keyword
MENU ▼
Read by QxMD icon Read
search

Neuropsychiatric lupus

keyword
https://www.readbyqxmd.com/read/28203329/pseudotumor-cerebri-as-the-first-manifestation-of-juvenile-systemic-lupus-erythematosus
#1
Seyed-Reza Raeeskarami, Leila Shahbaznejad, Raheleh Assari, Yahya Aghighi
INTRODUCTION: Headache is a common neuropsychiatric manifestation of juvenile systemic lupus erythematous (JSLE). Pseudotumor cerebri (PTC) is an uncommon cause of headache, presenting especially in active JSLE. In this paper, we report a case of missed intractable headache that was eventually diagnosed as PTC and presented as the first manifestation of JSLE. CASE PRESENTATION: A 9-year-old girl with a history of progressive headache for four months, fever, fatigue, myalgia, arthralgia, small-joint arthritis of the hands, and recent diplopia was referred to our clinic...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28190161/brain-white-matter-structural-networks-in-patients-with-non-neuropsychiatric-systemic-lupus-erythematosus
#2
Ling Zhao, Xiangliang Tan, Junjing Wang, Kai Han, Meiqi Niu, Jun Xu, Xiaojin Liu, Xixi Zhao, Miao Zhong, Qin Huang, Yikai Xu, Ruiwang Huang
Previous neuroimaging studies have revealed cognitive dysfunction in patients with systemic lupus erythematosus (SLE) and suggested that it may be related to disrupted brain white matter (WM) connectivity. However, no study has examined the topological properties of brain WM structural networks in SLE patients, especially in patients with non-neuropsychiatric SLE (non-NPSLE). In this study, we acquired DTI datasets from 28 non-NPSLE patients and 24 healthy controls, constructed their brain WM structural networks by using a deterministic fiber tracking approach, estimated the topological parameters of their structural networks, and compared their group differences...
February 11, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28178878/disease-characterization-of-systemic-lupus-erythematosus-sle-patients-in-quebec
#3
R Ng, S Bernatsky, E Rahme
Objective Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by an array of organ manifestations that can appear during flares and disappear during remissions. The objectives of this study were: (i) to examine SLE manifestation groups longitudinally in an SLE cohort; and (ii) to assess the association between early antimalarial treatment and renal manifestations. Methods Seven SLE manifestation groups-cutaneous, hematologic, lung, musculoskeletal, neuropsychiatric, serositis, renal-were tracked using Kaplan-Meier survival curves in an incident SLE cohort from Quebec health administrative data ( n = 2010)...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28178431/neuropsychiatric-systemic-lupus-erythematosus-involvement-towards-a-tailored-approach-to-our-patients
#4
REVIEW
Raquel Faria, João Gonçalves, Rita Dias
Neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) is a complex condition that remains poorly understood, and includes heterogeneous manifestations involving both the central and peripheral nervous system, with disabling effects. There are several models to improve NPSLE diagnosis when a neurological syndrome is present. In the last couple of years, the growing knowledge of the role of cytokines and antibodies in NPSLE, as well as the development of new functional imaging techniques, has brought some insights into the physiopathology of the disease, but their validation for clinical use remains undetermined...
