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Brachytherapy

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https://www.readbyqxmd.com/read/28228874/embolization-of-prostatic-brachytherapy-seeds-to-pulmonary-arteries-a-case-study
#1
Alexander D Calvert, Andrew W Dyer, Van A Montgomery
Pulmonary seed embolization is a complication of prostatic brachytherapy with varying incidence rates. Key factors that reportedly influence the incidence of seed embolization include planning volume, quantity of seeds, seed placement, and type of seeds (stranded vs free). The clinical implications of seed migration are unclear because sequelae were not demonstrated in multiple short-term studies yet there have been several reports of long-term complications. We report a case of a 56-year-old patient who presented with dyspnea approximately 6 years after brachytherapy treatment for a very low-risk prostate cancer...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228873/prostate-brachytherapy-seed-migration-to-the-heart-seen-on-cardiovascular-computed-tomographic-angiography
#2
Shilpa Sachdeva, Nneka S Udechukwu, Hossam Elbelasi, Kevin P Landwehr, William H St Clair, Michael A Winkler
Brachytherapy consists of placing radioactive sources into or adjacent to tumors, to deliver conformal radiation treatment. The technique is used for treatment of primary malignancies and for salvage in recurrent disease. Permanent prostate brachytherapy seeds are small metal implants containing radioactive sources of I-125, Pd-103, or Cs-131 encased in a titanium shell. They can embolize through the venous system to the lungs or heart and subsequently be detected by cardiovascular computed tomography. Cardiovascular imagers should be aware of the appearance of migrated seeds, as their presence in the chest is generally benign, so that unnecessary worry and testing are avoided...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28226705/non-rigid-mri-ct-registration-for-effective-planning-of-prostate-brachytherapy
#3
I Hamdan, G Dardenne, J Bert, D Visvikis, I Hamdan, G Dardenne, J Bert, D Visvikis, I Hamdan, G Dardenne, J Bert, D Visvikis
Prostate brachytherapy is an intraoperative radiotherapy technique for irradiating prostate tumors by placing radioactive sources inside the prostate. CT image is used to calculate a personalized dose distribution (PDD) while the MRI is used to visualize the tumor and the organs at risk. Therefore, a registration of preoperative MRI and CT is essential since it could improve the overall precision of the treatment planning, the placement of radioactive sources inside the prostate as well as the visualization of the dose distribution with respect to the tumor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224113/intensity-modulated-radiation-therapy-with-stereotactic-body-radiation-therapy-boost-for-unfavorable-prostate-cancer-a-report-on-3-year-toxicity
#4
Ima Paydar, Abigail Pepin, Robyn A Cyr, Joseph King, Thomas M Yung, Elizabeth G Bullock, Siyuan Lei, Andrew Satinsky, K William Harter, Simeng Suy, Anatoly Dritschilo, John H Lynch, Thomas P Kole, Sean P Collins
BACKGROUND: Recent data suggest that intensity-modulated radiation therapy (IMRT) plus brachytherapy boost for unfavorable prostate cancer provides improved biochemical relapse-free survival over IMRT alone. Stereotactic body radiation therapy (SBRT) may be a less invasive alternative to brachytherapy boost. Here, we report the 3-year gastrointestinal (GI) and genitourinary (GU) toxicities of IMRT plus SBRT boost. MATERIALS AND METHODS: Between March 2008 and September 2012, patients with prostate cancer were treated with robotic SBRT (19...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28222973/nationwide-multi-institutional-retrospective-analysis-of-high-dose-rate-brachytherapy-combined-with-external-beam-radiotherapy-for-localized-prostate-cancer-an-asian-prostate-hdr-bt-consortium
#5
Hiromichi Ishiyama, Nobuhiko Kamitani, Hidemasa Kawamura, Shingo Kato, Manabu Aoki, Shinji Kariya, Taisei Matsumura, Motoki Kaidu, Ken Yoshida, Yaichiro Hashimoto, Yasutaka Noda, Keith H C Lim, Takatsugu Kawase, Takeo Takahashi, Koji Inaba, Motoyasu Kumano, Nobuhiko Yoshikawa, Yasuo Yoshioka, Katsumasa Nakamura, Junichi Hiratsuka, Jun Itami, Kazushige Hayakawa
PURPOSE: To report outcomes and risk factors of high-dose-rate (HDR) brachytherapy combined with external beam radiotherapy with or without androgen deprivation therapy (ADT) in prostate cancer patients. MATERIALS AND METHODS: This multi-institutional retrospective analysis comprised 3424 patients with localized prostate cancer at 16 Asian hospitals. One-thirds (27.7%) of patients received only neoadjuvant ADT, whereas almost half (49.5%) of patients received both neoadjuvant and adjuvant ADT...
