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prevention rheumatoid arthritis

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https://www.readbyqxmd.com/read/29341125/gut-microbiota-and-probiotics-novel-immune-system-modulators-in-myasthenia-gravis
#1
REVIEW
Elena Rinaldi, Alessandra Consonni, Elena Guidesi, Marina Elli, Renato Mantegazza, Fulvio Baggi
Gut microorganisms (microbiota) live in symbiosis with the host and influence human nutrition, metabolism, physiology, and immune development and function. The microbiota prevents pathogen infection to the host, and in turn the host provides a niche for survival. The alteration of gut bacteria composition (dysbiosis) could contribute to the development of immune-mediated diseases by influencing the immune system activation and driving the pro- and anti-inflammatory responses in order to promote or counteract immune reactions...
January 17, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29315404/interplay-between-rnaseh2-and-mov10-controls-line-1-retrotransposition
#2
Jongsu Choi, Sung-Yeon Hwang, Kwangseog Ahn
Long interspersed nuclear element 1 is an autonomous non-long terminal repeat retrotransposon that comprises ∼17% of the human genome. Its spontaneous retrotransposition and the accumulation of heritable L1 insertions can potentially result in genome instability and sporadic disorders. Moloney leukemia virus 10 homolog (MOV10), a putative RNA helicase, has been implicated in inhibiting L1 replication, although its underlying mechanism of action remains obscure. Moreover, the physiological relevance of MOV10-mediated L1 regulation in human disease has not yet been examined...
January 5, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29313071/glucocorticoids-inflammation-and-bone
#3
REVIEW
Melek Güler-Yüksel, Jos N Hoes, Irene E M Bultink, Willem F Lems
The current review on glucocorticoids (GCs), inflammation and bone is focused on three aspects: (1) the mutual effects between GCs, inflammation and bone in inflammatory rheumatic diseases, (2) current views on fracture risk assessment in patients using GCs and (3) non-pharmacological and pharmacological treatment to prevent fractures in GC-using patients with inflammatory rheumatic diseases. The use of GCs results in increased risk for fractures due to both direct and indirect negative effects of GCs on bone mass, and on bone and muscle strength...
January 8, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29306884/retrospective-cohort-study-on-risk-of-hearing-loss-in-patients-with-rheumatoid-arthritis-using-claims-data
#4
Chung-Ming Huang, Hsuan-Ju Chen, Po-Hao Huang, Gregory J Tsay, Joung-Liang Lan, Fung-Chang Sung
OBJECTIVES: Population studies on hearing loss (HL) associated with rheumatoid arthritis (RA) are lacking. This study investigated the risk of developing HL in patients with RA using a nationwide population cohort. SETTING: The population-based insurance claims data in the Taiwan National Health Insurance Research Database. DESIGN: Retrospective cohort study followed up RA cohort and control cohort without RA frequency matched by sex, age and diagnosis year...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29306173/blocking-osteopontin-fibronectin-interactions-reduce-extracellular-fibronectin-deployment-and-arthritic-immunopathology
#5
Brij Bhushan Mehta, Saniya Sharma, Rakesh K Vasishta, Ramesh K Sen, Aman Sharma, Manni Luthra-Guptasarma
Elevated levels of a thrombin-cleaved fragment of osteopontin (OPNT) are seen in synovial fluid (SF) and tissues of rheumatoid arthritis (RA) patients. OPNT binds to integrins on cell surfaces, inducing adhesion, migration and survival of inflammatory cells in the synovial joints, where OPNT binds to fibronectin to link fibroblast-like synoviocytes (FLS) with B cells, stimulating the latter to produce inflammatory cytokines. Our aim was to block OPNT-fibronectin interactions and examine whether this reduces inflammation...
