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https://www.readbyqxmd.com/read/29245179/hot-off-the-press-sgem-196-gastroparesis-i-feel-like-throwing-up
#1
Corey Heitz, Justin Morgenstern, William K Milne
This randomized controlled trial compared haloperidol along with conventional therapy to placebo along with conventional therapy for gastroparesis in the emergency department. The primary outcomes of pain and nausea scores at 1 hour were significantly improved in the haloperidol group, but not in the placebo group. In this summary, we discuss a quality assessment of the article and summarized the social media commentary from the blog post/podcast. This article is protected by copyright. All rights reserved.
December 15, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29245154/acute-procedural-outcomes-of-orbital-atherectomy-for-the-treatment-of-profunda-femoris-artery-disease-subanalysis-of-the-confirm-registries
#2
Michael S Lee, Pratyaksh K Srivastava, Saif Al Yaseen, Daniel Heikali, John Hollowed, Ehtisham Mahmud
OBJECTIVES: We compared the angiographic outcomes of patients treated with orbital atherectomy for profunda femoris artery (PFA) and superficial femoral artery (SFA) disease from the CONFIRM I-III registries. BACKGROUND: Endovascular revascularization of the PFA is considered a high-risk procedure given that it is an important collateral vessel when the SFA becomes occluded. Data on outcomes of endovascular revascularization of calcified PFA disease are limited...
December 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29245142/the-chest-radiologist-s-role-in-invasive-breast-cancer-detection
#3
Laurie R Margolies, Mary Salvatore, Rowena Yip, Kathleen Tam, Alexandra Bertolini, Claudia Henschke, David Yankelevitz
PURPOSE: To assess the ability of chest CT to identify patients needing further evaluation of the breasts. METHODS: IRB approval was obtained with a waiver of consent. Women with chest CT and mammogram within 12months formed the cohort. A breast assessment and recommendation CT score (BARCS) analogous to mammographic BI-RADS was created and compared to the mammogram BI-RADS. RESULTS: BARCS and mammographic BI-RADS management recommendations were concordant for 77...
December 7, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29245022/cost-effective-way-to-reduce-stimulant-abuse-among-gay-bisexual-men-and-transgender-women-a-randomized-clinical-trial-with-a-cost-comparison
#4
S X Zhang, S Shoptaw, C J Reback, K Yadav, A M Nyamathi
OBJECTIVES: A randomized controlled study was conducted with 422 homeless, stimulant-using gay/bisexual (G/B) men and 29 transgender women (n = 451) to assess two community-based interventions to reduce substance abuse and improve health: (a) a nurse case-managed program combined with contingency management (NCM + CM) versus (b) standard education plus contingency management (SE + CM). STUDY DESIGN: Hypotheses tested included: a) completion of hepatitis A/B vaccination series; b) reduction in stimulant use; and c) reduction in number of sexual partners...
December 12, 2017: Public Health
https://www.readbyqxmd.com/read/29245013/combination-cancer-therapy-can-confer-benefit-via-patient-to-patient-variability-without-drug-additivity-or-synergy
#5
Adam C Palmer, Peter K Sorger
Combination cancer therapies aim to improve the probability and magnitude of therapeutic responses and reduce the likelihood of acquired resistance in an individual patient. However, drugs are tested in clinical trials on genetically diverse patient populations. We show here that patient-to-patient variability and independent drug action are sufficient to explain the superiority of many FDA-approved drug combinations in the absence of drug synergy or additivity. This is also true for combinations tested in patient-derived tumor xenografts...
December 14, 2017: Cell
https://www.readbyqxmd.com/read/29245009/fix-it-in-one-go-enhanced-factor-ix-gene-therapy-for-hemophilia-b
#6
David Lillicrap
A phase 1/2 clinical trial of AAV-mediated gene therapy in patients with hemophilia B using an enhanced specific activity factor IX (FIX) transgene reports sustained levels of FIX levels, leading to the near elimination of bleeding for more than a year and without serious adverse side effects. These results are the best outcome to date for hemophilia gene therapy.
