keyword
https://read.qxmd.com/read/38535492/iron-oxide-magnetite-based-nanobiomaterial-with-medical-applications-environmental-hazard-assessment-using-terrestrial-model-species
#21
JOURNAL ARTICLE
Susana I L Gomes, Janeck J Scott-Fordsmand, Mónica J B Amorim
Nanobiomaterials (NBMs) have tremendous potential applications including in cancer diagnosis and treatment. However, the health and environmental effects of NBMs must be thoroughly assessed to ensure safety. Fe3 O4 (magnetite) nanoparticles coated with polyethylene glycol (PEG) and poly (lactic-co-glycolic acid) (PLGA) were one of the focus NBMs within the EU project BIORIMA. Fe3 O4 PEG-PLGA has been proposed to be used as a contrast agent in magnetic resonance imaging for the identification of solid tumors and has revealed low cytotoxicity in several cell lines...
February 22, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535474/novel-1-3-4-thiadiazole-3-2-a-pyrimidin-5-ones-as-promising-biofilm-dispersal-agents-against-relevant-gram-positive-and-gram-negative-pathogens
#22
JOURNAL ARTICLE
Daniela Carbone, Camilla Pecoraro, Fabio Scianò, Valentina Catania, Domenico Schillaci, Barbara Manachini, Stella Cascioferro, Patrizia Diana, Barbara Parrino
Biofilm-associated infections pose significant challenges in healthcare settings due to their resistance to conventional antimicrobial therapies. In the last decade, the marine environment has been a precious source of bioactive molecules, including numerous derivatives with antibiofilm activity. In this study, we reported the synthesis and the biological evaluation of a new series of twenty-two thiadiazopyrimidinone derivatives obtained by using a hybridization approach combining relevant chemical features of two important classes of marine compounds: nortopsentin analogues and Essramycin derivatives...
March 15, 2024: Marine Drugs
https://read.qxmd.com/read/38535460/targeted-metabolite-fingerprints-of-thirteen-gambierdiscus-five-coolia-and-two-fukuyoa-species
#23
JOURNAL ARTICLE
J Sam Murray, Emillie M F Passfield, Lesley L Rhodes, Jonathan Puddick, Sarah C Finch, Kirsty F Smith, Roel van Ginkel, Elizabeth M Mudge, Tomohiro Nishimura, Hiroshi Funaki, Masao Adachi, Michèle R Prinsep, D Tim Harwood
The genus Gambierdiscus produces an array of bioactive hydrophilic and lipophilic secondary metabolites that range in mode of action and toxicity. In this study, the metabolite fingerprint was mapped for thirteen Gambierdiscus , five Coolia and two Fukuyoa species (34 isolates) by assessing the production of 56 characterised secondary metabolites. Gambierdiscus polynesiensis was the only species to produce Pacific-ciguatoxin-3B (P-CTX3B), P-CTX3C, iso-P-CTX3B/C, P-CTX4A, P-CTX4B and iso-P-CTX4A/B. G. australes produced maitotoxin-1 (MTX-1) and MTX-5, G...
March 2, 2024: Marine Drugs
https://read.qxmd.com/read/38535439/algae-based-nanoparticles-for-oral-drug-delivery-systems
#24
JOURNAL ARTICLE
Eliyahu Drori, Dhaval Patel, Sarah Coopersmith, Valeria Rahamim, Chen Drori, Suchita Suryakant Jadhav, Roni Avital, Yaakov Anker, Aharon Azagury
Drug administration by oral delivery is the preferred route, regardless of some remaining challenges, such as short resident time and toxicity issues. One strategy to overcome these barriers is utilizing mucoadhesive vectors that can increase intestinal resident time and systemic uptake. In this study, biomimetic nanoparticles (NPs) were produced from 14 types of edible algae and evaluated for usage as oral DDSs by measuring their size, surface charge, morphology, encapsulation efficiency, mucoadhesion force, and cellular uptake into Caco-2 cells...
February 21, 2024: Marine Drugs
https://read.qxmd.com/read/38535405/combinations-of-lemongrass-and-star-anise-essential-oils-and-their-main-constituent-synergistic-housefly-repellency-and-safety-against-non-target-organisms
#25
JOURNAL ARTICLE
Mayura Soonwera, Jirisuda Sinthusiri, Hataichanok Passara, Tanapoom Moungthipmalai, Cheepchanok Puwanard, Sirawut Sittichok, Kouhei Murata
The present study evaluated the housefly repellency of single-component formulations and combinations of lemongrass and star anise essential oils (EOs) and their main constituents. The efficacies of the combinations were compared against those of single-component formulations and DEET. Safety bioassays of all formulations and DEET on non-target species-guppy, molly, dwarf honeybee, and stingless bee-were conducted. GC-MS analysis showed that the main constituent of lemongrass EO was geranial (46.83%) and that of star anise EO was trans -anethole (92...
