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mimicking rheumatoid arthritis

L A Gauri, Ashok Thaned, Q Fatima, H Yadav, A Singh, H P Jaipal, A Chaudhary
OBJECTIVE: To find out clinical and laboratory profile of patients of chikungunya outbreak in 2006 in Bikaner (North-West Rajasthan) and follow up of chikungunya patients for 5 years. METHODS: Study was conducted among 50 chikungunya patients. For this study the inclusion criteria was clinical presentation consistent with chikungunya virus infection (e.g. abrupt onset of fever and/or polyarthralgia) and laboratory confirmation of chikungunya virus infection by IgM-capture ELISA...
March 2016: Journal of the Association of Physicians of India
M A Cosatti, C N Pisoni, J L Altuve, C Lorente
Non Hodking´s lymphoma (NHL) may involve bones but synovial involvement is uncommon. We describe a patient who presented with polyarthritis, sicca symptoms and rash suggestive of rheumatoid arthritis. An atypical skin rash prompted skin and synovial biopsies. A diagnosis of synovial and skin malignant large B-cell lymphoma anaplastic subtype was performed. Chemotherapy with dexamethasone, vincristine and rituximab was started. Following treatment the patient had complete resolution of cutaneous and articular lymphoma manifestations...
2016: Revista de la Facultad de Ciencias Médicas
Ripa Akter, Paul Boland, Peter Daley, Proton Rahman, Nayef Al Ghanim
Rat bite fever is rare in Western countries. It can be very difficult to diagnose as blood cultures are typically negative and a history of rodent exposure is often missed. Unless a high index of suspicion is maintained, the associated polyarthritis can be mistaken for rheumatoid arthritis. We report a case of culture-positive rat bite fever in a 46-year-old female presenting with fever and polyarthritis. The clinical presentation mimicked rheumatoid arthritis. Infection was complicated by discitis, a rare manifestation...
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
Xin Yan, Yurong Cen, Qin Wang
Previous studies have demonstrated that mesenchymal stem cell (MSC) transplantation reduces the severity of collagen-induced arthritis (CIA) in mice, which is a model for rheumatoid arthritis (RA) in humans. However, the underlying molecular mechanisms remain ill-defined. Here, we showed that MSC transplantation reduced the activities of NF-κB signaling and decreased microRNA-548e (miR-548e) levels in the joint tissue in CIA-mice, seemingly through activation of transforming growth factor β receptor signaling...
2016: Scientific Reports
Priyanka Chadha, Dorian Hobday, Edmund Fitzgerald O'Connor, David D'Cruz
We present the case of a 69-year-old man who was found collapsed close to a heat source and admitted to hospital for severe sepsis. He was also found to have widespread blistering and ulceration of his right leg; however, a history was unobtainable due to reduced consciousness levels. The leg lesions had the initial appearance of mixed depth burns and a management plan was made to transfer the patient to a burns unit for debridement. It was subsequently noted that the patient had a previous diagnosis of seropositive erosive rheumatoid arthritis...
2016: BMJ Case Reports
Sanjay Pandey, Hitesh Garg
Parkinson`s disease (PD) is the most common neurodegenerative disease and is characterized by tremor, rigidity and akinesia. Diagnosis is clinical in the majority of the patients. Patients with PD may have stooped posture but some of them develop different types of postural and striatal deformities. Usually these deformities are more common in atypical parkinsonian disorders such as progressive supranuclear palsy and multisystem atrophy. But in many studies it has been highlighted that these may also be present in approximately one third of PD patients leading to severe disability...
January 2016: Indian Journal of Medical Research
Toomas Talme, Eva Bergdahl, Karl-Gösta Sundqvist
Methotrexate (MTX) is a widely used treatment for inflammatory diseases such as rheumatoid arthritis and psoriasis, based on the concept that it is immunosuppressive. Its mechanism of action, however, remains unclear, although it is thought to depend on adenosine. Caffeine and theophylline, which have several targets including adenosine receptors, have been shown to suppress the beneficial clinical effects of MTX. Here we show that MTX and caffeine and theophylline differentially affect a motogenic T-cell mechanism driven by endogenous thrombospondin-1 (TSP-1) and its receptor, low density lipoprotein receptor-related protein 1 (LRP1)...
May 2016: European Journal of Immunology
Jean-Marie Berthelot, Jean Sibilia
Tropheryma Whipplei can induce rheumatism mimicking SpA or RA, but even more rampant bacterial/viral infections in epiphyseal bones could also contribute to the onset of RA and SpA. Indeed, as bone marrow stem cell niches are enriched in Tregs and myeloid derived suppressor cells, these areas are favourable for the persistence of quiescent viruses and/or dormant bacteria. This review focuses on the possibility that such silent infections of bone marrow stem cell niches might contribute to the pathogenesis of SpA and RA, at least during their onset...
