keyword
MENU ▼
Read by QxMD icon Read
search

Super enhancer

keyword
https://www.readbyqxmd.com/read/28729813/novel-design-integrating-a-microwave-applicator-into-a-crystallizer-for-rapid-temperature-cycling-a-direct-nucleation-control-study
#1
Rohit Kacker, Marilena Radoiu, Herman J M Kramer
The control of nucleation in crystallization processes is a challenging task due to the often lacking knowledge on the process kinetics. Inflexible (predetermined) control strategies fail to grow the nucleated crystals to the desired quality because of the variability in the process conditions, disturbances, and the stochastic nature of crystal nucleation. Previously, the concept of microwave assisted direct nucleation control (DNC) was demonstrated in a laboratory setup to control the crystal size distribution in a batch crystallization process by manipulating the number of particles in the system...
July 5, 2017: Crystal Growth & Design
https://www.readbyqxmd.com/read/28729405/super-enhancer-analysis-defines-novel-epigenomic-subtypes-of-non-apl-aml-including-an-rar%C3%AE-dependency-targetable-by-sy-1425-a-potent-and-selective-rar%C3%AE-agonist
#2
Michael R McKeown, M Ryan Corces, Matthew L Eaton, Chris Fiore, Emily Lee, Jeremy T Lopez, Mei Wei Chen, Darren Smith, Steven M Chan, Julie L Koenig, Kathryn Austgen, Matt G Guenther, David A Orlando, Jakob Lovén, Christian C Fritz, Ravindra Majeti
We characterized the enhancer landscape of 66 AML patients, identifying 6 novel subgroups and their associated regulatory loci. These subgroups are defined by their super-enhancer (SE) maps, orthogonal to somatic mutations, and are associated with distinct leukemic cell states. Examination of transcriptional drivers for these epigenomic subtypes uncovers a subset of patients with a particularly strong super-enhancer at the retinoic acid receptor alpha (RARA) gene locus. Presence of a RARA SE and concomitant high levels of RARA mRNA predisposes cell lines and ex vivo models to exquisite sensitivity to a selective agonist of RARα, SY-1425 (tamibarotene)...
July 20, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28726715/overexpression-of-the-osimp-gene-increases-the-accumulation-of-inositol-and-confers-enhanced-cold-tolerance-in-tobacco-through-modulation-of-the-antioxidant-enzymes-activities
#3
Rong-Xiang Zhang, Li-Jun Qin, De-Gang Zhao
Inositol is a cyclic polyol that is involved in various physiological processes, including signal transduction and stress adaptation in plants. l-myo-inositol monophosphatase (IMPase) is one of the metal-dependent phosphatase family members and catalyzes the last reaction step of biosynthesis of inositol. Although increased IMPase activity induced by abiotic stress has been reported in chickpea plants, the role and regulation of the IMP gene in rice (Oryza sativa L.) remains poorly understood. In the present work, we obtained a full-length cDNA sequence coding IMPase in the cold tolerant rice landraces in Gaogonggui, which is named as OsIMP...
July 20, 2017: Genes
https://www.readbyqxmd.com/read/28724918/contrast-enhancement-of-biological-nanoporous-materials-with-zinc-oxide-infiltration-for-electron-and-x-ray-nanoscale-microscopy
#4
L E Ocola, V Sampathkumar, N Kasthuri, R P Winarski
We show that using infiltration of ZnO metal oxide can be useful for high resolution imaging of biological samples in electron and X-ray microscopy. The method is compatible with standard fixation techniques that leave the sample dry, such as finishing with super critical CO2 drying, or simple vacuum drying up to 95 °C. We demonstrate this technique can be applied on tooth and brain tissue samples. We also show that high resolution X-ray tomography can be performed on biological systems using Zn K edge (1s) absorption to enhance internal structures, and obtained the first nanoscale 10 KeV X-ray absorption images of the interior regions of a tooth...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720843/clinical-study-of-genomic-drivers-in-pancreatic-ductal-adenocarcinoma
#5
Michael T Barrett, Ray Deiotte, Elizabeth Lenkiewicz, Smriti Malasi, Tara Holley, Lisa Evers, Richard G Posner, Timothy Jones, Haiyong Han, Mark Sausen, Victor E Velculescu, Jeffrey Drebin, Peter O'Dwyer, Gayle Jameson, Ramesh K Ramanathan, Daniel D Von Hoff
BACKGROUND: Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer with complex genomes and dense fibrotic stroma. This study was designed to identify clinically relevant somatic aberrations in pancreatic cancer genomes of patients with primary and metastatic disease enrolled and treated in two clinical trials. METHODS: Tumour nuclei were flow sorted prior to whole genome copy number variant (CNV) analysis. Targeted or whole exome sequencing was performed on most samples...
