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https://www.readbyqxmd.com/read/28918602/population-pharmacokinetics-and-optimal-sampling-strategy-for-model-based-precision-dosing-of-melphalan-in-patients-undergoing-hematopoietic-stem-cell-transplantation
#1
Kana Mizuno, Min Dong, Tsuyoshi Fukuda, Sharat Chandra, Parinda A Mehta, Scott McConnell, Elias J Anaissie, Alexander A Vinks
BACKGROUND: High-dose melphalan is an important component of conditioning regimens for patients undergoing hematopoietic stem cell transplantation. The current dosing strategy based on body surface area results in a high incidence of oral mucositis and gastrointestinal and liver toxicity. Pharmacokinetically guided dosing will individualize exposure and help minimize overexposure-related toxicity. OBJECTIVE: The purpose of this study was to develop a population pharmacokinetic model and optimal sampling strategy...
September 16, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28918338/a-short-term-swimming-speed-alteration-test-with-nauplii-of-artemia-franciscana
#2
Silvia Morgana, Noelia Estévez-Calvar, Chiara Gambardella, Marco Faimali, Francesca Garaventa
The presence of toxicant needs to be assessed within short time in order to effectively protect the aquatic environment from serious threat. Based on the observation that at high temperatures aquatic organisms become more vulnerable to stressors than those maintained at room temperature, a new test was developed. The proposed bioassay consisted in the evaluation of the swimming speed alteration (SSA) of nauplii of Artemia franciscana incubated at 39°C (± 1) for 6h, using a Swimming Behavior Recorder system (SBR)...
September 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28918337/ecotoxicological-and-microbiological-assessment-of-sewage-sludge-associated-with-sugarcane-bagasse
#3
Lais Roberta Deroldo Sommaggio, Dânia Elisa Christofoletti Mazzeo, Débora de Andrade E Silva Sant' Anna, Carlos Emílio Levy, Maria Aparecida Marin-Morales
Sewage sludge (SS) obtained after sewage treatment process may contain several toxic substances. Bioremediation can decrease the toxicity of the sludge, mainly when it is associated with stimulant agents, such as sugarcane bagasse (B). Samples of pure SS (SSP); SS+B; SS+Soil; and SS+B+Soil were bioremediated for 1, 3, and 6 months (T1, T2, and T3, respectively). After each period, the cytotoxic, genotoxic, and mutagenic potentials of the solid samples and their respective aqueous extracts (aqueous eluate and percolate water) were evaluated by the Allium cepa test...
September 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28918228/primary-photosensitization-and-contact-dermatitis-caused-by-malachra-fasciata-jacq-n-v-malvaceae-in-sheep
#4
Valber Onofre de Araújo, Temístocles Soares Oliveira Neto, Sara Vilar Dantas Simões, Thatyana Kelly Ferreira da Silva, Franklin Riet-Correa, Ricardo Barbosa Lucena
Farmers from Paraiba state, Northeast Brazil, claim that Malachra fasciata causes cutaneous lesions in sheep. To test its toxicity the plant was harvested daily and fed ad libitum for 21 days to 3 sheep as the sole food source (# 1-3). An additional sheep (# 4) was maintained as a control. Cutaneous lesions of photosensitization initiated after 7 days and increased continuously over the next 21 days. The dose ingested varied between 129 g/kg to 175 g/kg. Alopecia, hyperemia and crusting were observed in the animals...
September 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28917937/pyrazole-based-compounds-in-chitosan-liposomal-emulsion-for-antimicrobial-cotton-fabrics
#5
Ahmed Nada, Marwa Al-Moghazy, Ahmed A F Soliman, Gehan M T Rashwan, Taghreed Hosny Ahmed Eldawy, Ashraf Abd Elhakim Hasan, Galal Hosni Sayed
The chemistry of pyrazoles has gained increasing attention due to its diverse pharmacological properties such as antiviral, antagonist, antimicrobial, anticancer, anti-inflammatory, analgesic, anti-prostate cancer, herbicidal, acaricidal and insecticidal activities. 1-phenyl pyrazole-3, 5-diamine, 4-[2-(4-methylphenyl) diazenyl] and 1H- pyrazole-3 (1), 5-diamine, 4-[2-(4-methylphenyl) diazenyl] (2) were synthesized, characterized and encapsulated into liposomal chitosan emulsions for textile finishing. The chemical modifications of cotton fabrics were demonstrated by infrared analysis...
