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Lutien Bakker, Peter F Kemper, Cordula Wagner, Gepke O Delwel, Martine C de Bruijne
Background: Polypharmacy is common in the elderly population and is associated with an increased risk of adverse drug events. To diminish this risk, the guideline 'Polypharmacy in the Elderly' has been developed in 2012. This study examines, to what extent Dutch pharmacotherapeutic practice amongst elderly with polypharmacy mirrors the best practice described in this guideline and which barriers threaten it. Methods: An observational study was conducted in 2013/14 using a questionnaire distributed amongst Dutch healthcare professionals and elderly patients with polypharmacy...
August 1, 2017: European Journal of Public Health
C R Ralph, M N Lehman, R L Goodman, A J Tilbrook
This review focuses on the importance of cortisol in mediating the inhibitory effects of psychosocial stress on reproduction in females. In particular, we have summarized our research in sheep where we have systematically established whether cortisol is both sufficient and necessary to suppress reproductive hormone secretion and inhibit sexual behaviour. Our findings are put into context with previous work and are used to develop important concepts as well as to identify productive further lines of investigation...
July 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
Young-Min Goo, Eun-Heui Han, Jae Cheol Jeong, Sang-Soo Kwak, Jaeju Yu, Yun-Hee Kim, Mi-Jeong Ahn, Shin-Woo Lee
In a previous study, we have evidenced that the overexpression of the IbOr gene isolated from sweet potato conferred a tolerance activity against salinity and methyl viologen (MV) treatment in transgenic sweet potato calli along with an enhanced carotenoid content. In this study, to further examine the function of the IbOr gene in heterologous organism, we transformed the IbOr gene into potato under the direction of SWPA2 promoter, a strong inducible promoter upon treatment with various environmental stresses...
January 2015: Comptes Rendus Biologies
Edakkadath R Sindhu, Ramadasan Kuttan
Cisplatin is one of the most potent anticancer drugs available for the treatment of a variety of tumors. One of the side effects of this drug is nephrotoxicity. Current research evidence indicates that the renal toxicity is mainly due to the reactive oxygen molecules generated by cisplatin. In the present study, we evaluated the nephroprotective activity of lutein, a non-toxic carotenoid with strong antioxidant activity, to reduce cisplatin-induced renal damage in mice. Serum urea and creatinine levels in the cisplatin-induced mice were significantly elevated compared to those of the control group, and nephrotoxicity was reduced by the lutein treatments (P<0...
2013: Journal of Environmental Pathology, Toxicology and Oncology
Lutien Bakker, Wim H Van Brakel
INTRODUCTION: Many initiatives are undertaken to improve the empowerment of people with disabilities in developing countries. However, an overview of adequate measurement tools to evaluate such activities is not available to date. This systematic literature review aims to describe and assess the available tools to measure empowerment in people with disability, suitable for use in developing countries. METHODS: A systematic literature review was conducted. Articles were eligible when they described the development, validation, translation or the use of an instrument measuring empowerment in the context of disability...
June 2012: Leprosy Review
Paula Lutiene de Castro e Borges, Rose Procópio Bretas, Silvana Fernandes de Azevedo, Juliana Magalhães Machado Barbosa
This study focused on elderly members of community groups, specifically their physical, social, psychological, and economic conditions. A descriptive cross-sectional study included 197 individuals, using the modified Brazilian Old Age Schedule, with questions on physical health, medical services, activities of daily living, social and economic resources, and mental health. The majority of participants were women, widows, and had primary schooling; mean age was 71.66 +/- 6.8 years; 51.27% considered their health good; 85...
December 2008: Cadernos de Saúde Pública
Tapnarong Jarupanich, Surachai Lamlertkittikul, Verapol Chandeying
OBJECTIVES: To evaluate the efficacy, safety and acceptability of a seven-day, transdermal estradiol patch, in the treatment of menopausal symptoms. DESIGN: Open-label trial. SETTING: Hat Yai Regional Hospital, Thailand. SUBJECTS: Hysterectomized women with surgical or natural menopause. METHOD: The clients received a 12.5 cm2 matrix patch, containing 3.9 mg of estradiol delivering 0.05 mg/day, once a week for six months...
September 2003: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
K E Elkind-Hirsch, E Wallace, L R Malinak, J J Jerger
In an effort to characterize more completely the influence of sex hormones on auditory brainstem response (ABR) latency, we evaluated the ABRs of normal male and female subjects and women with previously diagnosed endocrinologic syndromes. We describe ABR latency results from the following subjects: five normal males, nine normally cycling females on no hormonal therapy, nine females using oral contraceptive pills, five females with premature ovarian failure (POF) undergoing cyclic estrogen-progesterone replacement therapy, and five hyperandrogenized females with polycystic ovarian disease (PCOD) treated with the gonadotropin-releasing hormone agonist, Lupron depot, to suppress ovarian steroid production...
January 1994: Otolaryngology—Head and Neck Surgery
T Hillensjö, L Hamberger, K Ahrén
In order to study substrate dependent respiration oocytes were isolated from antrum follicles obtained from ovaries of prepubertal rats. The oocytes used were either surrounded by 1 to 3 layers of granulosa cells (oocyte + corona radiata), or mechanically denuded from surrounding cells (denuded oocytes). By use of Cartesian micro-diver technique the respiratory rate could be determined in single oocyte + corona radiata cell complexes or in samples of a few denuded oocytes. The oocytes were incubated either in an isotonic Tris-HCL buffer or in a hypotonic phosphate buffer...
April 1975: Acta Endocrinologica
A Lemay, F Labrie, L Ferland, J P Raynaud
The administration of five subcutaneous 250-microgram doses of lutienizing hormone (LH)-releasing hormone (LHRH) at 4-hour intervals, the first injection being given at 8 A.M. on 1 or 2 consecutive days between days 1 and 9 following the LH surge in normal women, shortened the luteal phase from 1 to 4 days in 16 of 17 treatment cycles. There was a better efficiency of treatment when LHRH was administered on days 6 to 9 after the LH surge as compared with days 1 to 5. In fact, the luteal phase was shortened from 3...
January 1979: Fertility and Sterility
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