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5 Hydroxy Tryptophan

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https://www.readbyqxmd.com/read/28628213/changes-in-kynurenine-pathway-metabolism-in-parkinson-patients-with-l-dopa-induced-dyskinesia
#1
Jesper F Havelund, Andreas D Andersen, Michael Binzer, Morten Blaabjerg, Niels H H Heegaard, Egon Stenager, Nils J Faergeman, Jan Bert Gramsbergen
L-DOPA is the most effective drug in the symptomatic treatment of Parkinson's disease, but chronic use is associated with L-DOPA-induced dyskinesia in more than half the patients after 10 years of treatment. L-DOPA treatment may affect tryptophan metabolism via the kynurenine pathway. Altered levels of kynurenine metabolites can affect glutamatergic transmission and may play a role in the development of L-DOPA-induced dyskinesia. In this study we assessed kynurenine metabolites in plasma and cerebrospinal fluid of Parkinson's disease patients and controls...
June 19, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28585544/serotonin-modulates-a-depression-like-state-in-drosophila-responsive-to-lithium-treatment
#2
Ariane-Saskia Ries, Tim Hermanns, Burkhard Poeck, Roland Strauss
Major depressive disorder (MDD) affects millions of patients; however, the pathophysiology is poorly understood. Rodent models have been developed using chronic mild stress or unavoidable punishment (learned helplessness) to induce features of depression, like general inactivity and anhedonia. Here we report a three-day vibration-stress protocol for Drosophila that reduces voluntary behavioural activity. As in many MDD patients, lithium-chloride treatment can suppress this depression-like state in flies. The behavioural changes correlate with reduced serotonin (5-HT) release at the mushroom body (MB) and can be relieved by feeding the antidepressant 5-hydroxy-L-tryptophan or sucrose, which results in elevated 5-HT levels in the brain...
June 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28566493/urinary-amine-sampling-for-tumour-detection-revisiting-the-recommendations
#3
Jean-Benoit Corcuff, Laurence Chardon, Ines El Hajji Ridah, Julie Brossaud
Context Biogenic amines such as 5-hydroxy-indole acetic acid (5HIAA), the main metabolite of serotonin or metanephrines, catecholamines metabolites, are used as biomarkers of neuroendocrine tumours Objective To re-evaluate the recommendations for urinary sampling (preservatives, diet, drugs, …) as many of the reported analytical interferences supporting these recommendations are related to obsolete assays. Methods Bibliographic analysis of old and modern amine assays concerning preservation, extraction, assay and interferences...
May 31, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28434742/endocrine-and-metabolic-changes-in-transition-dairy-cows-are-affected-by-prepartum-infusions-of-a-serotonin-precursor
#4
Lorenzo E Hernández-Castellano, Laura L Hernandez, Helga Sauerwein, Rupert M Bruckmaier
Serotonin (5-HT) has been shown to be involved in calcium homeostasis, modulating calcium concentration in blood. In addition, 5-HT participates in a variety of metabolic pathways, mainly through the modulation of glucose and lipid metabolism. The hypothesis of the present study was that the prepartum administration of 5-hydroxy-l-tryptophan (5-HTP), a 5-HT precursor, would affect endocrine systems related to calcium homeostasis, and interact with other endocrine and metabolic pathways during the transition period...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28302759/preclinical-evaluation-of-11-c-sarcosine-as-a-substrate-of-proton-coupled-amino-acid-transporters-and-first-human-application-in-prostate-cancer
#5
Morand Piert, Xia Shao, David M Raffel, Mathew S Davenport, Jeffrey Montgomery, Lakshmi Kunju, Brian G Hockley, Javed Siddiqui, Peter J H Scott, Arul Chinnaiyan, Thekkelnaycke Rajandiran
Sarcosine is a known substrate of proton-coupled amino acid transporters (PAT), which are overexpressed in selected tissues and solid tumors. Sarcosine, an N-methyl derivative of the amino acid glycine and a metabolic product of choline, plays an important role for prostate cancer aggressiveness and progression. Methods: Carbon-11 radiolabeled sarcosine ((11)C-sarcosine) was tested as a new positron emission tomography (PET) imaging probe in comparison with (11)C-choline in two prostate cancer tumor xenograft models (DU-145 and PC-3)...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28294371/icariin-improves-the-sexual-function-of-male-mice-through-the-pi3k-akt-enos-no-signalling-pathway
#6
J Ding, Y Tang, Z Tang, X Zu, L Qi, X Zhang, G Wang
We aimed to investigate the effect and mechanism of icariin on male sexual function. Forty-eight Crl:CD1(ICR) male mice were randomly divided into control, low-, medium- and high-dose icariin group (intragastric administration of 50, 100 and 200 mg/kg/d for 21 days). Mating experiment was then performed at a ratio of 1: 3 (male: female). The mating behaviours of male mice were recorded. The genital indexes and serum testosterone, nitric oxide (NO), hypothalamic dopamine (DA) and 5- hydroxy tryptophan (5-HT) concentrations were measured...
