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prevention rheumatoid arthritis

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https://www.readbyqxmd.com/read/28214674/development-of-a-quick-serum-il-6-measuring-system-in-rheumatoid-arthritis
#1
Kensuke Koyama, Tetsuro Ohba, Kentaro Ishii, Giman Jung, Hirotaka Haro, Kenichi Matsuda
OBJECTIVE: Interleukin-6 (IL-6) plays a crucial role in the pathogenesis of rheumatoid arthritis (RA). Both fulfillment of remission criteria and assessment of other methods of evaluation of RA are important for preventing joint damage progression. Measurement of serum IL-6 concentrations has been reported to be useful for monitoring RA disease activity. However, it takes at least 4-5h to measure serum IL-6 concentrations using traditional methods, which limits its utility during routine assessment in daily clinical practice settings...
February 16, 2017: Cytokine
https://www.readbyqxmd.com/read/28209629/burden-of-musculoskeletal-disorders-in-the-eastern-mediterranean-region-1990-2013-findings-from-the-global-burden-of-disease-study-2013
#2
Maziar Moradi-Lakeh, Mohammad H Forouzanfar, Stein Emil Vollset, Charbel El Bcheraoui, Farah Daoud, Ashkan Afshin, Raghid Charara, Ibrahim Khalil, Hideki Higashi, Mohamed Magdy Abd El Razek, Aliasghar Ahmad Kiadaliri, Khurshid Alam, Nadia Akseer, Nawal Al-Hamad, Raghib Ali, Mohammad AbdulAziz AlMazroa, Mahmoud A Alomari, Abdullah A Al-Rabeeah, Ubai Alsharif, Khalid A Altirkawi, Suleman Atique, Alaa Badawi, Lope H Barrero, Mohammed Basulaiman, Shahrzad Bazargan-Hejazi, Neeraj Bedi, Isabela M Bensenor, Rachelle Buchbinder, Hadi Danawi, Samath D Dharmaratne, Faiez Zannad, Maryam S Farvid, Seyed-Mohammad Fereshtehnejad, Farshad Farzadfar, Florian Fischer, Rahul Gupta, Randah Ribhi Hamadeh, Samer Hamidi, Masako Horino, Damian G Hoy, Mohamed Hsairi, Abdullatif Husseini, Mehdi Javanbakht, Jost B Jonas, Amir Kasaeian, Ejaz Ahmad Khan, Jagdish Khubchandani, Ann Kristin Knudsen, Jacek A Kopec, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Azeem Majeed, Reza Malekzadeh, Kedar Mate, Alem Mehari, Michele Meltzer, Ziad A Memish, Mojde Mirarefin, Shafiu Mohammed, Aliya Naheed, Carla Makhlouf Obermeyer, In-Hwan Oh, Eun-Kee Park, Emmanuel Kwame Peprah, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Vafa Rahimi-Movaghar, Rahman Shiri, Sajjad Ur Rahman, Rajesh Kumar Rai, Saleem M Rana, Sadaf G Sepanlou, Masood Ali Shaikh, Ivy Shiue, Abla Mehio Sibai, Diego Augusto Santos Silva, Jasvinder A Singh, Jens Christoffer Skogen, Abdullah Sulieman Terkawi, Kingsley N Ukwaja, Ronny Westerman, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Zoubida Zaidi, Maysaa El Sayed Zaki, Stephen S Lim, Haidong Wang, Theo Vos, Mohsen Naghavi, Alan D Lopez, Christopher J L Murray, Ali H Mokdad
OBJECTIVES: We used findings from the Global Burden of Disease Study 2013 to report the burden of musculoskeletal disorders in the Eastern Mediterranean Region (EMR). METHODS: The burden of musculoskeletal disorders was calculated for the EMR's 22 countries between 1990 and 2013. A systematic analysis was performed on mortality and morbidity data to estimate prevalence, death, years of live lost, years lived with disability and disability-adjusted life years (DALYs)...
