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https://www.readbyqxmd.com/read/29673922/patient-reported-outcomes-after-treatment-for-clinically-localized-prostate-cancer-a-systematic-review-and-meta-analysis
#1
REVIEW
Mónica Ávila, Laila Patel, Silvia López, Laura Cortés-Sanabria, Olatz Garin, Àngels Pont, Ferran Ferrer, Ana Boladeras, Victor Zamora, Sophie Fosså, Anne H Storås, Martin Sanda, Vicky Serra-Sutton, Montse Ferrer
BACKGROUND: The aim of this systematic review is to assess the impact of primary treatments with curative intention in patients with localized prostate cancer, measured with Patient-Reported Outcomes (PROs), and to examine differences among modalities within treatments. METHODS: We conducted a systematic literature search for January 2005-March 2017 following PRISMA guidelines, including longitudinal studies measuring disease-specific PROs in localized prostate cancer patients with a follow-up from pre- to post-treatment (≥1 year)...
April 3, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29667307/reduction-of-seed-motion-using-a-bio-absorbable-polymer-coating-during-permanent-prostate-brachytherapy-using-a-mick-applicator-technique
#2
Gregory R Warrell, Yan Xing, Tarun K Podder, Bryan J Traughber, Rodney J Ellis
PURPOSE: The addition of a braided bio-absorbable vicryl coating to the surface of radioactive seeds used for low dose rate (LDR) prostate brachytherapy is intended to reduce the incidence of seed movement and migration. Here, we present a single-institution study of the frequency and severity of seed slippage (initial seed movement) of coated seeds in comparison with uncoated seeds. METHODS: Forty-seven patients received permanent prostate brachytherapy, with either coated (n = 26) or uncoated (n = 21) seeds...
April 17, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29663462/survival-benefit-of-local-versus-no-local-treatment-for-metastatic-prostate-cancer-impact-of-baseline-psa-and-metastatic-substages
#3
Raisa S Pompe, Derya Tilki, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Marco Bandini, Michele Marchioni, Philipp Gild, Zhe Tian, Nicola Fossati, Luca Cindolo, Shahrokh F Shariat, Hartwig Huland, Markus Graefen, Alberto Briganti, Pierre I Karakiewicz
BACKGROUND: To test whether local treatment (LT), namely radical prostatectomy (RP) or brachytherapy (BT) still confers a survival benefit versus no local treatment (NLT), when adjusted for baseline PSA (bPSA). To further examine whether the effect of LT might be modulated according to bPSA and M1 substages. METHODS: Of 13 906 mPCa patients within the SEER (2004-2014), 375 underwent RP, 175 BT, and 13 356 NLT. Multivariable competing risks regression (MVA CRR) analyses after 1:2 propensity score matching assessed the impact of LT versus NLT on cancer specific mortality (CSM)...
April 16, 2018: Prostate
https://www.readbyqxmd.com/read/29662542/meta-analysis-of-studies-comparing-oncologic-outcomes-of-radical-prostatectomy-and-brachytherapy-for-localized-prostate-cancer
#4
Gabriele Cozzi, Gennaro Musi, Roberto Bianchi, Danilo Bottero, Antonio Brescia, Antonio Cioffi, Giovanni Cordima, Maurizio Delor, Ettore Di Trapani, Matteo Ferro, Deliu Victor Matei, Andrea Russo, Francesco Alessandro Mistretta, Ottavio De Cobelli
Background: The aim of this study was to compare oncologic outcomes of radical prostatectomy (RP) with brachytherapy (BT). Methods: A literature review was conducted according to the 'Preferred reporting items for systematic reviews and meta-analyses' (PRISMA) statement. We included studies reporting comparative oncologic outcomes of RP versus BT for localized prostate cancer (PCa). From each comparative study, we extracted the study design, the number and features of the included patients, and the oncologic outcomes expressed as all-cause mortality (ACM), PCa-specific mortality (PCSM) or, when the former were unavailable, as biochemical recurrence (BCR)...
