keyword
https://read.qxmd.com/read/38546736/performance-of-gpt-4v-in-answering-the-japanese-otolaryngology-board-certification-examination-questions-evaluation-study
#21
JOURNAL ARTICLE
Masao Noda, Takayoshi Ueno, Ryota Koshu, Yuji Takaso, Mari Dias Shimada, Chizu Saito, Hisashi Sugimoto, Hiroaki Fushiki, Makoto Ito, Akihiro Nomura, Tomokazu Yoshizaki
BACKGROUND: Artificial intelligence models can learn from medical literature and clinical cases and generate answers that rival human experts. However, challenges remain in the analysis of complex data containing images and diagrams. OBJECTIVE: This study aims to assess the answering capabilities and accuracy of ChatGPT-4 Vision (GPT-4V) for a set of 100 questions, including image-based questions, from the 2023 otolaryngology board certification examination. METHODS: Answers to 100 questions from the 2023 otolaryngology board certification examination, including image-based questions, were generated using GPT-4V...
March 28, 2024: JMIR Medical Education
https://read.qxmd.com/read/38546705/amygdala-enlargement-in-temporal-lobe-epilepsy-histopathology-and-surgical-outcomes
#22
JOURNAL ARTICLE
Lubna Shakhatreh, Ben Sinclair, Catriona McLean, Elaine Lui, Andrew P Morokoff, James A King, Zhibin Chen, Piero Perucca, Terence J O'Brien, Patrick Kwan
OBJECTIVES: Amygdala enlargement is detected on magnetic resonance imaging (MRI) in some patients with drug-resistant temporal lobe epilepsy (TLE), but its clinical significance remains uncertain We aimed to assess if the presence of amygdala enlargement (1) predicted seizure outcome following anterior temporal lobectomy with amygdalohippocampectomy (ATL-AH) and (2) was associated with specific histopathological changes. METHODS: This was a case-control study. We included patients with drug-resistant TLE who underwent ATL-AH with and without amygdala enlargement detected on pre-operative MRI...
March 28, 2024: Epilepsia
https://read.qxmd.com/read/38546666/what-is-the-long-term-wear-of-a-5-mrad-highly-crosslinked-polyethylene-liner-a-14-year-rsa-study
#23
JOURNAL ARTICLE
Stuart A Callary, Deepti K Sharma, Taisha M D'Apollonio, Owain Critchley, Graham Mercer, Christopher Wilson, David G Campbell
BACKGROUND: Lower doses of irradiation (≤ 5 Mrad) during the manufacture of highly crosslinked polyethylene acetabular liners may result in less crosslinking and an increased wear rate. Radiostereometric analysis (RSA) studies have found that wear of more highly irradiated highly crosslinked polyethylene liners (7 to 10 Mrad) decreases at longer-term follow-up compared with earlier reports of the same cohorts. Although wear of 5-Mrad irradiated liners appears to increase at midterm follow-up, it is unclear whether that remains true at longer follow-up...
March 28, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38546642/neuroinvasive-west-nile-virus-infection-in-immunosuppressed-and-immunocompetent-adults
#24
JOURNAL ARTICLE
Amir A Mbonde, David Gritsch, Ehab Y Harahsheh, Sabirah N Kasule, Shemonti Hasan, Angela M Parsons, Nan Zhang, Richard Butterfield, Harn Shiue, Kathryn A Norville, Jenna L Reynolds, Holenarasipur R Vikram, Brian Chong, Marie F Grill
IMPORTANCE: West Nile virus (WNV) is the leading cause of human arboviral disease in the US, peaking during summer. The incidence of WNV, including its neuroinvasive form (NWNV), is increasing, largely due to the expanding distribution of its vector, the Culex mosquito, and climatic changes causing heavy monsoon rains. However, the distinct characteristics and outcomes of NWNV in individuals who are immunosuppressed (IS) and individuals who are not IS remain underexplored. OBJECTIVE: To describe and compare clinical and radiographic features, treatment responses, and outcomes of NWNV infection in individuals who are IS and those who are not IS...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38546609/in-vitro-assays-for-immuno-oncology-drug-efficacy-assessment-and-screening-for-personalized-cancer-therapy-scopes-and-challenges
#25
REVIEW
Marufur Rahman, Greg Wells, Juha K Rantala, Thomas Helleday, Munitta Muthana, Sarah J Danson
INTRODUCTION: Immunotherapies have revolutionized cancer treatment, but often fail to produce desirable therapeutic outcomes in all patients. Due to the inter-patient heterogeneity and complexity of the tumor microenvironment, personalized treatment approaches are gaining demand. Researchers have long been using a range of in-vitro assays including 2D models, organoid co-cultures, and cancer-on-a-chip platforms for cancer drug screening. A comparative analysis of these assays with their suitability, high-throughput capacity, and clinical translatability is required for optimal translational use...