February 17, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28222958/early-stage-favourable-anal-cancer-a-retrospective-analysis-of-clinical-outcomes-of-a-moderately-low-dose-elective-nodal-intensity-modulated-radiotherapy-schedule
#6
L Lestrade, T Zilli, M Kountouri, R Jumeau, O Matzinger, J Bourhis, R Miralbell, M Ozsahin, B De Bari
In this retrospective study we evaluated the long-term results of 35 early-stage favourable T1-2 N0 M0 anal cancer patients treated with intensity-modulated radiotherapy techniques combining low dose prophylactic inguinal-pelvic irradiation with dose-escalated boost. Optimal locoregional control and good tolerance makes this treatment a valuable alternative to brachytherapy boost and involved-field radiotherapy plans.
February 17, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28222069/patients-perceptions-of-the-negative-effects-following-different-prostate-cancer-treatments-and-the-impact-on-psychological-well-being-a-nationwide-survey
#7
Ulla-Sisko Lehto, Heli Tenhola, Kimmo Taari, Arpo Aromaa
BACKGROUND: Although the prognosis of localised prostate cancer is good, the negative effects of prostate cancer treatment often impair patient quality of life. A growing number of men experience these negative effects over a longer time because of the increased incidence of and prolonged survival in prostate cancer, and the ageing of the population. Only a few studies have investigated the adverse effects of different prostate cancer treatments using large population-based samples. METHODS: We conducted a nationwide survey (n=1239) to collect detailed information regarding the negative effects (i...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28217920/impact-of-target-area-selection-in-125-iodine-seed-brachytherapy-on-locoregional-recurrence-in-patients-with-non-small-cell-lung-cancer
#8
Wei-Liang Yan, Jin-Shuang Lv, Zhi-Yu Guan, Li-Yang Wang, Jing-Kui Yang, Ji-Xiang Liang
BACKGROUND: Computed tomography (CT)-guided percutaneous implantation of (125) Iodine radioactive seeds requires the precise arrangement of seeds by tumor shape. We tested whether selecting target areas, including subclinical areas around tumors, can influence locoregional recurrence in patients with non-small cell lung cancer (NSCLC). METHOD: We divided 82 patients with NSCLC into two groups. Target areas in group 1 (n = 40) were defined along tumor margins based on lung-window CT...
February 20, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28217870/adult-ocular-medulloepithelioma-diagnosed-by-transscleral-fine-needle-aspiration-a-case-report
#9
Amir Mahdjoubi, Nathalie Cassoux, Christine Levy-Gabriel, Laurence Desjardins, Jan Klos, Martial Caly, Tatjana Vlajnic, Sophie Gardrat, Jerzy Klijanienko
Ocular medulloepithelioma (ME) is a rare congenital tumor which occurs usually during childhood but is also reported in adults. They have seen an intraocular tumor in an 89 years-old female with a history of small cell lung carcinoma. Transscleral fine needle aspiration was performed. Aspirates were rich and composed of two distinctive populations of cells. The first consisted of epithelioid large cohesive cells with rare rosettes. Nuclei were oval and chromatin was delicate with small nucleoli. The second population consisted of smaller and dispersed cells with regular nuclei and dusty chromatin...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28215003/improved-electromagnetic-tracking-for-catheter-path-reconstruction-with-application-in-high-dose-rate-brachytherapy
#10
Elodie Lugez, Hossein Sadjadi, Chandra P Joshi, Selim G Akl, Gabor Fichtinger
PURPOSE: Electromagnetic (EM) catheter tracking has recently been introduced in order to enable prompt and uncomplicated reconstruction of catheter paths in various clinical interventions. However, EM tracking is prone to measurement errors which can compromise the outcome of the procedure. Minimizing catheter tracking errors is therefore paramount to improve the path reconstruction accuracy. METHODS: An extended Kalman filter (EKF) was employed to combine the nonlinear kinematic model of an EM sensor inside the catheter, with both its position and orientation measurements...
