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https://www.readbyqxmd.com/read/29036574/differential-expression-of-hypertensive-phenotypes-in-bxd-mouse-strains-in-response-to-angiotensin-ii
#1
Wenyuan Zhao, Tieqiang Zhao, Yuanjian Chen, Syamal K Bhattacharya, Lu Lu, Yao Sun
BACKGROUND: Besides environmental risk factors, genetic factors play a crucial role in the pathogenesis of primary hypertension. The current study is to unravel whether hypertensive phenotypes vary in mice with different genetic background. METHODS: Hypertension was induced in C57BL/6J (B6), DBA/2J (D2), and 25 BXD strains by administrating angiotensin (Ang)II (2.5 mg/kg/day infused by osmotic minipump) for 4 weeks. Systolic blood pressure was monitored before (baseline) and after 4 weeks of AngII treatment by tail cuff...
September 23, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29035289/molecular-evolution-of-mers-coronavirus-dromedaries-as-a-recent-intermediate-host-or-long-time-animal-reservoir
#2
Susanna K P Lau, Antonio C P Wong, Terrence C K Lau, Patrick C Y Woo
While dromedary camels are the immediate animal source of MERS coronavirus (MERS-CoV) infection, the evolutionary origin of MERS-CoV remains obscure. We analyzed 219 camel and human MERS-CoV genome sequences available in GenBank. Phylogenetic analysis showed that 5 and 214 strains belong to clade A and B, respectively, with clade A further divided into lineage A1 (3 human strains) and lineage A2 (2 camel strains), and clade B divided into B1 to B6 (each containing both human and camel strains). Recombination analysis showed potential recombination events in five strains from dromedaries in Saudi Arabia, with recombination between lineage B5 and B3 in four strains, and between lineage B3 and B4 in one strain...
October 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29035128/prospective-study-of-plasma-homocysteine-its-dietary-determinants-and-risk-of-age-related-macular-degeneration-in-men
#3
William G Christen, Nancy R Cook, Stephanie E Chiuve, Paul M Ridker, J Michael Gaziano
PURPOSE: Cross-sectional and case-control studies generally support a direct association between elevated plasma homocysteine and age-related macular degeneration (AMD), but data from prospective studies are limited. We examined the prospective relation of plasma homocysteine level, its dietary determinants, and risk of AMD in a large cohort of apparently healthy male physicians. METHODS: During a mean follow-up of 11.2 years, we identified 146 incident cases of visually significant AMD (responsible for a reduction of visual acuity to 20/30 or worse), and 146 controls matched for age, smoking status, and time of blood draw...
October 16, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29034851/nitrosopumilus-maritimus-gen-nov-sp-nov-nitrosopumilus-cobalaminigenes-sp-nov-nitrosopumilus-oxyclinae-sp-nov-and-nitrosopumilus-ureiphilus-sp-nov-four-marine-ammonia-oxidizing-archaea-of-the-phylum-thaumarchaeota
#4
Wei Qin, Katherine R Heal, Rasika Ramdasi, Julia N Kobelt, Willm Martens-Habbena, Anthony D Bertagnolli, Shady A Amin, Christopher B Walker, Hidetoshi Urakawa, Martin Könneke, Allan H Devol, James W Moffett, E Virginia Armbrust, Grant J Jensen, Anitra E Ingalls, David A Stahl
Four mesophilic, neutrophilic, and aerobic marine ammonia-oxidizing archaea, designated strains SCM1(T), HCA1(T), HCE1(T) and PS0(T), were isolated from a tropical marine fish tank, dimly lit deep coastal waters, the lower euphotic zone of coastal waters, and near-surface sediment in the Puget Sound estuary, respectively. Cells are straight or slightly curved small rods, 0.15-0.26 µm in diameter and 0.50-1.59 µm in length. Motility was not observed, although strain PS0(T) possesses genes associated with archaeal flagella and chemotaxis, suggesting it may be motile under some conditions...