March 28, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38546507/exploring-the-clinical-relevance-of-angico-gum-an-effective-biopolymer-for-topical-protection-of-oesophageal-mucosa-in-gastroesophageal-reflux-disease-patients
#26
JOURNAL ARTICLE
Rudy Diavila Bingana, Lucas Antonio Duarte Nicolau, Thiago Meneses Araújo Leite Sales, Suliana Mesquita Paula, João Pedro do Carmo Neto, Isabela Araújo Linhares Castro, Luiz Fernando Lopes Soares Teixeira, Alvaro Xavier Franco, Fábio de Oliveira Silva Ribeiro, Regina Célia Monteiro de Paula, Jand Venes Rolim Medeiros, Durcilene Alves da Silva, Daniel Sifrim, Marcellus Henrique Loiola Ponte Souza
OBJECTIVES: Angico gum (AG) (Anadenanthera colubrina var. Cebil [Griseb.] Altschul) is utilized by some Brazilian communities to alleviate symptoms from gastroesophageal reflux disease. Here, we aimed to investigate the "in vitro" topical protective capacity of AG on human esophageal mucosa. METHODS: Biopsies of the distal esophageal mucosa were collected from 35 patients with heartburn (24 non-erosive and 11 with erosive oesophagitis (EE)) and mounted in Üssing chambers...
March 28, 2024: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/38546424/multiple-sclerosis-associated-uveitis-a-case-report-of-refractory-bilateral-chronic-granulomatous-panuveitis-successfully-treated-with-tocilizumab
#27
JOURNAL ARTICLE
William Gil, Hassan Lagrib, Louis Olagne, Céline Tilignac, Maud Perie, Frédéric Taithe, Xavier Moisset, Frederic Chiambaretta, Pierre Clavelou, Marc Andre, Ludovic Trefond
PURPOSE: To report a case of uveitis associated with multiple sclerosis (MS) that was refractory to multiple lines of therapy but achieved remission with tocilizumab. METHODS: We conducted a retrospective analysis of the patient's medical record including clinical, biological and imaging data. RESULTS: A 33-year-old female patient with a history of MS inactive for 5 years on teriflunomide, and no significant medical or ophthalmological history, presented with bilateral granulomatous panuveitis...
March 28, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38546331/increasing-catecholamine-secretion-through-npy-in-pheochromocytomas-with-false-negative-123i-mibg-scintigraphy
#28
JOURNAL ARTICLE
Yutaro Ruike, Sawako Suzuki, Koutaro Yokote
INTRODUCTION: 123I-MIBG has been well established as a functional imaging tool, and 131I-MIBG therapy is being considered for catecholamine-secreting tumors. Tumors with the characteristics of a noradrenergic biochemical phenotype, small, malignant, metastatic, extra-adrenal, bilateral, and hereditary, especially SDHx-related tumors, are reported to correlate with reduced MIBG uptake. However, the potential molecular mechanisms influencing MIBG uptake have been poorly studied. PATIENTS AND METHODS: To identify critical genes that may enhance MIBG accumulation in pheochromocytomas (PCCs), we performed RNA-seq analyses for 16 operated patients with PCCs (6 MIBG-negative and 10 MIBG-positive) combined with RT-qPCR for 27 PCCs (5 MIBG-negative and 22 MIBG-positive) and examined primary cultures of the surgical tissues...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38546330/coronary-artery-disease-assessment-via-on-site-ct-fractional-flow-reserve-in-patients-undergoing-transcatheter-aortic-valve-replacement
#29
JOURNAL ARTICLE
Alexandra Steyer, Valentina O Puntmann, Eike Nagel, David M Leistner, Vitali Koch, Mariuca Vasa-Nicotera, Parveen Kumar, Christian Booz, Thomas J Vogl, Silvia Mas-Peiro, Simon S Martin
Purpose To examine the clinical feasibility of workstation-based CT fractional flow reserve (CT-FFR) for coronary artery disease (CAD) evaluation during preprocedural planning in patients undergoing transcatheter aortic valve replacement (TAVR). Materials and Methods In this retrospective single-center study, 434 patients scheduled for TAVR between 2018 and 2020 were screened for study inclusion; a relevant proportion of patients (35.0% [152 of 434]) was not suitable for evaluation due to insufficient imaging properties...