February 18, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28214368/evaluation-of-deformable-image-registration-between-external-beam-radiotherapy-and-hdr-brachytherapy-for-cervical-cancer-with-a-3d-printed-deformable-pelvis-phantom
#11
Noriyuki Kadoya, Yuya Miyasaka, Yujiro Nakajima, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Suguru Dobashi, Takaya Yamamoto, Noriyoshi Takahashi, Masaki Kubozono, Ken Takeda, Keiichi Jingu
PURPOSE: In this study, we developed a 3D-printed deformable pelvis phantom for evaluating spatial DIR accuracy. We then evaluated the spatial DIR accuracies of various DIR settings for cervical cancer. METHODS: A deformable female pelvis phantom was created based on patient CT data using 3D printing. To create the deformable uterus phantom, we first 3D printed both a model of uterus and a model of the internal cavities of the vagina and uterus. We then made a mold using the 3D printed uterus phantom...
February 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28213066/inguinal-lymph-node-presenting-as-the-delayed-site-of-metastasis-in-early-stage-endometrial-carcinoma-case-report
#12
Shomaila Amir M Akbar, Mutahir A Tunio, Wafa AlShakweer, AbdulAziz AlObaid, Mushabbab AlAsiri
INTRODUCTION: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked. CASE PRESENTATION: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma...
January 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28211128/staged-intraperitoneal-brachytherapy-and-hyperthermic-intraperitoneal-chemotherapy-in-an-adolescent-novel-anesthetic-challenges-for-pediatric-anesthetists
#13
Andrew D Weatherall, Tristan R Bennett, Mark Lovell, Winnie Fung, Jonathan de Lima
Newer techniques that have found a place in cancer management in adults are offered far less commonly in pediatric patients. We present a case of a patient with recurrent Wilms' tumor managed with a novel combination of cytoreductive surgery, intraperitoneal brachytherapy, and subsequent hyperthermic intraperitoneal chemotherapy. Each stage presents challenges that the pediatric anesthetist is unlikely to have faced before. Such cases require flexibility and thorough planning to manage the combination of major surgery, remote anesthesia with brachytherapy and hyperthermic chemotherapy with its potential for metabolic derangement, significant fluid shifts, analgesic care, and potential exposure of staff to cytotoxic agents...
February 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28210385/high-dose-rate-electronic-brachytherapy-a-nonsurgical-treatment-alternative-for-nonmelanoma-skin-cancer
#14
REVIEW
Ajay Bhatnagar, Rakesh Patel, William Philip Werschler, Roger I Ceilley, Robert Strimling
The authors summarized data from a group of physicians with experience using high-dose rate electronic brachytherapy for the treatment of nonmelanoma skin cancer. The data have been published or presented in abstract format at national dermatology and radiation oncology meetings. The data included 1,822 treated lesions from 2009 to 2014 in patients ranging in age from 52 to 104 years. Most lesions were basal cell carcinoma (57%) or squamous cell carcinoma (38%) less than 2cm in size (97%). Median follow-up at the various centers ranged from 4 to 16 months, and results yielded an extremely low recurrence rate of less than one percent...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28209912/detection-efficacy-of-hybrid-68-ga-psma-ligand-pet-ct-in-prostate-cancer-patients-with-biochemical-recurrence-after-primary-radiation-therapy-defined-by-phoenix-criteria
#15
Ingo Einspieler, Isabel Rauscher, Charlotte Düwel, Markus Krönke, Christoph Rischpler, Gregor Habl, Sabrina Dewes, Armin Ott, Hans-Jürgen Wester, Markus Schwaiger, Tobias Maurer, Matthias Eiber
The aim of this retrospective study was to evaluate the detection rate of Glu-NH-CO-NH-Lys-(Ahx)-[(68)Ga(HBED-CC)] ((68)Ga-PSMA ligand) positron emission tomography/computed tomography (PET/CT) in patients with biochemical recurrent prostate cancer (PC) defined by Phoenix criteria after external beam radiotherapy (EBRT) or brachytherapy as primary treatment. Methods: 118 patients were finally eligible for this retrospective analysis with a median prostate-specific antigen (PSA) of 6.4 ng/mL (range: 2.2-158...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28202343/endobronchial-brachytherapy-for-metastasis-from-extrapulmonary-malignancies-as-an-effective-treatment-for-palliation-of-symptoms
#16
E Donovan, E Timotin, T Farrell, B Donde, S Puksa, R Sur
PURPOSE: Endobronchial metastasis (EBM) originating from primary cancers outside the lung is rare. External beam radiotherapy is often attempted for control of symptoms with variable effectiveness and retreatment is challenging if symptoms recur. There is limited documentation of high-dose-rate brachytherapy for EBM in the literature. METHODS AND MATERIALS: A prospective database was created from 2006 to 2015. Patients with EBM who received high-dose-rate brachytherapy were included...
