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https://www.readbyqxmd.com/read/29352722/daily-intake-of-mucuna-pruriens-in-advanced-parkinson-s-disease-a-16-week-noninferiority-randomized-crossover-pilot-study
#1
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Benedetta Raspini, Michela Barichella, Gianni Pezzoli
BACKGROUND: Thousands of individuals with Parkinson's disease (PD) in low-income countries have limited access to marketed levodopa preparations. Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in tropical areas, may be a sustainable alternative therapy for indigent patients. Single-dose intake of MP proved noninferior to marketed levodopa preparations. METHODS: Fourteen PD patients with motor fluctuations and dyskinesias received MP powder (obtained from roasted seeds) and marketed levodopa/carbidopa (LD/CD) in a randomized order and crossover design over a 16-week period...
January 11, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29351432/diurnal-pattern-in-skin-na-and-water-content-is-associated-with-salt-sensitive-hypertension-in-etb-receptor-deficient-rats
#2
Joshua S Speed, Kelly A Hyndman, Malgorzata Kasztan, Jermaine G Johnston, Kaehler J Roth, Jens M Titze, David M Pollock
Impairment in the ability of the skin to properly store Na+ non-osmotically (without water) has recently been hypothesized as contributing to salt-sensitive hypertension. Our lab has shown that endothelial production of endothelin-1 (ET-1) is crucial to skin Na+ handling. Further, it is well established that loss of ETB receptor function impairs Na+ excretion by the kidney. Thus we hypothesized that rats lacking functional ETB receptors (ETB def) will have a reduced capacity of the skin to store Na+ during chronic high salt (HS) intake...
December 13, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351420/fourth-ventricular-tsh-induces-satiety-and-increases-body-temperature-in-rats
#3
Ulrika Smedh, Karen A Scott, Timothy H Moran
Besides its well-known action to stimulate thyroid hormone release, Thyrotropin mRNA is expressed within the brain and Thyrotropin and its receptor have been shown to be present in brain areas that control feeding and gastrointestinal function. Here, the hypothesis that Thyrotropin acts on receptors in the dorsal hindbrain to alter food intake and/or gastric function was tested. Fourth ventricular injections of Thyrotropin (0.06, 0.6 and 6.0 µg) were given to rats with chronic intracerebroventricular cannulas aimed at the fourth ventricle...
January 3, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351316/dexmedetomidine-reduces-lipopolysaccharide-induced-neuroinflammation-sickness-behavior-and-anhedonia
#4
Ching-Hua Yeh, Liang-Po Hsieh, Ming-Chung Lin, Tsui-Shan Wei, Hui-Ching Lin, Chia-Cheng Chang, Chung-Hsi Hsing
BACKGROUND: Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation and sickness behavior in mice. MATERIALS AND METHODS: BALB/c mice were intraperitoneally (i.p.) injected with Dex (50 ug/kg) or vehicle. One hour later, the mice were injected (i...
2018: PloS One
https://www.readbyqxmd.com/read/29350400/feasibility-of-enteral-protein-supplementation-in-critically-ill-children
#5
Yara M F Moreno, Daniela B Hauschild, Mayara D Martins, Lori J Bechard, Nilesh M Mehta
BACKGROUND: We describe the protein type and concentration in standard enteral nutrition (EN) formulas and the effect of protein supplementation on the osmolality of standard formulas. We also aimed to examine factors associated with optimal protein delivery in critically ill children. METHODS: Protein content and other characteristics of pediatric EN formulas used worldwide were recorded. Factors associated with achievement of recommended protein delivery and tolerance of protein-supplemented formulas were recorded prospectively in a cohort of critically ill children...
January 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29350399/biological-functions-of-elabela-a-novel-endogenous-ligand-of-apj-receptor
#6
REVIEW
Jin Xu, Linxi Chen, Zhisheng Jiang, Lanfang Li
The G protein-coupled receptor APJ and its cognate ligand, apelin, are widely expressed throughout human body. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, fluid homeostasis and energy metabolism regulation. Recently, a new endogenous peptidic ligand of APJ, named Elabela, has been identified and shown to play a crucial role in embryonic development. In addition, increasing evidences show that Elabela is also intimate associated with a large number of physiological processes in adulthood...