October 16, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29033988/comparing-the-effect-of-auriculotherapy-and-vitamin-b6-on-the-symptoms-of-premenstrual-syndrome-among-the-students-who-lived-in-the-dorm-of-isfahan-university-of-medical-sciences
#5
Sharareh Koleini, Mahboubeh Valiani
BACKGROUND: Premenstrual syndrome (PMS) is a series of physical and psychological symptoms before menstruation which its prevalence around the world has been reported to be 80%. Consumption of vitamin B6 is a common treatment for this syndrome, and this study was conducted to compare the effect of auriculotherapy and vitamin B6 on the symptoms of premenstrual syndrome. MATERIALS AND METHODS: This study was a clinical trial. Eighty-four female students who lived at the university dorm were randomly selected and allocated into two groups of 42...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29031499/micrornas-15a-and-16-1-activate-signaling-pathways-that-mediate-chemotaxis-of-immune-regulatory-b-cells-to-colorectal-tumors
#6
Ronghua Liu, Zhou Lu, Jie Gu, Jiajing Liu, Enyu Huang, Xiaoming Liu, Luman Wang, Jiao Yang, Yuting Deng, Jiawen Qian, Feifei Luo, Zhiming Wang, Hushan Zhang, Xuechao Jiang, Dan Zhang, Jing Qian, Guangwei Liu, Hongguang Zhu, Youcun Qian, Zhanju Liu, Yiwei Chu
BACKGROUND & AIMS: B cells infiltrate tumors but little is known about how they affect tumor growth and progression. microRNA15A (MIR15A or miRNA15A) and microRNA16-1 (MIR16-1 or miRNA16-1) regulate cell proliferation, apoptosis and drug resistance. We investigated their involvement in B cell-mediated immune suppression by colorectal tumors. METHODS: Mice with disruptions of the gene cluster that encodes MIR15A and MIR16-1 (KO mice), and control (C57BL/B6) mice were given azoxymethane with dextran sodium sulfate (AD) to induce formation of colorectal tumors...
October 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29030440/multiple-roles-of-two-efflux-pumps-in-a-polycyclic-aromatic-hydrocarbon-degrading-pseudomonas-putida-strain-b6-2-dsm-28064
#7
Xuemei Yao, Fei Tao, Kunzhi Zhang, Hongzhi Tang, Ping Xu
Microbial bioremediation is a promising approach for the removal of polycyclic aromatic hydrocarbon (PAH) contaminants. Many degraders of PAHs possess efflux pump genes in their genomes; however, their specific roles in the degradation of PAHs have not been clearly elucidated. In this study, two efflux pumps, TtgABC and SrpABC, were systematically investigated to determine their functions in a PAH-degrading Pseudomonas putida strain B6-2 (DSM 28064). The disruption of genes ttgABC or srpABC resulted in a defect in organic solvent tolerance...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29027347/a-two-step-evolutionary-process-establishes-a-non-native-vitamin-b6-pathway-in-bacillus-subtilis
#8
Jonathan Rosenberg, KahYen C Yeak, Fabian M Commichau
Pyridoxal 5'-phosphate (PLP), the most important form of vitamin B6 serves as a cofactor for many proteins. Two alternative pathways for de novo PLP biosynthesis are known: the short deoxy-xylulose-5-phosphate (DXP)-independent pathway, which is present in the Gram-positive model bacterium Bacillus subtilis and the longer DXP-dependent pathway, which has been intensively studied in the Gram-negative model bacterium Escherichia coli. Previous studies revealed that bacteria contain many promiscuous enzymes causing a so-called "underground metabolism", which can be important for the evolution of novel pathways...
October 13, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29023116/extended-concerted-rotation-technique-enhances-the-sampling-efficiency-of-computational-peptide-design-algorithm
#9
Xingqing Xiao, Yiming Wang, Joshua N Leonard, Carol K Hall
To enhance the sampling efficiency of our computational peptide-design algorithm in conformational space, the concerted rotation (CONROT) technique is extended to enable larger conformational perturbations of peptide chains. This allows us to make relatively-large peptide conformation changes during the process of designing peptide sequences to bind with high affinity to a specific target. Searches conducted using the new algorithm identified six potential λ N(2-22) peptide variants, called B1 to B6, which bind to boxB RNA with high affinity...
October 12, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28993090/possible-role-of-rivaroxaban-in-attenuating-pressure-overload-induced-atrial-fibrosis-and-fibrillation
#10
Hidekazu Kondo, Ichitaro Abe, Akira Fukui, Shotaro Saito, Miho Miyoshi, Kohei Aoki, Tetsuji Shinohara, Yasushi Teshima, Kunio Yufu, Naohiko Takahashi
BACKGROUND: Coagulation factor Xa (FXa) promotes thrombus formation and exacerbates inflammation via activation of protease-activated receptor (PAR)-2. We tested the hypothesis of whether administration of direct oral anticoagulant, rivaroxaban, would attenuate transverse aortic constriction (TAC)-induced atrial inflammatory fibrosis and vulnerability to atrial fibrillation (AF) in mice. METHODS: Ten-week-old male CL57/B6 mice were divided into a sham-operation (CNT) group and TAC-surgery group...
