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Brachytherapy

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https://www.readbyqxmd.com/read/29054374/comparative-analysis-of-clinical-outcomes-and-procedural-costs-between-the-conventional-two-stage-technique-and-4d-brachytherapy-for-early-prostate-cancer
#1
S E M Langley, J Uribe, S Uribe-Lewis, J Money-Kyrle, C Perna, S Khaksar, R Soares, R Laing
AIMS: To assess long-term outcomes and resource use of 4D Brachytherapy, a one-stage real-time implant for the treatment of prostate cancer that uses stranded and loose iodine-125 seeds, and to compare with the conventional two-stage (2S) technique. MATERIALS AND METHODS: Prospectively collected data of men who underwent 2S and 4D low dose rate brachytherapy in a single institution were analysed. Survival estimates were analysed using the Kaplan-Meier method and Log-rank test...
October 18, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29047403/successful-treatment-of-a-recurrent-granulation-polyp-in-the-airways-with-high-dose-rate-brachytherapy-a-case-report
#2
M Polke, J Oelmann-Avendano, A Warth, C P Heussel, F J F Herth, R Eberhardt
BACKGROUND: Benign central airway tumors are very rare diseases. Their unspecific symptoms are responsible for late diagnosis. Endoscopic interventions with different techniques and tools are widely used for their treatment. However, in certain cases interventional endoscopy might be unsuccessful and therefore other methods such as high-dose-rate brachytherapy could be a therapeutic option. CASE PRESENTATION: A 76-year-old white German woman was referred to our clinic for an endoscopic treatment of a recurrent granulation polyp in her left main bronchus...
October 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29045516/navigating-the-highlights-of-phase-iii-trials-a-watchful-eye-on-evidence-based-radiotherapy
#3
J C Trone, S Espenel, A Rehailia-Blanchard, E Guillaume, N Vial, C Rancoule, C Rodriguez-Lafrasse, M Ben Mrad, A El Meddeb Hamrouni, E Ollier, C Chargari, E Deutsch, A Vallard, N Magné
Background: Phase III randomized controlled trials (RCTs) are the cornerstone of evidence-based oncology. However, there is no exhaustive review describing the radiotherapy RTCs characteristics. The objective of the present study was to describe features of all phase III RCTs including at least a radiation therapy. Methods and materials: Requests were performed in the Medline database (via PubMed). The latest update was performed in April 2016, using the following MESH terms: 'clinical trials: phase III as topic', 'radiotherapy', 'brachytherapy', as keywords...
July 12, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#4
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29039108/preliminary-results-of-a-new-workflow-for-mri-ct-based-image-guided-brachytherapy-in-cervical-carcinoma
#5
Miho Watanabe Nemoto, Yuma Iwai, Gentaro Togasaki, Marie Kurokawa, Rintarou Harada, Hiroki Kobayashi, Takashi Uno
PURPOSE: We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. MATERIALS AND METHODS: The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained...
October 16, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29034790/minimal-toxicity-after-proton-beam-therapy-for-prostate-and-pelvic-nodal-irradiation-results-from-the-proton-collaborative-group-reg001-09-trial
#6
Michael D Chuong, William Hartsell, Gary Larson, Henry Tsai, George E Laramore, Carl J Rossi, J Ben Wilkinson, Adeel Kaiser, Carlos Vargas
BACKGROUND: Proton beam therapy (PBT) reduces normal organ dose compared to intensity modulated radiation therapy (IMXT) for prostate cancer patients who receive pelvic radiation therapy. It is not known whether this dosimetric advantage results in less gastrointestinal (GI) and genitourinary (GU) toxicity than would be expected from IMXT. MATERIAL AND METHODS: We evaluated treatment parameters and toxicity outcomes for non-metastatic prostate cancer patients who received pelvic radiation therapy and enrolled on the PCG REG001-09 trial...
October 14, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29033292/-dosimetric-verification-of-mammosite-treatment-plans-using-monte-carlo-simulations-and-measurements-with-a-2d-ionization-chamber-array
#7
Moritz Budde, Irenäus A Adamietz, Holger Sommer, Horst Hermani
The surgical removal of a breast tumour is often followed by postoperative irradiation of the surrounding tissue with a radioactive source (brachytherapy). When performing the MammoSite procedure, a spherical silicone balloon is inserted and filled with a NaCl solution. In a period of about five days in several sessions an iridium-192 source with high activity travels through a catheter into the balloon (afterloading) to irradiate the tumour cells remaining in the cavity. In this study, dose distributions of a MammoSite applicator are investigated based on measurements with a 2D detector array, Monte Carlo simulations and calculations with BrachyVision...
October 12, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29032802/radioembolisation-of-hepatocellular-carcinoma-a-primer
#8
REVIEW
N Venkatanarasimha, A Gogna, K T A Tong, K Damodharan, P K H Chow, R H G Lo, S Chandramohan
Transarterial radioembolisation (TARE) has gained increasing acceptance as an additional/alternative locoregional treatment option for hepatocellular carcinoma, and colorectal hepatic metastases that present beyond potentially curative options. This is a catheter-based transarterial selective internal brachytherapy that involves injection of radioactive microspheres (usually Y-90) that are delivered selectively to the liver tumours. Owing to the combined radioactive and microembolic effect, the findings at follow-up imaging are significantly different from that seen with other transarterial treatment options...