January 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29349652/social-factors-associated-with-non-initiation-and-cessation-of-predominant-breastfeeding-in-a-mother-child-cohort-in-spain
#7
Maria Villar, Loreto Santa-Marina, Mario Murcia, Pilar Amiano, Silvia Gimeno, Ferran Ballester, Jordi Julvez, Dora Romaguera, Ana Fernández-Somoano, Adonina Tardón, Jesús Ibarluzea
Objective The aim of the study was to identify factors associated with non-initiation and cessation of predominant breastfeeding (PBF) in a mother-child cohort from Spain. Materials and Methods The analysis included 2195 mother-infant from birth to 14 months post- delivery recruited between 2004 and 2008. Maternal characteristics were collected during the pregnancy. Lactation data were obtained at 6 and 14 months after delivery. PBF was defined as intake of breast milk plus liquids like juices or water. The PBF cessation was calculated using the date that women started PBF and the date that she reported to start giving infant formula and/or food...
January 18, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29348901/prevalence-and-risk-factors-of-lower-urinary-tract-symptoms-in-chinese-adult-men-a-multicentre-cross-sectional-study
#8
Meng Rao, Huangfang Shangguan, Zhengyan Zeng, Yi Zheng, Huiping Zhang, Honggang Li, Wei Xia, Changhong Zhu, Chengliang Xiong, Huangtao Guan
There has been no previous population-based study reporting the prevalence and risk factors of male lower urinary tract symptoms (LUTS) among men in mainland China. This cross-sectional study was conducted from 2013 to 2014 in three representative provinces of China: Guangdong, Hubei and Jiangsu. 3250 individuals participated in the interviews, which involved a questionnaire covering sociodemographic characteristics, lifestyle, dietary patterns and the International Prostate Symptom Score (IPSS). Blood was collected for lipids, glucose, insulin and reproductive hormone tests...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29344814/nutritional-therapy-in-autosomal-dominant-polycystic-kidney-disease
#9
REVIEW
Biagio R Di Iorio, Adamasco Cupisti, Claudia D'Alessandro, Antonio Bellasi, Vincenzo Barbera, Luca Di Lullo
CKD-related nutritional therapy (NT) is a crucial cornerstone of CKD patients' treatment, but the role of NT has not been clearly investigated in autosomal dominant polycystic kidney disease (ADPKD). Several clinical studies have focused on new pharmacological approaches to delay cystic disease progression, but there are no data on dietary interventions in ADPKD patients. The aim of this paper is to analyze the evidence from the literature on the impact of five nutritional aspects (water, sodium, phosphorus, protein intake, and net acid load) in CKD-related ADPKD extrapolating-where information is unavailable-from what occurs in CKD non-ADPKD patients Sodium intake restriction could be useful in decreasing the growth rate of cysts...
January 17, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29344080/effects-of-huang-bai-phellodendri-cortex-on-bone-growth-and-pubertal-development-in-adolescent-female-rats
#10
Sun Haeng Lee, Hyun Jeong Lee, Sung Hyun Lee, Young-Sik Kim, Donghun Lee, Jiu Chun, Jin Yong Lee, Hocheol Kim, Gyu Tae Chang
Background: To evaluate the effects of Huang Bai (Phellodendron amurense) on growth and maturation in adolescent female rats. Methods: Female Sprague-Dawley rats (28 days old; n = 72) were divided into six daily treatment groups: control (distilled water), Huang Bai (100 and 300 mg/kg), recombinant human GH (rhGH; 20 μg/kg), estradiol (1 μg/kg), and triptorelin (100 μg). Body weight, food intake, and vaginal opening were measured daily from postnatal day (PND) 28 to PND 43...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29342090/development-of-databases-on-iodine-in-foods-and-dietary-supplements
#11
REVIEW
Abby G Ershow, Sheila A Skeaff, Joyce M Merkel, Pamela R Pehrsson
Iodine is an essential micronutrient required for normal growth and neurodevelopment; thus, an adequate intake of iodine is particularly important for pregnant and lactating women, and throughout childhood. Low levels of iodine in the soil and groundwater are common in many parts of the world, often leading to diets that are low in iodine. Widespread salt iodization has eradicated severe iodine deficiency, but mild-to-moderate deficiency is still prevalent even in many developed countries. To understand patterns of iodine intake and to develop strategies for improving intake, it is important to characterize all sources of dietary iodine, and national databases on the iodine content of major dietary contributors (including foods, beverages, water, salts, and supplements) provide a key information resource...
