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https://www.readbyqxmd.com/read/29467880/the-role-of-immune-cell-subpopulations-in-the-growth-and-rejection-of-tc-1-a9-tumors-in-novel-mouse-strains-differing-in-the-h2-d-haplotype-and-nkc-domain
#1
Marie Indrová, Joanna Rossowska, Elzbieta Pajtasz-Piasecka, Romana Mikyšková, Jan Richter, Jozef Rosina, Radislav Sedlacek, Anna Fišerová
The present study aimed to elucidate the role of cluster of differentiation (CD)8+, CD4+, natural killer (NK), and myeloid (CD11b+) cells in the course of the growth and rejection of experimental major histocompatibility complex (MHC) class I-deficient, HPV16 E6/E7-associated TC-1/A9 tumors in mice. Stable mouse lines (F30 ) generated by inbreeding of Balb/c and C57BL/6 strains, which were characterized by H-2Db+d-NK1.1neg (B6-neg) and H-2Db-d+NK1.1high (Balb-high) phenotypes, were used for the present study...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467379/fluvirucin-b6-a-new-macrolactam-isolated-from-a-marine-derived-actinomycete-of-the-genus-nocardiopsis
#2
Alain S Leutou, Inho Yang, Tu Cam Le, Dongyup Hahn, Kyung-Min Lim, Sang-Jip Nam, William Fenical
A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.
February 21, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29466404/antioxidant-genes-of-plants-and-fungal-pathogens-are-distinctly-regulated-during-disease-development-in-different-rhizoctonia-solani-pathosystems
#3
Jamil Samsatly, Tanya R Copley, Suha H Jabaji
Biotic stress, as a result of plant-pathogen interactions, induces the accumulation of reactive oxygen species in the cells, causing severe oxidative damage to plants and pathogens. To overcome this damage, both the host and pathogen have developed antioxidant systems to quench excess ROS and keep ROS production and scavenging systems under control. Data on ROS-scavenging systems in the necrotrophic plant pathogen Rhizoctonia solani are just emerging. We formerly identified vitamin B6 biosynthetic machinery of R...
2018: PloS One
https://www.readbyqxmd.com/read/29465562/subacute-onset-leukodystrophy-and-visual-spatial-disorders-revealing-phenylketonuria-combined-with-homocysteinmia-in-adulthood-a-case-report
#4
Chunchen Wang, Jieying Li
RATIONALE: Phenylketonuria (PKU) is a metabolic disorder, which manifests a progressive irreversible neurological impairment during infancy and childhood. Hyperhomocysteinemia also showed that it might be involved in pathophysiology of many neuropsychiatric disorders. The late-onset clinical manifestations of these 2 diseases have not been reported elsewhere. We speculated that the late-onset PKU is caused by 2 kinds of metabolic dysfunction synergistically, especially a short period of irregular diet directly caused clinical symptoms...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465227/synthesis-and-applications-of-perfunctionalized-boron-clusters
#5
Jonathan C Axtell, Liban M A Saleh, Elaine A Qian, Alex I Wixtrom, Alexander M Spokoyny
This Viewpoint describes major advances pertaining to perfunctionalized boron clusters in synthesis and their respective applications. The first portion of this work highlights key synthetic methods, allowing one to access a wide range of polyhedral boranes (B4 and B6 -B12 cluster cores) that contain exhaustively functionalized vertices. The second portion of this Viewpoint showcases the historical developments in using these molecules for applications ranging from materials science to medicine. Last, we suggest potential new directions for these clusters as they apply to both synthetic methods and applications...
February 21, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29464564/the-cytochrome-b-6-f-complex-biophysical-aspects-of-its-functioning-in-chloroplasts
#6
Alexander N Tikhonov
This chapter presents an overview of structural properties of the cytochrome (Cyt) b6 f complex and its functioning in chloroplasts. The Cyt b6 f complex stands at the crossroad of photosynthetic electron transport pathways, providing connectivity between Photosystem (PSI) and Photosysten II (PSII) and pumping protons across the membrane into the thylakoid lumen. After a brief review of the chloroplast electron transport chain, the consideration is focused on the structural organization of the Cyt b6 f complex and its interaction with plastoquinol (PQH2 , reduced form of plastoquinone), a mediator of electron transfer from PSII to the Cyt b6 f complex...