November 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29661719/rectal-ulcer-and-pseudomalignant-epithelial-changes-after-prostate-seed-brachytherapy-a-rare-complication-with-a-diagnostic-pitfall
#5
Hwajeong Lee, Natallia Sheuka, Osama El-Kadi, Brian P Murray, Hugh A Fisher, Bhaskar V S Kallakury, Edward C Lee, Ann Boguniewicz, Timothy A Jennings
BACKGROUND: Implant brachytherapy (IBT) is a well-recognized treatment modality for early stage prostate cancer. Rectal ulcer and rectourethral fistula complicating IBT may cause an alteration of the normal anatomic landmarks. In this context, pseudomalignant radiation-induced changes within prostatic epithelium may be misinterpreted as a primary rectal malignancy. Such challenging and misleading findings have not been described, and may not be recognized as such. MATERIALS AND METHODS: We present the clinical and pathologic aspects of two patients who underwent IBT for low stage prostate cancer that was complicated by deep rectal ulcer...
April 4, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29659987/an-in-vitro-verification-of-strength-estimation-for-moving-an-125i-source-during-implantation-in-brachytherapy
#6
Kenichi Tanaka, Tsuyoshi Kajimoto, Takahiro Hayashi, Osamu Asanuma, Masakazu Hori, Ken-Ichi Kamo, Iori Sumida, Yutaka Takahashi, Kunihiko Tateoka, Gerard Bengua, Koh-Ichi Sakata, Satoru Endo
This study aims to demonstrate the feasibility of a method for estimating the strength of a moving brachytherapy source during implantation in a patient. Experiments were performed under the same conditions as in the actual treatment, except for one point that the source was not implanted into a patient. The brachytherapy source selected for this study was 125I with an air kerma strength of 0.332 U (μGym2h-1), and the detector used was a plastic scintillator with dimensions of 10 cm × 5 cm × 5 cm. A calibration factor to convert the counting rate of the detector to the source strength was measured and then the accuracy of the proposed method was investigated for a manually driven source...
April 11, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29659976/a-novel-radiation-shielding-undergarment-using-tungsten-functional-paper-for-patients-with-permanent-prostate-brachytherapy
#7
Masahiro Inada, Hajime Monzen, Kenji Matsumoto, Mikoto Tamura, Takafumi Minami, Kiyoshi Nakamatsu, Yasumasa Nishimura
Tungsten functional paper (TFP) is a paper-based radiation-shielding material, which is lead-free and easy to cut. We developed a radiation protection undergarment using TFP for prostate cancer patients treated with permanent 125I seed implantation (PSI). The aim of this study was to evaluate the shielding ability of the undergarment with respect to household contacts and members of the public. Between October 2016 and April 2017, a total of 10 prostate cancer patients treated with PSI were enrolled in this prospective study...
April 11, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29659412/photodynamic-therapy-as-primary-treatment-for-small-choroidal-melanoma
#8
Elif B Turkoglu, Renelle Pointdujour-Lim, Arman Mashayekhi, Carol L Shields
PURPOSE: To report outcomes of photodynamic therapy (PDT) as primary treatment for small amelanotic choroidal melanoma. METHODS: Retrospective interventional case series of 12 patients with small choroidal melanoma treated with standard-fluence PDT (83 seconds; 50 J/cm) using verteporfin. OUTCOME MEASURES: Tumor regression, subretinal fluid resolution, best-corrected visual acuity, and PDT complications. RESULTS: There were 12 eyes with melanoma, demonstrating amelanotic (10 [83%]) or lightly pigmented (n = 2, 17%) appearance...
April 13, 2018: Retina
https://www.readbyqxmd.com/read/29658281/-treatment-of-metastatic-progression-following-the-synchronous-occurrence-of-cutaneous-and-ocular-primary-melanomas
#9
Eleonóra Imrédi, Vanda Plótár, Péter Szavcsur, Gitta Pánczél, Krisztina Melegh, Krisztina Schlachter, Gabriella Liszkay
The incidence rates of cutaneous melanoma in non-Hispanic whites show an increasing tendency with age. While uveal melanoma in general is a rare disease, representing only 4% of all melanomas with an incidence rate of 0.6 per 100 000, it is still the most frequent malignancy of the eye. Synchronous occurrence of ocular and cutaneous melanoma is an exceptional rarity, due to the distinct genetic background of the diseases. We report the case of a 80-year-old man who underwent total excision of a cutaneous melanoma in 2008...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29651796/oncological-impact-of-neoadjuvant-hormonal-therapy-on-permanent-iodine-125-seed-brachytherapy-in-patients-with-low-and-intermediate-risk-prostate-cancer
#10
Atsushi Takamoto, Ryuta Tanimoto, Kensuke Bekku, Motoo Araki, Takuya Sadahira, Koichiro Wada, Shin Ebara, Norihisa Katayama, Hiroyuki Yanai, Yasutomo Nasu
OBJECTIVES: To determine whether neoadjuvant hormonal therapy improves oncological outcomes of patients with localized prostate cancer treated with permanent brachytherapy. METHODS: Between January 2004 and November 2014, 564 patients underwent transperineal ultrasonography-guided permanent iodine-125 seed brachytherapy. We retrospectively analyzed low- or intermediate-risk prostate cancer based on the National Comprehensive Cancer Network guidelines. The clinical variables were evaluated for influence on biochemical recurrence-free survival, progression-free survival, cancer-specific survival and overall survival...