February 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28205331/new-insights-to-the-mechanisms-underlying-atherosclerosis-in-rheumatoid-arthritis
#3
REVIEW
Mahdi Mahmoudi, Saeed Aslani, Reza Fadaei, Ahmad Reza Jamshidi
Rheumatoid arthritis (RA) is an inflammatory circumstance, which has been associated with increased risk of cardiovascular disease (CVD). Although RA management has been promoted, mortality rate due to CVD remains remarkable. Approximately, 50% of premature death cases in RA are attributable to CVD. RA patients develop atherosclerosis in a greater amount than the general population. Moreover, atherosclerotic lesions develop rapidly in RA patients and might be more susceptible to rupture. The inflammatory condition of RA, such as cytokines, abnormally activated immune cells, play a role in the initiation, perpetuation and exacerbation of atherosclerosis...
February 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28202745/plasma-levels-of-eicosapentaenoic-acid-are-associated-with-anti-tnf-responsiveness-in-rheumatoid-arthritis-and-inhibit-the-etanercept-driven-rise-in-th17-cell-differentiation-in-vitro
#4
Louisa Jeffery, Helena L Fisk, Philip C Calder, Andrew Filer, Karim Raza, Christopher D Buckley, Iain McInnes, Peter C Taylor, Benjamin A Fisher
OBJECTIVE: To determine whether levels of plasma n-3 polyunsaturated fatty acids are associated with response to antitumor necrosis factor (anti-TNF) agents in rheumatoid arthritis (RA), and whether this putative effect may have its basis in altering anti-TNF-driven Th17 cell differentiation. METHODS: Plasma was collected at baseline and after 3 months of anti-TNF treatment in 22 patients with established RA, and fatty acid composition of the phosphatidylcholine (PC) component was measured...
February 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28192119/leflunomide-induces-nad-p-h-quinone-dehydrogenase-1-enzyme-via-the-aryl-hydrocarbon-receptor-in-neonatal-mice
#5
Amrit Kumar Shrestha, Ananddeep Patel, Renuka T Menon, Weiwu Jiang, Lihua Wang, Bhagavatula Moorthy, Binoy Shivanna
Aryl hydrocarbon receptor (AhR) has been increasingly recognized to play a crucial role in normal physiological homeostasis. Additionally, disrupted AhR signaling leads to several pathological states in the lung and liver. AhR activation transcriptionally induces detoxifying enzymes such as cytochrome P450 (CYP) 1A and NAD(P)H quinone dehydrogenase 1 (NQO1). The toxicity profiles of the classical AhR ligands such as 3-methylcholanthrene and dioxins limit their use as a therapeutic agent in humans. Hence, there is a need to identify nontoxic AhR ligands to develop AhR as a clinically relevant druggable target...
February 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28169339/dna-methylation-governs-the-dynamic-regulation-of-inflammation-by-apoptotic-cells-during-efferocytosis
#6
Clare A Notley, Christine K Jordan, Jenny L McGovern, Mark A Brown, Michael R Ehrenstein
Efficient clearance of apoptotic cells (AC) is pivotal in preventing autoimmunity and is a potent immunosuppressive stimulus. However, activation of cells prior to apoptosis abolishes their immunoregulatory properties. Here we show using the antigen-induced model of arthritis that the degree of DNA methylation within AC confers their immunomodulatory plasticity. DNA isolated from resting and activated AC mimicked their respective immune effects. Demethylation of DNA abrogated the protective effect of AC whereas remethylation of AC DNA reversed the effects of activation and restored the ability to inhibit inflammation...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28168545/prevalence-of-musculoskeletal-disorders-in-azar-cohort-population-in-northwest-of-iran
#7
Sousan Kolahi, Alireza Khabbazi, Aida Malek Mahdavi, Amid Ghasembaglou, Arezoo Ghasembaglou, Nayyereh Aminisani, Mohammad Hossein Somi, Fariba Heidari
Musculoskeletal disorders (MSDs) are considered as major public health problems. The purpose of this study was to determine the prevalence of MSDs in Azar cohort population in northwest of Iran. Azar cohort study is a state level of a national cohort project (PERSIAN) which began in 2014. All adults over 35 years old in Khamene city in East Azarbaijan province were recruited for the pilot phase of the Azar cohort. For the purpose of the current study, a total of 952 subjects age range of 35-70 who completed the Community Oriented Program for the Control of Rheumatic Disease (COPCORD) questionnaire as supplementary were included...
