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prevention rheumatoid arthritis

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https://www.readbyqxmd.com/read/29137206/ancient-food-habits-dictate-that-food-can-be-medicine-but-medicine-cannot-be-food
#1
Hit Kishore Goswami, Hitendra Kumar Ram
Background: Extensive surveys of several population settlements in different parts of India-covering plains, mountains, valleys, river banks and deeper areas of forests at different altitudes-between 1968 and 2016 demonstrated that the basic vital need of hunger is being fulfilled since antiquity by plants in the wild. Methods: Based on collections, consultations with local population personnel and literature searches, this paper presents many plants that are commonly used as food and focuses on their products, which are rich in alkaloids, polysaccharides, steroids, terpenoids, flavonoids, aminoacids, fatty acids and antibiotics etc...
November 13, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29134229/decursin-and-decursinol-angelate-molecular-mechanism-and-therapeutic-potential-in-inflammatory-diseases
#2
REVIEW
Adeeb Shehzad, Sajida Parveen, Munibah Qureshi, Fazli Subhan, Young Sup Lee
Epidemiological studies have shown that inflammation plays a critical role in the development and progression of various chronic diseases, including cancers, neurological diseases, hepatic fibrosis, diabetic retinopathy, and vascular diseases. Decursin and decursinol angelate (DA) are pyranocoumarin compounds obtained from the roots of Angelica gigas. Several studies have described the anti-inflammatory effects of decursin and DA. Decursin and DA have shown potential anti-inflammatory activity by modulating growth factors such as vascular endothelial growth factor, transcription factors such as signal transducer and activator of transcription 3 and nuclear factor kappa-light-chain-enhancer of activated B cells, cellular enzymes including matrix metalloproteinases cyclooxygenase, and protein kinases such as extracellular receptor kinase, phosphatidylinositol-3-kinase, and protein kinase C...
November 13, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#3
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29126980/brain-derived-neurotrophic-factor-in-adjuvant-induced-arthritis-in-rats-relationship-with-inflammation-and-endothelial-dysfunction
#4
Martin Pedard, Céline Demougeot, Clément Prati, Christine Marie
OBJECTIVES: Both peripheral and central brain-derived neurotrophic factor (BDNF) levels are decreased in depression and normalized by efficient anti-depressive therapies. While depression symptoms are frequent in rheumatoid arthritis, BDNF has been poorly investigated in this pathology. Therefore, the present study explored cerebral and peripheral BDNF in arthritis rats as well as the link between brain BDNF and the two factors recently involved in the pathogenesis of depression and present in rheumatoid arthritis namely inflammation and endothelial dysfunction...
November 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29124434/effect-of-prednisone-treatment-for-30-and-90%C3%A2-days-on-bone-metabolism-in-collagen-induced-arthritis-cia-rats
#5
Xinle Zhang, Xuna Wu, Yalin Min, Jiaqi Lu, Xuemei Zhang, Wenshuang Chen, Liyi Zou, Xiaohua Lv, Liao Cui, Bilian Xu
Glucocorticoids (GCs) are often prescribed to treat rheumatoid arthritis (RA) in the long term, but there is still controversy in the administration of GCs, mainly because of the adverse reactions such as osteoporosis. Numerous studies have demonstrated that osteoporosis could be induced by GCs in normal rats. However, few experiments have focused on whether osteoporosis could be induced or aggravated by GCs in collagen induced arthritis (CIA) rats. We have investigated bone changes in CIA rats treated with prednisone at 4...
November 9, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29122658/endothelium-derived-contraction-in-a-model-of-rheumatoid-arthritis-is-mediated-via-angiotensin-ii-type-1-receptors
#6
Kayleigh Hamilton, Lynette Dunning, William R Ferrell, John C Lockhart, Andrew MacKenzie
A role for endothelium-derived constricting factors (EDCF), and the angiotensin II type 1 receptor (AT1R) pathway, in the vascular impairment found in the rat Freund's complete adjuvant (FCA)-model of rheumatoid arthritis (RA) was examined. FCA arthritis was induced in rats±losartan. Vehicle-treated rats served as controls. Knee-joint swelling and red blood cell (RBC) aggregation were measured as indicators of inflammation and endothelium reactivity assessed by response to acetylcholine (ACh) on aortic rings...
