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prevention rheumatoid arthritis

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https://www.readbyqxmd.com/read/28446753/histamine-and-histamine-h4-receptor-promotes-osteoclastogenesis-in-rheumatoid-arthritis
#1
Kyoung-Woon Kim, Bo-Mi Kim, Kyung-Ann Lee, Sang-Heon Lee, Gary S Firestein, Hae-Rim Kim
Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA). The concentration of histamine in synovial fluid (SF) and sera in patients with RA was measured using ELISA. After RA SF and peripheral blood (PB) CD14+ monocytes were treated with histamine, IL-17, IL-21 and IL-22, and a H4R antagonist (JNJ7777120), the gene expression H4R and RANKL was determined by real-time PCR. Osteoclastogenesis was assessed by counting TRAP-positive multinucleated cells in PB CD14+ monocytes cultured with histamine, Th17 cytokines and JNJ7777120...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442538/peripheral-tumor-necrosis-factor-alpha-tnf-%C3%AE-modulates-amyloid-pathology-by-regulating-blood-derived-immune-cells-and-glial-response-in-the-brain-of-ad-tnf-transgenic-mice
#2
Evi Paouri, Ourania Tzara, Georgia-Ioanna Kartalou, Sofia Zenelak, Spiros Georgopoulos
Increasing evidence has suggested that systemic inflammation along with local brain inflammation can play a significant role in Alzheimer's disease (AD) pathogenesis. Identifying key molecules that regulate the crosstalk between the immune and the central nervous system can provide potential therapeutic targets. TNF-α is a pro-inflammatory cytokine implicated in the pathogenesis of systemic inflammatory and neurodegenerative diseases such as rheumatoid arthritis (RA) and AD. Recent studies have reported that anti-TNF-α therapy or RA itself can modulate AD pathology, although the underlying mechanism is unclear...
April 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28441949/-it-s-so-hard-taking-pills-when-you-don-t-know-what-they-re-for-a-qualitative-study-of-patients-medicine-taking-behaviours-and-conceptualisation-of-medicines-in-the-context-of-rheumatoid-arthritis
#3
Boitshoko Kobue, Shirra Moch, Jennifer Watermeyer
BACKGROUND: Patients with chronic illnesses are often required to take lifelong medication to alleviate symptoms and prevent disease progression. Many patients find it difficult to adhere to prescribed medication for various reasons, some of which may link to the way they conceptualise medicines and understand their illness and treatment. This study explores the medicine taking behaviours of patients presenting with Rheumatoid Arthritis (RA), a chronic inflammatory autoimmune disease...
April 26, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28437445/knowledge-and-perception-of-cardiovascular-disease-risk-among-patients-with-rheumatoid-arthritis
#4
Sunjoo Boo, Hyunjin Oh, Erika S Froelicher, Chang-Hee Suh
Patients with rheumatoid arthritis are at increased risk for cardiovascular disease. The prerequisites for reducing the risk of cardiovascular disease are adequate levels of knowledge and being aware of the risk. In this study, the levels of knowledge about cardiovascular disease among patients with rheumatoid arthritis and the perception were evaluated in relation to their actual 10-year risk of cardiovascular disease. This cross-sectional study of 200 patients with rheumatoid arthritis was conducted in a university-affiliated hospital in South Korea...
2017: PloS One
https://www.readbyqxmd.com/read/28433815/patterns-and-predictors-of-persistent-opioid-use-following-hip-or-knee-arthroplasty
#5
Seoyoung C Kim, Niteesh Choudhry, Jessica M Franklin, Katsiaryna Bykov, Matthias Eikermann, Joyce Lii, Michael A Fischer, Brian T Bateman
OBJECTIVE: The relationship between arthroplasty and long-term opioid use in patients with knee or hip osteoarthritis is not well studied. We examined the prevalence, patterns and predictors of persistent opioid use after hip or knee arthroplasty. METHOD: Using claims data (2004-2013) from a U.S. commercial health plan, we identified adults who underwent hip or knee arthroplasty and filled ≥1 opioid prescription within 30 days after the surgery. We defined persistent opioid users as patients who filled ≥1 opioid prescription every month during the 1-year postoperative period based on group-based trajectory models...