September 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28917309/toxic-action-of-acmella-oleracea-extract-on-the-male-reproductive-system-of-amblyomma-cajennense-ticks
#6
Luís Adriano Anholeto, Patrícia Rosa de Oliveira, Rodney Alexandre Ferreira Rodrigues, Lais Thiemi Yamane, Karina Neoob de Carvalho Castro, Allan Roberto Fernandes Ferreira, Maria Izabel Camargo-Mathias
The present study evaluated through morphohistological and histochemical techniques the effects of different concentrations of crude ethanolic extract of A. oleracea (EEAO) (Jambu) on the male reproductive system of Amblyomma cajennense sensu stricto (s.s.) ticks. The toxicity of this natural chemical was stablished, signalizing the promising potential of the compound as a strategy to control ectoparasites in the near future. For the experiment, 100 males fed on host rabbits with homogeneous weight (p>0...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28917301/cysteine-protease-30-cp30-contributes-to-adhesion-and-cytopathogenicity-in-feline-tritrichomonas-foetus
#7
Emily N Gould, Richard Giannone, Stephen A Kania, M Katherine Tolbert
Tritrichomonas foetus (T. foetus) is a flagellated protozoan parasite that is recognized as a significant cause of diarrhea in domestic cats with a prevalence rate as high as 30%. No drugs have been shown to consistently eliminate T. foetus infection in all cats. Cysteine proteases (CPs) have been identified as mediators of T. foetus-induced adhesion-dependent cytotoxicity to the intestinal epithelium. These CPs represent novel targets for the treatment of feline trichomonosis. However, cats also produce CPs that are part of life-critical systems...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28917214/novel-5-nitrofurfuryl-substituted-esters-of-phosphonoglycine-their-synthesis-and-phyto-and-ecotoxicological-properties
#8
Jarosław Lewkowski, Marta Morawska, Rafał Karpowicz, Piotr Rychter, Diana Rogacz, Kamila Lewicka
Since aminophosphonate-based herbicides like glyphosate are currently one of the most popular and widely applied active agent in agrochemistry, there is an urgent need for searching new compounds among this family with potential herbicidal activity, but exhibiting low toxicity against surrounding environment. Six new (5-nitrofurfuryl)-derived aminophosphonates were synthesized for the first time and apart from the only one example of N-benzylamino(5-nitrofuryl)-methylphosphonic acid, it was the first time in the history, when this class of compounds was prepared...
September 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28917212/comparative-analytical-and-toxicological-assessment-of-methylcyclohexanemethanol-mchm-mixtures-associated-with-the-elk-river-chemical-spill
#9
Katharine A Horzmann, Chloe de Perre, Linda S Lee, Andrew J Whelton, Jennifer L Freeman
On January 9, 2014, a chemical mixture containing crude methylcyclohexanemethanol (MCHM) contaminated the water supply of Charleston, West Virginia. Although the mixture was later identified as a mix of crude MCHM and stripped propylene glycol phenyl ethers, initial risk assessment focused on 4-MCHM, the predominant component of crude MCHM. The mixture's exact composition and the toxicity differences between 4-MCHM, crude MCHM, and the tank mixture were unknown. We analyzed the chemical composition of crude MCHM and the tank mixture via GC/MS and, based on identified spectra, found that crude MCHM and the tank mixture differed in chemical composition...
September 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28917211/bactericidal-and-catalytic-performance-of-green-nanocomposite-based-on-chitosan-carbon-black-fiber-supported-monometallic-and-bimetallic-nanoparticles
#10
Fayaz Ali, Sher Bahadar Khan, Tahseen Kamal, Yasir Anwar, Khalid A Alamry, Abdullah M Asiri
Nanoparticles were synthesized on the surface of green nanocomposite based on carbon black dispersed in chitosan (CB-CS) fibres. The nanoparticles were monometallic Co, Ag and Cu and bimetallic Co + Cu and Co + Ag. The CB-CS fibres were prepared and introduced into separate metal salt solutions containing Co(2+), Ag(+) and Cu(2+) and mixed Co(2+)+Cu(2+) and Co(2+)+Ag(+) ions. The metal ions immobilized on the surface of CB-CS were reduced using sodium borohydride (NaBH4) as reducing agent to synthesize the corresponding zero-valent metal nanoparticles-loaded CB-CS fibres...
