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https://www.readbyqxmd.com/read/28736363/-clinical-characteristics-and-risk-factors-affecting-outcomes-of-elderly-patients-with-non-small-cell-lung-cancer-complicated-by-chronic-obstructive-pulmonary-disease
#1
Peng Wang, Dong Zhang, Xue-Guang Guo, Bao-Jun Sun, Xiang-Qun Fang, Ge-Ping Qu, Chang-Ting Liu
OBJECTIVE: To investigate the clinical features, treatment strategy and risk factors affecting the prognosis of elderly patients with non-small cell lung cancer (NSCLC) complicated by chronic obstructive pulmonary disease (COPD). METHODS: We retrospectively analyzed the data of elderly patietns (>60 years) with newly diagnosed NSCLC complicated by COPD at the Geriatric Institution of General Hospital of PLA between January, 2000 and June, 2015. The clinical data collected included history of smoking, pulmonary function test results, initial treatments, TNM stage, chief complaints, comorbidities and laboratory tests...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28735500/adherence-to-copd-management-guidelines-in-general-practice-a-review-of-the-literature
#2
REVIEW
J Sehl, J O'Doherty, R O'Connor, B O'Sullivan, A O'Regan
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive illness that is mostly managed in the general practice setting. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines are the international gold standard, and it is important to understand how these are being applied in general practice. AIMS: This review aimed to assess the current level of adherence to international best practice guidelines among general practitioners in relation to COPD...
July 22, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28732795/incidence-of-cancer-in-outpatients-with-chronic-obstructive-pulmonary-disease
#3
J M Figueira Gonçalves, R Dorta Sánchez, L I Pérez Méndez, L Pérez Negrín, I García-Talavera, A Pérez Rodríguez, D Díaz Pérez, P Viña Manrique, C Guzmán Sáenz
INTRODUCTION: The relationship between chronic obstructive pulmonary disease (COPD) and the overall incidence of cancer is poorly understood. The aim of this study was to analyse the incidence of cancer (pulmonary or extrapulmonary) in patients with COPD during follow-up in a specialised outpatient unit, as well as to assess its relationship with the degree of airflow obstruction. METHODOLOGY: A prospective observational study was conducted with a cohort of 308 patients with COPD in pulmonology outpatient follow-up consultations from January 2012 to December 2015...
July 18, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28730730/renal-impairment-hampers-bisphosphonate-treatment-in-a-quarter-of-lung-cancer-patients-with-bone-metastasis
#4
Katalin Fábián, Rita Puskás, Tímea Kakuk, László Prés, Dorottya Fejes, Zsolt Szegedi, Lívia Rojkó, Zoltán Szállási, Balázs Döme, Orsolya Pipek, Judit Moldvay
Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function parameters. Co-morbidities included hypertension (50%), COPD (33%) and diabetes mellitus (15%). Statistical analysis was performed with Fisher's exact tests and a Cox proportional hazards model...
July 21, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28725424/implementation-of-gold-consensus-report-in-real-life-results-from-the-velletri-lariano-vela-cohort
#5
G De Filippi, M Lallini, G De Riggi, G Marchetti, C M Dimartino, A M Russetti, E Ferrari, R Pistelli, M S Magnoni, M Riparbelli, A Rizzi, P Angeletti
BACKGROUND: COPD is one of the leading causes of morbidity and mortality. Pharmacotherapy improves quality of life and reduces exacerbations although low adherence with prescribed treatments may represent a barrier to optimal disease management. The first objective of this paper is to report the distribution of COPD patients according to GOLD categories, in a sample of patients from a cohort study in an area of the Latium region in Italy. The second objective is to evaluate the agreement between the distributions of severity obtained from the HCPs and the experts included in the study board (Board)...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28720132/efficacy-and-safety-of-direct-switch-to-indacaterol-glycopyrronium-in-patients-with-moderate-copd-the-crystal-open-label-randomised-trial
#6
Claus F Vogelmeier, Mina Gaga, Maryam Aalamian-Mattheis, Timm Greulich, Jose M Marin, Walter Castellani, Vincent Ninane, Stephen Lane, Xavier Nunez, Francesco Patalano, Andreas Clemens, Konstantinos Kostikas
BACKGROUND: Dual bronchodilation combining a long-acting β2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA) is the preferred choice of treatment recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 guidelines for the management of patients with moderate-to-severe chronic obstructive pulmonary disease (COPD). The once-daily (q.d.) fixed-dose combination (FDC) of LABA, indacaterol 110 μg and LAMA, glycopyrronium 50 μg (IND/GLY 110/50 μg q...
