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https://www.readbyqxmd.com/read/28337522/pre-symptomatic-autoimmunity-in-rheumatoid-arthritis-when-does-the-disease-start
#1
REVIEW
Alexander Tracy, Christopher D Buckley, Karim Raza
It is well recognised that a state of autoimmunity, in which immunological tolerance is broken, precedes the development of symptoms in the majority of patients with rheumatoid arthritis (RA). For individuals who will later develop seropositive disease, this manifests as autoantibodies directed against proteins that have undergone specific post-translational modifications. There is evidence that the induction of this autoantibody response occurs at peripheral extra-articular mucosal sites, such as the periodontium and lung...
March 23, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28336469/a-review-of-the-ethnopharmacology-phytochemistry-and-pharmacology-of-notopterygium-incisum
#2
REVIEW
John Teye Azietaku, Huifen Ma, Xie-An Yu, Jin Li, Mahmood Brobbey Oppong, Jun Cao, Mingrui An, Yan-Xu Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Notopterygium incisum Ting ex H.T. Chang, known in Chinese as 'Qianghuo' is a traditional Chinese medicinal herb with the rhizome and roots associated with meridians of the kidney and urinary bladder. It is pungent, bitter and warm in nature. It has been used over the years to disperse cold, prevent painful obstructions from wind, damp and warm pain. It has also been used with other herbs to treat wind-cold exterior syndrome and wind-cold-damp bi-syndromes and has been known to grow well in regions of high altitude such as Gansu, Tibet etc...
March 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28333949/metabolic-syndrome-and-its-components-among-rheumatoid-arthritis-patients-a-comprehensive-updated-systematic-review-and-meta-analysis
#3
Jamal Hallajzadeh, Saeid Safiri, Mohammad Ali Mansournia, Maliheh Khoramdad, Neda Izadi, Amir Almasi-Hashiani, Reza Pakzad, Erfan Ayubi, Mark J M Sullman, Nahid Karamzad
BACKGROUND: Estimating the current global prevalence of metabolic syndrome (MetS), and its components, among rheumatoid arthritis (RA) patients is necessary in order to formulate preventative strategies and to ensure there are adequate community resources available for these patients. Furthermore, the association between RA and MetS is controversial and has not previously been comprehensively assessed. Therefore, the present study aimed to: 1) determine the prevalence of MetS, and its components, among RA patients across the world 2) update the odds ratio of MetS in RA patients, compared to healthy controls, using a comprehensive systematic review and meta-analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28324133/foot-health-in-patients-with-rheumatoid-arthritis-a-scoping-review
#4
REVIEW
Minna Stolt, Riitta Suhonen, Helena Leino-Kilpi
Rheumatoid arthritis affects joints and can cause significant impairments in daily life. The foot is often the first site of symptoms and foot problems are strongly related to RA. The aim of this review was, therefore, to describe foot health in patients with rheumatoid arthritis and to identify how patients perform foot self-care. With this knowledge interventions to support foot health and functional ability in RA patients can be developed. The design of the review was a scoping review. A systematic literature search of three electronic databases, MEDLINE, CINAHL and Embase, was conducted in June 2016...
March 21, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28321538/microrna-192-suppresses-cell-proliferation-and-induces-apoptosis-in-human-rheumatoid-arthritis-fibroblast-like-synoviocytes-by-downregulating-caveolin-1
#5
Supin Li, Zhenmu Jin, Xiaobing Lu
Fibroblast-like synoviocytes (FLSs) play an important role in the pathogenesis of rheumatoid arthritis (RA). This study was conducted to explore the role of microRNA (miR)-192 in the regulation of the biology of RA-FLSs. The expression of miR-192 in RA and healthy synovial tissues was measured. The effects of overexpression of miR-192 on RA-FLS proliferation and apoptosis were investigated. Luciferase reporter assay and Western blot analysis were performed to identify direct target genes of miR-192. RA synovial tissues had significantly lower levels of miR-192 than healthy controls (P = 0...