December 14, 2017: Cell
https://www.readbyqxmd.com/read/29245008/on-the-design-of-combination-cancer-therapy
#7
James H Doroshow, Richard M Simon
Combination therapy programs are the hallmark of the successful treatment of all forms of human malignancies. In this issue of Cell, Palmer and Sorger present data suggesting that cell culture results indicative of synergistic anticancer drug interactions rarely translate clinically and that the results of combination therapies in mouse models or human clinical trials, even if successful, are best explained by the independent activities of the individually administered drugs.
December 14, 2017: Cell
https://www.readbyqxmd.com/read/29244995/proceedings-of-the-strategy-meeting-for-the-development-of-an-international-consortium-for-chinese-medicine-and-cancer
#8
Jeffrey D White, Hongsheng Lin, Libin Jia, Roy S Wu, Stephen Lam, Jie Li, Jinhui Dou, Nagi Kumar, Lizhu Lin, Lixing Lao
On November 3, 2014, in Bethesda, MD, the Office of Cancer Complementary and Alternative Medicine of the National Cancer Institute held a meeting to examine the potential utility and feasibility of establishing an international consortium for Chinese medicine and cancer. There is significant interest in the West in using components of Chinese medicine (CM) -such as botanicals and herbal medicines, acupuncture and acupressure, and qigong-in the field of oncology, as potential anticancer agents, for symptom management, and to improve quality of life...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244956/effects-of-carbohydrate-and-branched-chain-amino-acid-beverage-ingestion-during-acute-upper-body-resistance-exercise-on-performance-and-post-exercise-hormone-response
#9
JohnEric W Smith, Ben M Krings, Brandon D Shepherd, Hunter S Waldman, Steven A Basham, Matthew J McAllister
The purpose of this investigation was to examine the individual and combined effects of ingesting carbohydrates (CHO) and branched chain amino acids (BCAA) during high volume upper-body resistance exercise (RE) on markers of catabolism and performance. Thirteen resistance trained males completed four experimental trials with supplementation ingesting beverages containing CHO, BCAA, CHO+BCAA, or placebo (PLA) in a randomized, double-blind design. The beverages were ingested in 118 mL servings six times during a ~60 min RE session consisting of bench press, bent-over row, incline press, and close-grip row...
December 15, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29244893/effectiveness-of-intra-articular-injections-of-sodium-hyaluronate-or-corticosteroids-for-intracapsular-temporomandibular-disorders-a-systematic-review-and-meta-analysis
#10
Marlon A Moldez, Victor R Camones, Guillermo E Ramos, Mariela Padilla, Reyes Enciso
AIMS: To assess the effectiveness of intra-articular injections of sodium hyaluronate (NaH) or corticosteroids (CS) for treatment of intracapsular temporomandibular disorders (TMD). METHODS: Single- or double-blinded randomized controlled trials (RCTs) on the effectiveness of NaH or CS injections, compared to each other or to placebo, for the treatment of intracapsular TMD due to osteoarthritis and/or internal joint derangement were analyzed in this systematic review and meta-analysis...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29244861/reliability-of-the-parameters-of-the-power-duration-relationship-using-maximal-effort-time-trials-under-laboratory-conditions
#11
Christoph Triska, Bettina Karsten, Bernd Heidegger, Bernhard Koller-Zeisler, Bernhard Prinz, Alfred Nimmerichter, Harald Tschan
The purpose of this study was to assess the reliability of critical power (CP) and the total amount of work accomplished above CP (W´) across repeated tests using ecologically valid maximal effort time-trials (TT) under laboratory conditions. After an initial incremental exercise test, ten well-trained male triathletes (age: 28.5 ± 4.7 years; body mass: 73.3 ± 7.9 kg; height: 1.80 ± 0.07 m; maximal aerobic power [MAP]: 329 ± 41 W) performed three testing sessions (Familiarization, Test I and Test II) each comprising three TT (12, 7, and 3 min with a passive recovery of 60 min between trials)...
