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https://www.readbyqxmd.com/read/29138555/the-efficacy-of-extrafine-beclomethasone-dipropionate-formoterol-fumarate-in-copd-patients-who-are-not-frequent-exacerbators-a-post-hoc-analysis-of-the-forward-study
#1
Dave Singh, Stefano Vezzoli, Stefano Petruzzelli, Alberto Papi
The GOLD 2017 strategy document recommends that the pharmacological management of COPD patients be based on the risk of future exacerbations and the severity of symptoms. A threshold of two moderate exacerbations or one hospitalization is used to define high-risk patients. The FORWARD study was a randomized, double-blind, parallel-group trial that compared 48 weeks' treatment with extrafine beclomethasone dipropionate plus formoterol fumarate (BDP-FF) versus FF in severe COPD patients with a history of one or more exacerbations in the previous year...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29138554/characteristics-of-copd-patients-according-to-gold-classification-and-clinical-phenotypes-in-the-russian-federation-the-support-trial
#2
Vladimir Arkhipov, Daria Arkhipova, Marc Miravitlles, Andrey Lazarev, Ekaterina Stukalina
Background: The high prevalence of COPD in the Russian Federation has been demonstrated in several epidemiological studies. However, there are still no data on the clinical characteristics of these patients according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups and phenotypes, which could provide additional understanding of the burden of COPD, routine clinical practice, and ways to improve the treatment of patients with COPD in Russia. Patients and methods: SUPPORT was an observational multicenter study designed to obtain data about the distribution of patients with previously diagnosed COPD according to the severity of bronchial obstruction, symptom severity, risk of exacerbation, COPD phenotypes, and treatment of COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29135394/real-life-profile-of-asthma-and-chronic-obstructive-pulmonary-disease-patients-in-turkey
#3
Zeynep Mısırlıgil, Arif Çımrın, Hakan Günen, Tevfik Özlü, Aykut Çilli, Levent Akyıldız, Hasan Bayram, Bilun Gemicioğlu, Esra Uzaslan, Öznur Abadoğlu, Mecit Suerdem
Introduction: Despite the presentation of similar symptoms, the airway diseases have different underlying pathophysiological processes and must be distinguished to enable the administration of appropriate treatment. In several studies the clinician- and patient-related causes of poor compliance to treatment in asthma/chronic obstructive pulmonary disease (COPD) patients have been evaluated. This study aimed to determine the clinical and sociodemographic characteristics of newly diagnosed treatment-naïve asthma and COPD patients in Turkey...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29131048/the-correlation-of-serum-brain-natriuretic-peptide-and-interleukin-6-with-quality-of-life-using-chronic-obstructive-pulmonary-disease-assessment-test
#4
Hassan Ghobadi, Mohammad Reza Aslani, Adalat Hosseinian, Esmaeil Farzaneh
OBJECTIVE: The aim of this study was to determine the levels of serum pro-brain natriuretic peptide (pro-BNP) and interleukin (IL)-6 in patients with stable chronic obstructive pulmonary disease (COPD) and to correlate these markers with health-related quality of life using COPD assessment test (CAT). MATERIALS AND METHOD: Serum pro-BNP and IL-6 levels were measured in 82 patients with stable COPD. Serum pro-BNP and serum IL-6 levels, pulmonary function, and oxygen saturation (Spo2) were measured according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage and CAT score...
