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https://www.readbyqxmd.com/read/28818747/antidepressant-like-activity-of-methyl-jasmonate-involves-modulation-of-monoaminergic-pathways-in-mice
#1
Solomon Umukoro, Adaeze Adebesin, Gladys Agu, Osarume Omorogbe, Stephen Babajide Asehinde
PURPOSE: The efficacy of current antidepressant drugs has been compromised by adverse effects, low remission and delay onset of action necessitating the search for alternative agents. Methyl jasmonate (MJ), a bioactive compound isolated from Jasminum grandiflorum has been shown to demonstrate antidepressant activity but its mechanism of action remains unknown. Thus, the role of monoaminergic systems in the antidepression-like activity of MJ was investigated in this study. MATERIALS AND METHODS: Mice were given i...
August 14, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28815415/type-2-diabetes-with-comorbid-depression-in-relation-to-cognitive-impairment-an-opportunity-for-prevention
#2
David A Zhang, Vicky Lam, Vanessa Chu, Ming Li
Studies show poor glycemic control is associated with increased risk of dementia among patients with Type 2 diabetes, indicating potential for prevention of dementia with improved glycemia. Emerging evidence suggests that a relationship between short-term glycemic control and cognitive function exists in Type 2 diabetes. However, detailed mechanisms relating diabetic dementia are lacking, as other concurrent conditions, such as depression, may also increase the risk of dementia in Type 2 diabetes. We examined the effects of glycemic control and depression on cognitive function in 88 patients (mean age, 67 ± 4 years) whose A1c (glycosylated hemoglobin) levels, comorbid depression, mini-mental state examination (MMSE) scores were recorded at baseline...
August 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28810562/anti-depressant-like-effects-of-jieyu-chufan-capsules-in-a-mouse-model-of-unpredictable-chronic-mild-stress
#3
Hui Zhao, Bingyu Liang, Linjie Yu, Yun Xu
Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for depression; however, the molecular mechanism underlying its anti-depressant action has remained elusive. In the present study, the anti-depressant effects of JYCF and the potential mechanisms were investigated in a mouse model. Five groups of 12 C57BL/6 mice each were used in the study, including a normal control group (NC group), a model control group (MC group) and three groups, which received different doses of JYCF (1.25, 2.5 and 5 g/kg) orally for 21 days (JYCF groups)...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28803855/elucidating-the-functions-of-brain-gsk3%C3%AE-possible-synergy-with-gsk3%C3%AE-upregulation-and-reversal-by-antidepressant-treatment-in-a-mouse-model-of-depressive-like-behaviour
#4
Dmitrii Pavlov, Nataliia Markova, Lucien Bettendorff, Vladimir Chekhonin, Igor Pomytkin, Viktoria Lioudyno, Andrei Svistunov, Eugene Ponomarev, Klaus-Peter Lesch, Tatyana Strekalova
Glycogen synthase kinase 3 (GSK3) has been linked to the mechanisms of stress, mood regulation, and the effects of antidepressants. The functions of the GSK3β isoform have been extensively investigated, but little is known about the α-isoform, although they may functionally related. In a recently established modified swim test with a third delayed swim exposure, brain GSK3β mRNA expression positively correlated with floating behaviour on the third test. A two-week-long pretreatment regime with imipramine (7...
