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https://www.readbyqxmd.com/read/29843653/a-case-of-scleritis-associated-rheumatoid-arthritis-accompanying-an-intraocular-elevated-lesion
#1
Takatoshi Kobayashi, Nanae Takai, Rei Tada, Hiromi Shoda, Teruyo Kida, Tsunehiko Ikeda, Takurou Ozaki, Shigeki Makino
BACKGROUND: Scleritis and/or uveitis sometimes accompanies patients who suffer from rheumatoid arthritis. However, few studies have reported scleritis and/or uveitis accompanying a fundus elevated lesion, such as an intraocular tumor. In this study, we report a case of rheumatoid uveitis associated with an intraocular elevated lesion. CASE PRESENTATION: A 66-year-old female visited another eye clinic and was diagnosed as bilateral anterior uveitis, and was prescribed steroid eye drops for treatment...
May 30, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29804097/cardiomyopathy-oxidative-stress-and-impaired-contractility-in-a-rheumatoid-arthritis-mouse-model
#2
Gianluigi Pironti, Alex Bersellini-Farinotti, Nilesh M Agalave, Katalin Sandor, Teresa Fernandez-Zafra, Alexandra Jurczak, Lars H Lund, Camilla I Svensson, Daniel C Andersson
OBJECTIVES: Patients with rheumatoid arthritis (RA) display an increased risk of heart failure independent of traditional cardiovascular risk factors. To elucidate myocardial disease in RA, we have investigated molecular and cellular remodelling of the heart in an established mouse model of RA. METHODS: The collagen antibody-induced arthritis (CAIA) RA mouse model is characterised by joint inflammation and increased inflammatory markers in the serum. We used CAIA mice in the postinflammatory phase that resembles medically controlled RA or RA in remission...
May 26, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29776906/blood-induced-bone-loss-in-murine-hemophilic-arthropathy-is-prevented-by-blocking-the-irhom2-adam17-tnf%C3%AE-pathway
#3
Coline Haxaire, Narine Hakobyan, Tania Pannellini, Camila Carballo, David McIlwain, Tak W Mak, Scott Rodeo, Suchitra Acharya, Daniel Li, Jackie Szymonifka, Xiangqian Song, Sébastien Monette, Alok Srivastava, Jane E Salmon, Carl P Blobel
Hemophilic arthropathy (HA) is a debilitating degenerative joint disease that is a major manifestation of the bleeding disorder Hemophilia A. HA typically begins with hemophilic synovitis (HS) that resembles inflammatory arthritides such as rheumatoid arthritis (RA) and frequently results in bone loss in patients. A major cause of RA is inappropriate release of the pro-inflammatory cytokine tumor necrosis factor α (TNFα) by the TNFα convertase (TACE, also referred to as ADAM17) and its regulator, iRhom2...
May 18, 2018: Blood
https://www.readbyqxmd.com/read/29731464/-diagnosis-and-treatment-of-rheumatoid-arthritis-toward-the-best-practice-best-practice-with-jak-inhibitors
#4
Kunihiro Yamaoka
Janus kinase(JAK)inhibitor is a new orally available disease modifying anti-rheumatic drug that has shown anti-rheumatic effect resembling biologics. Clinical trials for autoinflammatory and autoimmune diseases are under investigation. Administration route is convenient compared to biologics and possess high anti-rheumatic effect, however specific side effects considered as a class-effect exists. I would like to offer the best conceivable practice with JAK inhibitors based on evidence from clinical trials and real world experiences...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29694398/commensurate-incidence-and-outcomes-of-liver-enzyme-elevation-between-anti-tumor-necrosis-factor-users-with-or-without-prior-hepatitis-b-virus-infections
#5
Ying-Ming Chiu, Mei-Shu Lai, K Arnold Chan
BACKGROUND AND OBJECTIVE: Potential hepatoxicity is an important clinical concern when administering immunosuppressive therapies to patients infected by hepatitis B virus (HBV). Tumor necrosis factor inhibitors (anti-TNF) increase the likelihood of hepatitis consequent to HBV reactivation, but reported risks and outcomes vary. We determined the risks of liver enzyme elevation in anti-rheumatic drug users from an HBV-endemic region with differing HBV serostatus. METHODS: We established retrospective cohorts with rheumatoid arthritis, ankylosing spondylitis, or psoriasis/psoriatic arthritis who: 1) received anti-TNF agents from 1 January 2004 to 30 June 2013; 2) received care from 1 June 2011 to 30 June 2013 but only ever used conventional disease-modifying anti-rheumatic drugs (DMARDs)...
