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Brachytherapy

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https://www.readbyqxmd.com/read/28529679/new-era-of-electronic-brachytherapy
#1
EDITORIAL
Prabhakar Ramachandran
Traditional brachytherapy refers to the placement of radioactive sources on or inside the cancer tissues. Based on the type of sources, brachytherapy can be classified as radionuclide and electronic brachytherapy. Electronic brachytherapy uses miniaturized X-ray sources instead of radionuclides to deliver high doses of radiation. The advantages of electronic brachytherapy include low dose to organs at risk, reduced dose to treating staff, no leakage radiation in off state, less shielding, and no radioactive waste...
April 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28528720/in%C3%A2-vivo-dosimetry-in-gynecological-applications-a-feasibility-study
#2
Marion P R Van Gellekom, Richard A M Canters, Frank J W M Dankers, Agnes Loopstra, Elzbieta M van der Steen-Banasik, Marie A D Haverkort
PURPOSE: To investigate the feasibility of in vivo dosimetry using microMOSFET dosimeters in patients treated with brachytherapy using two types of gynecological applicators. METHODS AND MATERIALS: In this study, a microMOSFET was placed in an empty needle of an Utrecht Interstitial Fletcher applicator or MUPIT (Martinez Universal Perineal Interstitial Template) applicator for independent verification of treatment delivery. Measurements were performed in 10 patients, with one to three microMOSFETs per applicator and repeated for one to four fractions, resulting in 50 in vivo measurements...
May 18, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28522118/a-national-survey-of-hdr-source-knowledge-among-practicing-radiation-oncologists-and-residents-establishing-a-willingness-to-pay-threshold-for-cobalt-60-usage
#3
Raymond Mailhot Vega, Wesley Talcott, Omar Ishaq, Patrice Cohen, Christina J Small, Tamara Duckworth, Gustavo Sarria Bardales, Carmen A Perez, Peter B Schiff, William Small, Matthew M Harkenrider
PURPOSE: Ir-192 is the predominant source for high-dose-rate (HDR) brachytherapy in United States markets. Co-60, with longer half-life and fewer source exchanges, has piloted abroad with comparable clinical dosimetry but increased shielding requirements. We sought to identify practitioner knowledge of Co-60 and establish acceptable willingness-to-pay (WTP) thresholds for additional shielding requirements for use in future cost-benefit analysis. METHODS AND MATERIALS: A nationwide survey of U...
May 15, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28521759/dosimetric-comparison-of-interstitial-brachytherapy-with-multi-channel-vaginal-cylinder-plans-in-patients-with-vaginal-tumors
#4
Lucas C Mendez, Moti Paudel, Matt Wronski, Ananth Ravi, Lisa Barbera, Eric Leung
BACKGROUND: To evaluate the dosimetric performance of multi-channel vaginal cylinder (MCVC) against interstitial brachytherapy (ISBT) for the treatment of vaginal tumors. METHODS: Vaginal tumors with extension of > 0.5 cm and ≤ 2 cm from the lateral vaginal wall and/or ≤ 1 cm in height above the vaginal vault were retrospectively selected from a ISBT registry trial database. The selected patients were treated with ISBT and targets included the intermediate (IRCTV) or high-risk (HRCTV) clinical target volumes...
May 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28516398/gynecological-brachytherapy-for-postoperative-endometrial-cancer-dosimetric-analysis-ir-192-vs-co-60
#5
V Tormo Ferrero, R Duque Ugarte, M Á Berenguer Francés, R Cardenal Maciá
INTRODUCTION: Endovaginal brachytherapy treatment dosimetry differences were studied using Ir-192 or Co-60 sources for postoperative endometrial cancer. MATERIALS AND METHODS: A prospective descriptive study was conducted. Thirty-six dosimetry plans of different patients were studied (15 by Ir-192 and 21 by Co-60). Variables studied included D2cc Rectum, D2cc Bladder, D2cc Sigmoid, dose percentage at point 0 (applicator surface on the top of the cylinder) and dose percentage at point 1 (5 mm deep on the top of the cylinder)...