March 20, 2024: Insects
https://read.qxmd.com/read/38535323/in-silico-analysis-of-novel-bacterial-metabolites-with-anticancer-activities
#26
JOURNAL ARTICLE
Pfariso Maumela, Mahloro Hope Serepa-Dlamini
Resistance to anticancer therapeutics is a major global concern. Thus, new anticancer agents should be aimed against novel protein targets to effectively mitigate the increased resistance. This study evaluated the potential of secondary metabolites from a bacterial endophyte, as new anticancer agents, against a novel protein target, fibroblast growth factor. In silico genomic characterization of the Bacillus sp. strain MHSD_37 was used to identify potential genes involved in encoding secondary metabolites with biological activity...
March 13, 2024: Metabolites
https://read.qxmd.com/read/38535267/a-comprehensive-study-on-folate-targeted-mesoporous-silica-nanoparticles-loaded-with-5-fluorouracil-for-the-enhanced-treatment-of-gynecological-cancers
#27
JOURNAL ARTICLE
Aliyah Almomen, Adel Alhowyan
BACKGROUND: Gynecological cancers are a significant public health concern, accounting for 40% of all cancer incidence and 30% of deaths in women. 5-Fluorouracil (5-FU) can be used with chemotherapy to improve treatment in advanced-stage gynecological cancer. Mesoporous silica nanoparticles (MSNs) can improve drug effectiveness and reduce toxicity. Folic acid can target folate receptors in epithelial malignancies like ovarian and cervical cancer. METHODS: The mixture of MSN-NH2 was synthesized by dissolving N-lauroylsarcosine sodium in a water-ethanol mixture, adding APTES and TEOS, and heating at 80 °C for 18 h, before being fully characterized...
March 20, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535245/influence-of-hybrid-surface-modification-on-biocompatibility-and-physicochemical-properties-of-ti-6al-4v-eli-titanium
#28
JOURNAL ARTICLE
Anna Woźniak, Weronika Smok, Janusz Szewczenko, Marcin Staszuk, Grzegorz Chladek
Titanium-based materials are the most widely used materials in biomedical applications. However, according to literature findings, the degradation products of titanium have been associated with potential allergic reactions, inflammation, and bone resorption. The corrosion process of Ti-6Al-4V in the human body environment may be exacerbated by factors such as reduced pH levels and elevated concentrations of chloride compounds. Coatings made of biopolymers are gaining attention as they offer numerous advantages for enhancing implant functionality, including improved biocompatibility, bioactivity, wettability, drug release, and antibacterial activity...
February 20, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535244/toxicity-assessment-of-new-ag-zno-ago-nanocomposites-an-in-vitro-and-in-vivo-approach
#29
JOURNAL ARTICLE
José Rodrigues do Carmo Neto, Pablo Igor Ribeiro Franco, Yarlla Loyane Lira Braga, Jordana Fernandes de Oliveira, Hugo Felix Perini, Luís Fernando Duarte Albuquerque, Danieli Brolo Martins, Fernanda Rodrigues Helmo, Anderson Assunção Andrade, Marina Pacheco Miguel, Mara Rúbia Nunes Celes, Thiago Lopes Rocha, Anielle Christine Almeida Silva, Juliana Reis Machado, Marcos Vinícius da Silva
Zinc oxide nanoparticles (ZnO NPs) are metal oxide nanomaterials, which are important for several applications: antibacterial, anthelmintic, antiprotozoal and antitumoral, among others. These applications are mainly related to the ability to spontaneously produce and induce the production of reactive oxygen species that are important components for the destruction of pathogens and tumor cells. While trying to potentiate ZnO NPs, studies have associated these NPs with silver oxide (AgO) or silver (Ag) NPs. It has already been reported that this combination (Ag-ZnO/AgO NPs) is able to enhance the microbicidal potential...