April 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28431044/leonurine-attenuates-fibroblast-like-synoviocyte-mediated-synovial-inflammation-and-joint-destruction-in-rheumatoid-arthritis
#6
Nan Li, Qiang Xu, Qingping Liu, Dongmei Pan, Yubao Jiang, Minying Liu, Mingling Liu, Hanshi Xu, Changsong Lin
Objective.: To explore the role of leonurine in the regulation of synovial inflammation and joint destruction inRA. Methods.: Fibroblast-like synoviocytes were isolated from synovial tissue from RA patients. Pro-inflammatory cytokine and MMP expression was evaluated using real-time PCR and a cytometric bead array. Cell migration and invasion in vitro were measured using the Boyden chamber method and the scratch assay, respectively. Protein expression was measured by western blotting...
April 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28428675/uveitis-associated-with-juvenile-idiopathic-arthritis-our-observations
#7
Almira Cosickic, Meliha Halilbasic, Amela Selimovic, Harun Avdagic
INTRODUCTION: Uveitis as extra-articular manifestation of juvenile idiopathic arthritis (JIA) is present in 20% of children with the persistent form, in 30% with the extended oligoarticular form, while it is present in psoriatic and polyarticular rheumatoid factor (RF) negative arthritis in 10% and 14%, respectively. AIM: The aim of the study was to evaluate the frequency of uveitis and its complications in children with JIA. MATERIAL AND METHODS: A retrospective study was conducted with an analysis of the medical records of children with JIA who were treated for the last 5 years...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28426445/small-dense-ldl-an-update
#8
Philipp A Gerber, Dragana Nikolic, Manfredi Rizzo
PURPOSE OF REVIEW: In this review, we summarize the latest findings on small, dense LDL (sdLDL) atherogenic particles, including their associations with other biomarkers. RECENT FINDINGS: Increased sdLDL levels have been reported not only in different metabolic disorders such as diabetes, obesity and metabolic syndrome, but also in patients with rheumatoid and psoriatic arthritis as well as hypothyroidism. A wide range of lipid-lowering, as well as other drug classes, including novel antidiabetic agents and nutraceuticals, exert favourable effects on these atherogenic particles...
April 19, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28426090/oleuropein-down-regulated-il-1%C3%AE-induced-inflammation-and-oxidative-stress-in-human-synovial-fibroblast-cell-line-sw982
#9
Maria Luisa Castejón, Maria Ángeles Rosillo, Tatiana Montoya, Alejandro González-Benjumea, Jose Maria Fernández-Bolaños, Catalina Alarcón-de-la-Lastra
Rheumatoid arthritis (RA) is a chronic and systemic inflammatory autoimmune disease mainly characterized by aggressive hyperproliferation of synovial fibroblasts (SFs). It is accompained by a massive infiltration of inflammatory immune cells inducing progressive matrix degradation, destruction of cartilage and bone erosion through the production of inflammatory mediators. Oleuropein is the most prevalent phenolic component in olive leaves, seed, pulp and peel of unripe olives and is responsible for the characteristic bitter taste of unprocessed olives...