May 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28515807/external-validation-of-the-procars-nomograms-and-comparison-of-existing-risk-stratification-tools-for-localized-prostate-cancer
#6
David Tiberi, George Rodrigues, Tom Pickles, Jim Morris, Juanita Crook, Andre-Guy Martin, Fabio Cury, Charles Catton, Himu Lukka, Andrew Warner, Daniel Taussky
INTRODUCTION: The purpose of this study was to perform a direct comparison of several existing risk-stratification tools for localized prostate cancer in terms of their ability to predict for biochemical failure-free survival (BFFS). Two large databases were used and an external validation of two recently developed nomograms on an independent cohort was also performed in this analysis. METHODS: Patients who were treated with external beam radiotherapy (EBRT) and/or brachytherapy for localized prostate cancer were selected from the multi-institutional Genitourinary Radiation Oncologists of Canada (GUROC) Prostate Cancer Risk Stratification (ProCaRS) database (n=7974) and the Centre Hospitalier de l'Université de Montréal (CHUM) validation database (n=2266)...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28511891/external-pelvic-and-vaginal-irradiation-vs-vaginal-irradiation-alone-as-postoperative-therapy-in-women-with-early-stage-uterine-serous-carcinoma-results-of-a-national-cancer-database-analysis
#7
Ankit Modh, Charlotte Burmeister, Adnan R Munkarah, Mohamed A Elshaikh
PURPOSE: Adjuvant treatment in early stage uterine serous carcinoma (USC) usually consists of chemotherapy with vaginal brachytherapy (VB), pelvic external beam radiation therapy (EBRT), or combination. We compared survival outcomes across these various radiation treatment modalities using the National Cancer Database. METHODS AND MATERIALS: The National Cancer Database was queried for adult females with histologically confirmed International Federation of Gynecology and Obstetrics 1988 Stage I-II USC diagnosed from 2003 to 2013 treated definitively with hysterectomy, adjuvant chemotherapy, and radiation therapy...
May 13, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28509080/evaluation-of-dose-enhancement-in-presence-of-gold-nanoparticles-in-eye-brachytherapy-by-103-pd-source
#8
Hadi Rezaei, Mansour Zabihzadeh, Mahdi Ghorbani, Foad Goli Ahmadabad, Hesameddin Mostaghimi
In recent years, the use of gold nanoparticles in radiation therapy has been introduced as a new approach in radiotherapy. The aim of this study is to investigate the effect of gold nanoparticles (GNPs) in plaque brachytherapy for choroidal melanoma using Monte Carlo (MC) simulation. MCNPX code was used for simulation of human eye, (103)Pd (model 200) brachytherapy source and the 20 mm COMS eye plaque that was loaded with 24 (103)Pd seeds and standardized by Collaborative Ocular Melanoma Study (COMS). The tumour was defined from the inner surface of choroid with 0...
May 16, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28507457/evaluating-the-performance-of-tg-43-protocol-in-esophageal-hdr-brachytherapy-viewpoint-to-trachea-inhomogeneity
#9
Seyed Mohsen Hosseini Daghigh, Hamid Reza Baghani, Seyed Mahmoud Reza Aghamiri, Seyed Rabi Mahdavi
AIM: The aim of this study is to evaluate the effect of air within trachea on dose calculations of esophageal HDR brachytherapy treatment planning. BACKGROUND: Dose calculations in esophageal HDR brachytherapy treatment planning systems are greatly based on TG-43 protocol which in all materials are considered to be water equivalent. MATERIALS AND METHODS: A cylindrical PMMA phantom with a tube in the center (neck equivalent phantom) accompanied by Flexitron HDR brachytherapy system was used in this study...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28501429/permanent-prostate-brachytherapy-postimplant-mri-dosimetry-using-positive-contrast-mri-markers
#10
Geoffrey V Martin, Thomas J Pugh, Usama Mahmood, Rajat J Kudchadker, Jihong Wang, Teresa L Bruno, Tharakeswara Bathala, Pierre Blanchard, Steven J Frank
PURPOSE: Permanent prostate brachytherapy dosimetry using computed tomography-magnetic resonance imaging (CT-MRI) fusion combines the anatomic detail of MRI with seed localization on CT but requires multimodality imaging acquisition and fusion. The purpose of this study was to compare the utility of MRI only postimplant dosimetry to standard CT-MRI fusion-based dosimetry. METHODS AND MATERIALS: Twenty-three patients undergoing permanent prostate brachytherapy with use of positive contrast MRI markers were included in this study...
