Read by QxMD icon Read

Super enhancer

Shuying Hu, Yi Zhou, Yantao Zhao, Yang Xu, Feimin Zhang, Ning Gu, Junqing Ma, Mark A Reynolds, Yang Xia, Hockin H K Xu
A main challenge for use of scaffolds in bone engineering involves non-invasive monitoring in vivo and enhanced bone regeneration. The tissue-repair effect of super-paramagnetic iron oxide nanoparticles (SPIONs) was demonstrated previously by our group. However, testing in vivo is needed to confirm in vitro results. Here, SPIONs loaded gelatin sponge (GS) was used as a scaffold (SPIONs-GS) and implanted in the incisor sockets of Sprague-Dawley rats. Incisor sockets filled with nothing and filled with GS served as controls...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
Flavia L Esposito, Hans Supèr
In line with a possible role of vergence in orienting visual attention, we sought to study this eye movement in young children to provide insights on face perception. For this purpose, we measured the modulation in the angle of eye vergence in a sample of 39 children aged 6-36 months and compared it when presenting static human face images versus their scrambled version. We observed enhanced vergence responses to faces compared with scrambled images. Our data suggest a role of eye vergence in face processing...
January 10, 2018: Neuroreport
Tobias C Messemaker, Selina M van Leeuwen, Patrick R van den Berg, Anke E J 't Jong, Robert-Jan Palstra, Rob C Hoeben, Stefan Semrau, Harald M M Mikkers
The transcription factor Sox2 controls the fate of pluripotent stem cells and neural stem cells. This gatekeeper function requires well-regulated Sox2 levels. We postulated that Sox2 regulation is partially controlled by the Sox2 overlapping long non-coding RNA (lncRNA) gene Sox2ot. Here we show that the RNA levels of Sox2ot and Sox2 are inversely correlated during neural differentiation of mouse embryonic stem cells (ESCs). Through allele-specific enhanced transcription of Sox2ot in mouse Sox2eGFP knockin ESCs we demonstrate that increased Sox2ot transcriptional activity reduces Sox2 RNA levels in an allele-specific manner...
January 10, 2018: Scientific Reports
Toshihiko Yoshizawa, Kouhei Ishikawa, Hiroki Nagasawa, Ikuto Takeuchi, Kei Jitsuiki, Kazuhiko Omori, Hiromichi Ohsaka, Youichi Yanagawa
A 35-year-old man (height, 169 cm; body weight,240 kg; BMI, 84) visited the Department of Dermatology due to left leg pain and swelling. Focused enhanced computed tomography (CT) of the left leg ruled out complications of deep venous thrombosis. Surgical exploration of the left leg resulted in a diagnosis of necrotic soft tissue infection, but amputation was ruled out due to his weight. The patient ultimately died of multiple organ failure on the fourth day of hospitalization. A culture of the surgical material revealed Streptococcus dysgalactiae...
January 11, 2018: Internal Medicine
Cian J Lynch, Raquel Bernad, Isabel Calvo, Sandrina Nóbrega-Pereira, Sergio Ruiz, Nuria Ibarz, Ana Martinez-Val, Osvaldo Graña-Castro, Gonzalo Gómez-López, Eduardo Andrés-León, Vladimir Espinosa Angarica, Antonio Del Sol, Sagrario Ortega, Oscar Fernandez-Capetillo, Enrique Rojo, Javier Munoz, Manuel Serrano
The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that RPAP1 is essential for the expression of cell identity genes and for cell viability. Depletion of RPAP1 triggers cell de-differentiation, facilitates reprogramming toward pluripotency, and impairs differentiation. Mechanistically, we show that RPAP1 is essential for the interaction between RNA polymerase II (RNA Pol II) and Mediator, as well as for the recruitment of important regulators, such as the Mediator-specific RNA Pol II factor Gdown1 and the C-terminal domain (CTD) phosphatase RPAP2...
January 9, 2018: Cell Reports
Roobala Chelladurai, Koushik Debnath, Nikhil R Jana, Jaydeep Kumar Basu
Interaction of functional nanoparticles with cells and model biomembranes have been widely studied to evaluate the effectiveness of the particles as potential drug delivery vehicles and bio-imaging labels as well as in understanding nanoparticle cytotoxicity effects. Charged nanoparticles, in particular, with tunable surface charge have been found to be effective in targeting cellular membranes as well as the sub-cellular matrix. However, a microscopic understanding of the underlying physical principles which govern nanoparticle binding, uptake or diffusion on cells is lacking...