October 6, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28986440/genetic-control-of-lyme-arthritis-by-borrelia-burgdorferi-arthritis-associated-locus-1-is-dependent-on-localized-differential-production-of-ifn-%C3%AE-and-requires-upregulation-of-myostatin
#11
Jackie K Paquette, Ying Ma, Colleen Fisher, Jinze Li, Sang Beum Lee, James F Zachary, Yong Soo Kim, Cory Teuscher, Janis J Weis
Previously, using a forward genetic approach, we identified differential expression of type I IFN as a positional candidate for an expression quantitative trait locus underlying Borrelia burgdorferi arthritis-associated locus 1 (Bbaa1). In this study, we show that mAb blockade revealed a unique role for IFN-β in Lyme arthritis development in B6.C3-Bbaa1 mice. Genetic control of IFN-β expression was also identified in bone marrow-derived macrophages stimulated with B. burgdorferi, and it was responsible for feed-forward amplification of IFN-stimulated genes...
October 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28983799/b-vitamin-complex-and-chemotherapy-induced-peripheral-neuropathy
#12
REVIEW
Janet Schloss, Maree Colosimo
PURPOSE OF REVIEW: The purpose of this mini review is to evaluate the literature on B vitamins and chemotherapy-induced peripheral neuropathy. RECENT FINDINGS: One hundred and five journal articles were evaluated and nine manuscripts were included. There was one in vitro, one was an animal and seven were human studies. The in vitro study was a safety study on vitamin B6 and oxaliplatin which was not directly related to CIPN. The animal study evaluated vitamin B3 on paclitaxel administration with positive results...
October 5, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28983685/congenic-mice-demonstrate-the-presence-of-qtls-conferring-obesity-and-hypercholesterolemia-on-chromosome-1-in-the-tallyho-mouse
#13
Jacaline K Parkman, James Denvir, Xia Mao, Kristy D Dillon, Sofia Romero, Arnold M Saxton, Jung Han Kim
The TALLYHO (TH) mouse presents a metabolic syndrome of obesity, type 2 diabetes, and hyperlipidemia. Highly significant quantitative trait loci (QTLs) linked to adiposity and hypercholesterolemia were previously identified on chromosome (Chr) 1 in a genome-wide scan of F2 mice from C57BL/6J (B6) x TH. In this study, we generated congenic mouse strains that carry the Chr 1 QTLs derived from TH on a B6 background; B6.TH-Chr1-128Mb (128Mb in size) and B6.TH-Chr1-92Mb (92Mb in size, proximally overlapping). We characterized these congenic mice on chow and high fat (HF) diets...
October 5, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28982388/t-bet-cd11c-b-cells-are-critical-for-antichromatin-immunoglobulin-g-production-in-the-development-of-lupus
#14
Ya Liu, Shiyu Zhou, Jie Qian, Yan Wang, Xiang Yu, Dai Dai, Min Dai, Lingling Wu, Zhuojun Liao, Zhixin Xue, Jiehua Wang, Goujun Hou, Jianyang Ma, John B Harley, Yuanjia Tang, Nan Shen
BACKGROUND: A hallmark of systemic lupus erythematosus is high titers of circulating autoantibodies. Recently, a novel CD11c(+) B-cell subset has been identified that is critical for the development of autoimmunity. However, the role of CD11c(+) B cells in the development of lupus is unclear. Chronic graft-versus-host disease (cGVHD) is a lupus-like syndrome with high autoantibody production. The purpose of this study was to explore the role of CD11c(+) B cells in the pathogenesis of lupus in cGVHD mice...
