in the muscles of cancer cachexia patients. Cancer cells affect host metabolism in two ways: (a) their own metabolism of nutrients into other metabolites and (b) circulating factors they secrete or induce the host to secrete...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29249637/corrigendum-to-moderate-blast-exposure-results-in-increased-il-6-and-tnfa-in-peripheral-blood-brain-behav-immun-65-2017-90-94
#10
Jessica Gill, Vida Motamedi, Nicole Osier, Kristine Dell, Lindsay Arcurio, Walter Carr, Peter Walker, Stephen Ahlers, Matthew Lopresti, Angela Yarnell
No abstract text is available yet for this article.
December 14, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29244820/probiotics-reduce-repeated-water-avoidance-stress-induced-colonic-microinflammation-in-wistar-rats-in-a-sex-specific-manner
#11
Ju Yup Lee, Nayoung Kim, Ryoung Hee Nam, Sung Hwa Sohn, Sun Min Lee, Daeun Choi, Hyuk Yoon, Yong Sung Kim, Hye Seung Lee, Dong Ho Lee
The colonic response to stress is greater in female rats than in male rats. The aim of this study was to evaluate the effect of probiotics in the repeated water avoidance stress (rWAS)-induced colonic microinflammation model of Wistar rats in a sex-specific manner. The three groups (no-stress, WAS, and WAS with probiotics) were exposed to r-WAS for 1 h daily for 10 days, and Lactobacillus farciminis was administered by oral gavage for 10 days to animals in the probiotics group. The visceromotor response (VMR) to colorectal distension (CRD) was assessed using a barostat and noninvasive manometry before and after WAS exposure...
2017: PloS One
https://www.readbyqxmd.com/read/29241982/monocyte-profile-in-peripheral-blood-of-gestational-diabetes-mellitus-patients
#12
Ana G S Angelo, Carla T C Neves, Thalita F Lobo, Ramon V C Godoy, Érika Ono, Rosiane Mattar, Silvia Daher
OBJECTIVE: Gestational diabetes Mellitus has been considered an inflammatory disease involving different cells and mediators in its development. The role of innate immune cells in GDM physiopathology remains unclear, therefore this study was conducted to assess monocyte profile in GDM patients. DESIGN: This was a case-control study including 20 glucose-tolerant pregnant women (controls) and 18 GDM patients. METHODS: Flow cytometry was used to assess peripheral blood monocytes subsets (classical, intermediate, non-classical), the expression of TLR4 and CCR2 chemokine receptor (CD192) and cytokines (TNFA, IL6, IL10) secretion by monocytes subsets...
December 11, 2017: Cytokine
https://www.readbyqxmd.com/read/29203182/the-generation-of-a-simian-adenoviral-vectored-hcv-vaccine-encoding-genetically-conserved-gene-segments-to-target-multiple-hcv-genotypes
#13
Annette von Delft, Timothy A Donnison, José Lourenço, Claire Hutchings, Caitlin E Mullarkey, Anthony Brown, Oliver G Pybus, Paul Klenerman, Senthil Chinnakannan, Eleanor Barnes
BACKGROUND: Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural infection. However, corresponding viral regions are highly variable at a population level, with a reduction in T-cell reactivity to these variants. We therefore designed and manufactured second generation simian adenovirus vaccines encoding genomic segments, conserved between viral genotypes and assessed these for immunogenicity...
December 1, 2017: Vaccine
https://www.readbyqxmd.com/read/29203103/association-of-tnfa-308g-a-ifng-874-a-t-and-il-10-819%C3%A2-c-t-polymorphisms-with-protection-and-susceptibility-to-dengue-in-brazilian-population
#14
Ana Caroline Melo Dos Santos, Edilson Leite de Moura, Jean Moises Ferreira, Alexandre Wendell Araujo de Moura, Ailson Darlan Sales Ferreira, Rubens Pereira Bezerra, Diego de Siqueira Figueiredo, Karol Fireman de Farias, Tiago Gomes de Andrade, Elaine Virgínia Martins de Souza Figueiredo
OBJECTIVE: To evaluate gene polymorphisms and their association with susceptibility to dengue. METHODS: A retrospective case-control study was performed with 262 subjects, comprising 78 dengue fever (DF) patients, 49 dengue hemorrhagic fever (DHF) patients and 135 healthy controls. Genotypic and allelic profiles were identified using polymerase chain reaction based in real time and amplification-refractory mutation system. RESULTS: We observed a protective association of IL-10 (-819 C/T) C allele (P = 0...
November 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29155425/granulocyte-derived-tnf%C3%AE-promotes-vascular-and-hematopoietic-regeneration-in-the-bone-marrow
#15
Emily Bowers, Anastasiya Slaughter, Paul S Frenette, Rork Kuick, Oscar M Pello, Daniel Lucas
Endothelial cells are a critical component of the bone marrow (BM) stromal network, which maintains and regulates hematopoietic cells. Vascular regeneration precedes, and is necessary for, successful hematopoietic stem cell (HSC) transplantation, the only cure for most hematopoietic diseases. Recent data suggest that mature hematopoietic cells regulate BM stromal-cell function. Whether a similar cross-talk regulates the BM vasculature is not known. Here we found that donor hematopoietic cells act on sinusoidal endothelial cells and induce host blood vessel and hematopoietic regeneration after BM transplantation in mice...