August 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28792172/concept-and-identification-of-soft-bipolarity-in-patients-presenting-with-depression-need-for-careful-screening-by-physicians
#5
Pooja Patnaik Kuppili, Priyanka Yadav, Raman Deep Pattanayak
The bipolar spectrum is a broader concept, which questions the strict dichotomous categorical division of erstwhile manic-depressive illness into two discrete categories viz. bipolar disorder and major depressive disorder, thereby overlooking a wide 'spectrum' of patients which lie 'in between' the two extremes. The presence of underlying bipolar 'spectrum' or 'soft bipolarity' often goes undetected in patients presenting with major depression. This sub-group of patients may not stabilize with indiscriminate use of anti-depressant drugs, and without proper management, it may be associated with continued non-responsive symptoms, increased suicidality and poorer prognosis...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28792097/a-closer-lens-cancer-survivors-supportive-intervention-preferences-and-interventions-received
#6
Joanna J Arch, Rachel Vanderkruik, Alex Kirk, Alaina L Carr
BACKGROUND: Cancer survivor preferences for formal interventions designed to provide psychological support remain relatively unknown. To address this gap, we evaluated cancer survivors' preferences for psychological intervention, whom they preferred to recommend such intervention, and how their preferences compared with what they currently received. METHODS: U.S. cancer survivors (n = 345) who were at least 2 months post-treatment for diverse forms of cancer were recruited online to complete a survey study...
August 9, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28789578/accelerated-itbs-treatment-in-depressed-patients-differentially-modulates-reward-system-activity-based-on-anhedonia
#7
Romain Duprat, Guo-Rong Wu, Rudi De Raedt, Chris Baeken
OBJECTIVES: Accelerated intermittent theta-burst stimulation (aiTBS) anti-depressive working mechanisms are still unclear. Because aiTBS may work through modulating the reward system and the level of anhedonia may influence this modulation, we investigated the effect of aiTBS on reward responsiveness in high and low anhedonic MDD patients. METHODS: In this registered RCT (NCT01832805), 50 MDD patients were randomised to a sham-controlled cross-over aiTBS treatment protocol over the left dorsolateral prefrontal cortex (DLPFC)...
August 9, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28782622/banxia-houpu-decoction-restores-glucose-intolerance-in-cums-rats-through-improvement-of-insulin-signaling-and-suppression-of-nlrp3-inflammasome-activation-in-liver-and-brain
#8
Ke-Ke Jia, Yan-Jing Zheng, Yan-Xiu Zhang, Jia-Hui Liu, Rui-Qing Jiao, Ying Pan, Ling-Dong Kong
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia-houpu decoction is a famous formula in traditional Chinese medicine (TCM) with the powerful anti-depressant activity. AIM OF THE STUDY: This study aimed to investigate the effect of Banxia-houpu decoction on glucose intolerance associated with anhedonia in chronic unpredictable mild stress (CUMS) rats, then to explore its underlying pharmacological mechanisms. MATERIALS AND METHODS: After 6-week CUMS procedure, male Wistar rats were given Banxia-houpu decoction (3...
August 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28777476/clinical-depression-as-an-unfavorable-prognostic-factor-following-kidney-transplantation-how-can-we-explain-it
#9
Jeffrey J Gaynor, Gaetano Ciancio
In this issue Lentine et al(1) provide a well thought-out analysis of the prognostic value of antidepressant medication use (as a surrogate measure of clinical depression) on post-transplant outcome. Specifically, they show that among 72,054 SRTR patients receiving a kidney transplant during 2008-2015, anti-depressant use (obtained from pharmaceutical fill records) within one year of transplant and during the first year post-transplant (12.6% and 18.0% of patients, respectively) correlated with a significantly higher death rate during the first and 2(nd) year post-transplant (P<...