October 9, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29032014/high-intermediate-prostate-cancer-treated-with-low-dose-rate-brachytherapy-with-or-without-androgen-deprivation-therapy
#9
Tom Pickles, W James Morris, Mira Keyes
PURPOSE: To describe outcomes of men with unfavorable (high-tier) intermediate risk prostate cancer (H-IR) treated with low-dose-rate (LDR) brachytherapy, with or without 6 months of androgen deprivation therapy (ADT). METHODS AND MATERIALS: Patients with H-IR prostate cancer, treated before 2012 with LDR brachytherapy without external radiation are included. Baseline tumor characteristics are described. Outcomes between groups receiving ADT are measured by Phoenix (nadir +2 ng/mL), and threshold 0...
October 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29031609/multi-atlas-based-segmentation-of-prostatic-urethra-from-planning-ct-imaging-to-quantify-dose-distribution-in-prostate-cancer-radiotherapy
#10
Oscar Acosta, Eugenia Mylona, Mathieu Le Dain, Camille Voisin, Thibaut Lizee, Bastien Rigaud, Carolina Lafond, Khemara Gnep, Renaud de Crevoisier
BACKGROUND AND PURPOSE: Segmentation of intra-prostatic urethra for dose assessment from planning CT may help explaining urinary toxicity in prostate cancer radiotherapy. This work sought to: i) propose an automatic method for urethra segmentation in CT, ii) compare it with previously proposed surrogate models and iii) quantify the dose received by the urethra in patients treated with IMRT. MATERIALS AND METHODS: A weighted multi-atlas-based urethra segmentation method was devised from a training data set of 55 CT scans of patients receiving brachytherapy with visible urinary catheters...
October 11, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29029889/brachytherapy-for-intermediate-risk-prostate-cancer-androgen-deprivation-and-the-risk-of%C3%A2-death
#11
Tom Pickles, Scott Tyldesley, Jeremy Hamm, Sean A Virani, W James Morris, Mira Keyes
PURPOSE: To determine whether the use of 6 months' adjuvant androgen deprivation therapy (ADT) combined with brachytherapy for intermediate-risk (IR) and low-risk (LR) prostate cancer is associated with an increased risk of cardiovascular death. METHODS AND MATERIALS: This is a retrospective analysis of prospectively collected data from men treated in the British Columbia Cancer Agency brachytherapy program from 1998 to 2012. Men were categorized by risk group and ADT use...
September 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29029888/reirradiation-using-permanent-interstitial-brachytherapy-a-potentially-durable-technique-for-salvaging-recurrent-pelvic-malignancies
#12
Jonathan Feddock, Dennis Cheek, Cole Steber, Jason Edwards, Stacey Slone, Wei Luo, Marcus Randall
PURPOSE: To present a time-to-failure (TTF) analysis for all patients treated with permanent interstitial brachytherapy (PIB) at our institution, with additional analyses to correlate successful reirradiation and to identify the frequency of severe grade 3 to 4 toxicity. METHODS AND MATERIALS: Forty-two previously irradiated patients received curative or palliative intent PIB for a recurrent pelvic malignancy between January 2009 and August 2016. Minimum follow-up was 6 months after the PIB procedure...
August 26, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29027402/impact-of-vaginal-cylinder-diameter-on-outcomes-following-brachytherapy-for-early-stage-endometrial-cancer
#13
Jack M Qian, John M Stahl, Melissa R Young, Elena Ratner, Shari Damast
OBJECTIVE: To examine the outcomes (tolerability, toxicity, and recurrence) of vaginal brachytherapy (VBT) among endometrial cancer (EC) patients treated with small cylinder size. METHODS: Patients with EC who received adjuvant VBT between September 2011 and December 2015 were reviewed. Patients were fitted with the largest vaginal cylinder they could comfortably accommodate, from 2.0-3.0 cm diameter. Small cylinders were defined as size 2.3 cm or less. Patient, tumor, or treatment characteristics were correlated with need for small cylinders...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29023697/neoadjuvant-radiation-therapy-for-the-management-of-myoepithelial-carcinoma-of-the-upper-extremity
#14
Rafi Kabarriti, Thomas J Quinn, Michelle R Ewart, Keyur J Mehta, Craig Lomita, David S Geller, Shalom Kalnicki, Jana L Fox
Myoepithelial tumors of the soft tissue are a rare tumor displaying myoepithelial elements and lacking obvious ductal differentiation. The rarity of these precludes any evidence-based consensus regarding optimal management. Nevertheless, the current approach to these lesions begins with amputation or complete excision. The efficacy of neoadjuvant or adjuvant radiation therapy or chemotherapy has not been established. Here, we present the first report to the authors' knowledge of neoadjuvant radiation therapy for the treatment of this rare soft tissue neoplasm and review the management and outcomes of published cases of myoepithelial carcinoma...