April 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28424695/b-cell-tolerance-to-deiminated-histones-in-balb-c-c57bl-6-and-autoimmune-prone-mouse-strains
#10
Nishant Dwivedi, Annica Hedberg, Ying Yi Zheng, Indira Neeli, Minoru Satoh, Laurence Morel, Ole Petter Rekvig, Marko Radic
Deimination, a posttranslational modification of arginine to citrulline carried out by peptidylarginine deiminases, may compromise tolerance of self-antigens. Patients with connective tissue autoimmunity, particularly rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or Felty's syndrome, present with autoantibodies to deiminated histones (dH), which thus form a category of antibodies to citrullinated protein antigens (ACPA). In general, ACPA are a sensitive diagnostic for RA and may form in response to the release of nuclear chromatin (DNA plus dH) from granulocytes, usually referred to as neutrophil extracellular traps...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28420491/telemedicine-for-patients-with-rheumatic-diseases-systematic-review-and-proposal-for-research-agenda
#11
REVIEW
Matteo Piga, Ignazio Cangemi, Alessandro Mathieu, Alberto Cauli
OBJECTIVE: To systematically review the scientific literature regarding tele-rheumatology and draw conclusions about feasibility, effectiveness, and patient satisfaction. METHODS: PubMed, Scopus, and Cochrane database searches were performed (April 2016) using relevant MeSH and keyword terms for telemedicine and rheumatic diseases. Articles were selected if reporting outcomes for feasibility, effectiveness, and patient satisfaction and methodologically appraised using the Cochrane Collaboration's tool for assessing risk of bias and a modified version of CONSORT 2010 Statement...
March 22, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28418334/juvenile-idiopathic-arthritis
#12
Kenan Barut, Amra Adrovic, Sezgin Şahin, Özgür Kasapçopur
Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28416952/asthma-and-the-risk-of-rheumatoid-arthritis-an-insight-into-the-heterogeneity-and-phenotypes-of-asthma
#13
REVIEW
Mary Claire Rolfes, Young Jun Juhn, Chung-Il Wi, Youn Ho Sheen
Asthma is traditionally regarded as a chronic airway disease, and recent literature proves its heterogeneity, based on distinctive clusters or phenotypes of asthma. In defining such asthma clusters, the nature of comorbidity among patients with asthma is poorly understood, by assuming no causal relationship between asthma and other comorbid conditions, including both communicable and noncommunicable diseases. However, emerging evidence suggests that the status of asthma significantly affects the increased susceptibility of the patient to both communicable and noncommunicable diseases...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28415811/il-33-st2-mediated-inflammation-in-macrophages-is-directly-abrogated-by-il-10-during-rheumatoid-arthritis
#14
Si Chen, Bingni Chen, Zhongyang Wen, Zhong Huang, Liang Ye
IL-10 is an immunosuppressive cytokine produced and sensed by many immune cells and exerts a protective role in autoimmune diseases. However, the underlying mechanism by which IL-10 contributes to prevent the arthritic inflammation in macrophages is poorly understood. Herein we report on a novel anti-arthritic property of IL-10 through the inhibition of IL-33 signaling by macrophages during collagen-induced arthritis (CIA) development. We show that IL-33 expression rather than its receptor (ST2) is positively correlated with IL-10 level in active RA...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411280/interrelationships-between-infliximab-and-rhtnf-%C3%AE-in-plasma-using-minimal-physiologically-based-pharmacokinetic-mpbpk-models
#15
Xi Chen, Debra C DuBois, Richard R Almon, William J Jusko
The soluble cytokine TNF-α is an important target for many therapeutic proteins used in the treatment of rheumatoid arthritis (RA). Biologics targeting TNF-α exert their pharmacological effects through binding and neutralizing this cytokine and preventing it from binding to its cell surface receptors. The magnitude of their pharmacological effects directly corresponds to the extent and duration of free TNF-α suppression. However, endogenous TNF-α is of low abundance and therefore it is quite challenging to assess the free TNF-α suppression experimentally...
April 14, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28407841/cardiovascular-comorbidity-in-inflammatory-rheumatological-conditions
#16
Jürgen Braun, Klaus Krüger, Bernhard Manger, Matthias Schneider, Christof Specker, Hans Joachim Trappe
BACKGROUND: Approximately 1.5 million adults in Germany suffer from an inflammatory rheumatological condition. The most common among these are rheumatoid arthritis and spondyloarthritis-above all axial spondyloarthritis, including ankylosing spondylitis (Bekhterev's disease) and psoriatic arthritis. These systemic inflammatory diseases often affect the heart as well. METHODS: This review is based on pertinent articles retrieved by a selective literature search, on current European guidelines, and on the authors' clinical experience...