November 2, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29129177/copd-x-australian-and-new-zealand-guidelines-for-the-diagnosis-and-management-of-chronic-obstructive-pulmonary-disease-2017-update
#5
Ian A Yang, Juliet L Brown, Johnson George, Sue Jenkins, Christine F McDonald, Vanessa M McDonald, Kirsten Phillips, Brian J Smith, Nicholas A Zwar, Eli Dabscheck
Chronic obstructive pulmonary disease (COPD) is characterised by persistent respiratory symptoms and chronic airflow limitation, and is associated with exacerbations and comorbidities. Advances in the management of COPD are updated quarterly in the national COPD guidelines, the COPD-X plan, published by Lung Foundation Australia in conjunction with the Thoracic Society of Australia and New Zealand and available at http://copdx.org.au. Main recommendations: Spirometry detects persistent airflow limitation (post-bronchodilator FEV1/FVC < 0...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29123389/alveolar-capillary-reserve-during-exercise-in-patients-with-chronic-obstructive-pulmonary-disease
#6
Mehrdad Behnia, Courtney M Wheatley, Alberto Avolio, Bruce D Johnson
Background: Factors limiting exercise in patients with COPD are complex. With evidence for accelerated pulmonary vascular aging, destruction of alveolar-capillary bed, and hypoxic pulmonary vasoconstriction, the ability to functionally expand surface area during exercise may become a primary limitation. Purpose: To quantify measures of alveolar-capillary recruitment during exercise and the relationship to exercise capacity in a cohort of COPD patients. Methods: Thirty-two subjects gave consent (53% male, with mean ± standard deviation age 66±9 years, smoking 35±29 pack-years, and Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification of 0-4: 2...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29122333/translation-and-validation-of-the-multidimensional-dyspnea-12-questionnaire
#7
Carlos Antonio Amado Diago, Luis Puente Maestu, Beatriz Abascal Bolado, Juan Agüero Calvo, Mercedes Hernando Hernando, Irene Puente Bats, Ramón Agüero Balbín
INTRODUCTION: Dyspnea is a multidimensional symptom, but this multidimensionality is not considered in most dyspnea questionnaires. The Dyspnea-12 takes a multidimensional approach to the assessment of dyspnea, specifically the sensory and the affective response. The objective of this study was to translate into Spanish and validate the Dyspnea-12 questionnaire. METHODS: The original English version of the Dyspnea-12 questionnaire was translated into Spanish and backtranslated to analyze its equivalence...
November 6, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29120273/triple-therapy-in-copd-what-we-know-and-what-we-don-t
#8
Peter M A Calverley, Helgo Magnussen, Marc Miravitlles, Jadwiga A Wedzicha
Triple inhaled therapy for chronic obstructive pulmonary disease (COPD) consists of an inhaled corticosteroid (ICS), a long-acting β2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA) taken in combination. Triple therapy is recommended by the Global initiative for Chronic Obstructive Lung Disease (GOLD) for patients who experience recurrent exacerbations despite treatment with either a dual bronchodilator (preferred initial therapy) or LABA/ICS combination (alternative initial therapy). Although there is evidence for the greater efficacy of triple therapy compared with LABA/ICS and LAMA monotherapy with regards to improved lung function, health status, and exacerbation rate, the efficacy of triple therapy when compared with dual bronchodilation (LABA/LAMA) is as yet unknown...
November 9, 2017: COPD
https://www.readbyqxmd.com/read/29118578/changes-in-definition-lead-to-changes-in-the-clinical-characteristics-across-copd-categories-according-to-gold-2017-a-national-cross-sectional-survey-in-china
#9
Lina Sun, Yahong Chen, Rui Wu, Ming Lu, Wanzhen Yao
Purpose: To investigate how the changes of definition in assessment of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stratification 2017 lead to changes of chronic obstructive pulmonary disease (COPD) patient clinical characteristics across categories in China. Patients and methods: COPD patients from 11 medical centers in China were stratified into old and new groups A-D twice according to the GOLD 2011 and 2017 comprehensive assessment. Demography and clinical characteristics were compared between old and new groups A-D...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29115881/a-review-of-current-and-developing-fixed-dose-laba-lama-combinations-for-treating-copd
#10
Chitra Lal, Charlie Strange
The current GOLD (Global Initiative for Chronic Obstructive Lung Disease) recommendations suggest using long acting β2 agonists (LABA) and long acting muscarinic antagonists (LAMA) in combination for group B COPD patients with persistent symptoms, group C COPD patients with further exacerbations on LAMA therapy alone and for group D COPD patients with or without combination with inhaled corticosteroids (ICS). Thus, there is a lot of interest in developing LABA/LAMA combinations for maintenance therapy of chronic stable COPD...
