Read by QxMD icon Read


J D Sobel, R Sobel
Clinicians are increasingly challenged by patients with refractory vulvovaginal candidiasis (VVC) caused by azole-resistant Candida species. Fluconazole resistant C.albicans is a growing and perplexing problem following years of indiscriminate drug prescription and unnecessary drug exposure and for which there are few therapeutic alternatives. Regrettably, although the azole class of drugs has expanded, new classes of antifungal drugs have not been forthcoming, limiting effective treatment options in patients with azole resistant Candida vaginitis...
June 22, 2018: Expert Opinion on Pharmacotherapy
Khoudia Diop, Awa Diop, Caroline Michelle, Magali Richez, Jaishriram Rathored, Florence Bretelle, Pierre-Edouard Fournier, Florence Fenollar
Three previously unidentified Gram-positive anaerobic coccoid bacteria, strains KhD-2T , KHD4T , and Kh-D5T , isolated from a vaginal swab, were characterized using the taxonogenomics concept. The phylogenic analysis, phenotypic characteristics, and genotypic data presented in this report attest that these three bacteria are distinct from previously known bacterial species with standing in nomenclature and represent three new Peptoniphilus species. Strain KhD-2T is most closely related to Peptoniphilus sp. DNF00840 and Peptoniphilus harei (99...
June 21, 2018: MicrobiologyOpen
Maria Eugênia Simões Onofre de Santi, Renato Araujo Prates, Cristiane Miranda França, Rúbia Garcia Lopes, Aline Silva Sousa, Luis Rodolfo Ferreira, Sandra Kalil Bussadori, Adjaci Uchoa Fernandes, Alessandro Melo Deana
In this work, we present the efficacy of photodynamic therapy against yeast cells in an animal model. We tested two photosensitizers, methylene blue and protoporphyrin IX. Thirty-seven female BALB-c mice with a body mass of 20-25 g were used. To achieve persistent vaginitis, estrus was induced by subcutaneous injection of 0.1 mg/mL estradiol valerate applied weekly. Three days after pseudo-estrus, intravaginal inoculation with Candida albicans was performed. Mice were anesthetized with ketamine (80 mg/kg) and xylazine (10 mg/kg) by intraperitoneal injection before inoculation, and antimicrobial photodynamic therapy (aPDT) was performed 5 days after fungal inoculation...
June 21, 2018: Lasers in Medical Science
Sasha R Howard, Roberto Oleari, Ariel Poliandri, Vasiliki Chantzara, Alessandro Fantin, Gerard Ruiz-Babot, Louise A Metherell, Claudia P Cabrera, Michael R Barnes, Karoliina Wehkalampi, Leonardo Guasti, Christiana Ruhrberg, Anna Cariboni, Leo Dunkel
Context: Self-limited delayed puberty (DP) segregates in an autosomal dominant pattern, but the genetic basis is largely unknown. Although DP is sometimes seen in relatives of patients with hypogonadotropic hypogonadism (HH), mutations in genes known to cause HH which segregate with the trait of familial self-limited DP have not yet been identified. Objective: To assess the contribution of mutations in genes known to cause HH to the phenotype of self-limited DP...
June 20, 2018: Journal of Clinical Endocrinology and Metabolism
Melanie K Stewart, Deidre M Mattiske, Andrew J Pask
Exposure to estrogenic endocrine disrupting chemicals (EDCs) during in utero development has been linked to the increasing incidence of disorders of sexual development (DSDs). Hypospadias, the ectopic placement of the urethra on the ventral aspect of the penis, is one of the most common DSDs affecting men, and can also affect women by resulting in the misplacement of the urethra. This study aimed to comprehensively assess the resulting hypospadias phenotypes in male and female mice exposed in utero from embryonic day 9...
June 21, 2018: Biology of Reproduction
Chin-Ru Ker, Kun-Ling Lin, Zi-Xi Loo, Yung-Shun Juan, Cheng-Yu Long
Hysterectomy is the empirical treatment for female pelvic organ prolapse (POP) without robust evidence to prove its efficacy. Uphold transvaginal mesh (TVM) system is an innovated device with smaller area, superior anterior/apical support with single incision to treat POP. The prospective cohort study aims to evaluate Uphold TVM's performance with or without concomitant hysterectomy. Inclusion criteria specify patients suffering from stage 2 or more anterior/apical prolapse without previous hysterectomy. Exclusion criteria specify those with contraindications to uterine preservation, such as leiomyomas, adenomyosis, endometrial hyperplasia, abnormal uterine bleeding, postmenopausal bleeding, cervical dysplasia, receiving tamoxifen treatment, family history of gynecology cancer, or colon cancer and incapability to be routinely followed...