March 20, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28320445/risk-factors-for-flare-and-treatment-of-disease-flares-during-pregnancy-in-rheumatoid-arthritis-and-axial-spondyloarthritis-patients
#6
Stephanie van den Brandt, Astrid Zbinden, Dominique Baeten, Peter M Villiger, Monika Østensen, Frauke Förger
BACKGROUND: During pregnancy, patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) can experience active disease, which might be influenced by adjustment of treatment around conception. The aim of this study was to identify possible risk factors of disease flares during pregnancy and to evaluate the effect of treatment in pregnant patients experiencing a flare. METHODS: Pregnant patients with RA and axSpA were prospectively followed before, during, and after pregnancy...
March 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28318613/latent-tuberculosis-infection-screening-prior-to-biological-treatment-in-tunisian-patients
#7
Marwa Slouma, Ines Mahmoud, Olfa Saidane, Selma Bouden, Leila Abdelmoula
OBJECTIVES: The screening of latent tuberculosis infection (LTBI) is necessary to prevent infection in patients with chronic inflammatory disease (CID) undergoing biological treatment. We aimed to assess the efficacy of LTBI screening prior to biological treatment in Tunisia, considered as a high-incidence area of active TB disease. METHODS: We conducted a retrospective study over a period of 8 years [2007-2014] including patients with chronic inflammatory rheumatism receiving biologic agents since at least 6 months...
February 24, 2017: Thérapie
https://www.readbyqxmd.com/read/28314855/def6-restrains-osteoclastogenesis-and-inflammatory-bone-resorption
#8
Nikolaus Binder, Christine Miller, Masaki Yoshida, Kazuki Inoue, Shinichi Nakano, Xiaoyu Hu, Lionel B Ivashkiv, Georg Schett, Alessandra Pernis, Steven R Goldring, F Patrick Ross, Baohong Zhao
Inflammatory bone resorption mediated by osteoclasts is a major cause of morbidity and disability in many inflammatory disorders, including rheumatoid arthritis (RA). The mechanisms that regulate osteoclastogenesis and bone resorption in inflammatory settings are complex and have not been well elucidated. In this study, we identify the immunoregulator differentially expressed in FDCP 6 homolog (Def6) as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions. Def6 deficiency in Def6(-/-) mice enhanced the sensitivity of osteoclast precursors to the physiological osteoclastogenic inducer receptor activator for NF-κB ligand, and Def6(-/-) osteoclasts formed actin rings...
March 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28314223/gv1001-immunotherapy-ameliorates-joint-inflammation-in-a-murine-model-of-rheumatoid-arthritis-by-modifying-collagen-specific-t-cell-responses-and-downregulating-antigen-presenting-cells
#9
In Ah Choi, Ji Yong Choi, Sundo Jung, Fathihah Basri, Seho Park, Eun Young Lee
This study investigated whether GV1001 may be useful for treating rheumatoid arthritis (RA). Two collagen-induced arthritis (CIA) experiments showed that therapeutic, but not preventive, GV1001 treatment reduced the severity of joint inflammation in CIA. The third CIA experiment indicated that, compared to vehicle treatment, therapeutic GV1001 treatment was associated with a significantly smaller area under the curve for the overall clinical joint score over the 98day observation period (p<0.05). GV1001 treatment was also associated with lower Day 98 serum IL-6 levels (p<0...
March 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28299914/the-onset-site-of-rheumatoid-arthritis-the-joints-or-the-lung
#10
G Cafaro, A Alunno, V Valentini, M C Leone, E Marcucci, E Bartoloni, R Gerli
The etiopathogenesis of rheumatoid arthritis (RA) is not yet fully elucidated and the site of inflammation onset is still a matter of debate. The presence of autoantibodies as well as clinical manifestations, such as interstitial lung disease, before the onset of arthritis seems to be in favour of the hypothesis that initial pathogenic events take place in tissues other than the joint. In this review article we summarize the most recent literature on extra-synovial autoimmunity triggers eventually leading to RA, with particular focus on the role of the lung...
