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https://www.readbyqxmd.com/read/28944583/venous-anastomosis-using-a-nonpenetrating-vascular-closure-system-in-orthotopic-liver-transplantation
#1
Yuan Wang, Zhao Xin, Bing Pan, Shao-Cheng Lv, Xing-Mao Zhang, Zhi-Hua Zhang, Li-Xin Li, Xian-Liang Li, Qiang He
BACKGROUND: A nonpenetrating vessel closure system (VCS-AnastoClip(®) ) may facilitate vascular anastomosis. The purpose of this study is to explore the utilization of a nonpenetrating VCS in orthotopic liver transplantation (OLT). METHODS: From January 2015 to February 2017, patients who underwent OLT were divided into two groups, i.e., those who underwent nonpenetrating VCS application for inferior vena cava (IVC) and portal vein (PV) reconstructions and those who underwent hand sewing for these purposes...
September 25, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28944326/the-anti-inflammatory-effect-of-hydrogen-sulphide-on-acute-necrotizing-pancreatitis-in-rats
#2
Kutay Sağlam, Etem Alhan, Serdar Türkyılmaz, Birgül Kural Vanizor, Cengiz Erçin
OBJECTIVE: The aim of this study was to investigate the dose-dependent anti-inflammatory effect of the Hydrogen sulfidedonor sodiumhydrosulphide on acute necrotizing pancreatitis in rats. MATERIAL AND METHODS: A total of 42 male Sprague-Dawley rats were divided into 4 groups: sham+saline (group 1), sham+NaHS (group 2), acute necrotizing pancreatitis+saline (group 3), and acute necrotizing pancreatitis+NaHS (group 4). Acute pancreatitis was induced in rats in groups 3 and 4 with the infusion of glycodeoxycholic acidinto the biliopancreatic canal and infusion of cerulein parenterally...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28943906/hepatectomy-for-spontaneous-rupture-of-hepatocellular-carcinoma-without-portal-triad-clamping
#3
Zhi-Ming Wang, Xin-Sheng Lu, Fu Qiu
Hepatectomy without portal triad clamping may decrease the incidence of liver injury; however, the effects of hepatectomy without portal triad clamping in the treatment of spontaneous rupture of hepatocellular carcinoma (SRHCC) remain unclear. The aims of the present study were to evaluate the therapeutic value of hepatectomy without portal triad clamping in the treatment of patients with SRHCC. The present study retrospectively reviewed patients with SRHCC who received hepatectomy without portal triad clamping (non-clamping group) and the therapeutic efficacy was compared with that of 20 patients with SRHCC undergoing the same surgery in the presence of portal triad clamping (clamping group)...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943446/evaluation-of-genotoxicity-and-subchronic-toxicity-of-the-standardized-leaves-infusion-extract-of-copaifera-malmei-harms-in-experimental-models
#4
Eduarda Pavan, Amilcar Sabino Damazo, Larissa Maria Scalon Lemos, Bulus Adzu, Sikiru Olaitan Balogun, Karuppusamy Arunachalam, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Copaifera malmei Harms (Fabaceae), known mainly as óleo-mirim, is a native and endemic plant found in the states of Mato Grosso and Goiás of Brazil. The plant's leaves infusion is popularly used by riverine communities of the northern Araguaia microregion, Mato Grosso, Brazil, for the treatment of gastric ulcers and inflammatory diseases of the respiratory tract. The gastric antiulcer activity of the standardized leaves infusion extract of Copaifera malmei (SIECm) in rodents has been reported...
September 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28943104/fructose-1-6-diphosphate-prevents-alcohol-induced-liver-injury-through-inhibiting-oxidative-stress-and-promoting-alcohol-metabolism-in-mice
#5
Ling Li, Yifei Wu, Fangyuan Yin, Qin Feng, Xiaoliang Dong, Ruhui Zhang, Zhimin Yin, Lan Luo
Fructose 1, 6-diphosphate (FDP), a glycolytic intermediate,has been identified to possess antioxidant activities. Here we show the protective effect of FDP against alcohol-induced liver injury in mice and the underlying mechanisms. The in vivo experiments demonstrated that FDP, orally administered to mice, dose-dependently suppressed alcohol (50%, v/v, 12ml/kg)-induced increase of serum activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), serum triglyceride (TG) level and hepatic malondialdehyde (MDA) level...