January 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29339246/absence-of-toxicity-in-swiss-mice-following-treatment-with-7-acetoxy-4-aryl-3-4-dihydrocoumarin-acute-and-repeated-dose-toxicity-study
#12
Gláucio Barros Saldanha, Glaucia Barros Saldanha, Marina Rebeca Soares Carneiro de Sousa, George Laylson da Silva Oliveira, Ana Paula Dos Santos C L da Silva, Jorge M David, Juceni Pereira David
Neoflavonoids, which are classified as 4-arylcoumarin (neoflavone), 3,4-dihydro-4-arylcoumarin and neoflavene, have been the subject of a number of studies with respect to their therapeutic potential and, despite promising in vitro, ex vivo and in vivo pharmacological activities, there is a lack of studies demonstrating their toxicological properties. Therefore, this study aims to evaluate the acute (14 days) and repeated-dose (28 days) toxicity of synthetic neoflavonoid 7-acetoxy-4-aryl-3,4-dihydrocoumarin in Swiss mice through parameters related to changes in body weight, food and water intake, hematological and biochemical parameters...
January 12, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29338950/sugar-sweetened-beverage-and-water-intake-in-relation-to-diet-quality-in-u-s-children
#13
Cindy W Leung, S Gemma DiMatteo, Wendi A Gosliner, Lorrene D Ritchie
INTRODUCTION: Sugar-sweetened beverages (SSBs) are a major contributor to children's added sugar consumption. This study examines whether children's SSB and water intakes are associated with diet quality and total energy intake. METHODS: Using data on children aged 2-18 years from the 2009-2014 National Health and Nutrition Examination Survey, linear regression models were used to analyze SSB and water intake in relation to Healthy Eating Index 2010 (HEI-2010) scores and total energy intake...
January 12, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29337622/isolation-of-avipoxvirus-from-tongue-of-canaries-serinus-canaria-show-severe-localized-proliferative-glossitis
#14
Salvatore Catania, Silvia Carnaccini, Marta Mainenti, Maria Luisa Moronato, Federica Gobbo, Terregino Calogero
Poxvirus was the causative agent of two unusual outbreaks of proliferative glossitis in canary ( Serinus canaria forma domestica) breeders in the Northern Italy. A total of 45, 7-9-mo-old canaries were submitted in fair postmortem conditions to the Istituto Zooprofilattico Sperimentale delle Venezie at the beginning of November 2005 for diagnostic investigation. Birds belonged to two unrelated and geographically distant aviaries in northern Italy, herein identified as Aviary A and Aviary B. The two breeder flocks had both attended the same bird exposition held at the beginning of October and started experiencing an onset of high mortality 3 wk after the show...
December 2017: Avian Diseases
https://www.readbyqxmd.com/read/29336891/cupua%C3%A3-u-extract-reduces-nitrosative-stress-and-modulates-inflammatory-mediators-in-the-kidneys-of-experimental-diabetes
#15
Giovana R Punaro, Deyse Y Lima, Adelson M Rodrigues, Samuel Pugliero, Margaret G Mouro, Marcelo M Rogero, Elisa M S Higa
BACKGROUND & AIMS: We have previously reported an increased nitrosative stress in the kidneys of diabetic animals, which was reduced by an antioxidant probiotic. The present study evaluated whether the extract of cupuaçu (EC), an antioxidant compound rich in polyphenols and theograndins, when administered at a dose that can be reasonably obtained through daily consumption, could delay the onset of diabetic complications in the kidney. METHODS: Mouse immortalized mesangial cells (MiMC) were placed in medium normal glucose (NG) or high glucose (HG), with or without EC (500, 100, 50 or 10 μg/mL) during 24, 48 or 72 h for analysis of viability, proliferation, nitric oxide (NO) levels and reactive oxygen species or nitrogen (ROS/RNS)...