December 31, 2016: Reumatismo
https://www.readbyqxmd.com/read/28292965/repurposed-jak1-jak2-inhibitor-reverses-established-autoimmune-insulitis-in-non-obese-diabetic-mice
#11
Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas
Recent advances in immunotherapeutics have not yet changed the routine management of autoimmune type 1 diabetes. There is an opportunity to repurpose therapeutics from other diseases to type 1 diabetes, especially when there is evidence for overlapping mechanisms. JAK1/JAK2 inhibitors are in development or clinical use for indications including rheumatoid arthritis. There is good evidence for activation of the JAK1/JAK2 and STAT1 pathway in human type 1 diabetes and in mouse models, especially in beta cells...
March 14, 2017: Diabetes
https://www.readbyqxmd.com/read/28277344/use-of-hydroxychloroquine-is-associated-with-improved-lipid-profile-in-rheumatoid-arthritis-patients
#12
Jose Felix Restrepo, Inmaculada Del Rincon, Emily Molina, Daniel F Battafarano, Agustin Escalante
BACKGROUND/PURPOSE: We examined the association between hydroxychloroquine (HCQ) and plasma lipid and glucose levels in rheumatoid arthritis (RA) cohort. METHODS: This is a retrospective cohort analysis of 1261 RA patients comparing fasting lipid profiles and plasma glucose between patients who were and were not taking HCQ. We divided patients into 3 groups based on HCQ exposure during follow-up: those who had never taken HCQ, those who took it intermittently, and those who took it continuously...
April 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28275536/rheumatoid-arthritis-associated-pulmonary-hypertension-clinical-challenges-reflecting-the-diversity-of-pathophysiology
#13
Evangelia Panagiotidou, Evdokia Sourla, Serafim Xrisovalantis Kotoulas, Sofia Akritidou, Vasileios Bikos, Vasileios Bagalas, Ioannis Stanopoulos, Georgia Pitsiou
The present article reports three clinical cases in order to elucidate the diversity of the pathophysiological mechanisms that underlie rheumatoid arthritis associated pulmonary hypertension. The condition's three major causes are: interstitial lung disease, vasculitis, and chronic thromboembolic disease, but it should be noted that the multiple pulmonary manifestations of rheumatoid arthritis, can all contribute to chronic lung disease or hypoxia. The first patient in this report suffered from moderate restriction due to fibrosis and was diagnosed with pulmonary hypertension during an episode of life threatening hypoxia...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28273301/to-prevent-rheumatoid-arthritis-look-past-the-joints-to-the-gums
#14
Jennifer Abbasi
No abstract text is available yet for this article.
March 8, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28270656/raising-awareness-of-bronchiectasis-in-primary-care-overview-of-diagnosis-and-management-strategies-in-adults
#15
James D Chalmers, Sanjay Sethi
Bronchiectasis is a chronic lung disease characterised by recurrent infection, inflammation, persistent cough and sputum production. The disease is increasing in prevalence, requiring a greater awareness of the disease across primary and secondary care. Mild and moderate cases of bronchiectasis in adults can often be managed by primary care clinicians. Initial assessments and long-term treatment plans that include both pharmacological and non-pharmacological treatments, however, should be undertaken in collaboration with a secondary care team that includes physiotherapists and specialists in respiratory medicine...
December 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28270202/rheumatology-in-africa-challenges-and-opportunities
#16
EDITORIAL
Girish M Mody
Africa faces many health challenges despite sustained growth and development over the past decade. Contributory factors are the lack of financial resources, an inadequate health professional workforce, a high burden of communicable diseases, and an increasing burden of non-communicable diseases. Rheumatology services are limited or non-existent in many parts of sub-Saharan Africa. Over the past decade, partnerships with international academic institutions have resulted in some progress in the training of rheumatologists and health professionals and development of rheumatology services in countries such as Kenya, Nigeria, and Zambia...