September 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28942826/nitric-oxide-synthase-inhibitors-protect-against-brain-and-liver-damage-caused-by-acute-malathion-intoxication
#6
Omar M E Abdel-Salam, Eman R Youness, Nadia A Mohammed, Noha N Yassen, Yasser A Khadrawy, Safinaz Ebrahim El-Toukhy, Amany A Sleem
OBJECTIVE: To investigate the effect of N(G)-nitro-l-arginine methyl ester (l-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, and 7-nitroindazole (7-NI), a selective neuronal NOS inhibitor, on oxidative stress and tissue damage in brain and liver and on DNA damage of peripheral blood lymphocytes in malathion intoxicated rats. METHODS: Malathion (150 mg/kg) was given intraperitoneally (i.p.) along with l-NAME or 7-NI (10 or 20 mg/kg, i.p.) and rats were euthanized 4 h later...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28942645/aggregation-induced-chirality-twist-and-stacking-handedness-of-the-biphenylene-groups-of-n-c12h25o-bp-co-ala-ala-dipeptides
#7
Lianglin Zhang, Jiaming Qin, Shuwei Lin, Yi Li, Baozong Li, Yonggang Yang
In mixtures of water and dimethyl sulfoxide, 4'-(n-dodecyloxy)-1,1'-biphenyl-4-carbonyl Ala-Ala dipeptides can self-assemble into tubular structures that are formed by coiled nanoribbons. The twist and stacking handedness of biphenylene groups were studied using circular dichroism and confirmed by theoretical chemical calculations. The handedness of the coiled nanoribbons and the stacking handedness of the biphenylene groups are controlled by the chirality of the alanine at the C-terminus, while the twist handedness of the biphenylene is determined by the chirality of the alanine at the N-terminus...
September 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28942274/the-environmental-neurotoxin-%C3%AE-n-methylamino-l-alanine-l-bmaa-is-deposited-into-birds-eggs
#8
Marie Andersson, Oskar Karlsson, Ingvar Brandt
The neurotoxic amino acid β-N-methylamino-L-alanine (BMAA) has been implicated in the etiology of neurodegenerative disorders. BMAA is also a known developmental neurotoxin and research indicates that the sources of human and wildlife exposure may be more diverse than previously anticipated. The aim of the present study was therefore to examine whether BMAA can be transferred into birds' eggs. Egg laying quail were dosed with (14)C-labeled BMAA. The distribution of radioactivity in the birds and their laid eggs was then examined at different time points by autoradiography and phosphoimaging analysis...
September 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28941826/icp-drc-ms-analysis-of-serum-essential-and-toxic-element-levels-in-postmenopausal-prediabetic-women-in-relation-to-glycemic-control-markers
#9
Margarita G Skalnaya, Anatoly V Skalny, Eugeny P Serebryansky, Vasily V Yurasov, Anastasia A Skalnaya, Alexey A Tinkov
PURPOSE: Assessment of the influence of prediabetes on serum trace element and electrolyte levels in postmenopausal women. METHODS: A total of 80 prediabetic and 80 healthy postmenopausal women took part in the present study. Serum was analyzed for glucose, insulin, insulin resistance index (HOMA-IR), total cholesterol (TC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT). Glycated haemoglobin (HbA1c) levels were also assessed...
September 14, 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28941695/antioxidant-and-hepatoprotective-effects-of-a-cerana-honey-against-acute-alcohol-induced-liver-damage-in-mice
#10
Haoan Zhao, Ni Cheng, Liangliang He, Guoxia Peng, Xiaofeng Xue, Liming Wu, Wei Cao
A. cerana honey, gathered from Apis cerana Fabricius (A. cerana), has not been fully studied. Samples of honey originating from six geographical regions (mainly in the Qinling Mountains of China) were investigated to determine their antioxidant and hepatoprotective effects against acute alcohol-induced liver damage. The results showed that A. cerana honeys from the Qinling Mountains had high total phenolic contents (345.1-502.1mgGAkg(-1)), ascorbic acid contents (153.8-368.4mgkg(-1)), and strong antioxidant activities in DPPH radical scavenging activity assays (87...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28941589/dexamethasone-prophylaxis-to-alleviate-postembolization-syndrome-after-transarterial-chemoembolization-for-hepatocellular-carcinoma-a-randomized-double-blinded-placebo-controlled-study
#11
Hyun Yang, Jein Seon, Pil Soo Sung, Jung Suk Oh, Hae Lim Lee, Bohyun Jang, Ho Jong Chun, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
PURPOSE: To test the hypothesis that prophylactic administration of dexamethasone alleviates postembolization syndrome (PES) after transarterial chemoembolization for the treatment of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This prospective, randomized, double-blinded, placebo-controlled trial was conducted in a single center from August 2015 to June 2016. A total of 88 patients with intermediate-stage HCC were enrolled. After randomization, 44 patients were assigned to the dexamethasone group and the other 44 to the control group...