January 30, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28154472/autoantibodies-to-nr2a-peptide-of-the-glutamate-nmda-receptor-in-patients-with-seizure-disorders-in-neuropsychiatric-systemic-lupus-erythematosus
#5
Yan Yang, Chao Yuan, Shu-Qun Shen, Xue-Er Wang, Qing-Hua Mei, Wen-Qing Jiang, Qin Huang
Objective. Seizure disorders are one of the most disabling, life-threatening, and the least understood syndromes associated with neuropsychiatric SLE (NPSLE). N-Methyl-D-aspartate (NMDA) receptors are a subgroup of the glutamate receptor family, whose NR2A subunit was found on neuronal cells (anti-NR2A) in NPSLE patients with different types of epilepsy. The present study was conducted to determine the serum levels of anti-NR2A antibodies in a large group of SLE patients, to investigate the possible correlation between the presence of the NR2A specific antibodies and NPSLE-related seizure disorders...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28134038/outcomes-of-847-childhood-onset-systemic-lupus-erythematosus-patients-in-three-age-groups
#6
S R M Lopes, N W S Gormezano, R C Gomes, N E Aikawa, R M R Pereira, M T Terreri, C S Magalhães, J C Ferreira, E M Okuda, A P Sakamoto, A M E Sallum, S Appenzeller, V P L Ferriani, C M Barbosa, S Lotufo, A A Jesus, L E C Andrade, L M A Campos, E Bonfá, C A Silva
Objective The objective of this study was to assess outcomes of childhood systemic lupus erythematosus (cSLE) in three different age groups evaluated at last visit: group A early-onset disease (<6 years), group B school age (≥6 and <12 years) and group C adolescent (≥12 and <18 years). Methods An observational cohort study was performed in ten pediatric rheumatology centers, including 847 cSLE patients. Results Group A had 39 (4%), B 395 (47%) and C 413 (49%). Median disease duration was significantly higher in group A compared to groups B and C (8...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28130617/prolactin-has-a-pathogenic-role-in-systemic-lupus-erythematosus
#7
Luis J Jara, Gabriela Medina, Miguel A Saavedra, Olga Vera-Lastra, Honorio Torres-Aguilar, Carmen Navarro, Monica Vazquez Del Mercado, Luis R Espinoza
Prolactin, a 23-kDa peptide hormone, is produced by the anterior pituitary gland and extrapituitary sites including the immune cells. Prolactin (PRL) participates in innate and adaptive immune response. PRL stimulates the immune cells by binding to receptor (PRL-R). Binding of PRL to its receptor activates the Janus kinase-signal transducer (JAK-STAT). Activation of these cascades results in endpoints such as immunoestimulator and immunosupressor action. Prolactin belongs to the network of immune-neuroendocrine interaction...
January 28, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28089970/spatial-working-memory-impairment-in-patients-with-non-neuropsychiatric-systemic-lupus-erythematosus-a-blood-oxygen-level-dependent-functional-magnetic-resonance-imaging-study
#8
Chun-Min Zhu, Ye Ma, Lei Xie, Jin-Zhuang Huang, Zong-Bo Sun, Shou-Xing Duan, Zhi-Rong Lin, Jing-Jing Yin, Hong-Bo Le, Dan-Miao Sun, Wen-Can Xu, Shu-Hua Ma
OBJECTIVE: Using ethology and functional magnetic resonance imaging (fMRI) to explore mild cognitive dysfunction and spatial working memory (WM) impairment in patients with systemic lupus erythematosus (SLE) without overt neuropsychiatric symptoms (non-NPSLE) and to study whether any clinical biomarkers could serve as predictors of brain dysfunction in this disease. METHODS: Eighteen non-NPSLE patients and 18 matched subjects were all tested using the Montreal cognitive assessment scale test and scanned using blood-oxygen-level dependent fMRI while performing the n-back task to investigate the activation intensity of some cognition-related areas...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28066709/alterations-of-white-matter-structural-networks-in-patients-with-non-neuropsychiatric-systemic-lupus-erythematosus-identified-by-probabilistic-tractography-and-connectivity-based-analyses
#9
Man Xu, Xiangliang Tan, Xinyuan Zhang, Yihao Guo, Yingjie Mei, Qianjin Feng, Yikai Xu, Yanqiu Feng
PURPOSE: Systemic lupus erythematosus (SLE) is a chronic inflammatory female-predominant autoimmune disease that can affect the central nervous system and exhibit neuropsychiatric symptoms. In SLE patients without neuropsychiatric symptoms (non-NPSLE), recent diffusion tensor imaging studies showed white matter abnormalities in their brains. The present study investigated the entire brain white matter structural connectivity in non-NPSLE patients by using probabilistic tractography and connectivity-based analyses...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28054310/modulation-of-neuroinflammation-in-the-central-nervous-system-role-of-chemokines-and-sphingolipids
#10
REVIEW
Roberta Gualtierotti, Laura Guarnaccia, Matteo Beretta, Stefania E Navone, Rolando Campanella, Laura Riboni, Paolo Rampini, Giovanni Marfia
Neuroinflammation is a process involved in the pathogenesis of different disorders, both autoimmune, such as neuropsychiatric systemic lupus erythematosus, and degenerative, such as Alzheimer's and Parkinson's disease. In the central nervous system, the local milieu is tightly regulated by different mediators, among which are chemoattractant cytokines, also known as chemokines. These small molecules are able to modulate trafficking of immune cells in the course of nervous system development or in response to tissue damage, and different patterns of chemokine molecule and receptor expression have been described in several neuroinflammatory disorders...