May 10, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28501419/brachytherapy-for-conservative-treatment-of-invasive-penile-carcinoma-prognostic-factors-and-long-term-analysis-of-outcome
#11
Alexandre Escande, Christine Haie-Meder, Renaud Mazeron, Pierre Maroun, Andrea Cavalcanti, Renaud de Crevoisier, Antoine Schernberg, Fanny Marsolat, Pierre Blanchard, Florent Martinetti, Alberto Bossi, Isabelle Dumas, Eric Deutsch, Cyrus Chargari
PURPOSE: To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma. METHODS AND MATERIALS: We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy. RESULTS: With a median follow-up of 10.7 years, local relapse as first failure was reported in 37 patients (18.9%), and 24 of 31 patients (77...
February 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28501391/long-term-visual-acuity-strabismus-and-nystagmus-outcomes-following-multimodality-treatment-in-group-d-retinoblastoma-eyes
#12
Ido D Fabian, Zishan Naeem, Andrew W Stacey, Tanzina Chowdhury, Catriona Duncan, M Ashwin Reddy, Mandeep S Sagoo
PURPOSE: To analyse the long-term visual acuity, strabismus and nystagmus outcomes in Group D retinoblastoma following multimodality treatments in a national retinoblastoma referral centre. DESIGN: Retrospective interventional case series. METHODS: A 13-year retrospective chart review of Group D eyes treated initially with intravenous chemotherapy (IVC) and followed-up for at least 1 year from last treatment. Risk factors for final visual acuity (VA) were analysed, and rate of strabismus and nystagmus at last follow-up visit were calculated...
May 10, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28499661/second-malignancies-after-permanent-implant-prostate-cancer-brachytherapy-a-single-institution-study-of-675%C3%A2-patients-treated-between-1999-and-2003
#13
J-M Cosset, L Belin, G Wakil, T Flam, N Thiounn, N Pierrat, D Pontvert, A Savignoni, L Chauveinc
PURPOSE: To analyse the rate of secondary malignancies observed in a series of 675 prostate cancer patients who underwent a permanent implant brachytherapy between 1999 and 2003, and to compare the incidence with the expected rate in a matched general French population. MATERIAL AND METHODS: The cohort included low-risk patients and a selection of "favourable-intermediate" risk patients. All patients were homogeneously treated using an intraoperative dynamic planning prostate brachytherapy technique, with loose 125-iodine seeds and a prescription dose of 145Gy...
May 9, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28499627/clinical-application-of-moskin-dosimeters-to-rectal-wall-in-vivo-dosimetry-in-gynecological-hdr-brachytherapy
#14
M Carrara, A Romanyukha, C Tenconi, D Mazzeo, A Cerrotta, M Borroni, D Cutajar, M Petasecca, M Lerch, J Bucci, A Richetti, S Presilla, C Fallai, G Gambarini, E Pignoli, A Rosenfeld
PURPOSE: Three MOSkins dosimeters were assembled over a rectal probe and used to perform in vivo dosimetry during HDR brachytherapy treatments of vaginal cancer. The purpose of this study was to verify the applicability of the developed tool to evaluate discrepancies between planned and measured doses to the rectal wall. MATERIALS AND METHODS: MOSkin dosimeters from the Centre for Medical Radiation Physics are particularly suitable for brachytherapy procedures for their ability to be easily incorporated into treatment instrumentation...
May 9, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28499488/in%C3%A2-vivo-dosimetry-with-alanine-electron-spin-resonance-dosimetry-to-evaluate-the-urethra-dose-during-high-dose-rate-brachytherapy
#15
Daniela Wagner, Markus Hermann, Andrea Hille
PURPOSE: To determine the dose of the urethra during Ir-192 high-dose-rate brachytherapy in 15 patients, a new detector form developed for in vivo measurements was used as described by Anton et al. 2009. METHODS AND MATERIALS: The detector consists of alanine powder with paraffin as binder which was filled in a shrinkable tube for measurements. The alanine strand so produced was inserted in the foley catheter during high-dose-rate brachytherapy of the prostate...
