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https://www.readbyqxmd.com/read/29674846/costs-of-medication-in-older-patients-before-and-after-comprehensive-geriatric-assessment
#1
Gulcin Done Unutmaz, Pinar Soysal, Busra Tuven, Ahmet Turan Isik
Background: Polypharmacy and inappropriate drug use cause numerous complications, such as cognitive impairment, frailty, falls, and functional dependence. The present study aimed to determine the effect of the comprehensive geriatric assessment (CGA) on polypharmacy, potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs), and to evaluate the economic reflections of medication changes. Methods: One thousand five hundred and seventy-nine older patients, who had undergone CGA, were retrospectively evaluated...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29674117/electroconvulsive-seizures-influence-dendritic-spine-morphology-and-bdnf-expression-in-a-neuroendocrine-model-of-depression
#2
Kristen R Maynard, John W Hobbs, Sumita K Rajpurohit, Keri Martinowich
BACKGROUND: Electroconvulsive therapy (ECT) is a rapid and effective treatment for major depressive disorder. Chronic stress-induced depression causes dendrite atrophy and deficiencies in brain-derived neurotrophic factor (BDNF), which are reversed by anti-depressant drugs. Electroconvulsive seizures (ECS), an animal model of ECT, robustly increase BDNF expression and stimulate dendritic outgrowth. OBJECTIVE: The present study aims to understand cellular and molecular plasticity mechanisms contributing to the efficacy of ECS following chronic stress-induced depression...
April 6, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29673237/panax-notoginseng-saponins-a-review-of-its-mechanisms-of-antidepressant-or-anxiolytic-effects-and-network-analysis-on-phytochemistry-and-pharmacology
#3
REVIEW
Weijie Xie, Xiangbao Meng, Yadong Zhai, Ping Zhou, Tianyuan Ye, Zhen Wang, Guibo Sun, Xiaobo Sun
Panax notoginseng (Burk) F. H. Chen , as traditional Chinese medicine, has a long history of high clinical value, such as anti-inflammatory, anti-oxidation, inhibition of platelet aggregation, regulation of blood glucose and blood pressure, inhibition of neuronal apoptosis, and neuronal protection, and its main ingredients are Panax notoginseng saponins (PNS). Currently, Panax notoginseng (Burk) F. H. Chen may improve mental function, have anti-insomnia and anti-depression effects, alleviate anxiety, and decrease neural network excitation...
April 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29666578/individual-experiences-in-four-cancer-patients-following-psilocybin-assisted-psychotherapy
#4
Tara C Malone, Sarah E Mennenga, Jeffrey Guss, Samantha K Podrebarac, Lindsey T Owens, Anthony P Bossis, Alexander B Belser, Gabrielle Agin-Liebes, Michael P Bogenschutz, Stephen Ross
A growing body of evidence shows that existential and spiritual well-being in cancer patients is associated with better medical outcomes, improved quality of life, and serves as a buffer against depression, hopelessness, and desire for hastened death. Historical and recent research suggests a role for psilocybin-assisted psychotherapy in treating cancer-related anxiety and depression. A double-blind controlled trial was performed, where 29 patients with cancer-related anxiety and depression were randomly assigned to treatment with single-dose psilocybin (0...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29653157/do-depressive-symptoms-affect-balance-in-older-adults-with-mild-cognitive-impairment-results-from-the-gait-and-brain-study
#5
Frederico Pieruccini-Faria, Susan W Muir-Hunter, Manuel Montero-Odasso
BACKGROUND: Mild cognitive impairment (MCI) and depression independently affect balance control in older adults. However, it is uncertain whether depressive symptoms would amplify balance problems in older adults with MCI. AIM: To evaluate if the presence of significant depressive symptoms affects postural sway under somatosensory challenges in a MCI population. METHODS: Eighty two participants (mean of 75.3 ± 6.4 years of age; 46% women) with MCI completed cognitive and balance assessments...