July 18, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28718439/super-enhancer-driven-transcriptional-dependencies-in-cancer
#6
Satyaki Sengupta, Rani E George
Transcriptional deregulation is one of the core tenets of cancer biology and is underpinned by alterations in both protein-coding genes and noncoding regulatory elements. Large regulatory elements, so-called super-enhancers (SEs), are central to the maintenance of cancer cell identity and promote oncogenic transcription to which cancer cells become highly addicted. Such dependence on SE-driven transcription for proliferation and survival offers an Achilles heel for the therapeutic targeting of cancer cells...
April 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28715178/flexible-and-robust-superomniphobic-surfaces-created-by-localized-photofluidization-of-azopolymer-pillars
#7
Jaeho Choi, Wonhee Jo, Seung Yeol Lee, Yeon Sik Jung, Shin-Hyun Kim, Hee-Tak Kim
Springtails, insects which breathe through their skins, possess mushroom-shaped nanostructures. As doubly re-entrant geometry in the mushroom head enhances the resistance against liquid invasion, the springtails have robust, liquid-free omniphobic skins. Although omniphobic surfaces are promising for various applications, it remains an important challenge to mimic the structural feature of springtails. This paper presents a pragmatic method to create doubly re-entrant nanostructures and robust superomniphobic surfaces by exploiting localized photofluidization of azopolymers...
July 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28714474/facultative-ctcf-sites-moderate-mammary-super-enhancer-activity-and-regulate-juxtaposed-gene-in-non-mammary-cells
#8
M Willi, K H Yoo, F Reinisch, T M Kuhns, H K Lee, C Wang, L Hennighausen
Precise spatiotemporal gene regulation is paramount for the establishment and maintenance of cell-specific programmes. Although there is evidence that chromatin neighbourhoods, formed by the zinc-finger protein CTCF, can sequester enhancers and their target genes, there is limited in vivo evidence for CTCF demarcating super-enhancers and preventing cross talk between distinct regulatory elements. Here, we address these questions in the Wap locus with its mammary-specific super-enhancer separated by CTCF sites from widely expressed genes...
July 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28712919/an-innovative-mwcnts-dox-tc-nanosystem-for-chemo-photothermal-combination-therapy-of-cancer
#9
Xia Dong, Zhiting Sun, Xiaoxiao Wang, Xigang Leng
Chemotherapy and photothermal therapy can be efficiently integrated to achieve enhanced antitumor efficacy by using carbon nanotubes (CNTs) which are super in delivering drug and converting near infrared radiation (NIR) into heat. We previously developed an innovative TAT-chitosan functionalized MWCNTs (MWCNTs/TC) based drug delivery system for doxorubicin (DOX) and preliminarily investigated its release profile and antitumor effect. In the present study, the application potential of MWCNTs/DOX/TC in chemo-photothermal combination therapy was further explored...
July 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28708120/on-operating-a-nanofiltration-membrane-for-olive-mill-wastewater-purification-at-sub-and-super-boundary-conditions
#10
Marco Stoller, Javier Miguel Ochando-Pulido, Robert Field
In the last decades, membrane processes have gained a significant share of the market for wastewater purification. Although the product (i.e., purified water) is not of high added value, these processes are feasible both technically and from an economic point of view, provided the flux is relatively high and that membrane fouling is strongly inhibited. By controlling membrane fouling, the membrane may work for years without service, thus dramatically reducing operating costs and the need for membrane substitution...
