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https://www.readbyqxmd.com/read/28938734/hyperspectral-microscopy-can-detect-metabolic-heterogeneity-within-bovine-post-compaction-embryos-incubated-under-two-oxygen-concentrations-7-versus-20
#1
Melanie L Sutton-McDowall, Martin Gosnell, Ayad G Anwer, Melissa White, Malcolm Purdey, Andrew D Abell, Ewa M Goldys, Jeremy G Thompson
STUDY QUESTION: Can we separate embryos cultured under either 7% or 20% oxygen atmospheres by measuring their metabolic heterogeneity? SUMMARY ANSWER: Metabolic heterogeneity and changes in metabolic profiles in morula exposed to two different oxygen concentrations were not detectable using traditional fluorophore and two-channel autofluorescence but were detectable using hyperspectral microscopy. WHAT IS KNOWN ALREADY: Increased genetic and morphological blastomere heterogeneity is associated with compromised developmental competence of embryos and currently forms the basis for embryo scoring within the clinic...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938420/bone-structural-characteristics-and-response-to-bisphosphonate-treatment-in-children-with-hajdu-cheney-syndrome
#2
Sophia Sakka, Rachel I Gafni, Justin H Davies, Bart Clarke, Peter Tebben, Mark Samuels, Vrinda Saraff, Klaus Klaushofer, Nadja Fratzl-Zelman, Paul Roschger, Frank Rauch, Wolfgang Högler
Context: Hajdu-Cheney syndrome (HJCYS) is a rare, multisystem, bone disease caused by heterozygous mutations in the NOTCH2 gene. Histomorphometric and bone ultrastructural analyses in children have not been reported and sparse evidence exists on response to bisphosphonate (BP) therapy. Objective: To investigate clinical and bone histomorphometric characteristics, bone matrix mineralization and the response of bone geometry and density to BP therapy. Patients: Five children with HJCYS (3 males) aged between 6...
September 8, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938417/new-perspectives-on-pheochromocytoma-and-paraganglioma-towards-a-molecular-classification
#3
Joakim Crona, David Taïeb, Karel Pacak
A new molecular biology based taxonomy has been proposed for pheochromocytoma and paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed clinically relevant prognostic and predictive biomarkers and stratified PPGLs into three main clusters. Each subgroup has a distinct molecular-biochemical-imaging signature. Concurrently, new methods for biochemical analysis, functional imaging, and medical therapies have also become available. The research community now strives to match the cluster biomarkers with the most superior intervention...
August 4, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28938410/gender-difference-in-the-clinical-presentation-of-primary-hyperparathyroidism-influence-of-menopausal-status
#4
Elena Castellano, Roberto Attanasio, Alberto Boriano, Micaela Pellegrino, Francesca Garino, Laura Gianotti, Giorgio Borretta
Background: Female to male ratio in primary hyperparathyroidism (PHPT) is 3:1, but data on gender impact on the clinical presentation are limited. Methods: We evaluated retrospectively gender difference in biochemistry and clinical presentation at diagnosis in a monocentric series of 417 patients with PHPT: 93 men (58.6 ±14.5 years), and 324 women (61.7 ± 12.8 years), of whom 54 were pre-menopausal (pre-F) and 270 post-menopausal (post-F). Results: Men were significantly younger (p = 0...
September 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938379/dark-endothelial-spots-after-descemet-membrane-endothelial-keratoplasty-may-appear-as-recurrent-fuchs-dystrophy-or-herald-graft-failure-or-rejection
#5
Vasiliki Zygoura, Lamis Baydoun, Claire Monnereau, Maria Satué, Silke Oellerich, Gerrit R J Melles
PURPOSE: To evaluate the clinical significance of dark spots in the donor endothelial cell layer as observed with specular microscopy, in patients who underwent Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). METHODS: Specular microscopy images of 83 consecutive eyes up to 7 years after DMEK were retrospectively reviewed in a masked fashion for the presence of dark spots and morphologic changes in the endothelial cell layer and processed for endothelial cell density (ECD) measurements...