November 8, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29113693/the-value-of-lactate-clearance-in-admission-decisions-of-patients-with-acute-exacerbation-of-copd
#11
Uğur Durmuş, Nurettin Özgür Doğan, Murat Pekdemir, Serkan Yılmaz, Elif Yaka, Adnan Karadaş, Seda Güney Pınar
BACKGROUND: Lactate and lactate clearance are being used as biomarkers in several critical conditions. The aim of this study was to examine the value of sixth hour lactate clearance in patients who were hospitalized with chronic obstructive pulmonary disease (COPD) exacerbations. METHODS: This single-center, cross-sectional study was conducted in a tertiary emergency department (ED) on patients who presented with acute exacerbation of COPD. Discharge or admission decisions were specified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria and the clinician's decision...
November 4, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29108795/severity-of-copd-and-its-relationship-with-il-10
#12
Bruna S A Silva, Fábio S Lira, Dionei Ramos, Juliana S Uzeloto, Fabrício Eduardo Rossi, Ana Paula C F Freire, Rebeca N Silva, Iara B Trevisan, Luis Alberto Gobbo, Ercy M C Ramos
BACKGROUND: The present study was designed to compare inflammatory and metabolic responses according to severity of airflow among patients with COPD and to verify the relationship between pulmonary function, body composition, metabolic and inflammatory profile. METHODS: Fifty-one patients with mild to very severe COPD were recruited and divided according lung function in Mild-moderate (GOLD 1-2) n= 21; Severe (GOLD 3) n=25 and Very severe (GOLD 4) n=5. Patients were submitted to assessments of lung function (spirometry), functional exercise capacity (6-min walk test), body composition (Octopolar bioelectrical impedance), metabolic profile (glucose, triglycerides, total cholesterol, HDL-cholesterol and albumin (colorimetric assay)) and inflammatory profile (cytokines: IL-6, IL-10, TNF-α and IL-15 (ELISA))...
November 3, 2017: Cytokine
https://www.readbyqxmd.com/read/29104679/physiotherapy-in-patients-with-chronic-obstructive-pulmonary-disease
#13
Antoaneta Dimitrova, Nikolay Izov, Ivan Maznev, Dance Vasileva, Milena Nikolova
BACKGROUND: Physiotherapy is an essential for the treatment of patients with chronic respiratory non-inflammatory diseases especially for chronic obstructive pulmonary disease (COPD). AIM: To assess the effect of six months physiotherapy (PT) program on functional status in patients with COPD. MATERIAL AND METHODS: The patients were divided into two groups according to the severity of the disease. Group A included 33 patients (mean age 68...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29099607/comparison-of-2017-and-2015-global-initiative-for-obstructive-lung-disease-impact-on-grouping-and-outcomes
#14
Carlos Cabrera López, Ciro Casanova Macario, José María Marín Trigo, Juan P de-Torres, Rebeca Sicilia Torres, Jesús María González, Francesca Polverino, Miguel Divo, Victor Pinto Plata, Javier J Zulueta, Bartolomé Celli
INTRODUCTION: The GOLD document has modified the grading system directing pharmacotherapy. But how this relates to the previous one of 2015 and to comorbidities, hospitalizations and mortality risk is unknown. METHODS: We prospectively enrolled and followed for a mean of 5 years, 819 COPD patients (84% male) in clinics in Spain and the United States. We determined anthropometrics, lung function (FEV1%), dyspnea score (mMRC), ambulatory and hospital exacerbations, the BODE and Charlson indexes...
