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https://www.readbyqxmd.com/read/29029138/the-female-genital-tract-microbiome-is-associated-with-vaginal-antiretroviral-drug-concentrations-in-human-immunodeficiency-virus-infected-women-on-antiretroviral-therapy
#1
Renee Donahue Carlson, Anandi N Sheth, Timothy D Read, Michael B Frisch, C Christina Mehta, Amy Martin, Richard E Haaland, Anar S Patel, Chou-Pong Pau, Colleen S Kraft, Igho Ofotokun
Background: The female genital tract (FGT) microbiome may affect vaginal pH and other factors that influence drug movement into the vagina. We examined the relationship between the microbiome and antiretroviral concentrations in the FGT. Methods: Over one menstrual cycle, 20 human immunodeficiency virus (HIV)-infected women virologically suppressed on tenofovir (TFV) disoproxil fumarate/emtricitabine and ritonavir-boosted atazanavir (ATV) underwent serial paired cervicovaginal and plasma sampling for antiretroviral concentrations using high-performance liquid chromatography-tandem mass spectrometry...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028571/identifying-ovarian-tissue-in-the-bitch-using-anti-m%C3%A3-llerian-hormone-amh-or-luteinizing-hormone-lh
#2
Helene Alm, Bodil S Holst
Reliable methods for determining whether or not a bitch has ovarian tissue present are needed for cases with unknown neutering status. Vaginal cytology consistent with heat is indicative of functional ovarian tissue. Other methods are required when the bitch is not presented in suspected heat. Progesterone can be analyzed during 2 months after suspected heat. During other stages, assays for the analyses of anti-Müllerian hormone (AMH) and luteinizing hormone (LH) have been used. The AMH assay is expected to give detectable concentrations (positive) in bitches with ovarian tissue, and the LH assay should give negative results in intact bitches, except during the pre-ovulatory LH peak...
September 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/29027940/zika-virus-persistently-and-productively-infects-primary-adult-sensory-neurons-in-vitro
#3
Brianna K Swartwout, Marta G Zlotnick, Ashley E Saver, Caroline M McKenna, Andrea S Bertke
Zika virus (ZIKV) has recently surged in human populations, causing an increase in congenital and Guillain-Barré syndromes. While sexual transmission and presence of ZIKV in urine, semen, vaginal secretions, and saliva have been established, the origin of persistent virus shedding into biological secretions is not clear. Using a primary adult murine neuronal culture model, we have determined that ZIKV persistently and productively infects sensory neurons of the trigeminal and dorsal root ganglia, which innervate glands and mucosa of the face and the genitourinary tract, respectively, without apparent injury...
October 13, 2017: Pathogens
https://www.readbyqxmd.com/read/29027639/robotic-laparoendoscopic-single-site-benign-gynecologic-surgery-a-single-center-experience
#4
J Jayakumaran, K Wiercinski, C Buffington, A Caceres
The da Vinci Xi surgical system was released with several upgrades and modifications compared to the previous robotic generations to facilitate minimal invasive surgery. Herein, we present our preliminary experience of robotic laparoendoscopic single-site gynecologic surgery performed for benign indications with the da Vinci Xi robotic system in a single center. Thirty-five female patients underwent robotic single-site surgery between June 2016 and January 2017. The median console time for hysterectomy with or without salpingo-oophorectomy was 41 min...