August 4, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28769008/ketamine-alleviates-depressive-like-behaviors-via-down-regulating-inflammatory-cytokines-induced-by-chronic-restraint-stress-in-mice
#10
Sijie Tan, Yan Wang, Ke Chen, Zhifeng Long, Ju Zou
The purpose of the present study was to investigate whether ketamine's rapid antidepressant effects were associated with its anti-inflammatory actions and to explore the underlying molecular mechanism. Depressive-like behaviors was induced in mice using chronic restraint stress (CRS) method. Anti-depressive effects of ketamine were evaluated by forced swimming tests (FST) and sucrose preference test (SPT). Subsequently, brain tissue was harvested to investigate inflammatory response in the hippocampus via investigating reactive microglia numbers, serum cytokines levels and the toll-like receptor type 4 (TLR4)/p38 mitogen-activated protein kinase (MAPK) pathway...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28763668/effects-of-exposure-to-pharmaceuticals-diclofenac-and-carbamazepine-spiked-sediments-in-the-midge-chironomus-riparius-diptera-chironomidae
#11
Elena Nieto, Carmen Corada-Fernández, Miriam Hampel, Pablo A Lara-Martín, Paloma Sánchez-Argüello, Julián Blasco
Human and veterinary pharmaceuticals and degradation products are continuously introduced into the environment. To date, there is a lack of information about the effects of pharmaceuticals in spiked toxicity tests with non-target organisms. In this study, we have evaluated the effects of exposure to two common pharmaceuticals in the midge Chironomus riparius in spiked sediment experiments. The selected pharmaceuticals are the nonsteroidal anti-inflammatory drug (NSAID): diclofenac (DF) and the anti-depressant drug carbamazepine (CBZ)...
July 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28748167/therapeutic-efficacy-of-rose-oil-a-comprehensive-review-of-clinical-evidence
#12
REVIEW
Safieh Mohebitabar, Mahboobeh Shirazi, Sodabeh Bioos, Roja Rahimi, Farhad Malekshahi, Fatemeh Nejatbakhsh
OBJECTIVE: Rose oil is obtained from the petals of difference Rosa species especially Rosa centifolia L. and Rosa damascena Mill. Various pharmacological properties have been attributed to rose oil. The aim of the present study was to review the rose oil therapeutic effects which had been clinically evaluated in trial studies. MATERIALS AND METHODS: Google scholar, PubMed, Cochrane Library, and Scopus were searched for human studies which have evaluated the therapeutic effects of rose oil and published in English language until August 2015...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28739180/uptake-of-mental-health-websites-in-primary-care-insights-from-an-australian-longitudinal-cohort-study-of-depression
#13
Jane Gunn, Jacqui Cameron, Konstancja Densley, Sandra Davidson, Susie Fletcher, Victoria Palmer, Patty Chondros, Christopher Dowrick, Jane Pirkis
OBJECTIVE: To describe the characteristics of primary care attendees with depressive symptoms who use mental health websites. METHODS: 789 individuals with depressive symptoms recruited and followed up annually for nine years. Self-reported written surveys included mental health, professional and self-help use, e-mental health interventions or therapeutic websites. Marginal logistic regression examined association between mental health website (MHW) use and patient's mental health, health services use, anti-depressant use and self-help strategies...
July 11, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28725139/hybrid-polymeric-matrices-for-oral-modified-release-of-desvenlafaxine-succinate-tablets
#14
Wael Samy, Ayman Elnoby, Hanan M El-Gowelli, Nazik Elgindy
Purpose: Desvenlafaxine succinate (DSV) is a water soluble anti-depressant drug, which is rapidly absorbed after oral administration exaggerating its side effects. The current work aimed to prepare controllable release DSV matrix to reduce DSV side effects related to its initial burst. Methods: Fifteen DSV matrix formulations were prepared using different polymers, polymer/drug ratios and matrix excipients and characterized using Differential Scanning Calorimetry (DSC), infrared (IR) spectroscopy, water uptake and in vitro DSV release...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28711395/silymarin-ameliorates-experimentally-induced-depressive-like-behavior-in-rats-involvement-of-hippocampal-bdnf-signaling-inflammatory-cytokines-and-oxidative-stress-response
#15
Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Patel
Silymarin is a polyphenolic flavonoid of Silybum marianum, exhibited neuroprotection and antidepressant like activity in acute restraint stressed mice. The main objective of the present study is to investigate possible antidepressant like activity of silymarin in experimentally induced depressive behavior in rats. The depressive behaviors were induced in rats by olfactory bulbectomized (OBX) technique. Wistar rats were administered with silymarin at a dose of 100mg/kg and 200mg/kg, by per oral in OBX and sham operated rats...