February 12, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28193241/present-state-and-issues-in-iort-physics
#17
REVIEW
Frank W Hensley
Literature was reviewed to assess the physical aspects governing the present and emerging technologies used in intraoperative radiation therapy (IORT). Three major technologies were identified: treatment with electrons, treatment with external generators of kV X-rays and electronic brachytherapy. Although also used in IORT, literature on brachytherapy with radioactive sources is not systematically reviewed since an extensive own body of specialized literature and reviews exists in this field. A comparison with radioactive sources is made in the use of balloon catheters for partial breast irradiation where these are applied in almost an identical applicator technique as used with kV X-ray sources...
January 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28192614/cone-beam-ct-based-adaptive-planning-improves-permanent-prostate-brachytherapy-dosimetry-an-analysis-of-1266-patients
#18
Hendrik Westendorp, Carel J Hoekstra, Jos J Immerzeel, Sandrine M G van de Pol, Charles G H J Niël, Robert A J Kattevilder, Tonnis T Nuver, André W Minken, Marinus A Moerland
PURPOSE: To evaluate adaptive planning for permanent prostate brachytherapy and to identify the prostate regions that needed adaptation. METHODS AND MATERIALS: After the implantation of stranded seeds, using real-time intraoperative planning, a transrectal ultrasound (TRUS)-scan was obtained and contoured. The positions of seeds were determined on a C-arm cone-beam Computed Tomography (CBCT)-scan. The CBCT-scan was registered to the TRUS-scan using fiducial gold markers...
February 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28190784/intraoperative-factors-associated-with-stranded-source-placement-accuracy-in-low-dose-rate-prostate-brachytherapy
#19
M F Jamaluddin, S Ghosh, M P Waine, M Tavakoli, J Amanie, A D Murtha, D Yee, N Usmani
PURPOSE: The quality of a low-dose rate prostate brachytherapy implant depends on the accurate placement of sources in their planned locations. This study investigates intraoperative factors that potentially contribute to stranded source placement inaccuracy in prostate brachytherapy. METHODS AND MATERIALS: Intraoperative video images of the brachytherapist's hand motions and needle insertions during the implant procedure were acquired for analysis. Using video analysis software, maximum and average needle insertion velocities were determined...
February 10, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28190783/a-retrospective-analysis-of-catheter-based-sources-in-intravascular-brachytherapy
#20
J DeCunha, C Janicki, S A Enger
PURPOSE: Coronary artery disease involves the deposition of plaque along the walls of a coronary artery leading to narrowed or blocked vessels (stenosis) and is one of the main causes of death in developed countries. Percutaneous transluminal coronary angioplasty (PTCA) is used to reverse stenosis. Restenosis (renarrowing) of the treated vessel is a major complication of PTCA. A metal mesh tube (stent) can be placed inside the vessel to prevent restenosis. Tissue stress incurred during PTCA and stenting can provoke neointimal cell proliferation leading to in-stent restenosis (ISR)...
February 10, 2017: Brachytherapy
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