February 20, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535119/adme-gene-related-pharmacogenomic-labeling-of-fda-approved-drugs-comparison-with-clinical-pharmacogenetics-implementation-consortium-cpic-evidence-levels
#30
JOURNAL ARTICLE
Subrata Deb, Robert Hopefl, Anthony Allen Reeves, Dena Cvetkovic
Pharmacogenomics (PGx) can facilitate the transition to patient-specific drug regimens and thus improve their efficacy and reduce toxicity. The aim of this study was to evaluate the overlap of PGx classification for drug absorption, distribution, metabolism, and elimination (ADME)-related genes in the U.S. Food and Drug Administration (FDA) PGx labeling and in the Clinical Pharmacogenetics Implementation Consortium (CPIC) database. FDA-approved drugs and PGx labeling for ADME genes were identified in the CPIC database...
February 20, 2024: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/38534839/use-of-biomaterials-in-3d-printing-as-a-solution-to-microbial-infections-in-arthroplasty-and-osseous-reconstruction
#31
REVIEW
Argyrios Periferakis, Aristodemos-Theodoros Periferakis, Lamprini Troumpata, Serban Dragosloveanu, Iosif-Aliodor Timofticiuc, Spyrangelos Georgatos-Garcia, Andreea-Elena Scheau, Konstantinos Periferakis, Ana Caruntu, Ioana Anca Badarau, Cristian Scheau, Constantin Caruntu
The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others...
March 1, 2024: Biomimetics
https://read.qxmd.com/read/38534722/antifungal-and-coagulation-properties-of-a-copper-i-oxide-nanopowder-produced-by-out-of-phase-pulsed-sonoelectrochemistry
#32
JOURNAL ARTICLE
Valérie Mancier, Sirine Fattoum, Hélène Haguet, Julie Laloy, Christina Maillet, Sophie C Gangloff, Jean-Paul Chopart
Copper (I) oxide (cuprite) is a material widely used nowadays, and its versatility is further amplified when it is brought to the nanometric size. Among the possible applications of this nanomaterial, one of the most interesting is that in the medical field. This paper presents a cuprite nanopowder study with the aim of employing it in medical applications. With regards to the environmental context, the synthesis used is related to green chemistry since the technique (out-of-phase pulsed electrochemistry) uses few chemical products via electricity consumption and soft conditions of temperature and pressure...
March 21, 2024: Antibiotics
https://read.qxmd.com/read/38534674/anti-microbial-activities-of-mussel-derived-recombinant-proteins-against-gram-negative-bacteria
#33
JOURNAL ARTICLE
Dong Yun Kim, You Bin Oh, Je Seon Park, Yu-Hong Min, Min Chul Park
Many anti-microbial peptides (AMPs) and pro-apoptotic peptides are considered as novel anti-microbial agents, distinguished by their different characteristics. Nevertheless, AMPs exhibit certain limitations, including poor stability and potential toxicity, which hinder their suitability for applications in pharmaceutics and medical devices. In this study, we used recombinant mussel adhesive protein (MAP) as a robust scaffold to overcome these limitations associated with AMPs. Mussel adhesive protein fused with functional peptides (MAP-FPs) was used to evaluate anti-microbial activities, minimal inhibitory concentration (MIC), and time-kill kinetics (TKK) assays against six of bacteria strains...
March 5, 2024: Antibiotics
https://read.qxmd.com/read/38534103/-in-vitro-activity-of-omadacycline-against-clinical-isolates-of-nocardia
#34
JOURNAL ARTICLE
Jonathan Pham, Russell J Benefield, Natali Baker, Shane Lindblom, Nicholas Canfield, Carlos A Gomez, Mark Fisher
Nocardiosis typically requires a prolonged treatment duration of ≥6 months and initial combination therapy with 2-3 antibiotics. First-line regimens for nocardiosis are associated with considerable toxicity; therefore, alternative therapies are needed. Omadacycline is an aminomethylcycline with broad antimicrobial activity whose in vitro activity against Nocardia species has not been formally assessed. The in vitro potency of omadacycline was evaluated against 300 Nocardia clinical isolates by broth microdilution...