October 13, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29027402/impact-of-vaginal-cylinder-diameter-on-outcomes-following-brachytherapy-for-early-stage-endometrial-cancer
#5
Jack M Qian, John M Stahl, Melissa R Young, Elena Ratner, Shari Damast
OBJECTIVE: To examine the outcomes (tolerability, toxicity, and recurrence) of vaginal brachytherapy (VBT) among endometrial cancer (EC) patients treated with small cylinder size. METHODS: Patients with EC who received adjuvant VBT between September 2011 and December 2015 were reviewed. Patients were fitted with the largest vaginal cylinder they could comfortably accommodate, from 2.0-3.0 cm diameter. Small cylinders were defined as size 2.3 cm or less. Patient, tumor, or treatment characteristics were correlated with need for small cylinders...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027397/comparing-treatment-outcomes-of-stage-iiib-cervical-cancer-patients-between-those-with-and-without-lower-third-of-vaginal-invasion
#6
Kanyarat Katanyoo
OBJECTIVE: To evaluate treatment outcomes between stage IIIB cervical cancer with and without lower third of vaginal invasion (LTI) in terms of response to treatment and overall survival (OS). METHODS: Matching one patient with LTI for 2 patients without LTI who had completed treatment between 1995 and 2012 were conducted by using treatment modalities (radiation therapy [RT] alone vs. concurrent chemoradiation therapy [CCRT]) and tumor histology (squamous cell carcinoma [SCC] vs...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027368/expression-of-fluorescent-proteins-in-lactobacillus-rhamnosus-to-study-host-microbe-and-microbe-microbe-interactions
#7
Irina Spacova, Elke Lievens, Tine Verhoeven, Hans Steenackers, Jos Vanderleyden, Sarah Lebeer, Mariya I Petrova
Probiotic Lactobacillus strains are widely used to benefit human and animal health, although the exact mechanisms behind their interactions with the host and the microbiota are largely unknown. Fluorescent tagging of live probiotic cells is an important tool to unravel their modes of action. In this study, the implementation of different heterologously expressed fluorescent proteins for the labelling of the model probiotic strains Lactobacillus rhamnosusGG (gastrointestinal) and Lactobacillus rhamnosusGR-1 (vaginal) was explored...
October 13, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29026991/trichomonas-vaginalis-clinical-isolates-cytoadherence-and-adherence-to-polystyrene-intrauterine-device-and-vaginal-ring
#8
Odelta Dos Santos, Graziela Vargas Rigo, Alexandre José Macedo, Tiana Tasca
The parasitism by Trichomonas vaginalis is complex and in part is mediated by cytoadherence accomplished via five surface proteins named adhesins and a glycoconjugate called lipophosphoglycan (TvLPG). In this study, we evaluated the ability of T. vaginalis isolates to adhere to cells, plastic (polystyrene microplates), intrauterine device (IUD), and vaginal ring. Of 32 T. vaginalis isolates, 4 (12.5%) were strong adherent. The T. vaginalis isolates TV-LACM6 and TV-LACM14 (strong polystyrene-adherent) were also able to adhere to IUD and vaginal ring...
October 13, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29026883/increased-weight-gain-by-c-section-functional-significance-of-the-primordial-microbiome
#9
Keith A Martinez, Joseph C Devlin, Corey R Lacher, Yue Yin, Yi Cai, Jincheng Wang, Maria G Dominguez-Bello
Epidemiological evidence supports a direct association between early microbiota impact-including C-section-and obesity. We performed antibiotic-free, fostered C-sections and determined the impact on the early microbiota and body weight during development. Mice in the C-section group gained more body mass after weaning, with a stronger phenotype in females. C-section-born mice lacked the dynamic developmental gut microbiota changes observed in control mice. The results demonstrate a causal relationship between C-section and increased body weight, supporting the involvement of maternal vaginal bacteria in normal metabolic development...