February 6, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28159704/effects-of-targeted-therapies-on-the-bone-in-arthritides
#8
REVIEW
Ágnes Szentpétery, Ágnes Horváth, Katalin Gulyás, Zsófia Pethö, Harjit Pal Bhattoa, Sándor Szántó, Gabriella Szücs, Oliver FitzGerald, Georg Schett, Zoltán Szekanecz
Inflammatory arthritides, such as rheumatoid arthritis (RA) and spondyloarthritides (SpA) have been associated with both localized bone resorption and/or formation, and generalized osteoporosis. Systemic inflammation may be the major driver for bone loss in arthritis. In RA and peripheral SpA the RANK-RANKL-OPG network is involved in bone resorption, while in axial SpA the Wnt-β-catenin axis and its inhibitors (DKK-1, sclerostin) are the most relevant. Targeted therapies including biologics and small molecule tyrosine kinase inhibitors may interfere with inflammatory bone metabolism...
January 31, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28153828/clinical-benefit-of-1-year-certolizumab-pegol-czp-add-on-therapy-to-methotrexate-treatment-in-patients-with-early-rheumatoid-arthritis-was-observed-following-czp-discontinuation-2-year-results-of-the-c-opera-study-a-phase-iii-randomised-trial
#9
Tatsuya Atsumi, Yoshiya Tanaka, Kazuhiko Yamamoto, Tsutomu Takeuchi, Hisashi Yamanaka, Naoki Ishiguro, Katsumi Eguchi, Akira Watanabe, Hideki Origasa, Shinsuke Yasuda, Yuji Yamanishi, Yasuhiko Kita, Tsukasa Matsubara, Masahiro Iwamoto, Toshiharu Shoji, Osamu Togo, Toshiyuki Okada, Désirée van der Heijde, Nobuyuki Miyasaka, Takao Koike
OBJECTIVES: To investigate the clinical impact of 1-year certolizumab pegol (CZP) therapy added to the first year of 2-year methotrexate (MTX) therapy, compared with 2-year therapy with MTX alone. METHODS: MTX-naïve patients with early rheumatoid arthritis (RA) with poor prognostic factors were eligible to enter Certolizumab-Optimal Prevention of joint damage for Early RA (C-OPERA), a multicentre, randomised, controlled study, which consisted of a 52-week double-blind (DB) period and subsequent 52-week post treatment (PT) period...
February 2, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28150360/tnfr1-and-tnfr2-differentially-mediate-tnf-%C3%AE-induced-inflammatory-responses-in-rheumatoid-arthritis-fibroblast-like-synoviocytes
#10
Hongfeng Zhang, Weiguo Xiao
TNF-α has long been implicated in the progression of rheumatoid arthritis (RA). However, how the receptors of TNF-α, namely TNFR1 and TNFR2, mediate TNF-α-induced inflammatory responses in fibroblast-like synoviocytes (FLS) in RA has not been elucidated. In the present study, primary FLS cells were isolated from RA patients and treated with TNF-α in vitro. The exogenous TNF-α induced the expression and release of endogenous TNF-α in FLS. In addition, TNF-α led to gradual downregulation of TNFR1 following 1 h treatment...
February 2, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28148840/therapy-with-ctla4-ig-and-an-antiviral-monoclonal-antibody-controls-chikungunya-virus-arthritis
#11
Jonathan J Miner, Lindsey E Cook, Jun P Hong, Amber M Smith, Justin M Richner, Raeann M Shimak, Alissa R Young, Kristen Monte, Subhajit Poddar, James E Crowe, Deborah J Lenschow, Michael S Diamond
In 2013, chikungunya virus (CHIKV) transmission was documented in the Western Hemisphere, and the virus has since spread throughout the Americas with more than 1.8 million people infected in more than 40 countries. CHIKV targets the joints, resulting in symmetric polyarthritis that clinically mimics rheumatoid arthritis and can endure for months to years. At present, no approved treatment is effective in preventing or controlling CHIKV infection or disease. We treated mice with eight different disease-modifying antirheumatic drugs and identified CLTA4-Ig (abatacept) and tofacitinib as candidate therapies based on their ability to decrease acute joint swelling...