May 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28499487/external-beam-radiation-therapy-with-or-without-low-dose-rate-brachytherapy-analysis-of-favorable-and-unfavorable-intermediate-risk-prostate-cancer-patients
#16
Ahmed E Abugharib, Robert T Dess, Payal D Soni, Vrinda Narayana, Cheryl Evans, Mohamed S Gaber, Felix Y Feng, Patrick W McLaughlin, Daniel E Spratt
PURPOSE: To compare the tumor control and toxicity in men with intermediate-risk prostate cancer treated with either external beam radiation therapy (EBRT) or EBRT plus low-dose-rate brachytherapy (combo-RT). METHODS AND MATERIALS: Between 1995 and 2012, 579 men with intermediate-risk prostate cancer were treated with either EBRT (n = 388) or combo-RT (n = 191). Outcomes assessed included biochemical recurrence-free survival (bRFS), distant metastasis-free survival (DMFS), and cumulative incidence of genitourinary (GU) and gastrointestinal toxicity...
May 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28498257/the-addition-of-adjuvant-chemotherapy-to-radiation-in-early-stage-high-risk-endometrial-cancer-survival-outcomes-and-patterns-of-care
#17
Dustin Boothe, Ned Williams, Bismarck Odei, Matthew M Poppe, Theresa L Werner, Gita Suneja, David K Gaffney
OBJECTIVE: Early-stage high-risk endometrial cancer (HREC) treated with adjuvant radiotherapy (aRT) alone has been associated with an increased risk of distant relapse. The addition of chemotherapy to radiotherapy (aCRT) may benefit overall survival (OS). We investigated the patterns-of-care and OS benefit of aCRT in HREC by analyzing a large national registry. METHODS: Our query was limited to patients with the International Federation of Gynecology and Obstetrics stage IB and II HREC with either papillary serous, clear cell, or grade 3 adenocarcinoma, diagnosed between 2004 and 2012...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28496367/radiation-induced-vaginal-stenosis-current-perspectives
#18
REVIEW
Lucinda Morris, Viet Do, Jennifer Chard, Alison H Brand
Treatment of gynecological cancer commonly involves pelvic radiation therapy (RT) and/or brachytherapy. A commonly observed side effect of such treatment is radiation-induced vaginal stenosis (VS). This review analyzed the incidence, pathogenesis, clinical manifestation(s) and assessment and grading of radiation-induced VS. In addition, risk factors, prevention and treatment options and follow-up schedules are also discussed. The limited available literature on many of these aspects suggests that additional studies are required to more precisely determine the best management strategy of this prevalent group after RT...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28495444/comparing-the-rtog-eortc-and-lent-soma-scoring-systems-for-the-evaluation-of-late-skin-toxicity-after-125-i-seed-brachytherapy-for-parotid-gland-cancer
#19
Ming-Hui Mao, Zhien Feng, Hua Li, Li-Zheng Qin, Jian-Hua Li, Xin Huang, Ru-Dong Xing, Jie Zhang, Jian-Guo Zhang, Zheng-Xue Han
PURPOSE: The Radiation Therapy Oncology Group (RTOG) and Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic (LENT-SOMA) scoring systems were compared for grading late skin effects after iodine-125 seed brachytherapy in parotid gland cancer patients. METHODS AND MATERIALS: A total of 109 patients diagnosed with parotid gland carcinoma were treated postoperatively with iodine-125 seed brachytherapy at a dose of 100-120 Gy. After 6-24 months of followup, telangiectasia, skin pigmentation, atrophy, fibrosis, and ulceration were scored according to both RTOG and LENT-SOMA scale criteria...
May 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28495443/dose-volume-correlation-of-cumulative-vaginal-doses-and-late-toxicity-after-adjuvant-external-radiation-and-brachytherapy-for-cervical-cancer
#20
Roshni Singh, Supriya Chopra, Reena Engineer, Siji Paul, Sadhana Kannan, Sarthak Mohanty, Jamema Swamidas, Umesh Mahantshetty, Jaya Ghosh, Amita Maheshwari, T Surappa Shylasree, Rajendra Kerkar, Sudeep Gupta, Shyam Shrivastava
PURPOSE: To investigate dose-response relationship between vaginal doses and long-term morbidity. METHODS AND MATERIALS: Patients receiving adjuvant pelvic (chemo) radiation and brachytherapy for cervical cancer from January 2011 to December 2014 were included. Baseline vaginal length was determined clinically and from imaging at BT planning. Dose points were defined along mucosa and at 5 mm depth at 12, 3, 6, and 9 'o' clock positions at every 2 cm from apex to introitus...
May 8, 2017: Brachytherapy
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