March 2016: Clinical and Experimental Rheumatology
Anne D Christensen, Claus Haase, Andrew D Cook, John A Hamilton
Neutrophils are an abundant cell type in many chronic inflammatory diseases such as rheumatoid arthritis (RA); however, their contribution to the pathology of RA has not been widely studied. A key cytokine involved in neutrophil development and function is granulocyte-colony stimulating factor (G-CSF). In this study we used the K/BxN serum-transfer arthritis (STA) model, mimicking the effector phase of RA, to investigate the importance of G-CSF in arthritis development and its relation to neutrophils. Here, we show for the first time in this model that G-CSF levels are increased both in the serum and in inflamed paws of arthritic mice and importantly that G-CSF blockade leads to a profound reduction in arthritis severity, as well as reduced numbers of neutrophils in blood...
May 2016: European Journal of Immunology
Gulsen Ozen, Nevsun Inanc, Ali Ugur Unal, Seda Bas, Gezmis Kimyon, Bunyamin Kisacik, Ahmet Mesut Onat, Sadiye Murat, Havva Keskin, Meryem Can, Alperen Mengi, Necati Cakir, Ayse Balkarli, Veli Cobankara, Neslihan Yilmaz, Ayten Yazici, Atalay Dogru, Mehmet Sahin, Ali Sahin, Kevser Gok, Soner Senel, Omer Nuri Pamuk, Sema Yilmaz, Ozun Bayindir, Kenan Aksu, Yonca Cagatay, Lutfi Akyol, Mehmet Sayarlioglu, Gozde Yildirim-Cetin, Sule Yasar-Bilge, Ilker Yagci, Sibel Zehra Aydin, Fatma Alibaz-Oner, Pamir Atagunduz, Haner Direskeneli
OBJECTIVE: To assess the performance of the new 2012 provisional European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) polymyalgia rheumatica (PMR) clinical classification criteria in discriminating PMR from other mimicking conditions compared with the previous 5 diagnostic criteria in a multicenter prospective study. METHODS: Patients older than 50 years, presenting with new-onset bilateral shoulder pain with elevated acute-phase reactants (APR), were assessed for the fulfillment of the new and old classification/diagnostic criteria sets for PMR...
May 2016: Journal of Rheumatology
Miguel Ariza-Prota, Ana Pando-Sandoval, Marta García-Clemente, Pere Casan
Poncet's disease is a rarely reported entity with an unknown pathogenesis. However, because it has a very favorable prognosis with antituberculosis drugs, we believe it should be considered as a differential diagnosis for patients with fever and polyarthritis of unknown cause, particularly if active tuberculosis is suspected.
January 2016: Clinical Case Reports
A A Fiogbe, G Liistro, D Hoton, T Pieters
INTRODUCTION: The incidence of atypical mycobacterial infection in Europe is estimated at one case per 100,000 persons/year. Despite the low incidence of Mycobacterium avium infection, it can result in a nodular lesion simulating lung cancer. We report a case of atypical mycobacteriosis, mimicking lung cancer, which led to a lobectomy. CASE REPORT: It was a right pulmonary upper lobe nodule found in a 63-year-old COPD patient, partially nephrectomized for renal carcinoma, and weekly treated by methotrexate for rheumatoid arthritis...
April 2016: Revue de Pneumologie Clinique
Genki Kato, Yasuhiro Shimizu, Yuki Arai, Natsuki Suzuki, Yasutaka Sugamori, Miki Maeda, Mariko Takahashi, Yukihiko Tamura, Noriyuki Wakabayashi, Ramachandran Murali, Takashi Ono, Keiichi Ohya, Setsuko Mise-Omata, Kazuhiro Aoki
INTRODUCTION: We designed OP3-4 (YCEIEFCYLIR), a cyclic peptide, to mimic the soluble osteoprotegerin (OPG), and was proven to bind to RANKL (receptor activator of NF-κB ligand), thereby inhibiting osteoclastogenesis. We recently found that another RANKL binding peptide, W9, could accelerate bone formation by affecting RANKL signaling in osteoblasts. We herein demonstrate the effects of OP3-4 on bone formation and bone loss in a murine model of rheumatoid arthritis. METHODS: Twenty-four seven-week-old male DBA/1J mice were used to generate a murine model of collagen-induced arthritis (CIA)...