November 6, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29121799/pueraria-lobate-inhibits-rankl-mediated-osteoclastogenesis-via-downregulation-of-creb-pgc1%C3%AE-c-fos-nfatc1-signaling
#7
Keun Ha Park, Dong Ryun Gu, Su Hyun Jin, Chi-Su Yoon, Wonmin Ko, Youn Chul Kim, Seoung Hoon Lee
Puerariae radix, the dried root of Pueraria lobate Ohwi, is known to prevent bone loss in ovariectomized mice; however, the precise molecular mechanisms are not understood. In this study, we investigated the effects and underlying mechanisms of action of Puerariae radix extract (PRE) on receptor activator of NF-[Formula: see text]B ligand (RANKL)-induced osteoclastogenesis. PRE dose-dependently inhibited osteoclast differentiation and formation, decreased the bone-resorbing activity of osteoclasts, and downregulated the expression of osteoclast differentiation marker genes...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29118439/preventing-progression-from-arthralgia-to-arthritis-targeting-the-right-patients
#8
REVIEW
Hanna W van Steenbergen, José A Pereira da Silva, Tom W J Huizinga, Annette H M van der Helm-van Mil
Early treatment is associated with improved outcomes in patients with rheumatoid arthritis (RA), suggesting that a 'window of opportunity', in which the disease is most susceptible to disease-modifying treatment, exists. Autoantibodies and markers of systemic inflammation can be present long before clinical arthritis, and maturation of the immune response seems to coincide with the development of RA. The pre-arthritis phase associated with symptoms such as as joint pain without clinical arthritis (athralgia) is now hypothesized to fall within the aforementioned window of opportunity...
November 9, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29105349/cost-effectiveness-of-bisphosphonates-for-prevention-of-fracture-related-to-glucocorticoid-induced-osteoporosis-in-malaysia
#9
Nurul-Ain Mohd-Tahir, Paraidathathu Thomas, Mohd-Shahrir Mohamed-Said, Mohd Makmor-Bakry, Shu-Chuen Li
INTRODUCTION: Glucocorticoid therapy is associated with an appreciable risk of bone loss leading to fractures that require expensive treatments. This study aimed to evaluate the cost-effectiveness of bisphosphonates for prevention of hip fracture in glucocorticoid-induced osteoporosis (GIOP) in Malaysia. METHOD: Retrospective data were collected from GIOP patients referred to the Universiti Kebangsaan Malaysia Medical Centre. Fracture events and direct medical costs were compared between bisphosphonates and calcium/vitamin D combination...
November 3, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29096669/anti-carbamylated-protein-antibodies-precede-disease-onset-in-monkeys-with-collagen-induced-arthritis
#10
Marije K Verheul, Michel P M Vierboom, Bert A 't Hart, Rene E M Toes, Leendert A Trouw
BACKGROUND: Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have also been described in rodent models of arthritis, while ACPA are not consistently detectable. Data on these RA-associated autoantibodies in primates are not available. Therefore, we investigated the presence of RF, anti-CarP antibodies and ACPA in rhesus monkeys before and after collagen-induced arthritis immunizations...
November 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29083085/cdk7-inhibition-suppresses-rheumatoid-arthritis-inflammation-via-blockage-of-nf-%C3%AE%C2%BAb-activation-and-il-1%C3%AE-il-6-secretion
#11
Honghai Hong, Yingmin Zeng, Wenxuan Jian, Lei Li, Liying Lin, Yousheng Mo, Meiling Liu, Shuhuan Fang, Yong Xia
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling, joint tenderness and destruction of synovial joints, leading to severe disability. Anti-inflammatory drugs and disease-modifying anti-rheumatic drugs (DMARDs) may improve RA process. However, in most patients the treatment effect is still not satisfactory. Cyclin-dependent kinase 7 (CDK7) plays a well-established role in the regulation of the eukaryotic cell division cycle, and recent studies indicated that it exerted anti-inflammatory effect...