September 21, 2017: Cornea
https://www.readbyqxmd.com/read/28938339/reduction-techniques-for-diaphyseal-femur-fractures
#6
Philip R Wolinsky, Justin F Lucas
Achieving and maintaining reduction in patients with a diaphyseal femur fracture may be difficult; therefore, thorough preoperative planning is required. To fully prepare for successful surgical management of diaphyseal femur fractures, surgeons must consider appropriate patient positioning and necessary tools, including surgical tables, traction devices, and instruments. Principles of acceptable reduction rely on the restoration of length, alignment, and rotation. Reduction of diaphyseal femur fractures should be attained in the least invasive manner, via percutaneous reduction techniques, if possible, to preserve fracture biology and promote successful fracture healing...
September 21, 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28938274/pain-free-3-t-mri-scans-in-cochlear-implantees
#7
Ingo Todt, Anja Tittel, Arne Ernst, Philipp Mittmann, Sven Mutze
OBJECTIVE: For cochlear implant recipients, undergoing magnetic resonance imaging (MRI) scans is associated with safety risks and potential side effects. Even following safety guidelines, potential complications (e.g., pain, magnet dislocation, image artifacts) are possible during 1.5 Tesla (T) MRI scans. The stronger static magnetic field of a 3.0 T scanner is associated with further risks of complication, including implant demagnetization. These complications led to the recent development of rotatable internal receiver magnets with a diametrical magnetization...
September 21, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28938246/the-evolving-landscape-of-new-diagnostic-tests-for-invasive-aspergillosis-in-hematology-patients-strengths-and-weaknesses
#8
Dieter Buchheidt, Mark Reinwald, Martin Hoenigl, Wolf-Karsten Hofmann, Birgit Spiess, Tobias Boch
PURPOSE OF REVIEW: The diagnosis of invasive aspergillosis in hematologic patients is a complex composite of clinical preconditions and features, imaging findings, biomarker combinations from appropriate clinical samples and microbiological and/or histological findings. RECENT FINDINGS: Recent developments in the evolving landscape of diagnostic tests for invasive aspergillosis in adult hematology patients are highlighted. SUMMARY: Novel approaches and tools are currently under development...
September 21, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28938160/nilotinib-enhances-tumor-angiogenesis-and-counteracts-vegfr2-blockade-in-an-orthotopic-breast-cancer-xenograft-model-with-desmoplastic-response
#9
Sara Zafarnia, Jessica Bzyl-Ibach, Igor Spivak, Yongping Li, Susanne Koletnik, Dennis Doleschel, Anne Rix, Sibylle Pochon, Isabelle Tardy, Seena Koyadan, Marc van Zandvoort, Moritz Palmowski, Fabian Kiessling, Wiltrud Lederle
Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)-targeted therapies predominantly affect nascent, immature tumor vessels. Since platelet-derived growth factor receptor (PDGFR) blockade inhibits vessel maturation and thus increases the amount of immature tumor vessels, we evaluated whether the combined PDGFR inhibition by nilotinib and VEGFR2 blockade by DC101 has synergistic therapy effects in a desmoplastic breast cancer xenograft model. In this context, besides immunohistological evaluation, molecular ultrasound imaging with BR55, the clinically used VEGFR2-targeted microbubbles, was applied to monitor VEGFR2-positive vessels noninvasively and to assess the therapy effects on tumor angiogenesis...
September 19, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28938151/elucidation-of-shared-and-specific-white-matter-findings-underlying-psychopathology-clusters-in-schizophrenia
#10
Jeanette Lim, Rowena Chin, New Fei Ho, Max Lam, Min Yi Sum, Simon Collinson, Lisa Phillips, Tih-Shih Lee, Balázs Zoltán Gulyás, Juan Zhou, Kang Sim
BACKGROUND: Schizophrenia is associated with diverse white matter (WM) brain abnormalities. In this study, we sought to examine the WM microstructural findings which underlie clinical psychopathology clusters in schizophrenia and hypothesized that these symptom clusters are associated with common and unique WM tracts. METHODS: Overall, 76 healthy controls (HC), and 148 patients with schizophrenia (SZ) were recruited and severity of symptomatology in schizophrenia was assessed using the Positive and Negative Syndrome Scale...