March 7, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28269183/segmentation-of-the-metacarpus-and-phalange-in-musculoskeletal-ultrasound-images-using-local-active-contours
#17
Nelson Martins, Malik Saad Sultan, Diana Veiga, Manuel Ferreira, Miguel Coimbra
This work presents a method for the automatic segmentation of metacarpus and phalange bones in ultrasound images of the second metacarpophalangeal joint (MCPJ) using Active Contours. The MCPJ is known to be the one of the first structures to be affected by rheumatic diseases like rheumatoid arthritis. The early detection and follow-up of this disease is important to prevent irreversible damage of the joints, which occurs continuously and faster if no treatment is used. To our knowledge, there is no automatic system to quantify the extension of the lesions resulting from rheumatic activity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266114/interaction-of-lifestyle-behaviour-or-systemic-diseases-with-dental-caries-and-periodontal-diseases-consensus-report-of-group-2-of-the-joint-efp-orca-workshop-on-the-boundaries-between-caries-and-periodontal-diseases
#18
Iain L C Chapple, Philippe Bouchard, Maria Grazia Cagetti, Guglielmo Campus, Maria-Clotilde Carra, Fabio Cocco, Luigi Nibali, Philippe Hujoel, Marja L Laine, Peter Lingstrom, David J Manton, Eduardo Montero, Nigel Pitts, Hélène Rangé, Nadine Schlueter, Wim Teughels, Svante Twetman, Cor Van Loveren, Fridus Van der Weijden, Alexandre R Vieira, Andreas G Schulte
Periodontal diseases and dental caries are the most common diseases of humans and the main cause of tooth loss. Both diseases can lead to nutritional compromise and negative impacts upon self-esteem and quality of life. As complex chronic diseases, they share common risk factors, such as a requirement for a pathogenic plaque biofilm, yet they exhibit distinct pathophysiologies. Multiple exposures contribute to their causal pathways, and susceptibility involves risk factors that are inherited (e.g. genetic variants), and those that are acquired (e...
March 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28264972/synovial-fibroblasts-selectively-suppress-th1-cell-responses-through-ido1-mediated-tryptophan-catabolism
#19
Lars-Oliver Tykocinski, Anna M Lauffer, Antonia Bohnen, Nathalie-Christin Kaul, Stefan Krienke, Theresa Tretter, Isabell Adam, Soumya R Mohapatra, Philippe Saikali, Max Löhning, Michel Neidhart, Steffen Gay, Iris Oezen, Michael Platten, Christiane A Opitz, Hanns-Martin Lorenz
The development of rheumatoid arthritis (RA) is linked to functional changes in synovial fibroblasts (SF) and local infiltration of T lymphocytes. Fibroblasts possess the capacity to suppress T cell responses, although the molecular mechanisms of this suppression remain incompletely understood. In this study, we aimed to define the mechanisms by which noninflammatory SF modulate Th cell responses and to determine the immunosuppressive efficacy of RASF. Hence, the influence of SF from osteoarthritis or RA patients on total Th cells or different Th cell subsets of healthy donors was analyzed in vitro...
March 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28259996/combined-treatment-with-vitamin-c-and-methotrexate-inhibits-triple-negative-breast-cancer-cell-growth-by-increasing-h2o2-accumulation-and-activating-caspase-3-and-p38-pathways
#20
Ching-Wen Wu, Hsiao-Chun Liu, Yung-Luen Yu, Yu-Ting Hung, Chyou-Wei Wei, Giou-Teng Yiang
Methotrexate (MTX) is widely used as both an anticancer and anti-rheumatoid arthritis drug. Although MTX has been used to inhibit the growth of many cancer cells, it cannot effectively inhibit growth of triple-negative breast cancer cells (TNBC cells). Vitamin C is an antioxidant that can prevent oxidative stress. In addition, vitamin C has been applied as adjunct treatment for growth inhibition of cancer cells. Recent studies indicated that combined treatment with vitamin C and MTX may inhibit MCF-7 and MDA-MB-231 breast cancer cell growth through G2/M elongation...
February 10, 2017: Oncology Reports
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