July 14, 2017: Membranes
https://www.readbyqxmd.com/read/28703137/platelet-function-is-modified-by-common-sequence-variation-in-megakaryocyte-super-enhancers
#11
Romina Petersen, John J Lambourne, Biola M Javierre, Luigi Grassi, Roman Kreuzhuber, Dace Ruklisa, Isabel M Rosa, Ana R Tomé, Heather Elding, Johanna P van Geffen, Tao Jiang, Samantha Farrow, Jonathan Cairns, Abeer M Al-Subaie, Sofie Ashford, Antony Attwood, Joana Batista, Heleen Bouman, Frances Burden, Fizzah A Choudry, Laura Clarke, Paul Flicek, Stephen F Garner, Matthias Haimel, Carly Kempster, Vasileios Ladopoulos, An-Sofie Lenaerts, Paulina M Materek, Harriet McKinney, Stuart Meacham, Daniel Mead, Magdolna Nagy, Christopher J Penkett, Augusto Rendon, Denis Seyres, Benjamin Sun, Salih Tuna, Marie-Elise van der Weide, Steven W Wingett, Joost H Martens, Oliver Stegle, Sylvia Richardson, Ludovic Vallier, David J Roberts, Kathleen Freson, Lorenz Wernisch, Hendrik G Stunnenberg, John Danesh, Peter Fraser, Nicole Soranzo, Adam S Butterworth, Johan W Heemskerk, Ernest Turro, Mikhail Spivakov, Willem H Ouwehand, William J Astle, Kate Downes, Myrto Kostadima, Mattia Frontini
Linking non-coding genetic variants associated with the risk of diseases or disease-relevant traits to target genes is a crucial step to realize GWAS potential in the introduction of precision medicine. Here we set out to determine the mechanisms underpinning variant association with platelet quantitative traits using cell type-matched epigenomic data and promoter long-range interactions. We identify potential regulatory functions for 423 of 565 (75%) non-coding variants associated with platelet traits and we demonstrate, through ex vivo and proof of principle genome editing validation, that variants in super enhancers play an important role in controlling archetypical platelet functions...
July 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28696566/super-resolution-imaging-of-subcortical-white-matter-using-stochastic-optical-reconstruction-microscopy-storm-and-super-resolution-optical-fluctuation-imaging-sofi
#12
Atticus H Hainsworth, Sarah Lee, Peter Foot, Anita Patel, Wayne W Poon, Alex E Knight
AIMS: The spatial resolution of light microscopy is limited by the wavelength of visible light (the "diffraction limit", approximately 250 nm). Resolution of sub-cellular structures, smaller than this limit, is possible with super resolution methods such as stochastic optical reconstruction microscopy (STORM) and super-resolution optical fluctuation imaging (SOFI). We aimed to resolve subcellular structures (axons, myelin sheaths and astrocytic processes) within intact white matter using STORM and SOFI...
July 11, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28682847/metastatic-neuroblastoma-in-adult-patient-presenting-as-a-super-scan-on-68ga-dotanoc-pet-ct-imaging
#13
Dharmender Malik, Abhiram Jois, Harmandeep Singh, Girdhar S Bora, Rajender Kumar Basher, Bhagwant Rai Mittal
We report a case of 23-year-old man who presented with complaints of progressive abdominal distension for the past 3 months along with the loss of appetite and weight and had a large solid cystic mass in the left half of the abdominal cavity revealed on ultrasonography and contrast-enhanced CT of the abdomen. Subsequent biopsy and histopathology revealed it to be neuroblastoma. Ga-DOTANOC PET/CT scan performed to rule out distant metastasis showed intense radiotracer uptake distributed throughout the skeleton, mimicking a super scan...
July 6, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28668636/optimizing-sensitivity-of-ultrasound-contrast-enhanced-super-resolution-imaging-by-tailoring-size-distribution-of-microbubble-contrast-agent
#14
Fanglue Lin, James K Tsuruta, Juan D Rojas, Paul A Dayton
Ultrasound contrast-enhanced super-resolution imaging has recently attracted attention because of its extraordinary ability to image vascular features much smaller than the ultrasound diffraction limit. This method requires sensitive detection of separable microbubble events despite a noisy tissue background to indicate the microvasculature, and any approach that could improve the sensitivity of the ultrasound system to individual microbubbles would be highly beneficial. In this study, we evaluated the effect of varying microbubble size on super-resolution imaging sensitivity...
June 28, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28667277/super-hydrophobic-multilayer-coatings-with-layer-number-tuned-swapping-in-surface-wettability-and-redox-catalytic-anti-corrosion-application
#15
Junaid Ali Syed, Shaochun Tang, Xiangkang Meng
The wetting characteristic of a metal surface can be controlled by employing different coating materials and external stimuli, however, layer number (n) modulated surface swapping between hydrophobicity and hydrophilicity in a multilayer structure to achieve prolonged anti-corrosion ability was not taken into consideration. In this study, we proposed a layer-by-layer (LbL) spin assembled polyaniline-silica composite/tetramethylsilane functionalized silica nanoparticles (PSC/TMS-SiO2) coating with the combined effect of super-hydrophobicity and enhanced anti-corrosion ability...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28663279/comparative-exploration-of-the-structure-activity-space-of-cloned-%C3%AE-like-octopamine-receptors-from-a-marine-and-a-terrestrial-arthropod
#16
Dhwanil A Dalwadi, John A Schetz
The α-like octopamine receptors are believed to be the evolutionary precursor to the vertebrate α2-adrenergic receptors (α2-ARs) based upon sequence similarity and the ability to interact with norepinephrine and a number of compounds that bind with high affinity to α2-ARs. Barnacles and fruit flies are two prominent model marine and terrestrial representatives of the Arthropoda phylum, and while α-like OctRs have been cloned from Balanus improvisus (BiOctR) and Drosophila melanogaster (DmOctR), little is known about the structure-activity space for these important species...