September 1, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28938107/lhermitte-duclos-disease-clinical-study-with-long-term-follow-up-in-a-single-institution
#11
Qiguang Wang, Si Zhang, Jian Cheng, Wenke Liu, Xuhui Hui
OBJECTIVE: LDD is a rare lesion, controversy about diagnosis and treatment of LDD and CS still exists. We aimed to clarify clinical and radiological characteristics, the optimal treatment timing and strategies of LDD with long-term follow-up. PATIENTS AND METHODS: From January 2004 to May 2017, 12 LDD patients were enrolled in our study. The clinical and radiological features, treatment strategies and long-term follow-up data were retrospectively analyzed. RESULTS: The mean follow-up was 89...
September 9, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28937828/the-effects-of-systemic-alfuzosin-and-tamsulosin-hydrochloride-on-choroidal-thickness-and-pupil-diameter-sizes-in-cases-with-benign-prostatic-hyperplasia
#12
Mustafa Dogan, Bunyamin Kutluksaman, Ibrahim Keles, Mustafa Karalar, Ahmet Omer Halat
PURPOSE: To compare the effects of alfuzosin hydrochloride and tamsulosin hydrochloride on choroidal thickness (CT) and pupil diameter (PD) sizes in patients with benign prostatic hyperplasia. SUBJECTS AND METHODS: Sixty-three men patients with newly diagnosis of benign prostatic hyperplasia were randomly assigned to either alfuzosin hydrochloride or to tamsulosin hydrochloride groups in this prospective, randomized, parallel-group clinical trial. Enhanced depth imaging spectral-domain optical coherence tomography, pupillography were obtained at baseline, 1st and 3rd month, and choroidal thicknesses and pupil diameter sizes were compared between the two groups...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937575/committee-opinion-no-723-guidelines-for-diagnostic-imaging-during-pregnancy-and-lactation
#13
(no author information available yet)
Imaging studies are important adjuncts in the diagnostic evaluation of acute and chronic conditions. However, confusion about the safety of these modalities for pregnant and lactating women and their infants often results in unnecessary avoidance of useful diagnostic tests or the unnecessary interruption of breastfeeding. Ultrasonography and magnetic resonance imaging are not associated with risk and are the imaging techniques of choice for the pregnant patient, but they should be used prudently and only when use is expected to answer a relevant clinical question or otherwise provide medical benefit to the patient...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937570/committee-opinion-no-723-summary-guidelines-for-diagnostic-imaging-during-pregnancy-and-lactation
#14
(no author information available yet)
Imaging studies are important adjuncts in the diagnostic evaluation of acute and chronic conditions. However, confusion about the safety of these modalities for pregnant and lactating women and their infants often results in unnecessary avoidance of useful diagnostic tests or the unnecessary interruption of breastfeeding. Ultrasonography and magnetic resonance imaging are not associated with risk and are the imaging techniques of choice for the pregnant patient, but they should be used prudently and only when use is expected to answer a relevant clinical question or otherwise provide medical benefit to the patient...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937545/non-contrast-pseudo-continuous-arterial-spin-labeling-and-accelerated-3-dimensional-radial-acquisition-intracranial-3-dimensional-magnetic-resonance-angiography-for-the-detection-and-classification-of-intracranial-arteriovenous-shunts
#15
Tilman Schubert, Zachary Clark, Carolina Sandoval-Garcia, Ryan Zea, Oliver Wieben, Huimin Wu, Patrick A Turski, Kevin M Johnson
OBJECTIVES: The aim of this study was to assess the sensitivity and specificity of pseudo-continuous arterial spin labeling (PCASL) magnetic resonance angiography (MRA) with 3-dimensional (3D) radial acquisition for the detection of intracranial arteriovenous (AV) shunts. MATERIALS AND METHODS: A total of 32 patients who underwent PCASL-MRA, clinical magnetic resonance imaging (MRI)/MRA exam, and digital subtraction angiography (DSA) were included in this retrospective analysis...