October 30, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29078090/swertiamarin-a-natural-steroid-prevent-bone-erosion-by-modulating-rankl-rank-opg-signaling
#12
M I Hairul-Islam, S Saravanan, K Thirugnanasambantham, M Chellappandian, C Simon Durai Raj, K Karikalan, M Gabriel Paulraj, S Ignacimuthu
Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete adjuvant (FCA) induced in-vivo model, in-vitro osteoblast and osteoclasts as well as in co-culture system and in-silico molecular docking analysis. The swertiamarin treatment decreased the expression of TRAP, RANKL, and RANK levels and increased the levels of OPG levels significantly in both in vitro and in vivo models...
October 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29075504/recipients-and-providers-perspectives-of-obesity-and-potential-barriers-to-weight-management-programmes-in-patients-with-rheumatoid-arthritis-ra-a-qualitative-study
#13
G Colligan, J Galloway, H Lempp
BACKGROUND: The UK rheumatology community serves an ageing and ethnically diverse population, with a growing public health concern about obesity. Overweight and obesity contribute to 2.8 million preventable deaths annually. A raised Body Mass Index (BMI) in those with Rheumatoid Arthritis (RA) can have a significant negative impact on clinical outcomes. The aim of the study was to examine patients' and providers' perceptions of obesity and potential barriers to participation in a future weight management programme to contribute to an appropriate intervention design...
2017: BMC Obesity
https://www.readbyqxmd.com/read/29074827/-update-on-recent-progress-in-vitamin-d-research-the-effects-of-vitamin-d-in-autoinflammatory-diseases
#14
Tomoka Ao, Junichi Kikuta, Masaru Ishii
Various kinds of immune cells -including dendritic cells, macrophages, T cells and B cells- express the vitamin D receptor and 1α-hydroxylase(CYP27B1). In vitro studies have shown the anti-inflammatory effect of 1,25-dihydroxyvitamin D:the active form of vitamin D. As vitamin D deficiency spread in our society, epidemiological studies have established the association between vitamin D deficiency and incidence or progression of several inflammatory diseases, including rheumatoid arthritis(RA), systemic lupus erythematosus(SLE), and multiple sclerosis(MS)...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29073669/prevalence-of-temporomandibular-disorders-in-rheumatoid-arthritis-and-associated-risk-factors-a-nationwide-study-in-taiwan
#15
Ching-Yueh Lin, Chi-Hsiang Chung, Heng-Yi Chu, Liang-Cheng Chen, Kuo-Hsien Tu, Chang-Huei Tsao, Yung-Tsan Wu, Wu-Chien Chien
AIMS: To investigate the association between temporomandibular disorders (TMD) and rheumatoid arthritis (RA), as well as potential risk factors for TMD and the preventive effect of medications on TMD, by using the Taiwan National Health Insurance Research Database. METHODS: In total, 17,317 patients newly diagnosed with RA and 17,317 matched controls without RA were followed up from 2000 to 2010. Cox regression was used to determine risk factors for developing TMD...
October 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29071567/novel-anti-adipogenic-activity-of-anti-malarial-amodiaquine-through-suppression-of-ppar%C3%AE-activity
#16
Tae Hee Kim, Hyo Kyeong Kim, Eun Sook Hwang
Amodiaquine (AQ) was developed as a selective drug against Plasmodium falciparum malaria infection and has received increasing attention as a therapeutic agent for the treatment of rheumatoid arthritis, Parkinson's disease, and cancer due to its anti-inflammatory, anti-proliferative, and autophagic-lysosomal blockade properties. As autophagy activation is involved in promoting adipogenic differentiation, we examined whether anti-autophagic AQ affected adipocyte differentiation of 3T3-L1 pre-adipocytes. AQ dose-dependently and significantly suppressed adipocyte differentiation in conjunction with decreases in lipid droplet formation and expression of adipogenic markers including adiponectin, adipocyte fatty acid-binding protein 2 (aP2), resistin, and leptin...