October 2017: Science Advances
https://www.readbyqxmd.com/read/29026793/sexual-function-mental-well-being-and-quality-of-life-among-kurdish-circumcised-women-in-iran
#10
Farzaneh Daneshkhah, Hamid Allahverdipour, Leila Jahangiri, Tatiana Andreeva
BACKGROUND: Female genital mutilation is an intentional inhumane procedure that threatens girls and women's health. It is especially widespread in developing countries due to cultural, traditional and religious preferences. The aim of the current study was to investigate how circumcision affects women's sexual function. METHODS: This cross-sectional study was conducted in the urban and rural area of Piranshahr County, Iran, in 2015 among convenience samples of 200 women, 15-49 yr old, who were applying to health care centers for receiving routine health care services...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29026756/gynecological-complaints-and-their-associated-factors-among-women-in-a-family-health-care-clinic
#11
Mateus de Paula von Glehn, Linconl Uchôa Sidon, Eleuza Rodrigues Machado
AIM: The aim of this study was to describe the most common gynecological complaints and possible associated factors among women of reproductive age attended at a family health-care clinic. METHODOLOGY: A transversal study conducted with a sample of an outpatient population consisting of women of reproductive age. Pregnant women and minors were excluded. The final sample consisted of women between 18 and 49 years of age. The participants answered a questionnaire in which the complaints of the last 4 weeks were registered...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026478/vaginal-reconstruction-for-vaginal-obliteration-secondary-to-stevens-johnson-syndrome-a-case-report-and-review-of-literature
#12
Gokhan Boyraz, Derman Basaran, M Coskun Salman, Nejat Ozgul, Kunter Yuce
Stevens-Johnson syndrome (SJS) is a rare and acute life-threatening condition, which is almost always precipitated by drugs. Genital mucositis in female patients may also be an important cause of long-term morbidity secondary to mucosal scarring. We present the case of a 33-year-old nulligravid woman with distal vaginal synechiae necessitating a surgical approach, which occurred after an episode of SJS. Also, we aimed to review the literature to reveal cases which required surgical management for long-term genital sequelae as well as discuss preventive measures...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29026375/sexual-risk-behavior-among-hiv-positive-persons-in-jamaica
#13
Butho Ncube, Jessica Ansong, Kewanna Daniels, Dianne Campbell-Stennett, Pauline E Jolly
BACKGROUND: HIV/AIDS remains a global public health challenge, especially in sub-Saharan Africa and the Caribbean. Sexual risk behaviors among HIV-positive persons place their partners at risk for HIV transmission and other sexually transmitted infections. Stopping transmission acts among HIV-positive people is crucial in reversing HIV incidence. OBJECTIVE: This study aimed to assess the prevalence and predictors of sexual risk behaviors among HIV-positive individuals in clinical care in Northwestern Jamaica...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29026065/urethral-diverticulum-presenting-as-a-large-vaginal-mass-complicating-pregnancy-and-delivery
#14
Everett F Magann, Lisa S Newton, Susan A Barr
BACKGROUND A case report of urethral diverticulum complicating pregnancy is presented. The diagnosis and management are challenging because of the rare nature of this condition, the varied presentations and differential diagnoses, and the possibility of misdiagnosis. CASE REPORT A 25-year-old primigravida with scheduled induction of labor at 39 weeks gestation due to gestational diabetes mellitus presented for a routine antenatal appointment at 38 weeks and four days. On digital cervical examination, she was found to have a large semi-solid anterior vaginal mass, shown by trans-vaginal ultrasound to have a nearly solid appearance of a 5×7 cm mass with septation...