January 4, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28043063/investigation-of-neuronal-auto-antibodies-in-systemic-lupus-erythematosus-patients-with-epilepsy
#11
Zerrin Karaaslan, Esme Ekizoğlu, Pınar Tektürk, Ece Erdağ, Erdem Tüzün, Nerses Bebek, Candan Gürses, Betül Baykan
PURPOSE: Epilepsy is an important feature for neuropsychiatric involvement in systemic lupus erythematosus (SLE) with unknown mechanism. Our aim was to investigate the presence of neuronal auto-antibodies (NAbs) in neuropsychiatric SLE (NPSLE). METHODS: Eighteen SLE patients (17 females, 1 male) experiencing recurrent seizures were enrolled to this study. Their clinical characteristics, EEG and MRI findings and follow-up information were evaluated from their files...
December 14, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28030595/prognosis-for-hospitalized-patients-with-systemic-lupus-erythematosus-in-china-5-year-update-of-the-jiangsu-cohort
#12
Xuebing Feng, Wenyou Pan, Lin Liu, Min Wu, Fuwan Ding, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Lingyun Sun
OBJECTIVE: To identify early signs associated with poor prognosis in Chinese patients with systemic lupus erythematosus (SLE) through a large population-based follow-up study. METHODS: Medical records of > 2,500 SLE patients that first hospitalized between 1999-2009 were collected from 26 centers across Jiangsu province, China, and entered into a database. These patients were followed-up for 5 to 15 years, and those remained contact and had known survival status in 2015 were assessed for the association of factors presented at the initial hospitalization with mortality at two time points (≤1year and > 1year)...
2016: PloS One
https://www.readbyqxmd.com/read/28028157/brain-histopathology-in-patients-with-systemic-lupus-erythematosus-identification-of-lesions-associated-with-clinical-neuropsychiatric-lupus-syndromes-and-the-role-of-complement
#13
Daniëlle Cohen, Emilie C Rijnink, Rob J A Nabuurs, Gerda M Steup-Beekman, Maarten J Versluis, Bart J Emmer, Malu Zandbergen, Mark A van Buchem, Cornelia F Allaart, Ron Wolterbeek, Jan A Bruijn, Sjoerd G van Duinen, Tom W J Huizinga, Ingeborg M Bajema
OBJECTIVES: Neuropsychiatric (NP) involvement is a poorly understood manifestation of SLE. We studied post-mortem histopathology in relation to clinical NPSLE syndromes and complement deposition in brains of NPSLE and SLE patients and controls. Furthermore, we investigated the correlation between cerebral post-mortem histopathology and ex vivo 7 T MRI findings in SLE and NPSLE. METHODS: A nationwide search for autopsy material yielded brain tissue from 16 NPSLE and 18 SLE patients...
January 2017: Rheumatology
https://www.readbyqxmd.com/read/27992660/the-challenges-of-diagnosing-cognitive-dysfunction-with-neuropsychiatric-systemic-lupus-erythematosus-in-childhood
#14
REVIEW
Ashwaq AlE'ed, Patricia Vega-Fernandez, Eyal Muscal, Claas Hinze, Lori B Tucker, Simone Appenzeller, Brigitte Bader-Meunier, Johannes Roth, Vicenç Torrente-Segarra, Marisa S Klein-Gitelman, Deborah M Levy, Tresa Roebuck-Spencer, Hermine Brunner
The diagnosis of Neuropsychiatric systemic lupus erythematosus disease (NPSLE) is challenging. The Automated Neuropsychological Assessment Metrics (ANAM) has been shown to be an accessible and promising tool for evaluating possible NPSLE in adult and childhood lupus. In this review, we present information about the development and use of Ped-ANAM; the benefit of using Ped-ANAM in children with and without NPSLE in the assessment and follow up of their disease condition; and the correlation of Ped-ANAM to imaging studies such as magnetic resonance imaging (MRI)...