October 25, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29068268/structural-insights-into-the-binding-mode-of-flavonols-with-the-active-site-of-matrix-metalloproteinase-9-through-molecular-docking-and-molecular-dynamic-simulations-studies
#17
Dhinakararajan Pradiba, Murali Aarthy, Velu Shunmugapriya, Sanjeev Kumar Singh, Mani Vasanthi
Cartilage degradation in rheumatoid arthritis is mediated principally by the collagenases and gelatinases. Gelatinase B (also calledMatrix metalloproteinase 9-MMP-9),is a valid target molecule which is known to participate in cartilage degradation as well as angiogenesis associated with the disease and inhibition of its activity shall prevent cartilage damage and angiogenesis. The focus of this study is to investigate the possibilities of MMP-9 inhibition by flavonol class of bioflavonoids by studying their crucial binding interactions at the active site of MMP 9using molecular docking(Glide XP and QPLD) and further improvisation by post docking MM-GBSA and molecular dynamic (MD) simulations...
October 25, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29066483/aquaporin-4-blockage-by-sirna-protects-rat-articular-chondrocytes-from-il-1%C3%AE-induced-apoptosis-by-inhibiting-p38-mapk-signal-pathway
#18
Li Cai, Chao Lei, Rong Li, Wei-Na Chen, Chun-Mei Li
Accumulating evidence reveals that articular chondrocytes undergo increased apoptosis in rheumatoid arthritis (RA) and inhibiting chondrocyte apoptosis might be a promising therapeutic strategy. We recently found that aquaporin-4 (AQP4) protein level in the cartilage of rats with adjuvant-induced arthritis was higher than normal rats. Herein, cultured rat articular chondrocyte impaired by interleukin-1 beta (IL-1β) was used as an in vitro model of chondrocyte apoptosis. We observed the protective effect of AQP4 blockage by siRNA on IL-1β-induced chondrocyte apoptosis and explored the underlying mechanisms...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29065914/seroprevalence-of-toxoplasma-gondii-infection-in-arthritis-patients-in-eastern-china
#19
Ai-Ling Tian, Yuan-Lin Gu, Na Zhou, Wei Cong, Guang-Xing Li, Hany M Elsheikha, Xing-Quan Zhu
BACKGROUND: There is accumulating evidence for an increased susceptibility to infection in patients with arthritis. We sought to understand the epidemiology of Toxoplasma gondii infection in arthritis patients in eastern China, given the paucity of data on the magnitude of T. gondii infection in these patients. METHODS: Seroprevalence of T. gondii infection was assessed by enzyme-linked immunosorbent assay using a crude antigen of the parasite in 820 arthritic patients, and an equal number of healthy controls, from Qingdao and Weihai cities, eastern China...
October 25, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29062314/harnessing-apoptotic-cell-clearance-to-treat-autoimmune-arthritis
#20
REVIEW
Philippe Saas, Francis Bonnefoy, Eric Toussirot, Sylvain Perruche
Early-stage apoptotic cells possess immunomodulatory properties. Proper apoptotic cell clearance during homeostasis has been shown to limit subsequent immune responses. Based on these observations, early-stage apoptotic cell infusion has been used to prevent unwanted inflammatory responses in different experimental models of autoimmune diseases or transplantation. Moreover, this approach has been shown to be feasible without any toxicity in patients undergoing allogeneic hematopoietic cell transplantation to prevent graft-versus-host disease...
2017: Frontiers in Immunology
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