January 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29303005/bone-targeted-methotrexate-alendronate-conjugate-inhibits-osteoclastogenesis-in-vitro-and-prevents-bone-loss-and-inflammation-of-collagen-induced-arthritis-in-vivo
#6
Zi'ang Xie, Guanxiong Liu, Pan Tang, Xuewu Sun, Shuai Chen, An Qin, Peizhi Zhu, Jianfeng Zhang, Shunwu Fan
Rheumatoid arthritis (RA), a disease that causes joint destruction and bone erosion, is related to osteoclast activity. RA is generally treated with methotrexate (MTX). In this study, a MTX-Alendronate (ALN) conjugate was synthesized and characterized. The conjugate dramatically inhibited osteoclast formation and bone resorption compared with MTX and ALN used alone or in combination. Due to the characteristics of ALN, the MTX-ALN conjugate can adhere to the exposed bone surface and enhance drug accumulation in the pathological region for targeted therapy against osteoclastogenesis...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29279424/-joint-disease-and-energy-metabolism
#7
Jun Hirose
Recently, it has been found that systemic metabolic disorders are associated with the onset and progression of various joint diseases. Although osteoarthritis(OA)is mainly a degradative condition of the articular cartilage induced by mechanical stress, there is a growing body of data demonstrating the involvement of metabolic factors including fat metabolism. Recent studies have revealed that adipokines including adiponectin and leptin are associated with inflammation of rheumatoid arthritis. A better understanding of these relationships may lead to new strategies to treat or prevent joint disease such as OA...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29276516/myostatin-promotes-interleukin-1%C3%AE-expression-in-rheumatoid-arthritis-synovial-fibroblasts-through-inhibition-of-mir-21-5p
#8
Sung-Lin Hu, An-Chen Chang, Chien-Chung Huang, Chun-Hao Tsai, Cheng-Chieh Lin, Chih-Hsin Tang
Rheumatoid arthritis (RA) is characterized by the infiltration of a number of pro-inflammatory cytokines into synovial fluid and patients with RA often develop joint destruction and deficits in muscle mass. The growth factor myostatin is a key regulator linking muscle mass and bone structure. We sought to determine whether myostatin regulates rheumatoid synovial fibroblast activity and inflammation in RA. We found that levels of myostatin and interleukin (IL)-1β (a key pro-inflammatory cytokine in RA) in synovial fluid from RA patients were overexpressed and positively correlated...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29275344/effects-of-a-12-week-cardiovascular-rehabilitation-programme-on-systemic-inflammation-and-traditional-coronary-artery-disease-risk-factors-in-patients-with-rheumatoid-arthritis-cardia-trial-a-randomised-controlled-trial
#9
Stefan Heinze-Milne, Volodko Bakowsky, Nicholas Giacomantonio, Scott A Grandy
INTRODUCTION: Patients with systemic inflammatory diseases such as rheumatoid arthritis (RA) have an increased risk of cardiovascular disease (CVD) above the baseline risk attributable to traditional CVD risk factors seen in the general population. Exercise in cardiac rehabilitation (CR) is designed specifically for high-risk primary prevention and those with established CVD. Even though the European League Against Rheumatism guidelines state that exercise is safe for individuals with RA and exercise can reduce CVD risk, patients with RA rarely participate in CR...
December 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29259960/factors-affecting-bone-mineral-density-measurement-after-fracture-in-south-korea
#10
Jin-Woo Kim, Yong-Chan Ha, Young-Kyun Lee
Background: Prior osteoporotic fractures are strongly associated with the subsequent fractures. To prevent this, the diagnosis of osteoporosis following an osteoporotic fracture is important. The measurement of bone mineral density (BMD) is the first step for the diagnosis and management of osteoporosis. Therefore, the purposes of this study are 1) to evaluate the rate of BMD measurement after osteoporotic fracture in Korean population; and 2) determine the associated factors with BMD measurement after fractures among Korean patients...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29250057/update-on-dendritic-cell-induced-immunological-and-clinical-tolerance
#11
REVIEW
Carolina Obregon, Rajesh Kumar, Manuel Antonio Pascual, Giuseppe Vassalli, Déla Golshayan
Dendritic cells (DCs) as highly efficient antigen-presenting cells are at the interface of innate and adaptive immunity. As such, they are key mediators of immunity and antigen-specific immune tolerance. Due to their functional specialization, research efforts have focused on the characterization of DCs subsets involved in the initiation of immunogenic responses and in the maintenance of tissue homeostasis. Tolerogenic DCs (tolDCs)-based therapies have been designed as promising strategies to prevent and control autoimmune diseases as well as allograft rejection after solid organ transplantation (SOT)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29249121/matrix-metalloproteinase-1-a-better-biomarker-for-squamous-cell-carcinoma-by-multiple-microarray-analyses
#12
Li-Qiang Zheng, Rui Wang, Su-Min Chi, Cheng-Xin Li
BACKGROUND: The present study aimed to validate MMP1 role in the development of squamous cell carcinoma (SCC) by bioinformatics methods. METHODS: Gene expression data of 10 GSE series (5 HNSCCs and 5 cSCCs) were obtained from the Gene Expression Omnibus (GEO) database and used to identify differentially expressed genes (DEGs). RESULTS: Higher expression of MMP1 was found rank number one in 9/10 GSE series of SCC. MMP1 was mainly focused on Gene Ontology (GO) terms of collagen catabolic process, extracellular matrix disassembly...
December 15, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29241159/oxymatrine-prevents-synovial-inflammation-and-migration-via-blocking-nf-%C3%AE%C2%BAb-activation-in-rheumatoid-fibroblast-like-synoviocytes
#13
Jiang Liang, Boyang Chang, Mingcheng Huang, Weichen Huang, Wukai Ma, Yang Liu, Wan Tai, Yi Long, Yun Lu
The fibroblast-like synoviocytes (FLSs) has the aggressive phenotype, which is very important for cartilage destruction in rheumatoid arthritis (RA). To the pathology of RA, the increased FLSs migration, activation and proliferation are essential factors. Oxymatrine is a traditional Chinese herb, which is the extraction from the root of Sophora flavescens and regarded as quinolizidine alkaloid compounds and has been shown to inhibit inflammation, proliferation and migration in vitro or vivo. However, whether oxymatrine effects in the treatment of RA FLSs is undefined...