December 19, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27992002/neuropsychiatric-lupus-in-clinical-practice
#15
Helena Alessi, Lívia Almeida Dutra, Pedro Braga, José Luiz Pedroso, Fabio F Toso, Cristiane Kayser, Orlando G P Barsottini
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury. The etiology of SLE is partially known, involving multiple genetic and environmental factors. As many as 50% of patients with SLE have neurological involvement during the course of their disease. Neurological manifestations are associated with impaired quality of life, and high morbidity and mortality rates. Nineteen neuropsychiatric syndromes have been identified associated with SLE, and can be divided into central and peripheral manifestations...
December 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27988431/clinical-utility-of-circulating-anti-n-methyl-d-aspartate-receptor-subunits-nr2a-b-antibody-for-the-diagnosis-of-neuropsychiatric-syndromes-in-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome-an-updated-meta-analysis
#16
REVIEW
Sen Hee Tay, Anna-Marie Fairhurst, Anselm Mak
BACKGROUND/PURPOSE: Neuropsychiatric (NP) events are found in patients with rheumatic diseases, commonly in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The standard nomenclature and case definitions for 19 NPSLE syndromes by the American College of Rheumatology (ACR) Committee on Research cover a wide range of NP events seen in both SLE and SS. Despite advances in the understanding of SLE and SS, NP syndromes continue to pose diagnostic challenges. Correct attribution of NP events is critical in determining the correct treatment and prognosis...
February 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27914592/hyperuricemia-in-systemic-lupus-erythematosus-is-it-associated-with-the-neuropsychiatric-manifestations-of-the-disease
#17
Mahdi Sheikh, Shafieh Movassaghi, Mohammad Khaledi, Maryam Moghaddassi
OBJECTIVES: To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS: This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was completed for all the participants and the medical records were reviewed regarding the occurrence of arterial or venous thrombotic events, stroke, seizure, depression, headache, psychosis, and peripheral neuropathy...
November 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27893665/is-it-relevant-to-screen-young-women-hospitalized-in-psychiatric-department-for-neuropsychiatric-systemic-lupus-erythematosus-npsle-a-prospective-study-of-100-psychiatric-inpatients
#18
Alexandra Audemard-Verger, Elizabeth Comby, Clément Nathou, Audrey Sultan, Mathieu Frémont, Aurélie Baldolli, Louis Simon Trumier, Vincent Marzloff, Brigitte Le Mauff, Jennifer Manuzak, Sonia Dollfus, Boris Bienvenu
On the basis that diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is sometimes difficult and systemic lupus erythematosus (SLE) can present with isolated psychiatric symptoms, we initiated a survey in a psychiatric department to screen for NPSLE in young female inpatients.We prospectively studied consecutive young female patients referred to the department of psychiatry. Antinuclear antibodies (ANA), anti-deoxyribonucleic acid (DNA), and antiextractable soluble nuclear antigens (ENA) in the serum of patients were screened...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27889859/chronic-high-dose-glucocorticoid-therapy-triggers-the-development-of-chronic-organ-damage-and-worsens-disease-outcome-in-systemic-lupus-erythematosus
#19
Tünde Tarr, Gábor Papp, Nikolett Nagy, Edina Cserép, Margit Zeher
Long-term survival of patients with systemic lupus erythematosus (SLE) improved worldwide; thus, prevention of cumulative organ damage became a major goal in disease management. The aim of our study was to investigate the chronic organ damages and their influence on disease outcome in SLE. We evaluated clinical conditions, laboratory findings and medications of 357 consecutive SLE patients and assessed their impact on Systemic Lupus Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) and disease outcome...
November 26, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27887767/vascular-endothelial-growth-factor-g1612a-rs10434-gene-polymorphism-and-neuropsychiatric-manifestations-in-systemic-lupus-erythematosus-patients
#20
Sherif Taha, Sherif Mohammed Gamal, Mohamed Nabil, Nahla Naeem, Dalia Labib, Ibrahim Siam, Tamer Atef Gheita
AIM: To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. PATIENTS AND METHODS: Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without...
October 28, 2016: Revista Brasileira de Reumatologia
keyword
keyword
491
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"