2018: PloS One
https://www.readbyqxmd.com/read/29554596/quercetin-attenuates-zymosan-induced-arthritis-in-mice
#6
Carla F S Guazelli, Larissa Staurengo-Ferrari, Ana C Zarpelon, Felipe A Pinho-Ribeiro, Kenji W Ruiz-Miyazawa, Fabiana T M C Vicentini, Josiane A Vignoli, Doumit Camilios-Neto, Sandra R Georgetti, Marcela M Baracat, Rubia Casagrande, Waldiceu A Verri
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by articular lesions, recruitment of inflammatory cells and increased levels of pro-inflammatory cytokine. The intra-articular administration of zymosan is an experimental model that promotes inflammatory parameters resembling RA. Therefore, this model was used to investigate the efficacy of quercetin as a treatment of articular inflammation. Treatment with quercetin dose-dependently reduced zymosan-induced hyperalgesia, articular edema and the recruitment of neutrophils to the knee joint cavity...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29543042/nintedanib-reduces-pulmonary-fibrosis-in-a-model-of-rheumatoid-arthritis-associated-interstitial-lung-disease
#7
Elizabeth F Redente, Martin A Aguilar, Bart P Black, Benjamin L Edelman, Ali N Bahadur, Stephen M Humphries, David A Lynch, Lutz Wollin, David W H Riches
Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) develops in ~20% of patients with RA. SKG mice, which are genetically prone to development of autoimmune arthritis, develop a pulmonary interstitial pneumonia that resembles human cellular and fibrotic nonspecific interstitial pneumonia. Nintedanib, a tyrosine kinase inhibitor approved for treatment of idiopathic pulmonary fibrosis, has been shown to reduce the decline in lung function. Therefore, we investigated the effect of nintedanib on development of pulmonary fibrosis and joint disease in female SKG mice with arthritis induced by intraperitoneal injection of zymosan (5 mg)...
June 1, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29540195/traditional-chinese-medicine-formula-bi-qi-capsule-alleviates-rheumatoid-arthritis-induced-inflammation-synovial-hyperplasia-and-cartilage-destruction-in-rats
#8
Kai Wang, Dongmei Zhang, Yan Liu, Xuan Wang, Jiantong Zhao, Tingting Sun, Tingting Jin, Baoli Li, Janak L Pathak
BACKGROUND: Traditional Chinese medicine (TCM) formula Bi-Qi capsule (Bi-Qi) is a commonly prescribed drug to treat rheumatoid arthritis (RA). However, the mechanism of Bi-Qi-mediated amelioration of RA pathogenesis is still a mystery. Collagen induced arthritis (CIA) in rats is an established model that shares many similarities with RA in humans. In this study we investigated the effect of Bi-Qi on the pathogenesis of CIA in rats. METHODS: CIA was developed in Sprague-Dawley (S...
March 14, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29536378/a-case-report-of-chikungunya-fever-rheumatoid-arthritis-and-felty-s-syndrome
#9
José Kennedy Amaral, Robert T Schoen
INTRODUCTION: Chronic chikungunya (CHIK) arthritis, an inflammatory arthritis, often follows acute CHIK fever (CHIKF), a viral infection. The pathogenesis of chronic CHIK arthritis is poorly characterized, but may resemble other forms of inflammatory arthritis. Clinically, chronic CHIK arthritis sometimes mimics rheumatoid arthritis (RA). CASE REPORT: We report a patient with well-characterized CHIKF followed 2 months later by chronic CHIK arthritis not only resembling RA clinically, but also associated with RA biomarkers and extra-articular features, including Felty's syndrome (FS)...