2015: Arthritis Research & Therapy
Stefan Bittner, Nicole Bobak, Majella-Sophie Hofmann, Michael K Schuhmann, Tobias Ruck, Kerstin Göbel, Wolfgang Brück, Heinz Wiendl, Sven G Meuth
Lymphocytes express potassium channels that regulate physiological cell functions, such as activation, proliferation and migration. Expression levels of K2P5.1 (TASK2; KCNK5) channels belonging to the family of two-pore domain potassium channels have previously been correlated to the activity of autoreactive T lymphocytes in patients with multiple sclerosis and rheumatoid arthritis. In humans, K2P5.1 channels are upregulated upon T cell stimulation and influence T cell effector functions. However, a further clinical translation of targeting K2P5...
2015: International Journal of Molecular Sciences
A S Dussouil, J Allardet-Servent, L Dunogeant, J L Grauer, S Ranque, V Nasser
Histoplasma capsulatum var. capsulatum is a dimorphic fungus endemic to America and subtropical regions. Several cases of this opportunist mycosis have been reported in immunocompromised patients. We report the case of a patient treated with methotrexate and corticosteroid therapy for rheumatoid arthritis and who presented with disseminated histoplasmosis that partially mimicked a dermatomyositis.
September 2015: British Journal of Dermatology
Galber Rodrigues Araujo, Emília Rezende Vaz, Patricia Tiemi Fujimura, João Eurico Fonseca, Lucélia Maria de Lima, Helena Canhão, Gabriela Venturini, Karina Helena Morais Cardozo, Valdemir Melechco Carvalho, Marcelo Henrique Napimoga, Luiz Ricardo Goulart, João Gonçalves, Carlos Ueira-Vieira
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects around 1% of the human population worldwide. RA diagnosis can be difficult as there is no definitive test for its detection. Therefore, the aim of this study was to identify biomarkers that could be used for RA diagnosis. METHODS: Sera from a collagen-induced arthritis mouse model were used to select potential biomarkers for RA diagnosis by phage display technology...
2015: Arthritis Research & Therapy
Cátia Fernandes-Cerqueira, Elena Ossipova, Sunithi Gunasekera, Monika Hansson, Linda Mathsson, Anca I Catrina, Yngve Sommarin, Lars Klareskog, Karin Lundberg, Johan Rönnelid, Ulf Göransson, Per-Johan Jakobsson
INTRODUCTION: We have previously identified endogenously citrullinated peptides derived from fibrinogen in rheumatoid arthritis (RA) synovial tissues. In this study, we have investigated the auto-antigenicity of four of those citrullinated peptides, and explored their feasibility to target anti-citrullinated protein/peptide antibodies (ACPA). METHODS: The autoantigenic potential of the fibrinogen peptides was investigated by screening 927 serum samples from the Epidemiological Investigation of RA (EIRA) cohort on a peptide microarray based on the ImmunoCAP ISAC® system...
2015: Arthritis Research & Therapy
Kentaro Ishii, Norihisa Ishii, Kazue Nakanaga, Kazuaki Nakano, Ikuo Saito, Akihiko Asahina
Mycobacterium haemophilum is a slow-growing non-tuberculous mycobacterium that is rarely known to cause human skin infection, particularly in immunocompromised patients. We recently experienced a 69-year-old Japanese woman with this infection who had been under immunosuppressive treatment for recalcitrant rheumatoid arthritis. The patient showed disseminated erythematous plaques and subcutaneous nodules on the face and extremities, and interestingly, the face manifested with a striking "facies leontina" appearance...
October 2015: Journal of Dermatology
C Ingvorsen, S Brix, S E Ozanne, L I Hellgren
Maternal obesity during pregnancy increases the child's risk of developing obesity and obesity-related diseases later in life. Key components in foetal programming of metabolic risk remain to be identified; however, chronic low-grade inflammation associated with obesity might be responsible for metabolic imprinting in the offspring. We have therefore surveyed the literature to evaluate the role of maternal obesity-induced inflammation in foetal programming of obesity and related diseases. The literature on this topic is limited, so this review also includes animal models where maternal inflammation is mimicked by single injections with lipopolysaccharide (LPS)...
August 2015: Acta Physiologica
David A Walsh, Paul I Mapp, Sara Kelly
Arthritis is the commonest cause of disabling chronic pain, and both osteoarthritis (OA) and rheumatoid arthritis (RA) remain major burdens on both individuals and society. Peripheral release of calcitonin gene-related peptide (CGRP) contributes to the vasodilation of acute neurogenic inflammation. Contributions of CGRP to the pain and inflammation of chronic arthritis, however, are only recently being elucidated. Animal models of arthritis are revealing the molecular and pathophysiological events that accompany and lead to progression of both arthritis and pain...
November 2015: British Journal of Clinical Pharmacology
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