September 20, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28941137/incidence-determinants-and-outcomes-of-pregnancy-associated-hepatitis-b-flares-a-regional-hospital-based-cohort-study
#12
Tatyana Kushner, Pamela A Shaw, Ankush Kalra, Lora Magaldi, Pooja Monpara, Gurneet Bedi, Karen Krok, Sierra Centkowski, Katherine Dalldorf, Julia D'souza, Dina Halegoua-De Marzio, David S Goldberg, Stacey Trooskin, Lisa D Levine, Sindhu K Srinivas, James D Lewis, Kimberly A Forde, Vincent Lo Re
BACKGROUND & AIMS: There is limited knowledge about hepatitis B virus (HBV) flare among pregnant women. We evaluated the incidence, determinants, and outcomes of HBV flare in a multicultural cohort of pregnant HBV-infected women in the United States. METHODS: We performed a retrospective cohort study of pregnant hepatitis B surface antigen-positive women cared for at hospital-based clinics of four medical centers in Southeastern Pennsylvania from 2006-2015. The main outcome was incident HBV flare (alanine aminotransferase [ALT] ≥2 times upper limit of normal) during pregnancy or within 6 months after delivery...
September 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28940824/clinical-implications-of-controlled-attenuation-parameter-in-a-health-check-up-cohort
#13
Min-Sun Kwak, Goh Eun Chung, Jong In Yang, Jeong Yoon Yim, Su Jin Chung, Se Young Jung, Joo Sung Kim
BACKGROUND & AIMS: Evaluation of the controlled attenuation parameter (CAP) is a promising noninvasive method for assessing hepatic steatosis. Despite the increasing reliability of the CAP for assessing steatosis in subjects with chronic liver disease, few studies have evaluated the CAP in asymptomatic subjects without overt liver disease. Therefore, we aimed to evaluate the usefulness of the CAP for a health check-up population. METHODS: We enrolled subjects who underwent abdominal ultrasonography (US), FibroScan (Echosens, France) and blood sampling during medical health check-ups...
September 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28940525/estimation-of-initial-phenobarbital-dosing-in-term-neonates-with-moderate-to-severe-hypoxic-ischaemic-encephalopathy-following-perinatal-asphyxia
#14
M Šíma, P Pokorná, J Hartinger, O Slanař
WHAT IS KNOWN AND OBJECTIVE: Phenobarbital is the first-line treatment of seizures in asphyxiated neonates; however, due to the high pharmacokinetic variability in this population, there is no consensus on the optimal dosage regimen. This study was conducted to identify variables that affect phenobarbital fate during routine clinical care and then to evaluate the dosage schedule that could be applied in term asphyxiated neonates with respect to achieving the target therapeutic range. METHODS: Phenobarbital pharmacokinetics was calculated based on serum concentrations measurements using one-compartmental model...
September 22, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28940498/twice-weekly-pulse-and-daily-continuous-dose-erlotinib-as-initial-treatment-for-patients-with-epidermal-growth-factor-receptor-mutant-lung-cancers-and-brain-metastases
#15
Kathryn C Arbour, Mark G Kris, Gregory J Riely, Ai Ni, Kathryn Beal, Mariza Daras, Sara A Hayes, Robert J Young, Christopher R Rodriguez, Linda Ahn, William Pao, Helena A Yu
BACKGROUND: In a phase 1 study of pulse/continuous-dose erlotinib, no patient had disease progression in the central nervous system (CNS). This expansion cohort of the phase 1 study tested the same regimen in a cohort of individuals with epidermal growth factor receptor (EGFR)-mutant lung cancers with untreated brain metastases. METHODS: Patients had not received EGFR tyrosine kinase inhibitors or radiation for brain metastases. All received 1200 mg of erlotinib on days 1 and 2 and 50 mg on days 3 to 7 weekly...