June 21, 2018: Scientific Reports
Brian J Gebhardt, John A Vargo, Hayeon Kim, Christopher J Houser, Scott M Glaser, Paniti Sukumvanich, Alexander B Olawaiye, Joseph L Kelley, Robert P Edwards, John T Comerci, Madeleine Courtney-Brooks, Sushil Beriwal
PURPOSE: Brachytherapy is integral to vaginal cancer treatment and is typically delivered using an intracavitary single-channel vaginal cylinder (SCVC) or an interstitial brachytherapy (ISBT) applicator. Multi-channel vaginal cylinder (MCVC) applicators allow for improved organ-at-risk (OAR) sparing compared to SCVC while maintaining target coverage. We present clinical outcomes of patients treated with image-based high dose-rate (HDR) brachytherapy using a MCVC. METHODS AND MATERIALS: Sixty patients with vaginal cancer (27% primary vaginal and 73% recurrence from other primaries) were treated with combination external beam radiotherapy (EBRT) and image-based HDR brachytherapy utilizing a MCVC if residual disease thickness was 7 mm or less after EBRT...
June 18, 2018: Gynecologic Oncology
Fatemeh Darsareh, Teamur Aghamolaei, Minoo Rajaei, Abdoulhossain Madani, Shahram Zare
PROBLEM: The steep increase and inappropriateness of caesarean birth represent a healthcare problem in Iran. AIM: The purpose of study was to evaluate the effect of a campaign based on social marketing to promote normal childbirth. METHOD: The study was designed as a prospective case control study. The social marketing campaign was implemented from March 2016 to January 2017. A demographic data questionnaire, obstetrical history questionnaire, maternal knowledge assessment questionnaire, and maternal health belief questionnaire comprised the instruments for this study...
June 18, 2018: Women and Birth: Journal of the Australian College of Midwives
Jiao Wang, Xin Qian, Qiang Gao, Chunmei Lv, Jie Xu, Hongbo Jin, Hui Zhu
BACKGROUND: Menopause is the most important sign of aging in women, and the ovary is the organ most sensitive to aging. Quercetin is a potential antioxidant and free radical scavenger that is widely found in fruits, vegetables, and leaves. However, the effect of quercetin on ovarian aging has not been elucidated, and the mechanism underlying its antioxidative effect remains unclear. The purpose of the current study was to investigate whether quercetin protects ovarian function by decreasing oxidative stress...
June 21, 2018: Journal of Ovarian Research
Briana B Rider, Hina Mehta, Lubna Merchant
BACKGROUND: Look-alike and sound-alike (LASA) drug name similarity is often cited as a major factor contributing to wrong drug errors. When present on a prescription, differing product characteristics or directions for use may help health care professionals differentiate between 2 LASA drug names. However, evidence suggests that 1% to 5% of prescriptions include only the signa "use as directed" rather than explicit directions for use. METHODS: Using nationally projected US outpatient physician survey data, we analyzed drug classes and their associated signa to identify products commonly prescribed with the signa "as directed...
January 1, 2018: Therapeutic Innovation & Regulatory Science
Cinzia Chiaramonte, Elettra Vestri, Flavia Tripi, Antonino Giulio Giannone, Marcello Cimador, Ferdinando Cataliotti
BACKGROUND: Female vaginoplasty reconstruction, by choice, is usually performed with adjacent tissue. However in some clinical conditions such as high urogenital confluence sinus, cloacal malformation with extreme vaginal hypoplasia, local tissue may not be available. When vaginal replacement is performed in pediatric patients intestinal segments is preferred to non-operative procedures that require continuative dilations. However mucus production, malignant transformation risk and diversion colitis are important side effects...
June 18, 2018: Journal of Pediatric and Adolescent Gynecology
Jessica Shim, Maggie Dwiggins, Veronica Gomez-Lobo
BACKGROUND: Postoperative complications after transverse vaginal septum excision include stricture formation. The purpose of this report is to describe use of intralesional corticosteroid injections for vaginal strictures. CASE: A 32-year-old gravida-0 with history of transverse vaginal septum and recurrent strictures presented for follow-up of chronic pelvic pain. After her fourth septum revision, the patient underwent a total of seven triamcinolone injections at the septum tissue...
June 18, 2018: Journal of Pediatric and Adolescent Gynecology
Catherine A Mowbray, Syema Shams, Git Chung, Anna Stanton, Phillip Aldridge, Andrejus Suchenko, Robert S Pickard, Ased Sm Ali, Judith Hall
Objectives: Recurrent urinary tract infections are associated with uropathogenic Escherichia coli (UPEC) ascending and infecting the urinary tract. Antibiotics provide only symptomatic relief, not prevent recurrence. Clinical evidence suggests that intravesical glycosaminoglycan therapy, such as hyaluronic acid (HA), helps reduce UTI recurrence. This has been investigated here using in vitro systems modelling the urogenital tract tissues. Methods: RT4 bladder cells were preconditioned with high molecular weight HA (> 1500 kDa) at 2 mg mL-1 and challenged with UPEC to analyse barrier protection and bacterial adherence...