November 3, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29098995/two-year-mortality-in-survivors-of-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-a-north-indian-study
#15
Parvaiz A Koul, Hilal A Dar, Rafi A Jan, Sanaullah Shah, Umar Hafiz Khan
OBJECTIVES: Data about long-term mortality of Indian patients following acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are scant. We set out to study the 2-year mortality in north Indian patients following discharge after AECOPD. MATERIALS AND METHODS: One hundred and fifty-one (96 male) patients admitted for AECOPD and discharged were followed for 2 years at 3, 6, 12, 18, and 24 months for mortality. Statistical analysis was performed to identify risk factors associated with mortality...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29084188/-evaluation-of-effect-of-indacaterol-onbrez-and-or-glycopyrronium-seebri-treatment-on-quality-of-life-of-copd-patients-in-medical-practice-in-poland-observational-study-osqo
#16
Tadeusz Płusa, Group Of Physicians From Medical Centers In Poland
Indacaterol, as well glycopyronium has been reimbursed lately in Poland, so patients have a greater access to this treatment in medical practice. Physicians do not realize the potential benefit of once daily ultra-LABA indacaterol and/or modern LAMA with fast-acting glycopyrronium on treatment results. AIM: The aim of the study was to evaluate the impact of routinely administered treatment with either indacaterol (Onbrez) or glycopyrronium (Seebri) or both on patient reported outcomes in form of the health status (CCQ score - clinical COPD questionnaire) and level of dyspnoea (mMRC - modified Medical Research Council) in treatment naive COPD patients after the change of treatment as addon from any other COPD treatment in "real life" settings...
October 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29082808/an-overview-of-the-current-management-of-chronic-obstructive-pulmonary-disease-can-we-go-beyond-the-gold-recommendations
#17
Mario Cazzola, Paola Rogliani, Ermanno Puxeddu, Josuel Ora, Maria Gabriella Matera
Treatment recommendations are based on randomized controlled trials (RCTs). However, only about 1 in 20 people meet the inclusion criteria for RCTs forming consensus guidelines in chronic obstructive pulmonary disease (COPD). Consequently, the one-size-fits-all approach focused merely on traditional symptoms and risk of exacerbations is inadequate to treat COPD. COPD needs a personalized medicine strategy because of the relevance of COPD heterogeneity for subject-based health risk assessment and stratification in the clinical arena...
November 3, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29081164/-prevalence-and-clinical-characteristics-of-blood-eosinophilia-in-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#18
Q L Zeng, X M Wang, S N Li, B Xiong, M Jian, G Huang, Y Q Wu, X H Wang, J Li, F Q Wen, H Zhou
Objective: To investigate the prevalence and clinical characteristics of peripheral blood eosinophilia (EOS) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: From July 2014 to June 2016, AECOPD patients in the Department of Respiratory Medicine of Affiliated Hospital of Chengdu University, were retrospectively stratified into two groups according to two standards of eosinophilic exacerbations (the peripheral blood eosinophil count ≥2% or ≥3% on admission). Demography, clinical symptoms, laboratory results, length of stay, total hospitalization expenses, and defined daily expenses were compared between groups...
October 31, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29075109/echo-intensity-of-the-rectus-femoris-in-stable-copd-patients
#19
Xiong Ye, Mingjie Wang, Hui Xiao
OBJECTIVE: The aim of this study was to investigate whether echo intensity of the rectus femoris when measured using ultrasound can distinguish muscles affected by COPD compared with healthy non-COPD affected muscles and whether the severity of ultrasonic abnormalities was associated with health-related quality of life (HRQoL). METHODS: Echo intensity, areas of the rectus femoris, and the thickness of quadriceps muscles were measured using ultrasound in 50 COPD outpatients and 21 age-matched non-COPD controls...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29066389/disease-severity-dependence-of-the-longitudinal-association-between-ct-lung-density-and-lung-function-in-smokers
#20
Alejandro A Diaz, Matthew Strand, Harvey O Coxson, James C Ross, Raul San Jose Estepar, David Lynch, Eva M van Rikxoort, Ivan O Rosas, Gary M Hunninghake, Rachel K Putman, Hiroto Hatabu, Andrew Yen, Gregory L Kinney, John E Hokanson, Edwin K Silverman, James Crapo, George R Washko
BACKGROUND: In smokers, the lung parenchyma is characterized by inflammation and emphysema, processes that can result in local gain and loss of lung tissue. CT measures of lung density might reflect lung tissue changes; however, longitudinal data regarding the effects of CT lung tissue on FEV1 in smokers with and without COPD are scarce. METHODS: The 15th percentile of CT lung density was obtained from the scans of 3,390 smokers who completed baseline and 5-year follow-up of the Genetic Epidemiology of COPD (COPDGene) study visits...
October 21, 2017: Chest
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