November 20, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29117667/association-of-a-genetic-polymorphism-of-il1rn-with-risk-of-acute-pancreatitis-in-a-korean-ethnic-group
#16
Jin Woo Park, Ja Sung Choi, Ki Joon Han, Sang Heun Lee, Eui Joo Kim, Jae Hee Cho
Background/Aims: Several epidemiological studies have validated the association of interleukin gene polymorphisms with acute pancreatitis (AP) in different populations. However, there have been few studies in Asian ethnic groups. We aimed to investigate the relationships between inflammatory cytokine polymorphisms and AP as pilot research in a Korean ethnic group. Methods: Patients who had been diagnosed with AP were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed...
November 10, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29101799/s-allyl-cysteine-improves-clinical-and-neuropathological-features-of-experimental-autoimmune-encephalomyelitis-in-c57bl-6-mice
#17
Hossein Zeinali, Tourandokht Baluchnejadmojarad, Soudabeh Fallah, Mohsen Sedighi, Nariman Moradi, Mehrdad Roghani
Multiple sclerosis (MS) is a deleterious autoimmune and demyelinating disorder of the central nervous system with debilitating sensory and motor complications. There is still no definite cure for it and the main focus for its treatment mostly pivots around subsiding its severity and recurrence. Experimental autoimmune encephalomyelitis (EAE) is an established animal model of MS. S-allyl cysteine (SAC) is the active and main constituent of aged garlic extract with anti-inflammatory and neuroprotective property...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29081763/inflammatory-gene-expression-in-whole-peripheral-blood-at-early-stages-of-sporadic-amyotrophic-lateral-sclerosis
#18
Pol Andrés-Benito, Jesús Moreno, Raúl Domínguez, Ester Aso, Mónica Povedano, Isidro Ferrer
OBJECTIVE: Characterization of altered expression of selected transcripts linked to inflammation in the peripheral blood of sporadic amyotrophic lateral sclerosis (sALS) patients at early stage of disease to increase knowledge about peripheral inflammatory response in sALS. METHODS: RNA expression levels of 45 genes were assessed by RT-qPCR in 22 sALS cases in parallel with 13 age-matched controls. Clinical and serum parameters were assessed at the same time. RESULTS: Upregulation of genes coding for factors involved in leukocyte extravasation (ITGB2, INPP5D, SELL, and ICAM1) and extracellular matrix remodeling (MMP9 and TIMP2), as well as downregulation of certain chemokines (CCL5 and CXC5R), anti-inflammatory cytokines (IL10, TGFB2, and IL10RA), pro-inflammatory cytokines (IL-6), and T-cell regulators (CD2 and TRBC1) was found in sALS cases independently of gender, clinical symptoms at onset (spinal, respiratory, or bulbar), progression, peripheral leukocyte number, and integrity of RNA...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29077717/a-polymorphism-in-the-haptoglobin-haptoglobin-related-protein-locus-is-associated-with-risk-of-human-sleeping-sickness-within-cameroonian-populations
#19
Elvis Ofon, Harry Noyes, Julius Mulindwa, Hamidou Ilboudo, Martin Simuunza, Vincent Ebo'o, Flobert Njiokou, Mathurin Koffi, Bruno Bucheton, Pythagore Fogue, Christiane Hertz-Fowler, Annette MacLeod, Gustave Simo
BACKGROUND: Human African Trypanosomiasis (HAT) is a neglected disease targeted for elimination as a public health problem by 2020. Elimination requires a better understanding of the epidemiology and clinical evolution of HAT. In addition to the classical clinical evolution of HAT, asymptomatic carriers and spontaneous cure have been reported in West Africa. A genetic component to human susceptibility to HAT has been suggested to explain these newly observed responses to infection. In order to test for genetic associations with infection response, genetic polymorphism in 17 genes were tested (APOL1, IL1B, IL4, IL4R, IL6, IL8, IL12B, IL12RB1, IL10, TNFA, INFG, MIF, HLA-G, HLA-A, HP, HPR and CFH)...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29075910/pyoderma-gangrenosum-and-pyogenic-arthritis-presenting-as-severe-sepsis-in-a-rheumatoid-arthritis-patient-treated-with-golimumab
#20
REVIEW
Anastasia Skalkou, Sofia-Magdalini Manoli, Alexandros Sachinidis, Vasilios Ntouros, Konstantinos Petidis, Eleni Pagkopoulou, Efstratios Vakirlis, Athina Pyrpasopoulou, Theodoros Dimitroulas
Rheumatoid arthritis is a systemic autoimmune disease resulting in joint destruction and deformities, but also associated with extraarticular and systemic manifestations. The later devastating conditions, such as the development of rheumatoid vasculitis, are more frequently encountered in seropositive patients and their incidence has been attenuated after the introduction of biologic disease modifying drugs, such as anti-tumor necrosis factor alpha (TNFa) agents, which generally have considerably contributed to the better control and long-term outcomes of the disease...
October 26, 2017: Rheumatology International
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