2018: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/29464563/organization-of-plant-photosystem-ii-and-photosystem-i-supercomplexes
#7
Roman Kouřil, Lukáš Nosek, Dmitry Semchonok, Egbert J Boekema, Petr Ilík
In nature, plants are continuously exposed to varying environmental conditions. They have developed a wide range of adaptive mechanisms, which ensure their survival and maintenance of stable photosynthetic performance. Photosynthesis is delicately regulated at the level of the thylakoid membrane of chloroplasts and the regulatory mechanisms include a reversible formation of a large variety of specific protein-protein complexes, supercomplexes or even larger assemblies known as megacomplexes. Revealing their structures is crucial for better understanding of their function and relevance in photosynthesis...
2018: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/29463319/performance-of-arma-chinensis-reared-on-an-artificial-diet-formulated-using-transcriptomic-methods
#8
D Y Zou, T A Coudron, L S Zhang, X S Gu, W H Xu, X L Liu, H H Wu
An artificial diet formulated for continuous rearing of the predator Arma chinensis was inferior to natural prey when evaluated using life history parameters. A transcriptome analysis identified differentially expressed genes in diet-fed and prey-fed A. chinensis that were suggestive of molecular mechanisms underlying the nutritive impact of the artificial diet. Changes in the diet formulation were made based on the transcriptome analysis and tested using life history parameters. The quantity of pig liver, chicken egg, tuna fish, biotin, nicotinamide, vitamin B6, thiamine, riboflavin, vitamin C, L-glutamine, and sucrose was reduced, and wheat germ oil, calcium pantothenate and folic acid were increased...
February 21, 2018: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/29460790/protein-and-micronutrient-deficiencies-in-patients-with-radiation-cystitis-and-outcome-after-hyperbaric-oxygen-therapy
#9
Valérie Platzer, Guillaume Perez, Anne Galinier, Michèle Genestal, Béatrice Riu-Poulenc, Leslie Gonzalez, Eric Huyghe, Sylvie Caspar-Bauguil
BACKGROUND & AIMS: Haemorrhagic radiation cystitis (HRC) is a late complication of pelvic radiotherapy. Severe cases are difficult to treat due to persistent or recurrent bleeding, despite urological and hyperbaric oxygen therapy (HBOT). However, wound healing requires a good nutritional status. In this respect, we aimed at analysing the nutritional status of patients with HRC prior to the onset of HBOT and at highlighting predictive nutritional factors of outcome. METHODS: Data were retrospectively collected from a cohort of 179 patients with HRC (between 2011 and 2015)...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29456899/facial-weakness-diplopia-and-fever-in-a-31-year-old-an-atypical-case-of-tuberculous-meningitis
#10
Ahmed H Qavi, Tasnim F Imran, Zachariah Hasan, Fariha Ilyas
Tuberculous meningitis (TBM) is an infection of the central nervous system (CNS) meninges that carries high morbidity and mortality. It is important to recognize, as patients may present with atypical symptoms. We describe the case of a 31-year-old man with a history of diabetes who presented with a sub-acute onset of right-sided facial weakness and right gaze difficulty with diplopia. History revealed low-grade fever, right-sided headache, fatigue and moderate weight loss for the past several weeks. The patient did not report neck stiffness, rigidity, fever, chills or cough...