February 1, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28148584/psoriatic-arthritis-state-of-the-art-review
#12
Laura C Coates, Philip S Helliwell
Psoriatic arthritis (PsA) accounts for around 20% of referrals to the early arthritis clinic and presents a significant diagnostic and management challenge. Early diagnosis is important to prevent long term functional disability and to ensure optimal management of arthritis and key comorbidities. From the rheumatologist's perspective, the differential diagnosis includes rheumatoid arthritis, gout and other inflammatory arthritides. Once diagnosed, it is essential to assess the disease fully, including arthritis, enthesitis, dactylitis, skin/nail disease and axial involvement...
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28143836/periodontitis-in-early-and-chronic-rheumatoid-arthritis-a-prospective-follow-up-study-in-finnish-population
#13
Leena Äyräväinen, Marjatta Leirisalo-Repo, Antti Kuuliala, Kirsi Ahola, Riitta Koivuniemi, Jukka H Meurman, Anna Maria Heikkinen
OBJECTIVES: To investigate the association between rheumatoid arthritis (RA) and periodontitis with special emphasis on the role of antirheumatic drugs in periodontal health. DESIGN: Prospective follow-up study. Patients with early untreated RA and chronic active RA were examined at baseline and 16 months later. Controls were examined once. SETTINGS AND PARTICIPANTS: The study was conducted in Finland from September 2005 to May 2014 at the Helsinki University Hospital...
January 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28130500/synthetic-retinoid-am80-ameliorates-lung-and-arthritic-autoimmune-responses-by-inhibiting-t-follicular-helper-and-th17-cell-responses
#14
Debdut Naskar, Fei Teng, Krysta M Felix, C Pierce Bradley, Hsin-Jung Joyce Wu
Rheumatoid arthritis is an autoimmune disorder that affects the joints and other organs. Pulmonary complications contribute significantly to rheumatoid arthritis mortality. Retinoic acid and its synthetic compound AM80 play roles in immunoregulation but their effect on mucosal autoimmunity remains largely unknown. T follicular helper (Tfh) and Th17 cells are known to promote inflammation and autoantibody production. Using the K/BxN autoimmune arthritis model, we elucidate a novel mechanism whereby oral AM80 administration suppressed lung mucosa-associated Tfh and autoantibody responses by increasing the gut-homing α4β7 integrin expression on Tfh cells...
January 27, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28122642/the-23-valent-pneumococcal-polysaccharide-vaccine-in-patients-with-rheumatoid-arthritis-a-double-blinded-randomized-placebo-controlled-trial
#15
Yasumori Izumi, Manabu Akazawa, Yukihiro Akeda, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Ryutaro Matsumura, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Nozomi Iwanaga, Yuka Jiuchi, Hideko Kozuru, Hiroshi Tsutani, Kouichirou Saisyo, Takao Sugiyama, Yasuo Suenaga, Yasumasa Okada, Masao Katayama, Kenji Ichikawa, Hiroshi Furukawa, Kenji Kawakami, Kazunori Oishi, Kiyoshi Migita
BACKGROUND: Pneumococcal pneumonia is the most frequent form of pneumonia. We herein assessed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in the prevention of pneumonia overall in rheumatoid arthritis (RA) patients at risk for infections. We hypothesized that PPSV23 vaccination is superior in preventing pneumococcal pneumonia compared with placebo in RA patients. METHODS: A prospective, multicenter, double-blinded, randomized, placebo-controlled (1:1) trial was conducted across departments of rheumatology in Japanese National Hospital Organization hospitals...