March 27, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38533913/case-report-systemic-lupus-erythematosus-combined-with-myocardial-hypertrophy
#35
JOURNAL ARTICLE
Shanshan Wang, Xinfeng Wei, Wenqing Yang, Dan Zhang
OBJECTIVE: Systemic lupus erythematosus (SLE) is a multisystem-involved, highly heterogeneous autoimmune disease with diverse clinical manifestations. We report an extremely rare case of SLE with severe diffuse myocardial hypertrophy. METHODS: The patient's echocardiography and cardiac magnetic resonance imaging (CMR) results indicated diffuse myocardial hypertrophy. After excluding coronary atherosclerosis, hypertensive cardiomyopathy, drug toxicity, and other causes, the patient was diagnosed with SLE-specific cardiomyopathy...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38533530/are-measures-and-related-symptoms-of-cachexia-recorded-as-outcomes-in-gastrointestinal-cancer-chemotherapy-clinical-trials
#36
JOURNAL ARTICLE
Ross Valaire, Frances Garden, Valentina Razmovski-Naumovski
BACKGROUND: Cachexia is prevalent in gastrointestinal cancers and worsens patient outcomes and chemotherapy compliance. We examined to what extent registered gastrointestinal cancer chemotherapy clinical trials record measures and related symptoms of cachexia as outcomes, and whether these were associated with trial characteristics. METHODS: Four public trial registries (2012-2022) were accessed for Phase II and/or III randomized controlled pancreatic, gastric, and colorectal cancer chemotherapy trial protocols...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38533155/granulocyte-colony-stimulating-factor-g-csf-induced-aortitis-a-case-report
#37
Masahiro Ito, Masakazu Amari, Akiko Sato, Masahiro Hikichi
Pegylated granulocyte colony-stimulating factor (G-CSF), commonly used in chemotherapy-induced neutropenia, has been associated with rare instances of aortitis. This study describes a 67-year-old female patient with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2-positive breast cancer, undergoing chemotherapy with an epirubicin/cyclophosphamide (EC) regimen (epirubicin, cyclophosphamide) and pegylated G-CSF for neutropenia prophylaxis. Post-treatment, she developed symptoms including intermittent fever and severe arthralgia...
February 2024: Curēus
https://read.qxmd.com/read/38532602/enhancing-the-antiproliferative-activity-of-perillyl-alcohol-against-glioblastoma-cell-lines-through-synergistic-formulation-with-natural-oils
#38
JOURNAL ARTICLE
Waleed S Alharbi, Abdullah A Alshehri, Tarek A Ahmed, Shadab Md, Alshaimaa M Almehmady, Manal A Alshabibi, Reem M Altamimi, Khalid M El-Say
BACKGROUND: Due to its volatility, photostability, and gastrointestinal toxicity, Perillyl Alcohol (POH), a monoterpenoid component of various plant species, is a chemotherapeutic drug with insufficient efficacy. Many naturally occurring bioactive compounds have well-known antiproliferative properties, including sefsol, jojoba, tea tree, and moringa oils. OBJECTIVE: This study sought to develop an oil-based Self Nanoemulsifying Drug Delivery System (SNEDDS) using tween 80 as the surfactant and Dimethyl Sulfoxide (DMSO) or Polyethylene Glycol (PEG) 400 as the cosurfactant; the oils were used in a range of 10-20% to boost POH's anticancer efficacy...
March 26, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38532510/care-management-and-use-of-ferrets-in-biomedical-research
#39
REVIEW
Ravindran Kumar Pramod, Pravin Kumar Atul, Mamta Pandey, S Anbazhagan, Suhas T Mhaske, R Barathidasan
The ferret (Mustela putorius furo) is a small domesticated species of the family Mustelidae within the order Carnivora. The present article reviews and discusses the current state of knowledge about housing, care, breeding, and biomedical uses of ferrets. The management and breeding procedures of ferrets resemble those used for other carnivores. Understanding its behavior helps in the use of environmental enrichment and social housing, which promote behaviors typical of the species. Ferrets have been used in research since the beginning of the twentieth century...
March 26, 2024: Laboratory Animal Research
https://read.qxmd.com/read/38532393/acceptability-and-usefulness-of-the-eortc-write-in-three-symptoms-problems-wisp-a-brief-open-ended-instrument-for-symptom-assessment-in-cancer-patients
#40
JOURNAL ARTICLE
Leslye Rojas-Concha, Juan Ignacio Arrarrás, Thierry Conroy, Tara Chalk, Monica Guberti, Bernhard Holzner, Olga Husson, Dagmara Kuliś, Omar Shamieh, Claire Piccinin, María José Puga, Gudrun Rohde, Mogens Groenvold
BACKGROUND: The use of open-ended questions supplementing static questionnaires with closed questions may facilitate the recognition of symptoms and toxicities. The open-ended 'Write In three Symptoms/Problems (WISP)' instrument permits patients to report additional symptoms/problems not covered by selected EORTC questionnaires. We evaluated the acceptability and usefulness of WISP with cancer patients receiving active and palliative care/treatment in Austria, Chile, France, Jordan, the Netherlands, Norway, Spain and the United Kingdom...
March 26, 2024: Health and Quality of Life Outcomes
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