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Super enhancer

Jing-Min Liu, Yao-Yao Liu, Dong-Dong Zhang, Guozhen Fang, Shuo Wang
The rise of multimodal nanoprobes has promoted the development of new methods to explore multiple molecular targets simultaneously, or to combine various bioimaging tools in one assay to more clearly delineate localization and expression of bio-markers. Persistent luminescence nanophosphors (PLNPs) have been qualified as the promising contrast agent for in vivo imaging. The easy surface modification and proper nanostructure design strategy would favor the fabrication of PLNPs based multi-functional nanoprobes for biological application...
October 19, 2016: ACS Applied Materials & Interfaces
Monica Perkins, Marien de Bruyne, Melita J Giummarra
There is growing evidence that enhanced sensitivity to painful clinical procedures and chronic pain are related to greater sensitivity to other sensory inputs, such as bitter taste. We examined cross-modal sensitivities in two studies. Study 1 assessed associations between bitter taste sensitivity, pain tolerance, and fear of pain in 48 healthy young adults. Participants were classified as non-tasters, tasters and super-tasters using a bitter taste test (6-n-propythiouracil; PROP). The latter group had significantly higher fear of pain (Fear of Pain Questionnaire) than tasters (p=...
October 14, 2016: Attention, Perception & Psychophysics
Lukas C Buelens, Vladimir V Galvita, Hilde Poelman, Christophe Detavernier, Guy B Marin
Efficient CO2 transformation from a waste product to carbon source for chemicals and fuels will require reaction conditions that effect its reduction. We develop a "super-dry" CH4 reforming reaction for enhanced CO production from CH4 and CO2 We used Ni/MgAl2O4 as a CH4 reforming catalyst, Fe2O3/MgAl2O4 as a solid oxygen carrier, and CaO/Al2O3 as a CO2 sorbent. The isothermal coupling of these three different processes resulted in higher CO production compared with conventional dry reforming by avoiding back reactions with water...
October 13, 2016: Science
Sheryl Southard, Ju-Ryoung Kim, SiewHui Low, Richard W Tsika, Christoph Lepper
When unperturbed, somatic stem cells are poised to affect immediate tissue restoration upon trauma. Yet, little is known regarding the mechanistic basis controlling initial and homeostatic 'scaling' of stem cell pool sizes relative to their target tissues for effective regeneration. Here, we show that TEAD1-expressing skeletal muscle of transgenic mice features a dramatic hyperplasia of muscle stem cells (i.e. satellite cells, SCs) but surprisingly without affecting muscle tissue size. Super-numeral SCs attain a 'normal' quiescent state, accelerate regeneration, and maintain regenerative capacity over several injury-induced regeneration bouts...
October 11, 2016: ELife
Song Jiao, Xu Li, Huimin Yu, Huan Yang, Xue Li, Zhongyao Shen
Surfactin-family lipopeptides are green biosurfactants with substantial industrial potential. The major problem prohibiting surfactin use is the low titer of the wild producer, Bacillus subtilis. Using transcriptomic analysis, four strong promoters, PgroE, Pcdd, PrplK and PsspE, were identified and cloned from the genome of B. subtilis THY-7, a novel surfactin producer that has been identified from soil with a 0.55 g/L surfactin titer. An optimal promoter, PgroE, was selected to replace the native THY-7 surfactin synthase (SrfA) promoter through single-cross homologous recombination; however, the resulting engineered strain containing the PgroE substitution did not synthesize surfactin...
October 10, 2016: Biotechnology and Bioengineering
Adam S Backer, Maurice Y Lee, W E Moerner
Single-molecule orientation measurements provide unparalleled insight into a multitude of biological and polymeric systems. We report a simple, high-throughput technique for measuring the azimuthal orientation and rotational dynamics of single fluorescent molecules, which is compatible with localization microscopy. Our method involves modulating the polarization of an excitation laser, and analyzing the corresponding intensities emitted by single dye molecules and their modulation amplitudes. To demonstrate our approach, we use intercalating and groove-binding dyes to obtain super-resolved images of stretched DNA strands through binding-induced turn-on of fluorescence...
2016: Optica
Satya Surbhi, Kiraat D Munshi, Paula C Bell, James E Bailey
OBJECTIVES: First, to investigate the prevalence and types of drug therapy problems and medication discrepancies among super-utilizers, and associated patient characteristics. Second, to examine the outcomes of pharmacist recommendations and estimated cost avoidance through care transitions support focused on medication management. DESIGN: Retrospective analysis of the pharmacist-led interventions as part of the SafeMed Program. SETTING: A large nonprofit health care system serving the major medically underserved areas in Memphis, Tennessee...