December 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29230210/checkpoint-blockade-toxicity-and-immune-homeostasis-in-the-gastrointestinal-tract
#14
REVIEW
Michael Dougan
Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has led to a new class of immune-related adverse events. In many respects, these immune toxicities resemble idiopathic autoimmune diseases, such as inflammatory bowel disease, autoimmune hepatitis, rheumatoid arthritis, and vitiligo...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29221603/emerging-therapies-for-pre-ra
#15
REVIEW
Andrew P Cope
The field of rheumatology has made major contributions to medicine through the identification of cellular and molecular targets and the development of therapies for the treatment of an impressive range of immune-mediated inflammatory diseases such as rheumatoid arthritis. In recent years, new milestones have been achieved. These include the recognition of an at-risk state, characterized by disease specific autoantibodies in serum and inflammatory joint pain, and the initiation of studies seeking to prevent high-risk individuals from progressing to a state of clinically apparent arthritis...
February 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29221599/symptoms-in-individuals-at-risk-of-rheumatoid-arthritis
#16
REVIEW
Gurpreet Singh Jutley, Zahira P Latif, Karim Raza
An increasing interest in treating individuals at risk of rheumatoid arthritis (RA) to prevent the development of this chronic condition has focussed attention on the identification of risk factors of this disease. Most patients who develop RA progress through a preceding symptomatic phase that may take the form of arthralgia, palindromic rheumatism or unclassified arthritis before a disease currently classifiable as RA is established. An understanding of symptoms that identify individuals as being at risk of RA is a critical issue...
February 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29221597/evolution-of-autoantibody-responses-in-individuals-at-risk-of-rheumatoid-arthritis
#17
REVIEW
Willem J J Falkenburg, Dirkjan van Schaardenburg
Autoantibodies such as rheumatoid factors (RFs), anti-citrullinated protein antibodies (ACPAs), and other anti-modified protein antibodies are important risk factors for the development of rheumatoid arthritis (RA) and probably play an important role in its pathogenesis. In the phase before clinical arthritis becomes apparent, different autoantibody responses can evolve because of increases in their level, isotype switching, affinity maturation, epitope spreading, and a changing glycosylation profile. This evolution may be crucial for the pathogenic properties of the autoantibody responses, and interfering with this process in individuals at risk may become a route to prevent RA...
February 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29221595/genetic-and-environmental-risk-factors-for-rheumatoid-arthritis
#18
REVIEW
Kevin D Deane, M Kristen Demoruelle, Lindsay B Kelmenson, Kristine A Kuhn, Jill M Norris, V Michael Holers
Multiple genetic and environmental factors have been associated with an increased risk for rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female sex, a family history of RA, the genetic factor the "shared epitope," and exposure to tobacco smoke. There is also renewed interest in mucosal inflammation and microbial factors as contributors to the development of RA. However, the identification of a "preclinical" period of RA that can be defined as local or systemic autoimmunity as measured by autoantibodies and other biomarkers prior to the development of clinically apparent synovitis suggests that the risk factors for RA are acting long prior to first clinical evidence of IA...
February 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29221594/periodontal-disease-and-periodontal-bacteria-as-triggers-for-rheumatoid-arthritis
#19
REVIEW
Zijian Cheng, Josephine Meade, Kulveer Mankia, Paul Emery, Deirdre A Devine
There is an epidemiological association between periodontitis and rheumatoid arthritis (RA), which is hypothesised to lead to enhanced generation of RA-related autoantibodies that can be detected years before the onset of RA symptoms. Periodontitis is a common dysbiotic disease; tissue damage occurs because the immune system fails to limit both the resident microbial community and the associated local immune response. Certain periodontal bacteria, including Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, may contribute to RA autoantibody production through direct post-translational modification of proteins or, indirectly, by influencing neutrophil-mediated neo-epitope generation...
February 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29216228/primary-prevention-of-myocardial-infarction-with-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-in-hypertensive-patients-with-rheumatoid-arthritis-a-nationwide-cohort-study
#20
Ting-Tse Lin, Cho-Kai Wu, Min-Tsun Liao, Yao-Hsu Yang, Pau-Chung Chen, Dong-Feng Yeih, Lian-Yu Lin
BACKGROUND: Rheumatoid arthritis (RA) is regarded as a high risk factor for myocardial infarction. Hypertension is a major modifiable risk factor contributing to increased risk of myocardial infarction (MI). Dual blood pressure (BP)-lowering and anti-inflammatory effect of renin-angiotensin-system (RAS) inhibitors may possess protective effect from MI in RA population. However, treatment of hypertension with RAS inhibitors and MI in RA population remains unclear. METHODS: We investigated whether RAS blockade could decrease risk of incident MI in hypertensive patients with RA...
2017: PloS One
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