July 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28719893/treatment-of-copd-exacerbation-in-switzerland-results-and-recommendations-of-the-european-copd-audit
#7
Michael Buess, Daniel Schilter, Tino Schneider, Marc Maurer, Heinz Borer, Robert Thurnheer, Erich Köhler, Lilian Junker, Kathleen Jahn, Michael Grob, Jochen Rüdiger, Thomas Geiser, Erich Helfenstein, Markus Solèr, René Fiechter, Thomas Sigrist, Patrick Brun, Jürg Barandun, Eva Koltai, José Luis López-Campos, Sylvia Hartl, Michael Roberts, Desiree M Schumann, Michael Tamm, Daiana Stolz
BACKGROUND: The European COPD Audit initiated by the European Respiratory Society (ERS) evaluated the management of hospital admissions due to exacerbation of chronic obstructive pulmonary disease (COPD) in several European countries. Data on the treatment of severe acute exacerbations of COPD (AECOPDs) in Switzerland are scarce. OBJECTIVES: In light of the GOLD 2010 guidelines, this work aims to examine the quality of care for AECOPD and to provide specific recommendations for the management of severe AECOPD in Switzerland...
July 19, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28719225/association-between-social-support-and-self-care-behaviors-in-adults-with-chronic-obstructive-pulmonary-disease
#8
Zijing Chen, Vincent S Fan, Basia Belza, Kenneth Pike, Huong Q Nguyen
RATIONALE: Higher social support is associated with a better quality of life and functioning in adults with chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine the association between structural and functional social support and self-care behaviors in adults with COPD. METHODS: This was a longitudinal study using data from the CASCADE (COPD Activity: Serotonin Transporter, Cytokines, and Depression) study which was focused on depression and functioning in COPD...
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28717072/the-relationship-of-bone-mineral-density-in-men-with-chronic-obstructive-pulmonary-disease-classified-according-to-the-global-initiative-for-chronic-obstructive-lung-disease-gold-combined-chronic-obstructive-pulmonary-disease-copd-assessment-system
#9
Yoriko Sakurai-Iesato, Naoko Kawata, Yuji Tada, Ken Iesato, Yukiko Matsuura, Misuzu Yahaba, Toshio Suzuki, Jun Ikari, Noriyuki Yanagawa, Yasunori Kasahara, James West, Koichiro Tatsumi
Objective Osteoporosis, which is now recognized as a major comorbidity of chronic obstructive pulmonary disease (COPD), must be diagnosed by appropriate methods. The aims of this study were to clarify the relationships between bone mineral density (BMD) and COPD-related clinical variables and to explore the association of BMD with the updated Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification in men. Methods We enrolled 50 Japanese men with clinically stable COPD who underwent dual-energy X-ray absorptiometry (DEXA), pulmonary function testing, and computerized tomography (CT) and who had completed a questionnaire (COPD assessment test [CAT])...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28715281/admission-for-copd-exacerbation-is-associated-with-the-clinical-diagnosis-of-pulmonary-hypertension-results-from-a-retrospective-longitudinal-study-of-a-veteran-population
#10
Sarah K Medrek, Amir Sharafkhaneh, Andrew M Spiegelman, Arnav Kak, Lavannya M Pandit
Patients with chronic obstructive pulmonary disease and pulmonary hypertension (PH-COPD) have an increased risk of hospitalizations and death compared to COPD alone. Identifying PH in COPD is challenging because performing right heart catheterization, the gold standard for PH diagnosis, is invasive and not routinely performed. Clinical characterization of COPD patients at risk who are progressing toward PH will aid therapeutic development at earlier stages of progressively fatal PH-COPD. We studied the records of 5,45,086 patients in a large Veterans Affairs healthcare network (2000-2012) with a primary discharge diagnosis of COPD based on encounters' ICD-9 codes and further stratified into those who received an additional ICD-9 code for a PH diagnosis...