March 15, 2017: Andrologia
https://www.readbyqxmd.com/read/28246291/-11-c-5-hydroxy-tryptophan-pet-for-assessment-of-islet-mass-during-progression-of-type-2-diabetes
#7
Lina Carlbom, Daniel Espes, Mark Lubberink, Mats Martinell, Lars Johansson, Håkan Ahlström, Per-Ola Carlsson, Olle Korsgren, Olof Eriksson
[(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP) PET of the pancreas has been shown to be a surrogate imaging biomarker of pancreatic islet mass. The change in islet mass in different stages of type 2 diabetes (T2D) as measured by non-invasive imaging is currently unknown. Here, we describe a cross-sectional study where subjects at different stages of T2D development with expected stratification of pancreatic islet mass were examined in relation to non-diabetic individuals. The primary outcome was the [(11)C]5-HTP uptake and retention in pancreas, as a surrogate marker for the endogenous islet mass...
February 28, 2017: Diabetes
https://www.readbyqxmd.com/read/27988124/increased-serum-serotonin-improves-parturient-calcium-homeostasis-in-dairy-cows
#8
Lorenzo E Hernández-Castellano, Laura L Hernandez, Samantha Weaver, Rupert M Bruckmaier
Hypocalcemia in dairy cows is caused by the sudden increase in calcium demand by the mammary gland for milk production at the onset of lactation. Serotonin (5-HT) is a key factor for calcium homeostasis, modulating calcium concentration in blood. Therefore, it is hypothesized that administration of 5-hydroxy-l-tryptophan (5-HTP), a 5-HT precursor, can increase 5-HT concentrations in blood and, in turn, induce an increase in blood calcium concentration. In this study, 20 Holstein dairy cows were randomly assigned to 2 experimental groups...
February 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27913850/two-novel-cyclic-hexapeptides-from-the-genetically-engineered-actinosynnema-pretiosum
#9
Chunhua Lu, Fei Xie, Chuan Shan, Yuemao Shen
Two novel cyclic hexapeptides designated actinosynneptides A (1) and B (2), together with three tryptophan containing diketopiperazines, namely cyclo(L-Trp-L-Trp) (3), cyclo(L-Trp-N-MeL-Trp) (4), and cyclo(N-MeL-Trp-N-MeL-Trp) (5), were isolated from the culture of the genetically engineered strain HGF052::asm18 derived from Actinosynnema pretiosum ATCC31565. Their structures were elucidated on the basis of spectroscopic analyses and single-crystal X-ray diffractions. Compound 1 is the first example of 3-amino-6-hydroxy-2-piperidone-containing cyclic peptides, and 1 and 2 showed moderate cytotoxic activities against HeLa and PC3 cell lines...
March 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27805190/a-study-of-dna-bsa-interaction-and-catalytic-potential-of-oxidovanadium-v-complexes-with-ono-donor-ligands
#10
Subhashree P Dash, Alok K Panda, Sarita Dhaka, Sagarika Pasayat, Ashis Biswas, Mannar R Maurya, Paresh Kumar Majhi, Aurélien Crochet, Rupam Dinda
The study of DNA/BSA interaction and the catalytic potential of four mononuclear oxidoalkoxido vanadium(v) [V(V)O(L(1-4))OEt] (1-4) and one dinuclear oxidoalkoxido mixed-ligand vanadium(v) [{VO(L(2))OEt}2(Q)]{Q = 4,4'-bipyridine}(5) complexes, with tridentate binegative aroylazine ligands are reported [where H2L(1) = anthranylhydrazone of 2-hydroxy-1-napthaldehyde, H2L(2) = salicylhydrazone of 2-hydroxy-1-napthaldehyde, H2L(3) = benzoylhydrazone of 2-hydroxy-1-acetonaphthone, H2L(4) = anthranylhydrazone of 2-hydroxy-1-acetonaphthone]...