April 2024: Radiology. Cardiothoracic imaging
https://read.qxmd.com/read/38546320/man-presenting-after-hydrochloric-acid-ingestion
#30
JOURNAL ARTICLE
Emma R Furlano, Gregory P Wu, Brendan Vosburgh, Cameron R Waldman, Jessica Noonan, Alexander Bracey
CASE PRESENTATION: We describe a case of a man who developed severe caustic injury of his upper gastrointestinal tract after ingestion of a commercially available 9.5% hydrochloric acidic cleaning solution. He rapidly deteriorated and required endotracheal intubation. He underwent several imaging modalities demonstrating his injuries and ultimately succumbed to his injuries. DISCUSSION: Acidic caustic ingestions may range in severity and uncommonly result in death...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546319/insidious-manifestations-of-cutaneous-t-cell-lymphoma
#31
JOURNAL ARTICLE
Alexis L Cates, Heather P Kahn
CASE PRESENTATION: A 66-year-old gentleman presented with several months of a generalized pruritic skin eruption along his face, thorax, and extremities. Although he had been seen previously, no diagnosis was made until he presented to the emergency department (ED) with worsening lesions. The patient was ultimately diagnosed with cutaneous T-cell lymphoma. DISCUSSION: Accurately diagnosing a rash in the ED is not always possible as more invasive studies may be needed...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546300/aortic-thrombus-with-bilateral-renal-infarcts-a-case-report
#32
JOURNAL ARTICLE
Lev Libet
INTRODUCTION: The presence of a hypercoagulable state predisposes to venous and arterial thrombi. While the relationship between protein C and S deficiencies with venous thrombus formation is clear, the relationship to arterial thrombi formation is less common. Thromboembolic disease of the renal arteries may result in renal infarction. The development of simultaneous bilateral renal infarction is rare and can lead to significant morbidity and mortality. CASE REPORT: This is a case of a 48-year-old male with known protein C deficiency who presented to the emergency department with sudden onset abdominal pain...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546277/a-prior-information-based-automatic-segmentation-method-for-the-clinical-target-volume-in-adaptive-radiotherapy-of-cervical-cancer
#33
JOURNAL ARTICLE
Xuanhe Wang, Yankui Chang, Xi Pei, Xie George Xu
OBJECTIVE: Adaptive planning to accommodate anatomic changes during treatment often requires repeated segmentation. In this study, prior patient-specific data was integrateda into a registration-guided multi-channel multi-path (Rg-MCMP) segmentation framework to improve the accuracy of repeated clinical target volume (CTV) segmentation. METHODS: This study was based on CT image datasets for a total of 90 cervical cancer patients who received two courses of radiotherapy...
March 28, 2024: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/38546265/myelin-oligodendrocyte-glycoprotein-antibody-associated-disease-with-clinical-presentation-as-multiple-episodes-of-isolated-meningeal-involvement-a-case-report
#34
JOURNAL ARTICLE
Xiaojie Wei, Chentong Zhao, Daqing Wang, Jingzhe Han
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) constitutes a group of autoimmune neuroinflammatory conditions that are characterized by positive serum MOG-immunoglobulin G antibodies. The relationship between MOGAD and immune factors remains unclear. Herein, we report a man in his early 30s who initially presented symptoms of headache and low-grade fever persisting for 20 days. The patient experienced isolated meningitis onset and had recurrent meningitis as the primary clinical feature, which manifested as low-grade fever, headache, and neck rigidity...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38546247/gastrointestinal-bezoars-in-paediatrics-case-series-and-literature-review
#35
JOURNAL ARTICLE
Mohamed Ahmed Elghazeery, Alhassan Mohamed Hassan
BACKGROUND: Bezoars are indigestible lumps which are usually found in stomach. Types of bezoar include phytobezoar, trichobezoar, lithobezoar, pharmacobezoar, plasticobezoar, lactobezoar and metal bezoar. Trichobezoars mostly affect females in 20s and 30s with a rarity in paediatrics. Unexplained complaints with a palpable mass are commonly found in these patients. Treatment involves retrieval of mass with searching for others. The purpose of this study was to present data and surgical management of cases with trichobezoars...