July 17, 2017: COPD
https://www.readbyqxmd.com/read/28715232/long-term-recording-of-night-time-respiratory-symptoms-in-patients-with-stable-copd-ii-iv
#11
Johannes Krönig, Olaf Hildebrandt, Andreas Weissflog, Werner Cassel, Volker Gross, Keywan Sohrabi, Patrick Fischer, Ulrich Koehler
INTRODUCTION: Night-time respiratory symptoms have a considerable impact on sleep and life quality in patients with chronic obstructive pulmonary disease (COPD). Lack of awareness of night-time symptoms can lead to worsened COPD control. Automated long-term monitoring of respiratory symptoms with LEOSound enables assessment of nocturnal wheezing and cough. METHODS: In this observational study we investigated the prevalence and severity of cough and wheezing in patients with stable COPD [Global Initiative for Chronic Obstructive Lung Disease (GOLD) II-IV] disease for two consecutive nights with the LEOSound system...
July 17, 2017: COPD
https://www.readbyqxmd.com/read/28714435/a-multicenter-family-practitioners-research-on-chronic-obstructive-pulmonary-disease-screening-using-the-copd-assessment-test
#12
Hakan Demirci, Koncuy Eniste, Ebru Onuker Basaran, Gokhan Ocakoglu, Zeynep Yilmaz, Sumeyye Tuna
OBJECTIVES: Spirometry is known to be a gold standard for the diagnosis of chronic obstructive pulmonary disease (COPD). COPD Assessment Test (CAT) is an eight-item questionnaire currently in use to evaluate patients with COPD. In the present study, we aimed to evaluate if CAT is an adequate tool for screening COPD. METHODS: In total, 600 persons aging ⩾40 years old were randomly selected from three different family practice units located in the city center. CAT was asked to the participants and a spirometry was used to assess pulmonary obstruction...
July 17, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28701317/redefining-the-overlap-of-asthma-and%C3%A2-copd
#13
(no author information available yet)
The term asthma-COPD overlap (ACO) has been suggested for people with chronic airflow obstruction that has features characteristic of both asthma and chronic obstructive pulmonary disease (COPD).(1) People with clinical features of asthma and COPD tend to have worse outcomes than those with either asthma or COPD alone, yet their clinical management has remained unclear. UK guidelines currently do not specifically address this issue,(2,3) but the Global Initiative for Asthma (GINA) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) have published a consensus-based report on the diagnosis and treatment of people with asthma, COPD and ACO...
July 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28694693/prevalence-and-characteristics-of-asthma-copd-overlap-syndrome-identified-by-a-stepwise-approach
#14
Hiromasa Inoue, Takahide Nagase, Satoshi Morita, Atsushi Yoshida, Tatsunori Jinnai, Masakazu Ichinose
BACKGROUND AND OBJECTIVE: There is increasing recognition of asthma-COPD overlap syndrome (ACOS), which shares some features of both asthma and COPD; however, the prevalence and characteristics of ACOS are not well understood. The aim of this study was to investigate the prevalence of ACOS among patients with COPD and its characteristics using a stepwise approach as stated in the recent report of the Global Initiative for Asthma (GINA) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28684907/anti-p-benzoquinone-antibody-level-as-a-prospective-biomarker-to-identify-smokers-at-risk-for-copd
#15
Santanu Banerjee, Parthasarathi Bhattacharyya, Subhra Mitra, Somenath Kundu, Samiran Panda, Indu B Chatterjee
BACKGROUND AND OBJECTIVE: Identification of smokers having predisposition to COPD is important for early intervention to reduce the huge global burden of the disease. Using a guinea pig model, we have shown that p-benzoquinone (p-BQ) derived from cigarette smoke (CS) in the lung is a causative factor for CS-induced emphysema. p-BQ is also derived from CS in smokers and it elicits the production of anti-p-BQ antibody in humans. We therefore hypothesized that anti-p-BQ antibody might have a protective role against COPD and could be used as a predictive biomarker for COPD in smokers...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28671162/study-of-oxidative-stress-biomarkers-in-chronic-obstructive-pulmonary-disease-and-their-correlation-with-disease-severity-in-north-indian-population-cohort
#16
Jyoti Bajpai, Ved Prakash, Surya Kant, Ajay Kumar Verma, Anand Srivastava, Darshan K Bajaj, M K Ahmad, Avinash Agarwal
BACKGROUND: Oxidant-antioxidant imbalance forms a prime component in pathogenesis of chronic obstructive pulmonary disease (COPD). Studies of oxidative stress markers in South Asians were sparse. METHODS: One hundred and eighty COPD patients and eighty healthy nonsmokers were enrolled in the study. Serum malondialdehyde (MDA) and iron levels were estimated for oxidative stress. Three antioxidant markers evaluated-catalase, superoxide dismutase (SOD), and serum copper...