December 7, 2017: Curēus
https://www.readbyqxmd.com/read/29456655/effect-of-immune-tolerance-induced-by-immature-dendritic-cells-and-ctla4-ig-on-systemic-lupus-erythematosus-an-in-vivo-study
#11
Cuili Huang, Lidan Zhang, Fang Ling, Sijian Wen, Yanyan Luo, Hui Liu, Jingping Liu, Wenjun Zheng, Ming Liang, Jian Sun, You-Kun Lin
Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease in which tissue damage is caused by autoantibodies. The induction of specific immune tolerance, including the utilization of immune regulatory cells, may enhance the therapeutic effects of organ transplantation in patients with SLE. Furthermore, inhibiting immune responses has been reported to be an effective treatment for SLE. However, few studies have explored the association between an increased immune tolerance and a decreased immune response in SLE treatment...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29447430/aucubin-protects-against-pressure-overload-induced-cardiac-remodelling-via-%C3%AE-3-ar-nnos-cascades
#12
Qing-Qing Wu, Yang- Xiao, Ming-Xia Duan, Yuan Yuan, Xiao-Han Jiang, Zheng Yang, Hai-Han Liao, Wei Deng, Qi-Zhu Tang
BACKGROUND AND PURPOSE: Aucubin, the predominant component of Eucommia ulmoides Oliv., plays an indispensable role in regulating oxidative stress. Considering that oxidative stress has previously been demonstrated to contribute to acute and chronic myocardial injury, we tested the effects of aucubin on cardiac remodelling and heart failure. EXPERIMENTAL APPROACH: In the first set of experiments, H9c2 cardiomyocytes and neonatal rat cardiomyocytes pre-treated with aucubin (1, 3 10, 25, 50 μM) were challenged with phenylephrine...
February 15, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29446079/dietary-intake-of-nutrients-involved-in-one-carbon-metabolism-and-risk-of-urothelial-cell-carcinoma-a-prospective-cohort-study
#13
Pierre-Antoine Dugué, Maree T Brinkman, Allison M Hodge, Julie K Bassett, Damien Bolton, Anthony Longano, John L Hopper, Melissa C Southey, Dallas R English, Roger L Milne, Graham G Giles
Nutrients involved in one-carbon metabolism may play a role in carcinogenesis through DNA replication, repair and methylation mechanisms. Most studies on urothelial cell carcinoma (UCC) have focused on folate. We sought to examine the association between B-group vitamins and methionine intake and UCC risk, overall and by subtype, and to test whether these associations are different for population subgroups whose nutritional status may be compromised. We followed participants in the Melbourne Collaborative Cohort Study (N=41,513) for over 20 years, and observed 500 UCC cases (89% originating in the bladder; superficial: 279, invasive: 221)...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29445184/parental-micronutrient-deficiency-distorts-liver-dna-methylation-and-expression-of-lipid-genes-associated-with-a-fatty-liver-like-phenotype-in-offspring
#14
Kaja H Skjærven, Lars Martin Jakt, Jorge M O Fernandes, John Arne Dahl, Anne-Catrin Adam, Johanna Klughammer, Christoph Bock, Marit Espe
Micronutrient status of parents can affect long term health of their progeny. Around 2 billion humans are affected by chronic micronutrient deficiency. In this study we use zebrafish as a model system to examine morphological, molecular and epigenetic changes in mature offspring of parents that experienced a one-carbon (1-C) micronutrient deficiency. Zebrafish were fed a diet sufficient, or marginally deficient in 1-C nutrients (folate, vitamin B12, vitamin B6, methionine, choline), and then mated. Offspring livers underwent histological examination, RNA sequencing and genome-wide DNA methylation analysis...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445107/progesterone-receptor-membrane-component-1-suppresses-the-p53-and-wnt-%C3%AE-catenin-pathways-to-promote-human-pluripotent-stem-cell-self-renewal
#15
Ji Yea Kim, So Young Kim, Hong Seo Choi, Min Kyu Kim, Hyun Min Lee, Young-Joo Jang, Chun Jeih Ryu
Progesterone receptor membrane component 1 (PGRMC1) is a multifunctional heme-binding protein involved in various diseases, including cancers and Alzheimer's disease. Previously, we generated two monoclonal antibodies (MAbs) 108-B6 and 4A68 against surface molecules on human pluripotent stem cells (hPSCs). Here we show that PGRMC1 is the target antigen of both MAbs, and is predominantly expressed on hPSCs and some cancer cells. PGRMC1 is rapidly downregulated during early differentiation of hPSCs. Although PGRMC1 knockdown leads to a spread-out morphology and impaired self-renewal in hPSCs, PGRMC1 knockdown hPSCs do not show apoptosis and autophagy...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444716/prevalence-of-inadequate-micronutrient-intakes-of-canadian-long-term-care-residents
#16
Heather H Keller, Christina Lengyel, Natalie Carrier, Susan E Slaughter, Jill Morrison, Alison M Duncan, Catriona M Steele, Lisa Duizer, K Stephen Brown, Habib Chaudhury, Minn N Yoon, Veronique Boscart, George Heckman, Lita Villalon
This study determines the prevalence of inadequate micronutrient intakes consumed by long-term care (LTC) residents. This cross-sectional study was completed in thirty-two LTC homes in four Canadian provinces. Weighed and estimated food and beverage intake were collected over 3 non-consecutive days from 632 randomly selected residents. Nutrient intakes were adjusted for intra-individual variation and compared with the Dietary Reference Intakes. Proportion of participants, stratified by sex and use of modified (MTF) or regular texture foods, with intakes below the Estimated Average Requirement (EAR) or Adequate Intake (AI), were identified...