April 12, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29650317/monte-carlo-based-assessment-of-magic-magicaug-pagatug-and-pagataug-polymer-gel-dosimeters-for-ovaries-and-uterus-organ-dosimetry-in-brachytherapy-nuclear-medicine-and-tele-therapy
#11
Karim Adinehvand, Fereidoun Nowshiravan Rahatabad
BACKGROUND AND OBJECTIVES: Calculation of 3D dose distribution during radiotherapy and nuclear medicine helps us for better treatment of sensitive organs such as ovaries and uterus. In this research, we investigate two groups of normoxic dosimeters based on meta-acrylic acid (MAGIC and MAGICAUG) and polyacrylamide (PAGATUG and PAGATAUG) for brachytherapy, nuclear medicine and Tele-therapy in their sensitive and critical role as organ dosimeters. METHODS: These polymer gel dosimeters are compared with soft tissue while irradiated by different energy photons in therapeutic applications...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29644176/robot-assisted-laparoscopic-implantation-of-brachytherapy-catheters-in-bladder-cancer-recent-interests-and-prospective
#12
EDITORIAL
Susovan Banerjee, Srijit Banerjee
No abstract text is available yet for this article.
March 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29643871/an-examination-of-the-sexual-functions-of-patients-who-underwent-a-gynecologic-cancer-operation-and-received-brachytherapy
#13
Ozlem Guner, Sureyya Gumussoy, Nigar Celik, Aynur Saruhan, Oya Kavlak
Objective: This study was planned as a descriptive study for the purpose of examining the sexual functions of patients' who underwent a gynecological operation and received brachytherapy. Methods: The study was conducted with 118 women who attended the Radiation Oncology Unit at Ege University Medical Faculty Hospital in Izmir Province for Gynecological Oncology follow-up, who participated voluntarily and were assigned using the random sampling method. The participants were married, sexually active, had a diagnosis of gynecologic cancer, underwent an operation and received brachytherapy for four months after the operation...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29630112/interstitial-brachytherapy-of-oral-squamous-cell-carcinoma-with-ultrasound-guided-iodine-125-radioactive-seed-implantation
#14
Q Tian, H-H Zhu, H Li
OBJECTIVE: In this study, we investigated the clinical effect of interstitial brachytherapy on oral squamous cell carcinoma (OSCC) with ultrasound or CT-guided 125I radioactive seed implantation. PATIENTS AND METHODS: 116 patients with advanced oral squamous cell carcinoma, who received initial treatment or retreatment, were enrolled. Therein, 35 patients in the control group were treated with external radiation, systemic chemotherapy or conservative treatment, 41 patients in the ultrasound group were treated with ultrasound-guided125I radioactive seed interstitial implantation brachytherapy, and 40 patients in the CT group were treated with CT-guided 125I radioactive seed interstitial implantation...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29628635/brachytherapy-localization-radiographs-with-conventional-diagnostic-x-ray-machine
#15
Ramamoorthy Ravichandran, Bandana Barman, Purnendu Deb Roy, Gopal Datta, Ravi Kannan
With conventional diagnostic X-ray machines with over couch X-ray tubes, it is not possible to obtain anteroposterior (AP) and lateral (Lat) radiographs without changing the posture of the patients. In an old 300 mA X-ray machine with a fluoroscopy screen (12.4 kg) (1995 model), by substituting the screen with suitable counterweight and making provision to take the hoist pillar up to the edge of the wall, we could get isocentric setup for a hospital stretcher kept near the chest stand. This setup provided acceptable AP-Lat radiographs for brachytherapy localization using "Perspex jig" (Nucletron, Netherlands) and field check radiographs in head and neck, esophagus patients for treatment planning...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29628630/interfraction-variations-in-organ-filling-and-their-impact-on-dosimetry-in-ct-image-based-hdr-intracavitary-brachytherapy
#16
Ramya Rangarajan