October 6, 2016: Journal of the American Pharmacists Association: JAPhA
Sue Llewellyn
Writing about dreaming, the poet Raymond Carver said "I feel as if I've crossed some kind of invisible line". In creative people, the "line" between wake, dreaming and psychopathology may be porous, engendering a de-differentiated, super-critical, hybrid state. Evidence exists for a relationship between creativity and psychopathology but its nature has been elusive. De-differentiation between wake, sleep and dreaming may be the common substrate, as dream-like cognition pervades wake and wake-like neurophysiology suffuses sleep...
October 5, 2016: Consciousness and Cognition
Matthew J Murray, Hannah M Ogden, Carlos Toro, Qingnan Liu, Amy S Mullin
We report state-resolved collision dynamics for CO molecules prepared in an optical centrifuge and measured with high resolution transient IR absorption spectroscopy.Time-resolved polarization-sensitive measurements of excited CO molecules in the J=29 rotational state reveal that oriented angular momentum of CO rotors is relaxed by impulsive collisions.Translational energy gains for molecules in the initial plane of rotation are 3-fold larger than for randomized angular momentum orientations, indicating the presence of anisotropic kinetic energy...
October 6, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Emily J Faivre, Denise Wilcox, Xiaoyu Lin, Paul Hessler, Maricel Torrent, Wei He, Tamar Uziel, Daniel H Albert, Keith McDaniel, Warren Kati, Yu Shen
: Competitive inhibitors of acetyl-lysine binding to the bromodomains of the BET (bromodomain and extra terminal) family are being developed for the treatment of solid and hematologic malignancies. The function of BET family member BRD4 at enhancers/super-enhancers has been shown to sustain signal-dependent or pathogenic gene expression programs. Here the hypothesis was tested that the transcription factor drivers of castration-resistant prostate cancer (CRPC) clinical progression, including the Androgen Receptor (AR), are critically dependent on BRD4 and thus represent a sensitive solid tumor indication for the BET inhibitor ABBV-075...
October 5, 2016: Molecular Cancer Research: MCR
Min He, Yue Ding, Jing Chen, Yanlin Song
Fast removal of condensates from surfaces is of great significance due to the enhancing thermal transfer coefficient and continuous condensation. But the losing super-hydrophobicity of lotus leaves questions us what kind of surface morphologies meets the self-removal of condensates? The uphill movement of condensates in textured surfaces is vital to avoiding flood and facilitating self-removal. Here, super-hydrophobic micro-tower arrays were designed to explore the spontaneous uphill movement and Wenzel to Cassie transition as well as the self-removal of condensates...
October 5, 2016: ACS Nano
Jong Sang Youn, Janae Csavina, Kyle P Rine, Taylor Shingler, Mark Patrick Taylor, A Eduardo Sáez, Eric A Betterton, Armin Sorooshian
This study examines size-resolved physicochemical data for particles sampled near mining and smelting operations and a background urban site in Arizona with a focus on how hygroscopic growth impacts particle deposition behavior. Particles with aerodynamic diameters between 0.056 - 18 µm were collected at three sites: (i) an active smelter operation in Hayden, AZ, (ii) a legacy mining site with extensive mine tailings in Iron King, AZ, and (iii) an urban site, inner-city Tucson, AZ. Mass size distributions of As and Pb exhibit bimodal profiles with a dominant peak between 0...
October 4, 2016: Environmental Science & Technology
Pei-Lun Hsieh, Shih-Han Wang, Ching-Min Chen, Junko Wake, Chien-Chia Yeh
The proportion of elderly in Taiwan reached 11.99% of the population in 2014. Further, Taiwan is expected to become a super-aged society, as defined by the United Nations, in 2025. Elderly and long-term care needs have increased dramatically and long-term care (LTC) has become an increasingly important focus of policymaking. Japan, already a super-aged society, enacted LTC insurance in 2000 and has since implemented comprehensive LTC services nationwide. This article describes the evolution of the LTC insurance plan in Japan and the function of the Community Inclusive Care System...
October 2016: Hu Li za Zhi the Journal of Nursing
Asifkhan Shanavas, Sisini Sasidharan, Dhirendra Bahadur, Rohit Srivastava
Hybrid nanoparticles with magnetic poly (lactide-co-glycolide) (PLGA) nanoparticle 'core', surface modified with folate-chitosan (fol-cht) conjugate 'shell' are evaluated as simultaneous anti-cancer therapeutic and MRI contrast agent. The fol-cht conjugate is prepared using carbodiimide crosslinking chemistry at an optimized folate to amine (chitosan) molar ratio for further coating on PLGA nanoparticles loaded with docetaxel and well packed super paramagnetic iron oxide nanoparticles (SPIONs). Apart from possessing a targeting moiety, the coating provides a physical barrier to avoid undesired burst release of drug and also imparts sensitivity to acidic pH, due to protonated amine group dependent decondensation of the coating and subsequent drug release...