October 13, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29025850/protocol-for-a-pilot-randomised-double-blinded-placebo-controlled-trial-of-prophylactic-use-of-tranexamic-acid-for-preventing-postpartum-haemorrhage-tapph-1
#15
Asim Alam, Ameya Bopardikar, Shelly Au, Jon Barrett, Jeannie Callum, Alex Kiss, Stephen Choi
INTRODUCTION: Postpartum haemorrhage (PPH) is the leading cause of maternal morbidity and mortality worldwide. Despite the availability of multiple uterotonic agents, the incidence of PPH continues to rise. Tranexamic acid (TXA) has been shown to be a safe, effective and inexpensive therapeutic option for the treatment of PPH, however, its use prophylactically in mitigating the risk of PPH is unknown. This pragmatic randomised prospective trial assesses the feasibility and safety of administering TXA at the time of delivery for the prevention of PPH...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025533/negative-%C3%AE-hcg-and-molar-pregnancy-the-hook-effect
#16
Isabel Lobo Antunes, Joana Curado, Ana Quintas, Alcides Pereira
Molar pregnancy, included in gestational trophoblastic disease, is a benign pathology with ability to metastasize, usually occurring with excessively high βhCG levels. Clinical scenario is usually a woman in extremes of reproductive age presenting with amenorrhoea, pain and vaginal blood loss; signs derived from high βhCG levels may be present (hyperthyroidism, hyperemesis). Diagnosis is based on a positive pregnancy test - usually a qualitative urinary test. The limitation of this test results from its inability to become positive in presence of markedly high levels of βhCG, saturating the antigens used - known as the 'hook effect'...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29025038/selective-progesterone-receptor-modulators-for-fertility-preservation-in-women-with-symptomatic-uterine-fibroids
#17
Mohamed Ali, Ayman Al-Hendy
Uterine Fibroids (UF, AKA: leiomyoma) are the most important benign neoplastic threat to women's health, with costs up to hundreds of billions of health care dollars worldwide. UF caused-morbidities exert a tremendous health toll, impacting the quality of life of women of all ethnicities, especially women of color. Clinical presentations include heavy vaginal bleeding, pelvic pain, bulk symptoms, subfertility, and obstetric complications. Current management strategies heavily lean towards surgical procedures, nonetheless the choice of treatment is generally subject to patient's age and her desire to preserve future fertility...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024913/retrospective-study-on-de-novo-postoperative-urinary-incontinence-after-pelvic-organ-prolapse-surgery
#18
Aiste Ugianskiene, Niels Kjærgaard, Anna Sofie Inger Lindquist, Thomas Larsen, Karin Glavind
OBJECTIVE: Reported incidences of de novo urinary incontinence (UI) following pelvic organ prolapse (POP) surgery in preoperatively continent women vary between 2% and 43%. The aim of this study was to investigate the incidence and the types of de novo UI and differences between operations in different compartments. STUDY DESIGN: Retrospective study of 678 women with POP surgery using native tissue repair during a 3-year period. Patients completed three modified prolapse questions from the International Consultation on Incontinence-Vaginal Symptoms (ICIQ-VS) and the International Consultation on Incontinence Questionnaire- Urinary Incontinence Short Form (ICIQ-UI SF) before undergoing surgery and 3 months postoperatively...
October 4, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29024881/a-pilot-randomised-controlled-trial-exploring-the-effects-of-antenatal-reflexology-on-labour-outcomes
#19
Julie Em Mccullough, Ciara Close, S Dianne Liddle, Marlene Sinclair, Ciara M Hughes
OBJECTIVE: to investigate the effects of antenatal reflexology on labour outcomes. DESIGN: secondary analysis of a pilot three-armed randomised controlled trial conducted between July 2012 and September 2013. SETTING: a large UK inner city hospital maternity department. PARTICIPANTS: ninety primiparous women with a singleton pregnancy experiencing low back and / or pelvic girdle pain. INTERVENTIONS: six weekly 30-minute reflexology treatments compared to sham (footbath) treatments or usual antenatal care only...
September 14, 2017: Midwifery
https://www.readbyqxmd.com/read/29024799/treatment-for-uterine-isthmocele-a-pouch-like-defect-at-the-site-of-cesarean-section-scar
#20
REVIEW
Antonio Setubal, João Alves, Filipa Osório, Adalgisa Guerra, Rodrigo Fernandes, Jaime Albornoz, Zacharoula Sidiroupoulou
Isthmocele appears as a fluid pouch-like defect in the anterior uterine wall at the site of a prior Cesarean section and ranges in prevalence from 19% to 84%, a direct relation to the increase in Cesarean sections performed worldwide. Many definitions have been suggested for the dehiscence resulting from Cesarean section, and we propose standardization with a single term for all cases: isthmocele. Patients are not always symptomatic, but symptoms typically include intermittent abnormal bleeding, pain, and infertility...
October 9, 2017: Journal of Minimally Invasive Gynecology
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