Aim: Since anatomical and geometric variations occur with every fraction, planning, and dose optimization is necessary for every fraction of high-dose rate intracavitary brachytherapy of carcinoma cervix. In this study, we have tried to quantify the differences in doses to organs at risk (OAR) for each fraction of brachytherapy. Methods and Materials: One hundred and seventy computed tomography datasets of cervical cancer patients receiving intracavitary brachytherapy at our institution between January and April 2015 were analyzed...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29627137/fatigue-insomnia-and-hot-flashes-after-definitive-radiochemotherapy-and-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer-an-analysis-from-the-embrace-study
#17
Stéphanie Smet, Richard Pötter, Christine Haie-Meder, Jacob C Lindegaard, Ina Schulz-Juergenliemk, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Peter Hoskin, Bhavana Rai, Fleur Huang, Rachel Cooper, Erik van Limbergen, Kari Tanderup, Kathrin Kirchheiner
OBJECTIVE: To evaluate the pattern of manifestation of fatigue, insomnia and hot flashes within the prospective, observational, multi-center EMBRACE study. METHODS: Morbidity was prospectively assessed according to CTCAE v.3 and patient-reported outcome with EORTC QLQ-C30/CX24 at baseline and regular follow-up. Analyses of crude incidence, prevalence rates and actuarial estimates were performed. RESULTS: A total of 1176 patients were analyzed with a median follow-up of 27 months...
April 4, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29625808/high-dose-rate-brachytherapy-for-prostate-cancer-a-prospective-toxicity-evaluation-of-a-one-day-schedule-including-two-13-5-gy-fractions
#18
Gorka Nagore, Jose Luis Lopez Guerra, Evita Krumina, Mark Lagos, Beatriz Ovalles, Antonio Miró, Lourdes Beltran, Emilia Gómez, Juan Manuel Praena-Fernandez, Eleonor Rivin Del Campo, Ignacio Azinovic, Alfonso Gomez-Iturriaga
BACKGROUND AND PURPOSE: High dose-rate (HDR) brachytherapy (BT) provides a highly conformal method of dose delivery to the prostate. The purpose of this study is to prospectively determine the toxicity of the treatment protocol of 13.5 Gy × 2 fractions. MATERIALS AND METHODS: From 2010 through 2017, 119 patients with low (71%) or intermediate-risk prostate cancer were prospectively treated in a single institute with HDR-BT at 13.5 Gy × 2 fractions within one day...
April 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29619061/the-effect-of-tandem-ovoid-titanium-applicator-on-points-a-b-bladder-and-rectum-doses-in-gynecological-brachytherapy-using-192-ir
#19
Mohammad Hosein Sadeghi, Sedigheh Sina, Amir Mehdizadeh, Reza Faghihi, Vahed Moharramzadeh, Ali Soleimani Meigooni
Purpose: The dosimetry procedure by simple superposition accounts only for the self-shielding of the source and does not take into account the attenuation of photons by the applicators. The purpose of this investigation is an estimation of the effects of the tandem and ovoid applicator on dose distribution inside the phantom by MCNP5 Monte Carlo simulations. Material and methods: In this study, the superposition method is used for obtaining the dose distribution in the phantom without using the applicator for a typical gynecological brachytherapy (superposition-1)...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29619060/reduction-of-applicator-displacement-in-mr-ct-guided-cervical-cancer-hdr-brachytherapy-by-the-use-of-patient-hover-transport-system
#20
Megan Andrew, Yusung Kim, Timothy Ginader, Brian J Smith, Wenqing Sun, Dongxu Wang
Purpose: To quantify the reduction of relative displacement between the implanted intracavitary applicator and the patient bony anatomy, due to the use of a hover transport system during the patient transports between the imaging table and the treatment table. Material and methods: The displacement of the applicator inside the patient was measured by comparing the distance between the tip of the tandem and the pubic bone on X-ray radiography images taken before and after moving a patient to magnetic resonance/computed tomography imaging...
February 2018: Journal of Contemporary Brachytherapy
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