April 1, 2024: African Journal of Paediatric Surgery: AJPS
https://read.qxmd.com/read/38546234/recognition-of-glaucomatous-fundus-images-using-machine-learning-methods-based-on-optic-nerve-head-topographic-features
#36
JOURNAL ARTICLE
Chao-Wei Wu, Tzu-Yu Huang, Yeong-Cheng Liou, Shih-Hsin Chen, Kwou-Yeung Wu, Han-Yi Tseng
PURPOSE: The aim was to compare the effectiveness of clinical discriminant rules and machine learning classifiers in identifying glaucomatous fundus images based on optic disc topographic features. DESIGN: Retrospective case-control study. METHODS: The study used a total of 800 fundus images, half of which were glaucomatous cases and the other half non- glaucomatous cases obtained from an open database and clinical work. The images were randomly divided into training and testing sets with equal numbers of glaucomatous and non-glaucomatous images...
March 29, 2024: Journal of Glaucoma
https://read.qxmd.com/read/38546140/accuracy-of-cone-beam-computed-tomography-in-imaging-the-components-of-the-periodontal-phenotype
#37
REVIEW
Ralf Schulze, Emilio Couso-Queiruga, Christos Katsaros
The components and dimensions of the periodontal and peri-implant phenotype have a high relevance in contemporary dental research and should be taken into consideration in the decision-making process in the management of a variety of clinical scenarios to optimize the outcomes of therapy. Various assessment methods for quantifying and classifying the phenotypical dimensions have emerged and developed in recent decades. Nevertheless, the use of cone-beam computed tomography (CBCT) scans remains the most commonly used approach worldwide...
March 28, 2024: Periodontology 2000
https://read.qxmd.com/read/38546135/heterogeneity-of-coronary-vascular-function-and-myocardial-oxygenation-in-women-with-angina-and-non-obstructive-coronary-artery-disease
#38
JOURNAL ARTICLE
Elizabeth Hillier, Malik Elharram, James A White, Todd Anderson, Judy Luu, Dina Labib, Muhammad Alhussein, Matthias G Friedrich, Louise Pilote
AIMS: Women with angina and non-obstructive coronary artery disease (ANOCA) have a heightened risk for cardiovascular events, and the pathophysiology for ischemic symptoms may be related to alterations in microvascular structure and function. We examined the use of breathing-enhanced oxygenation-sensitive cardiac magnetic resonance imaging (OS-CMR) using vasoactive breathing maneuvers to assess myocardial oxygenation in women with ANOCA. METHODS AND RESULTS: We recruited women (aged 40-65 years) from two sites in Canada who presented to healthcare with persistent retrosternal chest pain and found to have ANOCA, or without a history of cardiovascular disease...
March 28, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38546075/dynamic-contrast-enhanced-mri-and-apparent-diffusion-coefficient-quantitation-for-differentiate-hepatocellular-carcinoma-from-hepatocellular-adenoma
#39
JOURNAL ARTICLE
Hayder Suhail Najm Alareer, Hayder Jasim Taher, Ayoob Dinar Abdullah
BACKGROUND: Due to their overlapping radiological characteristics, hepatic lesions, such as hepatocellular carcinoma (HCC) and hepatocellular adenoma (HCA), present a substantial diagnostic challenge. Accurate differentiation between HCC and HCA is essential for the best clinical treatment and therapeutic decision-making. This study aims to assess the potential role of DCE-MRI and Apparent Diffusion Coefficient (ADC) quantitation in the diagnosis of hepatocellular carcinoma (HCC) from hepatocellular adenoma (HCA)...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38546011/cocaine-gut-a-rare-case-of-cocaine-induced-esophageal-gastric-and-small-bowel-necrosis
#40
JOURNAL ARTICLE
Lefika Bathobakae, Sacide S Ozgur, Rammy Bashir, Tyler Wilkinson, Phenyo Phuu, Ruhin Yuridullah, Gabriel Melki, Jessica Escobar, Sohail Qayyum
Cocaine is an indirect-acting sympathomimetic drug that inhibits norepinephrine and dopamine reuptake in the adrenergic presynaptic cleft. Cocaine use has been associated with strokes, angina, arrhythmias, and agitation. Data on gastrointestinal complications such as mesenteric ischemia, bowel necrosis, ulceration, and perforation are scarce. Here, we present a rare case of cocaine-induced esophageal, gastric, and small bowel necrosis that contributes to the limited literature on this subject. Diagnosis of cocaine-induced gastrointestinal complications involves a combination of imaging studies, laboratory assessments, and histopathological examinations...
2024: Journal of Investigative Medicine High Impact Case Reports
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