April 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29615471/pharmacological-characterizations-of-h05-a-novel-potent-serotonin-and-noradrenaline-reuptake-inhibitor-with-moderate-5-ht2a-antagonist-activity-for-anti-depression
#6
Xiangqing Xu, Yaqin Wei, Qiang Guo, Song Zhao, Zhiqiang Liu, Ting Xiao, Yani Liu, Yinli Qiu, Yuanyuan Hou, Guisen Zhang, Kewei Wang
Multi-target antidepressants selectively inhibiting monoaminergic transporters and 5-HT2A receptors have demonstrated higher efficacy and fewer side effects than selective serotonin reuptake inhibitors (SSRIs). In the present study, we synthesized a series of novel 3-(benzo[d] [1, 3] dioxol-4-yloxy)-3-arylpropyl amine derivatives, among which H05 was identified as a lead compound with potent inhibition effects on both serotonin (Ki=4.81 nM) and norepinephrine (Ki=6.72 nM) transporters and moderate 5-HT2A antagonist activity (IC50=60...
April 3, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29606554/the-effects-of-exercise-on-sexual-function-in-women
#7
REVIEW
Amelia M Stanton, Ariel B Handy, Cindy M Meston
BACKGROUND: Acute exercise is associated with transient changes in metabolic rate, muscle activation, and blood flow, whereas chronic exercise facilitates long-lasting adaptations that ultimately improve physical performance. Exercise in general is known to improve both physical and psychological health, but the differential effects of brief bouts of exercise vs long-term exercise regimens on sexual function are less clear. AIM: The purpose of this review was to assess the direct and indirect effects of both acute and chronic exercise on multiple domains of sexual function in women...
March 29, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29600729/astroglial-5-ht-2b-receptor-in-mood-disorders
#8
Liang Peng, Dan Song, Baoman Li, Alexei Verkhratsky
Astroglia represent the main cellular homeostatic system of the central nervous system (CNS). Astrocytes are intimately involved in regulation and maintenance of neurotransmission by regulating neurotransmitters removal and turnover and by supplying neurons with neurotransmitters precursors. Astroglial cells are fundamental elements of monoaminergic transmission in the brain and in the spinal cord. Astrocytes receive monoaminergic inputs and control catabolism of monoamines through dedicated transporters and intracellular enzymatic pathways...
March 30, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29596898/histamine-deficient-mice-do-not-respond-to-the-antidepressant-like-effects-of-oleoylethanolamide
#9
Alessia Costa, Claudia Cristiano, Tommaso Cassano, Cristina Anna Gallelli, Silvana Gaetani, Carla Ghelardini, Patrizio Blandina, Antonio Calignano, M Beatrice Passani, Gustavo Provensi
It has been suggested that the bioactive lipid mediator oleoylethanolamide (OEA), a potent agonist of the peroxisome proliferator-activated receptor-alpha (PPAR-α) possesses anti-depressant-like effects in several preclinical models. We recently demonstrated that several of OEA's behavioural actions require the integrity of the brain histaminergic system, and that an intact histaminergic neurotransmission is specifically required for selective serotonin re-uptake inhibitors to exert their anti-depressant-like effect...