August 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28917210/single-and-mixture-toxicity-of-abamectin-and-difenoconazole-to-adult-zebrafish-danio-rerio
#11
Ana Letícia Madeira Sanches, Bruna Horvath Vieira, Marina Vanderlei Reghini, Raquel Aparecida Moreira, Emanuela Cristina Freitas, Evaldo L G Espíndola, Michiel A Daam
Concerns have been raised in recent years on the potential risks related with pesticide mixtures that are likely to be present in agricultural edge-of-field waterbodies. Despite the high use of pesticides in tropical countries like Brazil, studies evaluating pesticide mixtures are especially scarce in the tropics. The insecticide abamectin and the fungicide difenoconazole are the main pesticides intensively used in Brazilian strawberry crop and are hence likely to occur simultaneously. The aim of the present study was therefore to evaluate the toxicity of abamectin, difenoconazole and their mixture to the tropical fish Danio rerio...
September 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28916285/profiling-of-bisphenol-s-towards-nuclear-receptors-activities-in-human-reporter-cell-lines
#12
Ondrej Zenata, Zdenek Dvorak, Radim Vrzal
Bisphenol S (BPS) is heat-stable structural analog of bisphenol A (BPA), a known endocrine disruptor. Due to the effort to replace BPA with BPS, it is essential to know if BPS is suitable non-toxic replacement without reported deleterious effects of BPA. Since most of the BPA effects are ascribed to its ability to activate nuclear receptors, we screened some prominent members of this family in order to confirm or refute some recent findings. We found that BPS insignificantly activated aryl hydrocarbon receptor (AhR) in reporter gene assay and no induction of AhR target gene CYP1A1 was observed in human hepatocytes (HH)...
September 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28916171/neurobehavioral-assessment-of-mice-following-repeated-oral-exposures-to-domoic-acid-during-prenatal-development
#13
Motohiro Shiotani, Toby B Cole, Sungwoo Hong, Julie Ju Young Park, William C Griffith, Thomas M Burbacher, Tomomi Workman, Lucio G Costa, Elaine M Faustman
Domoic acid (DA) is an algal toxin which has been associated with significant neurotoxicity in humans, non-human primates, rodents, and marine mammals. Developmental exposure to DA is believed to result in neurotoxicity that may persist into adulthood. DA is produced by harmful algal blooms of Pseudo-nitzschia, raising concerns about the consumption of contaminated seafood. We evaluated oral exposures to DA during pregnancy in mice. Doses of 0 (vehicle), 1 or 3mg/kg/d of DA were administered by gavage to C57BL/6J mice on gestational days 10 to 17...
September 12, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28916105/selective-imaging-of-cancer-cells-with-a-ph-activatable-lysosome-targeting-fluorescent-probe
#14
Rongguang Shi, Lu Huang, Xiaoxue Duan, Guohao Sun, Gui Yin, Ruiyong Wang, Jun-Jie Zhu
Fluorescence imaging with tumor-specific fluorescent probe has emerged as a tool to aid surgeons in the identification and removal of tumor tissue. We report here a new lysosome-targeting fluorescent probe (NBOH) with BODIPY fluorephore to distinguish tumor tissue out of normal tissue based on different pH environment. The probe exhibited remarkable pH-dependent fluorescence behavior in a wide pH range from 3.0 to 11.0, especially a sensitive pH-dependent fluorescence change at pH range between 3.5 and 5.5, corresponding well to the acidic microenvironment of tumor cells, in aqueous solution...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915692/biomarker-analysis-of-the-phase-3-torch-trial-for-first-line-erlotinib-versus-chemotherapy-in-advanced-non-small-cell-lung-cancer-patients
#15
Lucia Kim, Mauro Saieg, Massimo Di Maio, Ciro Gallo, Charles Butts, Fortunato Ciardiello, Ronald Feld, Dengxiao Cheng, Vittorio Gebbia, Marco Angelo Burgio, Yasmin Alam, Simona Signoriello, Antonio Rossi, Natasha Leighl, Paolo Maione, Alessandro Morabito, Geoffrey Liu, Ming-Sound Tsao, Francesco Perrone, Cesare Gridelli
BACKGROUND: The TORCH phase III trial compared the efficacy of first-line erlotinib followed by chemotherapy at progression (experimental arm) with the reverse sequence (standard arm) in unselected advanced non-small cell lung cancer (NSCLC) patients. Here we report biomarker analyses. METHODS: EGFR and KRAS mutation, expression of EGFR family members and of cMET and PTEN and EGFR and ABCG2 germline polymorphisms were tested on tumor tissue or blood samples to either confirm previously proposed predictive role or describe it in an explorative setting...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915507/ambient-fine-particulate-matters-induce-cell-death-and-inflammatory-response-by-influencing-mitochondria-function-in-human-corneal-epithelial-cells
#16
Eun-Jung Park, Jae-Byoung Chae, Jungmook Lyu, Cheolho Yoon, Sanghwa Kim, Changjoo Yeom, Younghun Kim, Jaerak Chang
Ambient fine particulate matter (AFP) is a main risk factor for the cornea as ultraviolet light. However, the mechanism of corneal damage following exposure to AFP has been poorly understood. In this study, we first confirmed that AFP can penetrate the cornea of mice, considering that two-dimensional cell culture systems are limited in reflecting the situation in vivo. Then, we investigated the toxic mechanism using human corneal epithelial (HCET) cells. At 24h after exposure, AFP located within the autophagosome-like vacuoles, and cell proliferation was clearly inhibited in all the tested concentration...
