Anna B Montgomery, Shang Yang Chen, Yidan Wang, Gaurav Gadhvi, Maximilian G Mayr, Carla M Cuda, Salina Dominguez, Hadijat-Kubura Moradeke Makinde, Miranda G Gurra, Alexander V Misharin, Arthur M Mandelin, Eric M Ruderman, Anjali Thakrar, Simran Brar, Mary Carns, Kathleen Aren, Mahzad Akbarpour, Andrew Filer, Saba Nayar, Ana Teososio, Triin Major, Ankit Bharat, G R Scott Budinger, Deborah R Winter, Harris Perlman
Monocytes are abundant immune cells that infiltrate inflamed organs. However, the majority of monocyte studies focus on circulating cells, rather than those in tissue. Here, we identify and characterize an intravascular synovial monocyte population resembling circulating non-classical monocytes and an extravascular tissue-resident monocyte-lineage cell (TR-MC) population distinct in surface marker and transcriptional profile from circulating monocytes, dendritic cells, and tissue macrophages that are conserved in rheumatoid arthritis (RA) patients...
May 18, 2023: Cell Reports