November 2, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27701875/possible-role-of-aprepitant-for-intractable-nausea-and-vomiting-following-whole-brain-radiotherapy-a-case-report
#11
Deepti Ahuja, Sachidanand J Bharati, Nishkarsh Gupta, Ritesh Kumar, Sushma Bhatnagar
Radiation-induced nausea and vomiting (RINV) is one of the most distressing symptoms that adversely affects quality of life (QOL) as well as the ongoing management plan of cancer patients. Although there are protocols for management of chemotherapy induced nausea and vomiting (CINV) but such guidelines are still lacking for RINV. Various agents like 5-hydroxy tryptophan 3 (5-HT3) antagonist, dexamethasone, metoclopramide and haloperidol are used in clinical practice for RINV but the results are not very encouraging...
October 2016: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/27623092/kynurenine-pathway-metabolism-following-prenatal-kmo-inhibition-and-in-mecp2-mice-using-liquid-chromatography-tandem-mass-spectrometry
#12
Caroline M Forrest, Peter G E Kennedy, Jean Rodgers, R Neil Dalton, Charles Turner, L Gail Darlington, Stuart R Cobb, Trevor W Stone
To quantify the full range of tryptophan metabolites along the kynurenine pathway, a liquid chromatography - tandem mass spectrometry method was developed and used to analyse brain extracts of rodents treated with the kynurenine-3-mono-oxygenase (KMO) inhibitor Ro61-8048 during pregnancy. There were significant increases in the levels of kynurenine, kynurenic acid, anthranilic acid and 3-hydroxy-kynurenine (3-HK) in the maternal brain after 5 h but not 24 h, while the embryos exhibited high levels of kynurenine, kynurenic acid and anthranilic acid after 5 h which were maintained at 24 h post-treatment...
September 10, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27619930/kynurenine-pathway-and-white-matter-microstructure-in-bipolar-disorder
#13
Sara Poletti, Aye Mu Myint, Gregor Schüetze, Irene Bollettini, Elena Mazza, Doris Grillitsch, Clara Locatelli, Markus Schwarz, Cristina Colombo, Francesco Benedetti
Decreased availability of serotonin in the central nervous system has been suggested to be a central factor in the pathogenesis of depression. Activation of indoleamine 2-3 dioxygenase following a pro-inflammatory state could reduce the amount of tryptophan converted to serotonin and increase the production of tryptophan catabolites such as kynurenic acid, an antagonist of ionotropic excitatory aminoacid receptors, whose levels are reduced in bipolar disorder. Abnormalities in white matter (WM) integrity have been widely reported in BD...
September 12, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/27514255/-changes-in-levels-of-human-nutritious-metabolites-after-exposure-to-abnormal-acceleration-of-sea-state
#14
RANDOMIZED CONTROLLED TRIAL
F F Mo, X Wang, X L Wang, H W Zhang, M Li
OBJECTIVE: To investigate the changes in the levels of human blood nutritious metabolites and its major regulating factors after exposure to abnormal acceleration of sea state, and to provide clues for further investigating the mechanism of fatigue due to maritime operations. METHODS: Using randomly sampling method, 60 healthy male adults from one troop were selected as the subjects on April 20, 2010. All subjects were exposed to six degrees of freedom motion simulator ship for 15 min...
April 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27473286/altered-tryptophan-metabolism-in-human-meningioma
#15
Noble Kumar Talari, Manas Panigrahi, Sailaja Madigubba, Sundaram Challa, Prakash Babu Phanithi
Meningiomas are the neoplasms that arise from the arachnoid cells of the meninges. It was reported that cancer cells escape from immune system through the metabolism of an aromatic essential amino acid tryptophan (TRP) via Kynurenine (KYN) pathway. However, the role of TRP metabolites such as, 5-Hydroxy tryptophan (5-HTP), 5-Hydroxy tryptamine (5-HT), N-acetyl serotonin (NAS), Melatonin (MEL), KYN, N-acetyl tryptamine, 5-Hydroxy indole acetic acid (5-HIAA) and 5-Methoxy indole acetic acid is not yet evaluated in human meningioma...