September 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/28915492/enhancement-of-5-aminolevulinic-acid-phototoxicity-by-encapsulation-in-polysaccharides-based-nanocomplexes-for-photodynamic-therapy-application
#17
Antonio Di Martino, Alena Pavelkova, Pavel S Postnikov, Vladimir Sedlarik
Polysaccharides based nanocomplexes have been developed for encapsulation, controlled delivery and to enhance the phototoxicity of the photosensitizer 5-aminolevulinic acid for application in photodynamic therapy. The nanocomplexes were prepared by coacervation in a solvent free environment using chitosan as polycation while alginic and polygalacturonic acid as polyanions. The complexes showed average dimension in the range 90-120nm, good stability in simulated physiological media and high drug encapsulation efficiency, up to 800μg per mg of carrier...
August 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28915432/new-uses-for-old-complexes-the-very-first-report-on-the-trypanocidal-activity-of-symmetric-trinuclear-ruthenium-complexes
#18
Bruna Possato, Zumira Aparecida Carneiro, Sérgio de Albuquerque, Sofia Nikolaou
This work reports on the trypanocidal activity of a series of symmetric triruthenium complexes combined with azanaphthalene ligands of general formula [Ru3O(CH3COO)6(L)3]PF6 (L=(1) quinazoline (qui), (2) 5-nitroisoquinoline (5-nitroiq), (3) 5-bromoisoquinoline (5-briq), (4) isoquinoline (iq), (5) 5-aminoisoquinoline (5-amiq), and (6) 5,6,7,8-tetrahydroisoquinoline (thiq)). All complexes within the series presented in vitro trypanocidal activity against both the trypomastigote and amastigote forms of T. cruzi...
August 31, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28914992/an-effective-thermal-therapy-against-cancer-using-an-e-jet-3d-printing-method-to-prepare-implantable-magnetocaloric-mats
#19
Yikun Yang, Chunyi Tong, Juchang Zhong, Ruiying Huang, Weihong Tan, Zhikai Tan
Magnetic hyperthermia has been rapidly developed as a potential cancer treatment in recent years. Artificially induced hyperthermia close to a tumor can raise the temperature to 45°C causing tumor cell death. Herein, we introduce a novel method for rapid preparation of anti-cancer magnetocaloric PCL/Fe3 O4 mats capable of high-performance hyperthermia using E-jet 3D printing technology. Our 3D printed mats not only maintained the heating efficiency of traditional techniques for magnetic hyperthermia but also prolonged the effective therapy in vivo...
September 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28914589/hplc-dad-method-development-and-validation-for-the-quantification-of-hydroxymethylfurfural-in-corn-chips-by-means-of-response-surface-optimization
#20
Sara Salvatierra Virgen, Silvia Guillermina Ceballos-Magaña, Vilma Del Carmen Salvatierra-Stamp, Maria Teresa Sumaya-Martínez, Francisco Javier Martínez-Martínez, Roberto Muñiz-Valencia
In recent years, there has been an increased concern about the presence of toxic compounds derived from the Maillard reaction produced during food cooking at high temperatures. The main toxic compounds derived from this reaction are acrylamide and hydroxymethylfurfural (HMF). The majority of analytical methods require sample treatments using solvents which are highly polluting for the environment. The difficulty for quantifying HMF in complex fried food matrices encourages the development of new analytical methods...
September 15, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
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