July 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28668545/increased-production-of-tgf-%C3%AE-1-from-sputum-cells-of-copd-relationship-with-airway-obstruction
#17
Laurent Godinas, Jean-Louis Corhay, Monique Henket, Julien Guiot, Renaud Louis, Catherine Moermans
Chronic obstructive pulmonary disease (COPD) is a chronic airway disease characterized by a profound airway remodelling that leads to airway obstruction. A role for transforming growth factor-β1 (TGF-β1) has been proposed in airway remodelling of COPD. Regarding the TGF-β1 production at local level, the results seemed to be controversial. In this study, an original model of sputum cell culture thought to maintain important cells interactions, was used. We investigated the production of TGF-β1 from sputum cell culture in 33 COPD encompassing the whole severity spectrum and compared the results with those found in 39 healthy controls...
June 29, 2017: Cytokine
https://www.readbyqxmd.com/read/28668356/frequency-of-exacerbations-in-patients-with-chronic-obstructive-pulmonary-disease-an-analysis-of-the-spiromics-cohort
#18
MeiLan K Han, Pedro M Quibrera, Elizabeth E Carretta, R Graham Barr, Eugene R Bleecker, Russell P Bowler, Christopher B Cooper, Alejandro Comellas, David J Couper, Jeffrey L Curtis, Gerard Criner, Mark T Dransfield, Nadia N Hansel, Eric A Hoffman, Richard E Kanner, Jerry A Krishnan, Carlos H Martinez, Cheryl B Pirozzi, Wanda K O'Neal, Stephen Rennard, Donald P Tashkin, Jadwiga A Wedzicha, Prescott Woodruff, Robert Paine, Fernando J Martinez
BACKGROUND: Present treatment strategies to stratify exacerbation risk in patients with chronic obstructive pulmonary disease (COPD) rely on a history of two or more events in the previous year. We aimed to understand year to year variability in exacerbations and factors associated with consistent exacerbations over time. METHODS: In this longitudinal, prospective analysis of exacerbations in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) cohort, we analysed patients aged 40-80 years with COPD for whom 3 years of prospective data were available, identified through various means including care at academic and non-academic medical centres, word of mouth, and existing patient registries...
June 28, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28663549/determinants-of-initial-inhaled-corticosteroid-use-in-patients-with-gold-a-b-copd-a-retrospective-study-of-uk-general-practice
#19
James D Chalmers, Abigail Tebboth, Alicia Gayle, Andrew Ternouth, Nick Ramscar
Initial use of inhaled corticosteroid therapy is common in patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) A or B chronic obstructive pulmonary disease, contrary to GOLD guidelines. We investigated UK prescribing of inhaled corticosteroid therapy in these patients, to identify predictors of inhaled corticosteroid use in newly diagnosed chronic obstructive pulmonary disease patients. A cohort of newly diagnosed GOLD A/B chronic obstructive pulmonary disease patients was identified from the UK Clinical Practice Research Datalink (June 2005-June 2015)...
June 29, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28647926/importance-of-gold-guidelines-for-chronic-obstructive-pulmonary-disease
#20
J Sadlonova, D Osinova, E Rozborilova, O Osina, E Novakova, V Sadlonova
In December 2011, a major revision of GOLD 2011 guidelines was published based on the evidence-based medicine. The goal of GOLD 2011 is to determine the severity of the disease, its impact on the patient's health, and the risk of future events; all of which eventually guide therapy. A combined COPD assessment according to GOLD 2011 considers the patient's level of symptoms, spirometry abnormalities, risk of exacerbation, and the presence of comorbidities. GOLD 2011 stratifies patients into four basic groups labeled A, B, C, and D...
June 25, 2017: Advances in Experimental Medicine and Biology
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