September 28, 2016: Journal of Colloid and Interface Science
Yang Li, Lei Wang, Bo Li, Meicheng Zhang, Rui Wen, Xinghua Guo, Xing Li, Ji Zhang, Shoujian Li, Lijian Ma
A new strategy combining pore-free matrix and cooperative-chelating was proposed in the present paper in order to effectively avoid undesired non-selective physical adsorption and intra-particle diffusion caused by pores and voids in porous sorbents, and to greatly enhance uranium-chelating capability based on hyperbranched amidoxime ligands on the surface of nanodiamond particles. Thus a pore-free, amidoxime-terminated hyperbranched nanodiamond (ND-AO) was designed and synthesized. The experimental results demonstrate that the strategy endows the as-synthesized ND-AO with following expected features: (1) distinctively high uranium selectivity (SU = qe-U /qe-tol ×100 %) from over 80% to nearly 100 % over the whole weak acidity range (pH < 4...
October 4, 2016: ACS Applied Materials & Interfaces
Emily J Guggenheim, Abdullah Khan, Jeremy Pike, Lynne Chang, Iseult Lynch, Joshua Z Rappoport
The potential for human exposure to manufactured nanoparticles (NPs) has increased in recent years, in part through the incorporation of engineered particles into a wide range of commercial goods and medical applications. NP are ideal candidates for use as therapeutic and diagnostic tools within biomedicine, however concern exists regarding their efficacy and safety. Thus, developing techniques for the investigation of NP uptake into cells is critically important. Current intracellular NP investigations rely on the use of either Transmission Electron Microscopy (TEM), which provides ultrahigh resolution, but involves cumbersome sample preparation rendering the technique incompatible with live cell imaging, or fluorescent labelling, which suffers from photobleaching, poor bioconjugation and, often, alteration of NP surface properties...
2016: PloS One
John Maringa Githaka, Anthony R Vega, Michelle A Baird, Michael W Davidson, Khuloud Jaqaman, Nicolas Touret
Nanoclustering is an emerging organizational principle of membrane-associated proteins. The functional consequences of nanoclustering for receptor signaling remain largely unknown. Here we applied quantitative, multi-channel high- and super-resolution imaging to the endothelial cell surface receptor CD36, the clustering of which upon binding to multivalent ligands such as the anti-angiogenic factor thrombospondin-1 (TSP-1) is thought to be critical for signaling. We found that a substantial fraction of unligated CD36 exists in nanoclusters which not only promote TSP-1 binding but are also enriched with the downstream effector Fyn...
September 30, 2016: Journal of Cell Science
Emre Balta, Julian Stopp, Laura Castelletti, Henning Kirchgessner, Yvonne Samstag, Guido H Wabnitz
Neutrophils or polymorphonuclear cells (PMN) eliminate bacteria via phagocytosis and/or NETosis. Apart from these conventional roles, PMN also have immune-regulatory functions. They can transdifferentiate and upregulate MHCII as well as ligands for costimulatory receptors which enables them to behave as antigen presenting cells (APC). The initial step for activating T-cells is the formation of an immune synapse between T-cells and antigen-presenting cells). However, the immune synapse that develops at the PMN/T-cell contact zone is as yet hardly investigated due to the non-availability of methods for analysis of large number of PMN interactions...
September 27, 2016: Methods: a Companion to Methods in Enzymology
Rui Liu, Jun-Hua Wang, Chengxiong Xu, Bo Sun, Sa-Ouk Kang
Activin belongs to transforming growth factor (TGF)-β super family of growth and differentiation factors and activin pathway participated in broad range of cell process. Studies elaborated activin pathway maintain pluripotency in human stem cells and suggest that the function of activin/nodal signaling in self-renew would be conserved across embryonic and adult stem cells. In this study, we tried to determine the effect of activin signaling pathway in regulation of cancer stem cells as a potential target for cancer therapy in clinical trials...
October 28, 2016: Biochemical and Biophysical Research Communications
Sina Heimer, Patrick R Schmidlin, Malgorzata Roos, Bogna Stawarczyk
STATEMENT OF PROBLEM: Polyetheretherketone (PEEK) can be used as a framework material for fixed dental prostheses. However, information about laboratory and chairside polishing methods is still scarce. PURPOSE: The purpose of this in vitro study was to determine the effects of laboratory and chairside polishing methods on the surface roughness (SR) and surface free energy (SFE) of PEEK, an autopolymerizing poly(methyl methacrylate), and a veneering composite resin...
September 28, 2016: Journal of Prosthetic Dentistry
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