June 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29490707/a-pyoderma-gangrenous-like-cutaneous-leishmaniasis-in-a-libyan-woman-with-rheumatoid-arthritis-a-case-report
#10
Hamida Al-Dwibe, Ahmad Amro, Aisha Gashout, Ali El-Zurghany, Said El-Zubi, Mohamed El-Hashme, Omar Hamarsheh, Mokhtar Maree
BACKGROUND: Several case reports describe diseases presenting with skin ulcerations, which resemble pyoderma gangrenosum especially in immune-compromised patients, often proven on further workup, to have an infective or malignant etiology. However, treatment of pyoderma gangrenosum by systemic steroids or other immunosuppressive agents may worsen the condition. CASE PRESENTATION: We report here, a 45 year-old Libyan woman with rheumatoid arthritis on low dose steroids with pyoderma gangrenosum-like skin lesions and positive pathergy...
March 1, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29431121/methotrexate-limits-inflammation-through-an-a20-dependent-cross-tolerance-mechanism
#11
Cristina Municio, Ángeles Dominguez-Soto, Sara Fuentelsaz-Romero, Amalia Lamana, Nuria Montes, Víctor D Cuevas, Raquel García Campos, José L Pablos, Isidoro González-Álvaro, Amaya Puig-Kröger
OBJECTIVES: Methotrexate (MTX) is the anchor drug for treatment of rheumatoid arthritis (RA), but the mechanism of its anti-inflammatory action is not fully understood. In RA, macrophages display a proinflammatory polarisation profile that resembles granulocyte-macrophage colony-stimulating factor (GM-CSF)-differentiated macrophages and the response to MTX is only observed in thymidylate synthase+ GM-CSF-dependent macrophages. To determine the molecular basis for the MTX anti-inflammatory action, we explored toll-like receptor (TLR), RA synovial fluid (RASF) and tumour necrosis factor receptor (TNFR)-initiated signalling in MTX-exposed GM-CSF-primed macrophages...
May 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29426059/brief-report-the-genetic-profile-of-rheumatoid-factor-positive-polyarticular-juvenile-idiopathic-arthritis-resembles-that-of-adult-rheumatoid-arthritis
#12
Anne Hinks, Miranda C Marion, Joanna Cobb, Mary E Comeau, Marc Sudman, Hannah C Ainsworth, John Bowes, Mara L Becker, John F Bohnsack, Johannes-Peter Haas, Daniel J Lovell, Elizabeth D Mellins, J Lee Nelson, Ellen Nordal, Marilynn Punaro, Ann M Reed, Carlos D Rose, Alan M Rosenberg, Marite Rygg, Samantha L Smith, Anne M Stevens, Vibeke Videm, Carol A Wallace, Lucy R Wedderburn, Annie Yarwood, Rae S M Yeung, Carl D Langefeld, Susan D Thompson, Wendy Thomson, Sampath Prahalad
OBJECTIVE: Juvenile idiopathic arthritis (JIA) comprises 7 heterogeneous categories of chronic childhood arthritides. Approximately 5% of children with JIA have rheumatoid factor (RF)-positive arthritis, which phenotypically resembles adult rheumatoid arthritis (RA). Our objective was to compare and contrast the genetics of RF-positive polyarticular JIA with those of RA and selected other JIA categories, to more fully understand the pathophysiologic relationships of inflammatory arthropathies...
June 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29382365/increase-of-mzb1-in-b-cells-in-systemic-lupus-erythematosus-proteomic-analysis-of-biopsied-lymph-nodes
#13
Aya Miyagawa-Hayashino, Hajime Yoshifuji, Koji Kitagori, Shinji Ito, Takuma Oku, Yoshitaka Hirayama, Adeeb Salah, Toshiki Nakajima, Kaori Kiso, Norishige Yamada, Hironori Haga, Tatsuaki Tsuruyama
BACKGROUND: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease in which dysregulation of B cells has been recognized. Here, we searched for potential biomarkers of SLE using liquid chromatography-tandem mass spectrometry (LC-MS). METHODS: Lymph nodes from SLE patients and controls were analyzed by LC-MS. To validate the identified molecules, immunoblotting and immunohistochemistry were performed and B cells from SLE patients were analyzed by quantitative RT-PCR...