July 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28699310/the-effects-of-seh-inhibitor-on-depression-like-behavior-and-neurogenesis-in-male-mice
#16
Qiong Wu, Hongyang Cai, Jingfang Song, Quanzhong Chang
Currently antidepressants take several weeks to be effective, which is one of the main reasons why patients with depression quit therapy. In the present study, we examine the acute and subacute effects of soluble epoxide hydolase (sEH) inhibitor (sEHI), a compound shown to have antidepressant effects, on mice. We found that acute administration of sEHI TPPU decreases immobility time in the forced swimming test and reduces latency to feed in the novelty suppressed-feeding test in adult male mice. Intraperitoneal administration of TPPU for seven days also increased interaction time of socially defeated mice in the social defeat test...
July 12, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28697488/the-interpersonal-adverse-effects-reported-by-1008-users-of-antidepressants-and-the-incremental-impact-of-polypharmacy
#17
John Read, Aimee Gee, Jacob Diggle, Helen Butler
Antidepressant drugs are being prescribed at ever increasing rates internationally, despite marginal benefit compared to placebo and a range of adverse effects. Most studies of adverse effects focus on biological phenomena. This article presents the results of an online survey of 1008 self-selected anti-depressant users in Britain, which asked about five adverse effects in the interpersonal domain. The most commonly reported among participants who took only antidepressants were: Sex Life - 43.7%, Work or Study - 27...
July 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28695536/molecular-mechanisms-underlying-the-anti-depressant-effects-of-resveratrol-a-review
#18
REVIEW
Marcos Roberto de Oliveira, Aline Lukasievicz Chenet, Adriane Ribeiro Duarte, Giselli Scaini, João Quevedo
Major depression is a public health problem, affecting 121 million people worldwide. Patients suffering from depression present high rates of morbidity, causing profound economic and social impacts. Furthermore, patients with depression present cognitive impairments, which could influence on treatment adherence and long-term outcomes. The pathophysiology of major depression is not completely understood yet but involves reduced levels of monoamine neurotransmitters, bioenergetics, and redox disturbances, as well as inflammation and neuronal loss...
July 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28694433/antidepressant-effect-of-taurine-in-chronic-unpredictable-mild-stress-induced-depressive-rats
#19
Gao-Feng Wu, Shuang Ren, Ri-Yi Tang, Chang Xu, Jia-Qi Zhou, Shu-Mei Lin, Ying Feng, Qun-Hui Yang, Jian-Min Hu, Jian-Cheng Yang
Depression, a psychiatric and dysthymic disorder, severely affects the learning, work and life quality. The main pathogenesis of depression is associated with central nervous system (CNS) dysfunction. Taurine has been demonstrated to exert protective effects on the brain development and can improve learning ability and memory. Our study investigated the antidepressant-like effects of taurine pre-treatment by examining the changes in depression-like behavior, hormones, neurotransmitters, inflammatory factors and neurotrophic factors in the hippocampus of a chronic unpredictable mild stress (CUMS)-induced depressive rat model...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28687902/decreased-brain-serotonin-turnover-rate-following-administration-of-sharbat-e-ahmed-shah-produces-antidepressant-and-anxiolytic-effect-in-rats
#20
Muhammad Ahmed, Aisha Azmat
Sharbat-e-Ahmed Shah (SAS) has usually been used in Traditional Unani Medicine (TUM) for depression and insomnia but still not evaluated for its anti-depressant and Neuropharmacological activity. In the present study, a Human dose of SAS (0.6 ml/kg/d) was administered orally to the rats for 15 consecutive days. Antidepressant and anxiolytic were screened scientifically in rats by using Forced swim test and light and dark box test. At the end of study high-performance liquid chromatographic (HPLC) method with electrochemical (EC) detector was used for the measurement of blood and brain tryptophan and brain serotonin levels...
July 7, 2017: Metabolic Brain Disease
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