September 20, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28937524/self-inflicted-laser-handheld-laser-induced-maculopathy-a-novel-ocular-manifestation-of-factitious-disorder
#16
Alessandro Rabiolo, Riccardo Sacconi, Chiara Giuffrè, Eleonora Corbelli, Adriano Carnevali, Lea Querques, David Sarraf, K Bailey Freund, SriniVas Sadda, Francesco Bandello, Giuseppe Querques
PURPOSE: To report a case of factitious self-inflicted handheld laser-induced maculopathy. METHODS: A 29-year-old man presented to our clinic complaining of a step-wise progressive loss of vision that abruptly began in his left eye but then became bilateral. He underwent comprehensive ocular examination, including visual acuity testing, biomicroscopic, dilated funduscopic examination, structural optical coherence tomography, en face structural optical coherence tomography, optical coherence tomography angiography, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography...
September 19, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28937496/characterizing-intraorbital-optic-nerve-changes-on-diffusion-tensor-imaging-in-thyroid-eye-disease-before-dysthyroid-optic-neuropathy
#17
Hwa Lee, Young Hen Lee, Sang-Il Suh, Eun-Kee Jeong, Sehyun Baek, Hyung Suk Seo
OBJECTIVE: The aim of this study was to determine whether the optic nerve is affected by thyroid eye disease (TED) before the development of dysthyroid optic neuropathy with diffusion-tensor imaging (DTI). METHODS: Twenty TED patients and 20 controls were included. The mean, axial, and radial diffusivities and fractional anisotropy (FA) value were measured at the optic nerves in DTI. Extraocular muscle diameters were measured on computed tomography. The diffusivities and FA of the optic nerves were compared between TED and controls and between active and inactive stages of TED...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937492/magnetic-resonance-imaging-of-the-soft-tissue-vascular-anomalies-in-torso-and-extremities-in-children-an-update-with-2014-international-society-for-the-study-of-vascular-anomalies-classification
#18
Elizabeth Snyder, Kate Puttgen, Sally Mitchell, Shivani Ahlawat, Aylin Tekes
Vascular anomalies can occur anywhere in the body, and the majority present in the pediatric population. Accurate classification is essential for proper clinical evaluation, particularly because multidisciplinary care is often required. The International Society for the Study of Vascular Anomalies classification offers a comprehensive classification for all subspecialties. In this review article, we present a magnetic resonance imaging protocol with exemplary cases of the most common types of vascular anomalies in the pediatric trunk and extremities using the current International Society for the Study of Vascular Anomalies classification...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937491/improved-calcium-scoring-at-dual-energy-computed-tomography-angiography-using-a-high-z-contrast-element-and-novel-material-separation-technique
#19
Jack W Lambert, Yuxin Sun, Karen G Ordovas, Robert G Gould, Sizhe Wang, Benjamin M Yeh
OBJECTIVES: The aim of this study was to compare the accuracy of existing dual-energy computed tomography (CT) angiography coronary artery calcium scoring methods to those obtained using an experimental tungsten-based contrast material and a recently described contrast material extraction process (CMEP). METHODS: Phantom coronary arteries of varied diameters, with different densities and arcs of simulated calcified plaque, were sequentially filled with water, iodine, and tungsten contrast materials and scanned within a thorax phantom at rapid-kVp-switching dual-energy CT...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937488/the-significance-of-arachnoid-granulation-in-patients-with-idiopathic-intracranial-hypertension
#20
Gaurav Vishwasrao Watane, Bhumi Patel, Derek Brown, M Reza Taheri
PURPOSE: The aim of this article was to study the significance of arachnoid granulations (AGs) in patients with idiopathic intracranial hypertension (IIH). METHODS: In an institutional review board-approved retrospective chart review study, 79 patients with clinical diagnosis of idiopathic increased intracranial pressure were compared with 63 patients with a diagnosis of multiple sclerosis. Inclusion criteria also included available magnetic resonance imaging (MRI) of the brain, older than 18 years, and female sex...
September 20, 2017: Journal of Computer Assisted Tomography
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