June 29, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28659592/ultra-broadband-enhancement-of-nonlinear-optical-processes-from-randomly-patterned-super-absorbing-metasurfaces
#17
Nan Zhang, Ziheng Ji, Alec R Cheney, Haomin Song, Dengxin Ji, Xie Zeng, Borui Chen, Tianmu Zhang, Alexander N Cartwright, Kebin Shi, Qiaoqiang Gan
Broadband light trapping and field localization is highly desired in enhanced light-matter interaction, especially in harmonic generations. However, due to the limited resonant bandwidth, most periodic plasmonic nanostructures cannot cover both fundamental excitation wavelength and harmonic generation wavelength simultaneously. Therefore, most previously reported plasmonic nonlinear optical processes are low in conversion efficiency. Here, we report a strong enhancement of second harmonic generation based on a three-layered super absorbing metasurface structure consisting of a dielectric spacer layer sandwiched by an array of random metallic nanoantennas and a metal ground plate...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28655697/banana-fruit-pulp-and-peel-involved-in-antianxiety-and-antidepressant-effects-while-invigorate-memory-performance-in-male-mice-possible-role-of-potential-antioxidants
#18
Noreen Samad, Aqsa Muneer, Najeeb Ullah, Aqal Zaman, M Mazhar Ayaz, Ijaz Ahmad
The present study was aimed to investigate the anti-stress and memory enhancing effects of banana (Musa sapientum L.) fruit pulp and peel extract in male mice. Locally bred albino Wistar mice were divided into control and 2 test groups (n=10). Control rats received drinking water while test groups were treated with banana fruit pulp (600 mg/kg; oral administration) and extract of banana peel (400mg/kg; oral administration). Behavioral activities of animals were monitored 14 days post administration of banana pulp and peel extract...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28652597/defect-induced-local-variation-of-crystal-phase-transition-temperature-in-metal-halide-perovskites
#19
Alexander Dobrovolsky, Aboma Merdasa, Eva L Unger, Arkady Yartsev, Ivan G Scheblykin
Solution-processed organometal halide perovskites are hybrid crystalline semiconductors highly interesting for low-cost and efficient optoelectronics. Their properties are dependent on the crystal structure. Literature shows a variety of crystal phase transition temperatures and often a spread of the transition over tens of degrees Kelvin. We explain this inconsistency by demonstrating that the temperature of the tetragonal-to-orthorhombic phase transition in methylammonium lead triiodide depends on the concentration and nature of local defects...
June 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28650485/neuroblastoma-is-composed-of-two-super-enhancer-associated-differentiation-states
#20
Tim van Groningen, Jan Koster, Linda J Valentijn, Danny A Zwijnenburg, Nurdan Akogul, Nancy E Hasselt, Marloes Broekmans, Franciska Haneveld, Natalia E Nowakowska, Johannes Bras, Carel J M van Noesel, Aldo Jongejan, Antoine H van Kampen, Linda Koster, Frank Baas, Lianne van Dijk-Kerkhoven, Margriet Huizer-Smit, Maria C Lecca, Alvin Chan, Arjan Lakeman, Piet Molenaar, Richard Volckmann, Ellen M Westerhout, Mohamed Hamdi, Peter G van Sluis, Marli E Ebus, Jan J Molenaar, Godelieve A Tytgat, Bart A Westerman, Johan van Nes, Rogier Versteeg
Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has sparked an interest in their epigenetic regulation. Several tumor types include phenotypically divergent cells, resembling cells from different lineage development stages. It has been proposed that super-enhancer-associated transcription factor (TF) networks underlie lineage identity, but the role of these enhancers in intratumoral heterogeneity is unknown. Here we show that most neuroblastomas include two types of tumor cells with divergent gene expression profiles...
June 26, 2017: Nature Genetics
keyword
keyword
49126
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"