2017: PloS One
https://www.readbyqxmd.com/read/29244844/diagnostic-markers-for-the-detection-of-ovarian-cancer-in-brca1-mutation-carriers
#12
Daphne Gschwantler-Kaulich, Sigrid Weingartshofer, Christine Rappaport-Fürhauser, Robert Zeilinger, Dietmar Pils, Daniela Muhr, Elena I Braicu, Marie-Therese Kastner, Yen Y Tan, Lorenz Semmler, Jalid Sehouli, Christian F Singer
BACKGROUND: Screening for ovarian cancer (OC) in women at high risk consists of a combination of carbohydrate antigen 125 (CA125) and transvaginal ultrasound, despite their low sensitivity and specificity. This could be improved by the combination of several biomarkers, which has been shown in average risk patients but has not been investigated until now in female BRCA mutation carriers. METHODS: Using a multiplex, bead-based, immunoassay system, we analyzed the concentrations of leptin, prolactin, osteopontin, insulin-like growth factor II, macrophage inhibitory factor, CA125 and human epididymis antigen 4 in 26 healthy wild type women, 26 healthy BRCA1 mutation carriers, 28 wildtype OC patients and 26 OC patients with BRCA1 mutation...
2017: PloS One
https://www.readbyqxmd.com/read/29244829/cost-effectiveness-analysis-of-introducing-malaria-diagnostic-testing-in-drug-shops-a-cluster-randomised-trial-in-uganda
#13
Kristian Schultz Hansen, Siân E Clarke, Sham Lal, Pascal Magnussen, Anthony K Mbonye
BACKGROUND: Private sector drug shops are an important source of malaria treatment in Africa, yet diagnosis without parasitological testing is common among these providers. Accurate rapid diagnostic tests for malaria (mRDTs) require limited training and present an opportunity to increase access to correct diagnosis. The present study was a cost-effectiveness analysis of the introduction of mRDTs in Ugandan drug shops. METHODS: Drug shop vendors were trained to perform and sell subsidised mRDTs and artemisinin-based combination therapies (ACTs) in the intervention arm while vendors offered ACTs following presumptive diagnosis of malaria in the control arm...
2017: PloS One
https://www.readbyqxmd.com/read/29244810/synaptic-augmentation-in-a-cortical-circuit-model-reproduces-serial-dependence-in-visual-working-memory
#14
Daniel P Bliss, Mark D'Esposito
Recent work has established that visual working memory is subject to serial dependence: current information in memory blends with that from the recent past as a function of their similarity. This tuned temporal smoothing likely promotes the stability of memory in the face of noise and occlusion. Serial dependence accumulates over several seconds in memory and deteriorates with increased separation between trials. While this phenomenon has been extensively characterized in behavior, its neural mechanism is unknown...
2017: PloS One
https://www.readbyqxmd.com/read/29244806/cellular-selectivity-of-aav-serotypes-for-gene-delivery-in-neurons-and-astrocytes-by-neonatal-intracerebroventricular-injection
#15
Sean L Hammond, Ashley N Leek, Evan H Richman, Ronald B Tjalkens
The non-pathogenic parvovirus, adeno-associated virus (AAV), is an efficient vector for transgene expression in vivo and shows promise for treatment of brain disorders in clinical trials. Currently, there are more than 100 AAV serotypes identified that differ in the binding capacity of capsid proteins to specific cell surface receptors that can transduce different cell types and brain regions in the CNS. In the current study, multiple AAV serotypes expressing a GFP reporter (AAV1, AAV2/1, AAVDJ, AAV8, AAVDJ8, AAV9, AAVDJ9) were screened for their infectivity in both primary murine astrocyte and neuronal cell cultures...