October 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29022484/prognostic-implication-of-simultaneous-anemia-and-lymphopenia-during-concurrent-chemoradiotherapy-in-cervical-squamous-cell-carcinoma
#15
Oyeon Cho, Mison Chun, Young-Taek Oh, O Kyu Noh, Suk-Joon Chang, Hee-Sug Ryu, Eun Ju Lee
Radioresistance often leads to poor survival in concurrent chemoradiotherapy-treated cervical squamous cell carcinoma, and reliable biomarkers can improve prognosis. We compared the prognostic potential of hemoglobin, absolute neutrophil count, and absolute lymphocyte count with that of squamous cell carcinoma antigen in concurrent chemoradiotherapy-treated squamous cell carcinoma. We analyzed 152 patients with concurrent chemoradiotherapy and high-dose-rate intracavitary brachytherapy-treated cervical squamous cell carcinoma...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29021662/embolized-prostatic-brachytherapy-seeds-mimicking-acute-chest-pain-syndromes
#16
Nirmal Guragai, Upamanyu Rampal, Rahul Vasudev
A 59-year-old male with a history of nonobstructive coronary artery disease, diabetes mellitus, hypertension, and prostate cancer presented to the hospital with 1-day history of pleuritic chest pain. Initial workup for acute coronary event was unremarkable. Chest X-ray revealed multiple small radial densities which were linear and hyperdense, consistent with embolization of metallic seeds to the pulmonary circulation. The patient was noted to have had radioactive metallic seeds implanted for prostate cancer 6 months ago...
October 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29018577/palliative-treatment-with-radiation-emitting-metallic-stents-in-unresectable-bismuth-type-iii-or-iv-hilar-cholangiocarcinoma
#17
Jian Lu, Jin-He Guo, Hai-Dong Zhu, Guang-Yu Zhu, Yong Wang, Qi Zhang, Li Chen, Chao Wang, Tian-Fan Pan, Gao-Jun Teng
BACKGROUND: The emerging data for stenting in combination with brachytherapy in unresectable hilar cholangiocarcinoma are encouraging. The aim of this study was to evaluate the efficacy and safety of radiation-emitting metallic stents (REMS) for unresectable Bismuth type III or IV hilar cholangiocarcinoma. PATIENTS AND METHODS: Consecutive patients who underwent percutaneous placement with REMS or uncovered self-expandable metallic stent (SEMS) for unresectable Bismuth type III or IV hilar cholangiocarcinoma between September 2011 and April 2016 were identified into this retrospective study...
2017: ESMO Open
https://www.readbyqxmd.com/read/29016456/new-ultra-wide-field-angiographic-grading-scheme-for-radiation-retinopathy-after-iodine-125-brachytherapy-for-uveal-melanoma
#18
Tara A McCannel, EunAh Kim, Mitchell Kamrava, James Lamb, Joseph Caprioli, Dong Yang, Colin A McCannel
PURPOSE: Radiation retinopathy remains incompletely characterized and may cause severe vision loss. Ultra-wide-field fluorescein angiography provides a pan-fundus view of vascular alterations caused by radiation treatment and may predict visual and ocular outcomes. We have developed a grading scheme to describe pan-fundus severity and to predict the progression of radiation retinopathy in patients treated for uveal melanoma with iodine-125 brachytherapy. METHODS: A retrospective review of patients treated with standard iodine-125 brachytherapy for uveal melanoma at the Ophthalmic Oncology Center at the University of California, Los Angeles, who had undergone both baseline and postbrachytherapy ultra-wide-field fluorescein angiography...
October 6, 2017: Retina
https://www.readbyqxmd.com/read/28993798/challenges-for-quality-assurance-of-target-volume-delineation-in-clinical-trials
#19
REVIEW
Amy Tien Yee Chang, Li Tee Tan, Simon Duke, Wai-Tong Ng
In recent years, new radiotherapy techniques have emerged that aim to improve treatment outcome and reduce toxicity. The standard method of evaluating such techniques is to conduct large scale multicenter clinical trials, often across continents. A major challenge for such trials is quality assurance to ensure consistency of treatment across all participating centers. Analyses from previous studies have shown that poor compliance and protocol violation have a significant adverse effect on treatment outcomes...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28993108/evaluation-of-interfractional-variation-of-organs-and-displacement-of-catheters-during-high-dose-rate-interstitial-brachytherapy-for-gynecologic-malignancies
#20
Soyoung Lee, Ellis Rodney, Bryan Traughber, Tithi Biswas, Valdir Colussi, Tarun Podder
PURPOSE: To investigate the dosimetric effects due to interfractional changes in catheter position and variation in patient's anatomy during the course of interstitial high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: A total of 15 patients with either cervical or vaginal cancer underwent interstitial HDR brachytherapy. Interstitial catheters and fiducials were placed under fluoroscopy and intraoperative 3T MRI to confirm the desired catheter placement for adequate target volume coverage...
October 6, 2017: Brachytherapy
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