March 24, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28397479/estimation-of-diagnostic-markers-in-rheumatoid-arthritis-and-ankylosing-spondylitis
#17
Nasrin Dashti, Zahra Javadi, Fatemeh Safari, Solmaz Farahvash, Mitra Zarebavani
BACKGROUND: Laboratory examination is a great value to confirm a diagnosis and estimate disease activity of Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS). Since little research related to the diagnosis of RA and AS has been done in Iran, the aim of the present study was to evaluate the diagnosis markers in patients with RA and AS. METHODS: This study was conducted among 104 patients with RA and 42 patients with AS in Iran during 2016. Inclusion criteria were according to the American College of Rheumatology (ACR) and European League against Rheumatism (EULAR) criteria...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28395174/loss-of-parkin-reduces-inflammatory-arthritis-by-inhibiting-p53-degradation
#18
Yu Yeon Jung, Dong Ju Son, Hye Lim Lee, Dae Hwan Kim, Min Jong Song, Young Wan Ham, Youngsoo Kim, Sang Bae Han, Mi Hee Park, Jin Tae Hong
Parkin is associated with various inflammatory diseases, including Parkinson's disease (PD) and rheumatoid arthritis (RA). However, the precise role of Parkin in RA is unclear. The present study addressed this issue by comparing the development of RA between non-transgenic (non-Tg) mice and PARK2 knockout (KO) mice. We found that cyclooxygenase-2 and inducible nitric oxide synthase expression and nuclear factor-κB activity were reduced but p53 activation was increased in PARK2 KO as compared to non-Tg mice...
April 5, 2017: Redox Biology
https://www.readbyqxmd.com/read/28392428/modulation-of-experimental-arthritis-by-vagal-sensory-and-central-brain-stimulation
#19
Gabriel Shimizu Bassi, Daniel Penteado Martins Dias, Marcelo Franchin, Jhimmy Talbot, Daniel Gustavo Reis, Gustavo Batista Menezes, Jaci Airton Castania, Norberto Garcia-Cairasco, Leonardo Barbosa Moraes Resstel, Helio Cesar Salgado, Fernando Queiróz Cunha, Thiago Mattar Cunha, Luis Ulloa, Alexandre Kanashiro
Articular inflammation is a major clinical burden in multiple inflammatory diseases, especially in rheumatoid arthritis. Biological anti-rheumatic drug therapies are expensive and increase the risk of systemic immunosuppression, infections, and malignancies. Here, we report that vagus nerve stimulation controls arthritic joint inflammation by inducing local regulation of innate immune response. Most of the previous studies of neuromodulation focused on vagal regulation of inflammation via the efferent peripheral pathway toward the viscera...
April 6, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28383442/the-ratio-of-nurse-consultation-and-physician-efficiency-index-of-senior-rheumatologists-is-significantly-higher-than-junior-physicians-in-rheumatology-residency-training-a-new-efficiency-measure-in-a-cohort-exploratory-study
#20
Amir Emamifar, Morten Hai van Bui Hansen, Inger Marie Jensen Hansen
To elucidate the difference between ratios of nurse consultation sought by senior rheumatologists and junior physicians in rheumatology residency training, and also to evaluate physician efficiency index respecting patients with rheumatoid arthritis (RA).Data regarding outpatient visits for RA patients between November 2013 and 2015 were extracted. The mean interval (day) between consultations, the nurse/physician visits ratio, and physician efficiency index (nurse/physician visits ratio × mean interval) for each senior and junior physicians were calculated...
April 2017: Medicine (Baltimore)
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