February 15, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29434784/effects-of-intratumoral-injection-of-immunoactivator-after-microwave-ablation-on-antitumor-immunity-in-a-mouse-model-of-hepatocellular-carcinoma
#17
Hao Wu, Bin Chen, Baogang Peng
This study investigated the effects of intratumoral injection of immunoactivator after microwave ablation on antitumor immunity in a mouse model of hepatocellular carcinoma. Hepatocellular carcinoma cell line Hepa1-6 was subcutaneously injected into C57/B6 mice to establish a mouse model of hepatocellular carcinoma. When tumor diameter reached 8 mm, microwave ablation was performed for 3 min with temperature controlled at 55°C. Cytokine sustained-release microspheres (CytoMPS) containing human interleukin-2 (hIL-2) and mouse granulocyte macrophage colony-stimulating factor (mGM-CSF) were injected into the tumor of mice in the experimental group (n=5) at 3, 7 and 14 days after ablation, while sustained-release microspheres containing no cytokine were used in the control group (n=5)...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434602/identification-of-a-novel-cd8-t-cell-epitope-derived-from-plasmodium-berghei-protective-liver-stage-antigen
#18
Alexander Pichugin, Stasya Zarling, Leah Perazzo, Patrick Emmet Duffy, Hidde Lolke Ploegh, Urszula Krzych
We recently identified novel Plasmodium berghei (Pb) liver stage (LS) genes that as DNA vaccines significantly reduce Pb LS parasite burden (LPB) in C57Bl/6 (B6) mice through a mechanism mediated, in part, by CD8 T cells. In this study, we sought to determine fine antigen (Ag) specificities of CD8 T cells that target LS malaria parasites. Guided by algorithms for predicting MHC class I-restricted epitopes, we ranked sequences of 32 Pb LS Ags and selected ~400 peptides restricted by mouse H-2Kb and H-2Db alleles for analysis in the high-throughput method of caged MHC class I-tetramer technology...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29433806/non-vmat2-inhibitor-treatments-for-the-treatment-of-tardive-dyskinesia
#19
REVIEW
Chih-Chun Lin, William G Ondo
Although VMAT2-inhibitors are now established as first-line treatment for tardive dyskinesia, not all patients respond to, or tolerate them. Numerous other agents have been adopted to treat tardive dyskinesia, but with variable results and generally lower quality methodologic reports. Amantadine is the most promising but benzodiazepines, branched chain neutral amino acids, Vitamin B6, several nutraceuticals, and botulinum toxin injections might help some patients. In all cases, better placebo controlled trials are needed before definitive recommendations can be made...
February 5, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29429180/-the-experimental-study-on-endoplasmic-reticulum-stress-participated-outer-hair-cell-apoptosis-in-cadherin-23-gene-mutant-mice
#20
J Hu, Z C Chen, Y Z Zhang, P Han, W J Ma, Q Zhang, M Xu
Objective: To test the mechanism and upstream pathway of outer hair cell apoptosis in Cadherin 23 (Cdh23) gene mutant mice. Method: The mutant Cdh23(erl/erl)(erl) mice were collected as the study group, while the C57BL/6J (B6) mice were chosen as the control group. A total of 70 mice per group were used in this study. The study group and control group underwent auditory-evoked brainstem response (ABR) tests at the same age. The terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay was performed to detect outer hair cell(OHC) apoptosis...
February 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
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