January 10, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Dakota E McCoy, Teresa Feo, Todd Alan Harvey, Richard O Prum
Many studies have shown how pigments and internal nanostructures generate color in nature. External surface structures can also influence appearance, such as by causing multiple scattering of light (structural absorption) to produce a velvety, super black appearance. Here we show that feathers from five species of birds of paradise (Aves: Paradisaeidae) structurally absorb incident light to produce extremely low-reflectance, super black plumages. Directional reflectance of these feathers (0.05-0.31%) approaches that of man-made ultra-absorbent materials...
January 9, 2018: Nature Communications
Abhishek Kumar, Mohit Kothari, Anastasios Grigoriadis, Mats Trulsson, Peter Svensson
Tooth loss, decreased mass and strength of the masticatory muscles leading to difficulty in chewing have been suggested as important determinants of eating and nutrition in the elderly. To compensate for the loss of teeth, in particular, a majority of the elderly rely on dental prosthesis for chewing. Chewing function is indeed an important aspect of oral health and therefore, oral rehabilitation procedures should aim to restore or maintain adequate function. However, even if the possibilities to anatomically restore lost teeth and occlusion have never been better; conventional rehabilitation procedures may still fail to optimally restore oral functions...
January 3, 2018: Journal of Oral Rehabilitation
Zhihe Liu, Hua Tan, Jianping Xin, Jiazhi Duan, Xiaowen Su, Pin Hao, Junfeng Xie, Jie Zhan, Jing Zhang, Jian-Jun Wang, Hong Liu
Transition metal nitrides have attracted a great deal of interest as electrocatalysts for water splitting due to their super metallic performance, high efficiency and good stability. Herein, we report a novel design of hierarchical electrocatalyst based on Ni3FeN, where the presence of carbon fiber cloth as scaffold can effectively alleviate the aggregation of Ni3FeN nanostructure and form 3D conducting networks to enlarge the surface area and simultaneously enhance the charge transfer. The composition and morphological variations of NiFe-precursors during annealing in different atmosphere were investigated...
January 9, 2018: ACS Applied Materials & Interfaces
Enrico Ne, Robert-Jan Palstra, Tokameh Mahmoudi
In this review, we cover transcription regulation of human immunodeficiency virus type 1 (HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research over the years, toward the field of transcription. In this context, the HIV promoter can be considered to be a well-studied model promoter, which although a viral promoter, is subject to the same cellular regulatory mechanisms that modulate the transcriptional control of endogenous host cellular genes. The molecular control of HIV-1 transcription has been well studied and considerable knowledge toward development of alternative strategies for therapies aimed at eradicating both active but also latent HIV-1 has been obtained...
2018: International Review of Cell and Molecular Biology
Chandana Sampath Kumara Ranasinghe, Akira Yamakata
Behaviors of photogenerated charge carriers and structural changes of water molecules on TiO2 photoelectrodes were investigated by using time-resolved visible to mid-IR absorption spectroscopy. From the spectra measured in the visible to NIR region, it was shown that the lifetime of trapped electrons and holes becomes longer upon applying more positive potentials. This result was reasonably explained by the enhancement of the upward band bending at the water/TiO2 interface. On the other hand, from the spectra measured in the mid-IR region, structural changes of the water molecules were observed...
January 4, 2018: Physical Chemistry Chemical Physics: PCCP
Mei Ma, Shouwu Guo, Wenzhuo Shen
Tetravalent metal phosphates (M(HPO4)2, M=Zr, Sn, and Ti) have robust layered structure with the interlayer d-spacing over 7.5 Å, but show poor electric conductivity. On the other hand, single-atomic-layered reduced graphene oxide (rGO) sheets exhibit a high electric conductivity. In this work, the combination of rGO and M(HPO4)2 is explored for their potential as anode materials for lithium ion batteries (LIBs). Specifically, rGO/M(HPO4)2 composites are prepared, and their electrochemical performances are investigated systematically...
January 3, 2018: ACS Applied Materials & Interfaces
Luyao Zheng, Xiaoyan Wang, Yonggao Xia, Senlin Xia, Ezzeldin Metwalli, Bao Qiu, Qing Ji, Shanshan Yin, Shuang Xie, Kai Fang, Suzhe Liang, Meimei Wang, Xiuxia Zuo, Ying Xiao, Zhaoping Liu, Jin Zhu, Peter Muller-Buschbaum, Ya-Jun Cheng
Li4Ti5O12 (LTO) is regarded as a promising lithium-ion battery anode due to its stable cyclic performance and reliable operation safety. The moderate rate performance originated from the poor intrinsic electron and lithium-ion conductivities of the LTO has significantly limited its wide applications. A facile scalable synthesis of hierarchical Li4Ti5O12/C nanohybrids with super-small LTO nanoparticles (ca. 17 nm in diameter) homogeneously embedded in the continuous micrometer sized carbon matrix is developed...