December 26, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29336229/parasites-of-importance-for-human-health-on-edible-fruits-and-vegetables-in-nigeria-a-systematic-review-and-meta-analysis-of-published-data
#16
Solomon Ngutor Karshima
Contamination of edible fruits and vegetables is now a global public health issue despite their health benefits as non-pharmacological prophylaxis against chronic diseases. Studies that will harness the extent of parasitic contaminations will ensure public health protection. Here, the prevalence and distribution of parasites of importance for human health on fruits and vegetables in Nigeria were determined through a systematic review and meta-analysis of published data. The random-effects model was used to determine pooled prevalence estimate (PPE)...
January 16, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29335423/evaluation-of-the-effects-of-space-allowance-on-measures-of-animal-welfare-in-laboratory-mice
#17
Jeremy D Bailoo, Eimear Murphy, Justin A Varholick, Janja Novak, Rupert Palme, Hanno Würbel
We studied how space allowance affects measures of animal welfare in mice by systematically varying group size and cage type across three levels each in both males and females of two strains of mice (C57BL/6ByJ and BALB/cByJ; n = 216 cages, a total of 1152 mice). This allowed us to disentangle the effects of total floor area, group size, stocking density, and individual space allocation on a broad range of measures of welfare, including growth (food and water intake, body mass); stress physiology (glucocorticoid metabolites in faecal boli); emotionality (open field behaviour); brain function (recurrent perseveration in a two-choice guessing task); and home-cage behaviour (activity, stereotypic behaviour)...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335398/massive-post-obstructive-diuresis
#18
Stewart W Shankel
BACKGROUND The purpose of presenting this case is to demonstrate the degree to which the kidney is capable of selectively excreting a massive load of sodium and water when challenged with both of these, without altering the plasma levels of other ions. CASE REPORT An 8-year-old boy was admitted in severe renal failure. Workup demonstrated a high grade obstruction of a single kidney. Following dialysis, the patient underwent surgery to correct the obstruction and he developed post-obstructive diuresis. Within one week he was receiving 34 liters of essentially 1/2 Na by IV and by mouth and was excreting 70% of his filtered load of water and 50% of his filtered load of sodium...
January 16, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29335230/application-of-a-health-risk-assessment-model-for-cattle-exposed-to-pesticides-in-contaminated-drinking-waters-a-study-case-from-the-pampas-region-argentina
#19
Sabrina Dubny, Fabio Peluso, Ignacio Masson, Natalia Othax, José González Castelain
Using the USEPA methodology we estimated the probabilistic chronic risks for calves and adult cows due to pesticide exposure through oral intake of contaminated surface and ground waters in Tres Arroyos County (Argentina). Because published data on pesticide toxicity endpoints for cows are scarce, we used threshold levels based on interspecies extrapolation methods. The studied waters showed acceptable quality for cattle production since none of the pesticides were present at high-enough concentrations to potentially affect cow health...
January 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29329773/total-energy-expenditure-and-body-composition-of-children-with-developmental-disabilities
#20
Michele Polfuss, Kathleen J Sawin, Paula E Papanek, Linda Bandini, Bethany Forseth, Andrea Moosreiner, Kimberley Zvara, Dale A Schoeller
BACKGROUND: Obesity prevalence is increased in children with developmental disabilities, specifically in children with spina bifida and Down syndrome. Energy expenditure, a critical aspect of weight management, has been extensively studied in the typically developing population, but not adequately studied in children with developmental disabilities. OBJECTIVE: Determine energy expenditure, fat-free mass and body fat percentile and the impact of these findings on recommended caloric intake in children with spina bifida and Down syndrome...
December 28, 2017: Disability and Health Journal
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