2017: PloS One
https://www.readbyqxmd.com/read/29244792/tight-glycemic-control-in-critically-ill-pediatric-patients-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#16
Yiyang Zhao, Yang Wu, Bo Xiang
BACKGROUND: There still are controversies in the impact of tight glycemic control (TGC) in critically ill children. The aim of this study was to assess the benefits and risks of TGC compared with conventional glycemic control (CGC) in critically ill pediatric patients admitted to the pediatric intensive care unit (PICU) by using data retrieved from randomized controlled trials (RCTs). METHOD: EMBASE, CNKI, PubMed and the Cochrane Database were searched for RCTs comparing TGC with CGC in critically ill children in PICU...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244782/efficacy-of-blunt-force-trauma-a-novel-mechanical-cervical-dislocation-device-and-a-non-penetrating-captive-bolt-device-for-on-farm-euthanasia-of-pre-weaned-kits-growers-and-adult-commercial-meat-rabbits
#17
Jessica L Walsh, Aaron Percival, Patricia V Turner
The commercial meat rabbit industry is without validated on-farm euthanasia methods, potentially resulting in inadequate euthanasia protocols. We evaluated blunt force trauma (BFT), a mechanical cervical dislocation device (MCD), and a non-penetrating captive bolt device (NPCB) for euthanasia of pre-weaned kits, growers, and adult rabbits. Trials were conducted on three commercial meat rabbit farms using 170 cull rabbits. Insensibility was assessed by evaluating absence of brainstem and spinal reflexes, rhythmic breathing, and vocalizations...
December 15, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29244779/omega-3-long-chain-polyunsaturated-fatty-acids-and-preeclampsia-trials-say-no-but-is-it-the-final-word
#18
REVIEW
Denis I Burchakov, Irina V Kuznetsova, Yuliya B Uspenskaya
Preeclampsia is a dangerous disorder of pregnancy, defined as hypertension with proteinuria. Its nature remains elusive, and measures of prevention and treatment are limited. Observational studies have suggested that preeclampsia is associated with low intake of omega-3 long-chain polyunsaturated fatty acids (LCPUFA). In recent decades, researchers studied LCPUFA supplementation as a measure to prevent preeclampsia. Most of these trials and later systematic reviews yielded negative results. However, these trials had several important limitations associated with heterogeneity and other issues...
December 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29244745/immunotherapeutic-potential-of-oncolytic-h-1-parvovirus-hints-of-glioblastoma-microenvironment-conversion-towards-immunogenicity
#19
Assia L Angelova, Milena Barf, Karsten Geletneky, Andreas Unterberg, Jean Rommelaere
Glioblastoma, one of the most aggressive primary brain tumors, is characterized by highly immunosuppressive microenvironment. This contributes to glioblastoma resistance to standard treatment modalities and allows tumor growth and recurrence. Several immune-targeted approaches have been recently developed and are currently under preclinical and clinical investigation. Oncolytic viruses, including the autonomous protoparvovirus H-1 (H-1PV), show great promise as novel immunotherapeutic tools. In a first phase I/IIa clinical trial (ParvOryx01), H-1PV was safe and well tolerated when locally or systemically administered to recurrent glioblastoma patients...
December 15, 2017: Viruses
https://www.readbyqxmd.com/read/29244743/hematological-and-hemodynamic-responses-to-acute-and-short-term-creatine-nitrate-supplementation
#20
Ryan L Dalton, Ryan J Sowinski, Tyler J Grubic, Patrick B Collins, Adriana M Coletta, Aimee G Reyes, Brittany Sanchez, Majid Koozehchian, Yanghoon P Jung, Christopher Rasmussen, Mike Greenwood, Peter S Murano, Conrad P Earnest, Richard B Kreider
In a double-blind, crossover, randomized and placebo-controlled trial; 28 men and women ingested a placebo (PLA), 3 g of creatine nitrate (CNL), and 6 g of creatine nitrate (CNH) for 6 days. Participants repeated the experiment with the alternate supplements after a 7-day washout. Hemodynamic responses to a postural challenge, fasting blood samples, and bench press, leg press, and cycling time trial performance and recovery were assessed. Data were analyzed by univariate, multivariate, and repeated measures general linear models (GLM)...
December 15, 2017: Nutrients
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