October 5, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28978164/comparative-efficacy-and-safety-of-chinese-herbal-injections-combined-with-the-folfox-regimen-for-treating-gastric-cancer-in-china-a-network-meta-analysis
#15
Dan Zhang, Jiewen Zheng, Mengwei Ni, Jiarui Wu, Kuaihuan Wang, Xiaojiao Duan, Xiaomeng Zhang, Bing Zhang
BACKGROUND: Chinese herbal injections (CHIs) have been proven beneficial to patients with gastric cancer for improving clinical efficacy and relieving adverse reactions (ADRs) of chemotherapy. A network meta-analysis (NMA) was conducted in this study to assess the comparative efficacy and safety of CHIs combined with FOLFOX regimen for treating gastric cancer. RESULTS: A total of 2316 records were searched, and 81 eligible RCTs involving 15 types of CHIs and 5978 patients were included in the NMA...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28973555/the-effects-of-an-environmentally-relevant-level-of-arsenic-on-the-gut-microbiome-and-its-functional-metagenome
#16
Liang Chi, Xiaoming Bian, Bei Gao, Pengcheng Tu, Hongyu Ru, Kun Lu
Multiple environmental factors induce dysbiosis in the gut microbiome and cause a variety of human diseases. Previously, we have first demonstrated that arsenic alters the composition of the gut microbiome. However, the functional impact of arsenic on the gut microbiome has not been adequately assessed, particularly at environmentally relevant concentrations. In this study, we used 16S rRNA sequencing and metagenomics sequencing to investigate how exposure to 100 ppb arsenic for 13 weeks alters the composition and functional capacity of the gut microbiome in mice...
August 29, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28972091/cd8-t-cells-prevent-lethality-from-neonatal-murine-roseolovirus-infection
#17
Swapneel J Patel, Wayne M Yokoyama
A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic CD4(+) cells during neonatal infection of BALB/c mice. Despite significant disruptions to the normal adaptive immune response, infected BALB/c mice reproducibly recover from infection, consistent with prior studies on a related virus, mouse thymic virus. In this article, we show that, in contrast to published studies on mouse thymic virus, MRV appears to robustly infect neonatal C57BL/6 (B6) mice, causing severe depletion of thymocytes and peripheral T cells...
October 2, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28971270/calcium-calmodulin-dependent-protein-kinase-iv-camkiv-mediates-acute-skeletal-muscle-inflammatory-response
#18
DanDan Shi, RuiCai Gu, YaFeng Song, MaoChao Ding, Tao Huang, MengXia Guo, JiangWei Xiao, WenHua Huang, Hua Liao
The objective of this study is to investigate the role of Calmodulin-dependent protein kinase IV (CaMKIV) in Cardiotoxin (CTX)-induced mice muscle inflammation. CTX injection i.m. was performed to induce B6 mice acute tibialis anterior (TA) muscle injury. The mice were then injected i.p. with the recombinant CaMKIV protein or its antagonist KN-93. Immunoblotting was used to assess Calmodulin (CaM) and CaMKIV levels. Immunofluorescence was used to detect intramuscular infiltration or major histocompatibility complex (MHC)-I expression in damaged muscle...
October 2, 2017: Inflammation
https://www.readbyqxmd.com/read/28968861/in-colon-epithelia-clostridium-perfringens-enterotoxin-causes-focal-leaks-by-targeting-claudins-which-are-apically-accessible-due-to-tight-junction-derangement
#19
Miriam Eichner, Christian Augustin, Anja Fromm, Anna Piontek, Wolfgang Walther, Roland Bücker, Michael Fromm, Gerd Krause, Jörg-Dieter Schulzke, Dorothee Günzel, Jörg Piontek
Clostridium perfringens enterotoxin (CPE) causes food poisoning and antibiotic-associated diarrhea. It uses some claudin tight junction proteins (e.g. claudin-4) as receptors to form Ca2+-permeable pores in the membrane damaging epithelial cells in small intestine and colon. We demonstrate that only a subpopulation of colonic enterocytes which are characterized by apical dislocation of claudins are CPE-susceptible. CPE-mediated damage was enhanced if paracellular barrier was impaired by Ca2+-depletion, proinflammatory cytokine TNFα or dedifferentiation...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968683/a-systems-level-analysis-of-drug-target-disease-associations-for-drug-repositioning
#20
Kayleigh D Rutherford, Gaston K Mazandu, Nicola J Mulder
Drug repositioning is the process of finding new therapeutic uses for existing, approved drugs-a process thathas value when considering the exorbitant costs of novel drug development. Several computational strategies exist as a way to predict these alternative applications. In this study, we used datasets on: (1) human biological drug targets and (2) disease-associated genes and, based on a direct functional interaction between them, searched for potential opportunities for drug repositioning. From the set of 1125 unique drug targets and their 88 490 interactions with disease-associated genes, 30 drug targets were analyzed and (3) discussed in detail for the purpose of this article...
August 17, 2017: Briefings in Functional Genomics
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