January 3, 2018: ACS Applied Materials & Interfaces
Aleksander Szczurek, Udo Birk, Hans Knecht, Jurek Dobrucki, Sabine Mai, Christoph Cremer
Methods of super-resolving light microscopy (SRM) have found an exponentially growing range of applications in cell biology, including nuclear structure analyses. Recent developments have proven that Single Molecule Localization Microscopy (SMLM), a type of SRM, is particularly useful for enhanced spatial analysis of the cell nucleus due to its highest resolving capability combined with very specific fluorescent labeling. In this commentary we offer a brief review of the latest methodological development in the field of SMLM of chromatin designated DNA Structure Fluctuation Assisted Binding Activated Localization Microscopy (abbreviated as fBALM) as well as its potential future applications in biology and medicine...
January 3, 2018: Nucleus
Mariana Lanzarini-Lopes, Anca G Delgado, Yuanming Guo, Paul Dahlen, Paul Westerhoff
Remediation of polluted groundwater often requires oxygen delivery into subsurface to sustain aerobic bacteria. Air sparging or injection of oxygen containing solutions (e.g., hydrogen peroxide) into the subsurface are common. In this study visible light was delivered into the subsurface using radially emitting optical fibers. Phototrophic organisms grew near the optical fiber in a saturated sand column. When applying light in on-off cycles, dissolved oxygen (DO) varied from super saturation levels of >15 mg DO/L in presence of light to under-saturation (<5 mg DO/L) in absence of light...
December 14, 2017: Chemosphere
Chongze Yuan, Hong Hu, Muyu Kuang, Zongwei Chen, Xiaoting Tao, Shengjian Fang, Yihua Sun, Yawei Zhang, Haiquan Chen
Purpose: Tyrosine kinase inhibitors (TKIs) are widely used to treat lung adenocarcinoma patients with EGFR mutations or ALK-fusions. However, patients with wild-type genes or TKIs-resistant mutations lack effective therapeutic targets. Extensive studies reveal that super enhancer (SE), a large cis-regulatory element, is associated with key oncogenes in a variety of cancers. By comparing the effect of SE on lung adenocarcinoma cell lines with normal cell line, this work attempts to find new biomarkers and potential therapeutic targets for lung adenocarcinoma...
December 1, 2017: Oncotarget
Ruei Han Jiang, Ta-Jen Yen, Chi Chen, Ding-Zheng Lin, He Chun Chou, Jen-You Chu
Near-field scanning optical microscopy (NSOM) enables observation of a light-matter interaction with the spatial resolution far below the diffraction limit without vacuum environment. However, modern NSOM technique encounters a few fundamental restrictions so far. For example, for the aperture tip (a-tip), the throughput is extremely low and lateral resolution is poor, which are limited by aperture size; for the scattering tip (s-tip), the signal-to-noise ratio (SNR) appear almost zero, so that one cannot directly use the measurement data...
December 27, 2017: Nano Letters
Yang Yang, Xiangjia Li, Xuan Zheng, Zeyu Chen, Qifa Zhou, Yong Chen
Biomimetic functional surfaces are attracting increasing attention for various technological applications, especially the superhydrophobic surfaces inspired by plant leaves. However, the replication of the complex hierarchical microstructures is limited by the traditional fabrication techniques. In this paper, superhydrophobic micro-scale artificial hairs with eggbeater heads inspired by Salvinia molesta leaf was fabricated by the Immersed surface accumulation three dimensional (3D) printing process. Multi-walled carbon nanotubes were added to the photocurable resins to enhance the surface roughness and mechanical strength of the microstructures...
December 27, 2017: Advanced Materials
Hayley B Schultz, Nicky Thomas, Shasha Rao, Clive A Prestidge
The method of supersaturation for achieving high drug loads in lipid-based formulations is under exploited and relatively unexplored, especially in the case of solid-state lipid-based formulations. Silica-lipid hybrids are solid-state lipid-based formulations designed for improving the oral delivery of poorly water-soluble drugs. However, their application to compounds of low potency and requiring large doses is limited by their low drug loading capacity. Here, an innovative technique to fabricate supersaturated silica-lipid hybrid formulations (super-SLH) has been established and the relationship between drug load and performance investigated...
December 22, 2017: European Journal of Pharmaceutics and Biopharmaceutics
Kyoung-Ho Kim, You-Shin No
In this review, we introduce novel plasmonic and metamaterial devices based on one-dimensional subwavelength nanostructures with cylindrical symmetry. Individual single devices with semiconductor/metal core/shell or dielectric/metal core/multi-shell structures experience strong light-matter interaction and yield unique optical properties with a variety of functions, e.g., invisibility cloaking, super-scattering/super-absorption, enhanced luminescence and nonlinear optical activities, and deep subwavelength-scale optical waveguiding...
2017: Nano Convergence
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"