2018: Clinical & Translational Immunology
Michiko Honda, Akira Tsuchiya, Wataru Isono, Mikiko Takahashi, Akihisa Fujimoto, Masashi Kawamoto, Osamu Nishii
In order to diagnose endometrial cancer preoperatively, outpatient endometrial biopsy with a curette is frequently performed owing to its convenience. However, in some cases, gynecologists fail to diagnose endometrial cancer via outpatient endometrial biopsy because of the cancer's distribution in the uterus and its consistency. A 57-year-old Japanese woman (gravida 4 para 4) presented with a 6-month history of light but intermittent postmenopausal vaginal bleeding. A malignant uterine tumor was strongly suspected after imaging using ultrasound examination and magnetic resonance imaging; however, a precise pathological diagnosis was not achieved despite multiple outpatient endometrial biopsies with the aid of office hysteroscopy...
May 2018: Case Reports in Oncology
Michael Williamson, Felice Vanacore, Caroline Hing
Pubic symphysis diastasis injuries typically occur following a high velocity force such as road traffic accidents, horse riding, crush injuries and falls from a height. There are reports of a range of injuries caused by waterslides including spinal fractures, head injuries and vaginal injuries. Here we report the case of a 50-year-old female who suffered a pelvic diastasis injury during the use of a waterslide.
June 2018: Journal of Clinical Orthopaedics and Trauma
Hachem Djeffal, Marie Blouet, Anne-Cécile Pizzoferrato, Delphine Vardon, Frederique Belloy, Jean-Pierre Pelage
Tubal sterilization with Essure inserts has become a prevalent alternative to laparoscopic sterilization because of its minimal invasiveness. It is a well-tolerated ambulatory procedure that provides reliable permanent contraception without the risks associated with laparoscopic surgery and general anesthesia. Correct positioning of the Essure device is necessary to achieve the fibrotic reaction induced by the polyethylene terephthalate fibers, subsequently resulting in tubal occlusion usually within 3 months...
June 21, 2018: British Journal of Radiology
John Owen
Leigh and colleagues (Leigh et al, BJOG 2018) have performed a cost-consequence analysis using data from a randomized trial of 602 hypertensive and mostly nulliparous women in India. The trial compared oral misoprostol 25-50 mcg every two hours (for a maximum of 24 h) to cervical ripening with a Foley catheter followed by oxytocin. For this analysis they focused on the trial's clinical outcomes, in particular the significantly higher rates of vaginal delivery within 24 h (57% vs 47%) and lower mean per-patient costs in the misoprostol group ($117...
June 21, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Aram Kim, Min Seo Kim, Young-Jin Park, Woo Suk Choi, Hyoung Keun Park, Sung Hyun Paick, Myung-Soo Choo, Hyeong Gon Kim
OBJECTIVES: To assess and compare the long-term efficacy and safety of single-incision mini-slings (SIMS) except tension-free vaginal tape (TVT)-Secur with standard midurethral slings (SMUS) for female stress urinary incontinence through an updated systematic review and meta-analysis of randomized controlled trials (RCTs) comparing these 2 surgical methods. MATERIALS AND METHODS: A literature review of all RCTs comparing SIMS (Mini-Arc, Contasure-Needleless, Ophira, Tissue Fixation System, and Ajust) except TVT-Secur with SMUS was performed...
June 21, 2018: BJU International
Kelly L Mirowska-Allen, Megan Sewell, Samantha Mooney, Peter Maher, Damian J Ianno, Sonia R Grover
BACKGROUND: Clinician and patient factors impact on the management of chronic pelvic pain (CPP) with medical, surgical or combined approaches possible, although none have proven superior. AIMS: To understand the characteristics of women offered laparoscopic pelvic surgery for CPP. MATERIALS AND METHODS: We performed an observational study of women referred with CPP. They were asked to complete a study questionnaire regarding their symptoms, medical history, quality of life and pain catastrophisation...
June 21, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
J Lv, F Liu, N Feng, X Sun, J Tang, L Xie, Y Wang
BACKGROUND: Pain is one of the major adverse clinical outcomes of cesarean section (CS). In the past few years, researchers and physicians have been optimizing post-operative analgesic modalities, but the results are still undesirable for the parturient. The cytochrome P-450 3A4 (CYP3A4) gene has been reported to contribute significantly to human liver microsomal oxidation of sufentanil and alfentanil. METHODS: We detected the frequency of CYP3A4 mutant allele, which is associated with the metabolism of diverse drugs, including opioids used for anesthesia...
June 21, 2018: Acta Anaesthesiologica Scandinavica
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"