July 29, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27358029/tryptophan-and-kynurenines-continuing-to-court-controversy
#16
Trevor W Stone
The role of the amino acid tryptophan in the generation of 5-hydroxy-tryptamine (5-HT) has been expanded over the past 30 years with recognition that its oxidation by indoleamine-2,3-dioxygenase (IDO) results in the formation of kynurenine and metabolites which regulate neuronal excitability, psychiatric status, immune cell activity and balance, and probably implantation and the development of embryos. While the amount of work on this kynurenine pathway continues to accelerate, it is important that disagreements about results, differences of interpretation or problems with technical issues are presented openly and discussed thoroughly so that new research is not mis-led in ways that could have been foreseen...
August 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27325286/positron-emission-tomography-to-assess-the-outcome-of-intraportal-islet-transplantation
#17
Olof Eriksson, Ramkumar Selvaraju, Torsten Eich, Mariam Willny, Torkel B Brismar, Lina Carlbom, Håkan Ahlström, Gunnar Tufvesson, Torbjörn Lundgren, Olle Korsgren
No imaging methodology currently exists to monitor viable islet mass after clinical intraportal islet transplantation. We investigated the potential of the endocrine positron emission tomography (PET) marker [(11)C]5-hydroxytryptophan ([(11)C]5-HTP) for this purpose. In a preclinical proof-of-concept study, the ex vivo and in vivo [(11)C]5-HTP signal was compared with the number of islets transplanted in rats. In a clinical study, human subjects with an intraportal islet graft (n = 8) underwent two [(11)C]5-HTP PET and MRI examinations 8 months apart...
September 2016: Diabetes
https://www.readbyqxmd.com/read/27228162/is-fluorescence-valid-to-monitor-removal-of-protein-bound-uremic-solutes-in-dialysis
#18
Jürgen Arund, Merike Luman, Fredrik Uhlin, Risto Tanner, Ivo Fridolin
The aim of this study was to evaluate the contribution and removal dynamics of the main fluorophores during dialysis by analyzing the spent dialysate samples to prove the hypothesis whether the fluorescence of spent dialysate can be utilized for monitoring removal of any of the protein bound uremic solute. A high performance liquid chromatography system was used to separate and quantify fluorophoric solutes in the spent dialysate sampled at the start and the end of 99 dialysis sessions, including 57 hemodialysis and 42 hemodiafiltration treatments...
2016: PloS One
https://www.readbyqxmd.com/read/27203729/serotonin-containing-neurons-in-basal-insects-in-search-of-ground-patterns-among-tetraconata
#19
Torben Stemme, Michael Stern, Gerd Bicker
The ventral nerve cord of Tetraconata contains a comparably low number of serotonin-immunoreactive neurons, facilitating individual identification of cells and their characteristic neurite morphology. This offers the rather unique possibility of establishing homologies at single cell level. Since phylogenetic relationships within Tetraconata are still discussed controversially, comparisons of individually identifiable neurons can help to unravel these issues. Serotonin immunoreactivity has been investigated in numerous tetraconate taxa, leading to reconstructions of hypothetical ground patterns for major lineages...
May 20, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27191773/synthesis-radiolabeling-and-biological-evaluation-of-5-hydroxy-2-18-f-fluoroalkyl-tryptophan-analogues-as-potential-pet-radiotracers-for-tumor-imaging
#20
Aristeidis Chiotellis, Adrienne Müller Herde, Simon L Rössler, Ante Brekalo, Erika Gedeonova, Linjing Mu, Claudia Keller, Roger Schibli, Stefanie D Krämer, Simon M Ametamey
Aiming at developing mechanism-based amino acid (18)F-PET tracers for tumor imaging, we synthesized two (18)F-labeled analogues of 5-hydroxy-l-[β-(11)C]tryptophan ([(11)C]5HTP) whose excellent in vivo performance in neuroendocrine tumors is mainly attributed to its decarboxylation by aromatic amino acid decarboxylase (AADC), an enzyme overexpressed in these malignancies. Reference compounds and precursors were synthesized following multistep synthetic approaches. Radiosynthesis of tracers was accomplished in good radiochemical yields (15-39%), high specific activities (45-95 GBq/μmol), and excellent radiochemical purities...
June 9, 2016: Journal of Medicinal Chemistry
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