January 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28121204/efficacy-of-golimumab-for-preventing-large-joint-destruction-in-patients-with-rheumatoid-arthritis-as-determined-by-the-arashi-score
#16
Katsuaki Kanbe, Koei Oh, Junji Chiba, Yasuo Inoue, Masashi Taguchi, Akiko Yabuki
OBJECTIVES: To investigate the inhibitory effect of golimumab on large joint destruction in patients with rheumatoid arthritis. METHODS: We recruited 45 patients with rheumatoid arthritis and evaluated the radiographic severity of large joint destruction using the ARASHI (assessment of rheumatoid arthritis by scoring of large joint destruction and healing in radiographic imaging) score. We evaluated 450 large joints including the elbow, shoulder, hip, knee and ankle at baseline and 52 weeks after treatment with golimumab...
January 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28104368/interaction-of-capsaicin-with-calf-thymus-dna-a-multi-spectroscopic-and-molecular-modelling-study
#17
Faizan Abul Qais, K M Abdullah, Md Maroof Alam, Imrana Naseem, Iqbal Ahmad
Studying the mode of interaction between small molecules and DNA has received much attention in recent years, as many drugs have been reported to directly interact with DNA thereby regulating the expression of many genes. Capsaicin is a capsaiciniods family phytocompound having many therapeutic applications including diabetic neuropathy, rheumatoid arthritis, prevention of DNA strand breaks and chromosomal aberrations. In this study, we have investigated the interaction of capsaicin with calf thymus DNA using a number of biophysical techniques to get an insight and better understanding of the interaction mechanism...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28101910/a-practical-approach-to-vaccination-of-patients-with-autoimmune-inflammatory-rheumatic-diseases-in-australia
#18
REVIEW
Peter Kk Wong, Hanish Bagga, Claire Barrett, Paddy Hanrahan, Doug Johnson, Amel Katrib, Karin Leder, Mona Marabani, Peta Pentony, John Riordan, Ray White, Laurel Young
Autoimmune inflammatory rheumatic diseases (AIIRD) such as rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are often complicated by infection, which results in significant morbidity and mortality. The increased risk of infection is probably due to a combination of immunosuppressive effects of the AIIRD, comorbidities, and the use of immunosuppressive conventional synthetic disease modifying anti-rheumatic drugs (DMARDS) and more recently, targeted synthetic DMARDS and biologic DMARDS which block specific pro-inflammatory enzymes, cytokines or cell types...
January 19, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28099214/rheumatoid-arthritis-selecting-monotherapy-versus-combination-therapy
#19
Nimish Mehta, Lynne Kolton Schneider, Emilie McCardell
The overall goal of therapy for patients with rheumatoid arthritis (RA) is to achieve low disease activity or remission and to prevent or control joint damage, prevent loss of function, and decrease pain. However, many patients with RA do not have the disease adequately controlled, and only a minority attain consistent remission. To successfully treat to target, rheumatologists need practical guidance to select monotherapy and combination therapy regimens based on available data. Differences in study design, dosing regimens, and data from defined and specific patient populations pose challenges to clinicians who treat patients with diverse characteristics and needs...
January 18, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28093980/emerging-advances-in-nanomedicine-as-a-nanoscale-pharmacotherapy-in-rheumatoid-arthritis-state-of-the-art
#20
REVIEW
Mahfoozur Rahman, Gajanand Sharma, Kanika Thakur, Firoz Anwar, O P Katare, Vijay G Goni, Vikas Kumar, Mazin A Zamzami, Sohail Akhter
There are several significant setbacks including limited bioavailability, high clearance, and further current therapies require higher and frequent dosing to gain desired therapeutic effects. Nanomedicines have been widely investigated for rheumatoid arthritis (RA). Though, higher doses also increase the incidence of dreadful adverse effects. Further, nanocarrier properties are tuned by the use of different approaches like varied methods of loading, hydrophilic polymers and targeting ligands, to change the physicochemical properties including higher encapsulation, better penetrating ability to biological barriers, thus preventing the uptake of various nanocarriers by liver and spleen...
2017: Current Topics in Medicinal Chemistry
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