March 26, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29588852/treating-refractory-depression-in-parkinson-s-disease-a-meta-analysis-of-transcranial-magnetic-stimulation
#10
REVIEW
Alexandra M Lesenskyj, Megan P Samples, Jill M Farmer, Christina R Maxwell
Background: Parkinson's disease (PD) is often accompanied by clinically identified depression. Providing effective pharmacotherapies that concomitantly treat both motor and psychological symptoms can pose a challenge to physicians. For this reason, alternatives to standard anti-depressant treatments, such as repetitive transcranial magnetic stimulation (rTMS), have been evaluated within the Parkinson's population. Methods: A literature search was conducted on the PubMed database for all studies that evaluated rTMS as a treatment in patients with both depression and PD...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29582531/metabolic-control-of-type-1-diabetes-in-youth-with-autism-spectrum-disorder-a-multicenter-diabetes-patienten-verlaufsdokumentation-analysis-based-on-61-749-patients-up-to-20-years-of-age
#11
J-F Lemay, S Lanzinger, D Pacaud, P L Plener, A Fürst-Burger, T Biester, D Hilgard, E Lilienthal, A Galler, G Berger, R W Holl
BACKGROUND: A paucity of reports in the literature exists concerning the co-existence between autism spectrum disorder (ASD) and type 1 diabetes (T1D). OBJECTIVE: To compare clinical characteristics, diabetes management and metabolic control in youth with T1D and ASD (T1D-ASD) with youth without ASD (T1D-non ASD). METHODS: Using the German/Austrian diabetes patient follow-up registry, this study analyzed aggregated data from the last available year of observation for each patient with T1D, ages 1-20 with consistent data on insulin regimen and glycated hemoglobin (A1C), between January, 2005 and March, 2017...
March 26, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29573734/a-systematic-data-acquisition-and-mining-strategy-for-chemical-profiling-of-aster-tataricus-rhizoma-ziwan-by-uhplc-q-tof-ms-and-the-corresponding-anti-depressive-activity-screening
#12
Yupeng Sun, Li Li, Man Liao, Min Su, Changchen Wan, Lantong Zhang, Hailin Zhang
In this study, a systematic data acquisition and mining strategy aimed at the traditional Chinese medicine (TCM) complex system based on ultra high-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry (UHPLC-Q-TOF-MS) was reported. The workflow of this strategy is as follows: First, the high resolution mass data are acquired by both data-dependent acquisition mode (DDA) and data-independent acquisition mode (DIA). Then a global data mining that combined targeted and non-targeted compound finding is applied to analyze mass spectral data...
March 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29566235/case-reports-of-fatalities-involving-tianeptine-in-the-united-states
#13
Erica L Bakota, Warren C Samms, Teresa R Gray, Deanna A Oleske, Merrill O Hines
Tianeptine is a tricyclic anti-depressant that is also known to have opioid receptor activity. We present two fatal cases of tianeptine intoxication in Texas in which tianeptine was used recreationally. The first case involved a 28-year-old white male found alone on the floor of his locked residence. He had a history of drug abuse but no other toxicological findings. The second case involved a 30-year-old white male found on the floor of the bathroom in his home. Drug paraphernalia and bags labeled as tianeptine powder were found at both scenes...
March 16, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29563960/compassion-fatigue-and-substance-use-among-nurses
#14
Reem Jarrad, Sawsan Hammad, Tagreed Shawashi, Naser Mahmoud
Aim: This study aimed to detect if there were differences in compassion fatigue (CF) among nurses based on substance use and demographic variables of gender, marital status, type of health institution and income. Background: Compassion fatigue is considered an outcome of poorly handled stressful situations in which nurses may respond with self-harming behaviours like substance use. Evidence in this area is critically lacking. Methods: This study used a descriptive design to survey differences in CF of 282 nurses...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29561801/development-and-validation-of-a-hplc-esi-ms-ms-method-for-simultaneous-quantification-of-fourteen-alkaloids-in-mouse-plasma-after-oral-administration-of-the-extract-of-corydalis-yanhusuo-tuber-application-to-pharmacokinetic-study
#15
Weijuan Du, Lisha Jin, Liping Li, Wei Wang, Su Zeng, Huidi Jiang, Hui Zhou
The tuber of Corydalis yanhusuo is a famous traditional Chinese medicine and found to have potent pharmacological effects, such as antinociceptive, antitumor, antibacterial, anti-inflammatory, and anti-depressive activities. Although there are several methods to be developed for the analysis and detection of the bioactive ingredients' alkaloids, so far, only few prominent alkaloids could be quantified, and in vitro and in vivo changes of comprehensive alkaloids after oral administration are still little known...