January 30, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29230210/checkpoint-blockade-toxicity-and-immune-homeostasis-in-the-gastrointestinal-tract
#14
REVIEW
Michael Dougan
Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has led to a new class of immune-related adverse events. In many respects, these immune toxicities resemble idiopathic autoimmune diseases, such as inflammatory bowel disease, autoimmune hepatitis, rheumatoid arthritis, and vitiligo...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29183642/tick-borne-diseases-and-autoimmunity-a-comprehensive-review
#15
REVIEW
Yhojan Rodríguez, Manuel Rojas, M Eric Gershwin, Juan-Manuel Anaya
Tick-borne diseases (TBDs) are emerging and reemerging diseases transmitted by ticks, which portray wide heterogeneity and global distribution. TBDs may present acute clinical pictures that resemble those of autoimmune diseases (i.e., musculoskeletal symptoms, cutaneous involvement, neurologic impairment, renal failure, etc.), and in some cases infection is considered a triggering factor for autoimmunity (e.g., rheumatoid arthritis, autoimmune thyroid disease, vasculitides). The clinician should consider TBDs among the differential diagnoses when approaching autoimmune-like signs in areas of tick infestation...
March 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29181398/rheumatoid-arthritis-affecting-the-upper-cervical-spine-biomechanical-assessment-of-the-stabilizing-ligaments
#16
Carolin Meyer, Jan Bredow, Elisa Heising, Peer Eysel, Lars Peter Müller, Gregor Stein
Diameters of anterior and posterior atlantodental intervals (AADI and PADI) are diagnostically conclusive regarding ongoing neurological disorders in rheumatoid arthritis. MRI and X-ray are mostly used for patients' follow-up. This investigation aimed at analyzing these intervals during motion of cervical spine, when transverse and alar ligaments are damaged. AADI and PADI of 10 native, human cervical spines were measured using lateral fluoroscopy, while the spines were assessed in neutral position first, in maximal inclination second, and in maximal extension at last...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29126253/enabling-phenotypic-big-data-with-phenorm
#17
Sheng Yu, Yumeng Ma, Jessica Gronsbell, Tianrun Cai, Ashwin N Ananthakrishnan, Vivian S Gainer, Susanne E Churchill, Peter Szolovits, Shawn N Murphy, Isaac S Kohane, Katherine P Liao, Tianxi Cai
Objective: Electronic health record (EHR)-based phenotyping infers whether a patient has a disease based on the information in his or her EHR. A human-annotated training set with gold-standard disease status labels is usually required to build an algorithm for phenotyping based on a set of predictive features. The time intensiveness of annotation and feature curation severely limits the ability to achieve high-throughput phenotyping. While previous studies have successfully automated feature curation, annotation remains a major bottleneck...
January 1, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29077694/practical-approach-to-the-evaluation-and-management-of-rheumatoid-arthritis-interstitial-lung-disease-based-on-its-proven-and-hypothetical-mechanisms
#18
Francisco Paulin, Alejandra Babini, Marta Mamani, Juan Mercado, Fabián Caro
The prevalence of interstitial lung disease in patients with rheumatoid arthritis varies from 10 to 42%. Rheumatoid arthritis patients with interstitial lung disease have three times the risk of death compared with those without the disease. Prognosis seems to be related to the high-resolution computed tomography pattern. Usual interstitial pneumonia pattern, resembling idiopathic pulmonary fibrosis, carries a worse prognosis. Validated strategies to identify different phenotypes and assess the disease activity in rheumatoid arthritis interstitial lung disease are lacking...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29059085/multicentric-reticulohistiocytosis-a-multicenter-case-series-and-review-of-literature
#19
Bharat Kumar, Namrata Singh, S Rahnama-Moghadam, Karolyn A Wanat, Jacob W Ijdo, Victoria P Werth
No abstract text is available yet for this article.
January 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28978351/the-caspase-8-ripk3-signaling-axis-in-antigen-presenting-cells-controls-the-inflammatory-arthritic-response
#20
Salina Dominguez, Anna B Montgomery, G Kenneth Haines, Christina L Bloomfield, Carla M Cuda
BACKGROUND: Caspase-8 is a well-established initiator of apoptosis and suppressor of necroptosis, but maintains functions beyond cell death that involve suppression of receptor-interacting serine-threonine kinases (RIPKs). A genome-wide association study meta-analysis revealed an SNP associated with risk of rheumatoid arthritis (RA) development within the locus containing the gene encoding for caspase-8. Innate immune cells, like macrophages and dendritic cells, are gaining momentum as facilitators of autoimmune disease pathogenesis, and, in particular, RA...
October 4, 2017: Arthritis Research & Therapy
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