September 21, 2017: Cancer
https://www.readbyqxmd.com/read/28938996/gender-specific-metabolic-responses-in-gonad-of-mussel-perna-viridis-to-triazophos
#16
Linbao Zhang, Wei Sun, Zhe Zhang, Haigang Chen, Xiaoping Jia, Wengui Cai
Triazophos, as a lipophilic organophosphate pesticide, displays higher bioaccumulation in the gonads of shellfish. To study the reproductive toxicity of triazophos, we applied metabolomics to characterize the gender-specific metabolic responses in mussel Perna viridis exposed to triazophos. Metabolites were differently altered by triazophos in ovaries of mussel at different concentrations and time intervals, while basically similar metabolic response patterns were observed in male mussels at the two tested concentrations after exposure for 24 and 48h...
September 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28938766/dietary-effects-of-bacillus-subtilis-fmbj-on-the-antioxidant-capacity-of-broilers-at-an-early-age
#17
Lili Zhang, Kaiwen Bai, Jingfei Zhang, Wen Xu, Qiang Huang, Tian Wang
This study was designed to evaluate the usage of Bacillus subtilis fmbj (BS fmbj) in broiler diets, and its effects on the antioxidant capacity of broilers at an early age. A total of 240 day-old male Arbor Acres (AA) broilers were randomly assigned to 4 groups, namely the control (CON) group (fed basal diets with 0 cfu/kg BS fmbj), the BS-1 group (fed basal diet with 0.2 × 1011 cfu/kg BS fmbj), BS-2 group (fed basal diet with 0.3 × 1011 cfu/kg BS fmbj), and BS-3 group (fed basal diet with 0.4 × 1011 cfu/kg BS fmbj)...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938634/a-novel-predictive-model-using-routinely-clinical-parameters-to-predict-liver-fibrosis-in-patients-with-chronic-hepatitis-b
#18
Jian Wang, Xiaomin Yan, Yue Yang, Haiyan Chang, Bei Jia, Xiang-An Zhao, Guangmei Chen, Juan Xia, Yong Liu, Yuxin Chen, Guiyang Wang, Li Wang, Zhaoping Zhang, Weimao Ding, Rui Huang, Chao Wu
OBJECTIVES: Noninvasive models have been established for the assessment of liver fibrosis in patients with chronic hepatitis B(CHB). However, the predictive performance of these established models remains inconclusive. We aimed to develop a novel predictive model for liver fibrosis in CHB based on routinely clinical parameters. RESULTS: Platelets(PLT), the standard deviation of red blood cell distribution width(RDW-SD), alkaline phosphatase(ALP) and globulin were independent predictors of significant fibrosis by multivariable analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938424/adiponectin-predicts-hdl-cholesterol-efflux-capacity-in-adults-irrespective-of-body-mass-index-and-fat-distribution
#19
Gunther Marsche, Sieglinde Zelzer, Andreas Meinitzer, Sabine Kern, Sabine Meissl, Gudrun Pregartner, Daniel Weghuber, Gunter Almer, Harald Mangge
Context: Obesity is associated with hypoadiponectemia, dyslipidemia and increased risk of coronary vascular disease (CVD). Mechanisms linking these conditions remain to be fully understood. Cholesterol efflux capacity (CEC) is a crucial functional property of high-density lipoprotein (HDL) that strongly predicts CVD incidence. Objective: To investigate whether age, fat distribution, and other obesity related factors affect CEC in juvenile and adult overweight/obese participants of the STYJOBS/EDECTA cohort (NCT00482924)...
August 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938073/transfer-learning-from-markov-models-leads-to-efficient-sampling-of-related-systems
#20
Mohammad Muneeb Sultan, Vijay S Pande
We recently showed that the time-structure based independent component analysis method from Markov state model literature provided a set of variationally optimal slow collective variables for Metadynamics (tICA-Metadynamics). In this paper, we extend the methodology towards efficient sampling of related mutants by borrowing ideas from transfer learning methods in machine learning. Our method explicitly assumes that a similar set of slow modes and metastable states are found in both the wild type (base line) and its mutants...
September 22, 2017: Journal of Physical Chemistry. B
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