March 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29558731/polymorphism-genotyping-based-on-loop-mediated-isothermal-amplification-and-smartphone-detection
#16
Eric Seiti Yamanaka, Luis A Tortajada-Genaro, Nuria Pastor, Ángel Maquieira
The genotyping of a single-nucleotide polymorphism (SNP) is addressed through methods based on loop-mediated isothermal amplification (LAMP) combined with user-friendly optical read-outs to cover the current demand for point-of-care DNA biomarker detection. The modification of primer design and reaction composition improved the assay selectivity yielding allele-specific results and reducing false-positive frequency. Furthermore, the reduced cost, ease of use and effectiveness of colorimetric detection (solution and hybridisation chip formats) were availed for the image capture by a smartphone, reching high sensitivity...
March 8, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29529676/evaluation-of-the-neurobehavioral-properties-of-naringin-in-swiss-mice
#17
Benneth Ben-Azu, Ekene Enekabokom Nwoke, Solomon Umukoro, Adegbuyi Oladele Aderibigbe, Abayomi Mayowa Ajayi, Ezekiel O Iwalewa
OBJECTIVES: This study was carried out to investigate the neurobehavioral properties of naringin, a flavonoid compound formed from naringenin on behavioral models in mice. METHOD: The neurobehavioral property of naringin (2.5, 5 and 10 mg/kg) administered intraperitoneally (i.p.) was assessed on novelty-induced rearing, locomotor behavior using open field test; anxiolytic effect was evaluated using hole-board, light and dark box, and elevated-plus maze paradigms...
March 12, 2018: Drug Research
https://www.readbyqxmd.com/read/29525447/-epidemiology-and-associated-factors-with-depression-among-people-suffering-from-epilepsy-a-transversal-french-study-in-a-tertiary-center
#18
C Vallée, A Biraben, A Nica, M Loiseau
OBJECTIVES: The occurrence of depression in people with epilepsy is almost twice as common as in the general population. Furthermore, depression is the first cause of lower quality of life among those patients. Which is why the main goal of this study was to assess the epidemiology of depression and its associated factors among the patients from the tertiary department of epileptology in Rennes. METHODS/RESULTS: The subjects were included prospectively and consecutively at the moment of their consultation or hospitalisation in the department...
March 7, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29520002/stimulated-left-dlpfc-nucleus-accumbens-functional-connectivity-predicts-the-anti-depression-and-anti-anxiety-effects-of-rtms-for-depression
#19
Lian Du, Huan Liu, Wanyi Du, Fenglei Chao, Lei Zhang, Kejian Wang, Chunxia Huang, Yuan Gao, Yong Tang
Not all depression patients effectively respond to repeated transcranial magnetic stimulation (rTMS). We tested whether the intrinsic functional connectivity (FC) strength between the stimulated left dorsolateral prefrontal cortex (DLPFC) and left nucleus accumbens (NAcc) might predict effects of rTMS. Twenty-two medication-naïve depression patients received rTMS on left DLPFC for 2 weeks and underwent baseline functional magnetic resonance imaging (fMRI). We compared the amplitude of the low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) in the stimulated target (the cortex region directly stimulated by rTMS) located in the left DLPFC, and the left NAcc, as well as the intrinsic FC of the DLPFC-NAcc between early improvers and non-improvers...
March 9, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29514323/israeli-general-practitioners-dissatisfaction-with-their-own-primary-healthcare
#20
Galia Zacay, Fabienne Hershkowitz Sikron, Anthony David Heymann
Background: Many physicians treat themselves despite established guidelines against such practice. Aims: To examine whether general practitioners (GPs) are satisfied with their personal primary care and how this could be improved. Methods: We sent a questionnaire to GPs in Israel. We examined the gap between preference to use formal medical care and use in practice, satisfaction with physicians' primary healthcare, self-prescribing and ways to improve physician access to care...
March 5, 2018: Occupational Medicine
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