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https://www.readbyqxmd.com/read/29746300/impact-of-glycemic-status-on-longitudinal-cognitive-performance-in-men-with-and-without-hiv-infection
#1
Jingyan Yang, Lisa P Jacobson, James T Becker, Andrew Levine, Eileen M Martin, Cynthia A Munro, Frank J Palella, Jordan E Lake, Ned C Sacktor, Todd T Brown
OBJECTIVES: To determine the relationship between glycemic status and cognitive performance in men living with (MLWH) and without HIV infection. DESIGN: A prospective HIV/AIDS cohort study in four U.S. cities between 1999 and 2016. METHODS: Glycemic status was categorized as normal glucose (NG), impaired fasting glucose (IFG), controlled diabetes mellitus (DM) and uncontrolled DM at each semi-annual visit. Cognitive performance was evaluated using nine neuropsychological tests which measure attention, constructional ability, verbal learning, executive functioning, memory, and psychomotor speed...
May 8, 2018: AIDS
https://www.readbyqxmd.com/read/29739366/angiocentric-lymph-proliferative-disorder-lymphomatoid-granulomatosis-in-a-person-with-newly-diagnosed-hiv-infection-a-case-report
#2
Cecilia T Costiniuk, Jason Karamchandani, Ali Bessissow, Jean-Pierre Routy, Jason Szabo, Charles Frenette
BACKGROUND: Angiocentric lymph proliferative disorder (ALPD) is a granulomatous lymphoproliferative condition associated with various primary and secondary immunodeficiency states. ALPD is so rare that its prevalence has not been established. Typically affecting middle-aged adults, this condition is often found in the context of Epstein Bar Virus infection and consists of angiocentric and angioinvasive pulmonary infiltrates. Herein, we present a biopsy-proven case of a patient manifesting with a viral meningoencephalomyelitis-like picture with brain, spinal cord, renal and splenic lesions...
May 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29731256/antiretroviral-therapy-potentiates-high-fat-diet-induced-obesity-and-glucose-intolerance
#3
Mark E Pepin, Lindsey E Padgett, Ruth E McDowell, Ashley R Burg, Manoja K Brahma, Cassie Holleman, Teayoun Kim, David Crossman, Olaf Kutsch, Hubert M Tse, Adam R Wende, Kirk M Habegger
OBJECTIVE: Breakthroughs in HIV treatment, especially combination antiretroviral therapy (ART), have massively reduced AIDS-associated mortality. However, ART administration amplifies the risk of non-AIDS defining illnesses including obesity, diabetes, and cardiovascular disease, collectively known as metabolic syndrome. Initial reports suggest that ART-associated risk of metabolic syndrome correlates with socioeconomic status, a multifaceted finding that encompasses income, race, education, and diet...
April 20, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29684319/lipid-accumulation-product-index-in-hiv-infected-patients-a-marker-of-cardiovascular-risk
#4
Milena Maria Moreira Guimarães, Dirceu Bartolomeu Greco, Allyson Nogueira Moreira, Nathalia Sernizon Guimarães, Cláudia Maria Vilas Freire, Bruna Guimarães Rolfs, Lucas José de Campos Machado
The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels...
April 20, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29672576/malnutrition-and-lipid-abnormalities-in-antiretroviral-na%C3%A3-ve-hiv-infected-adults-in-addis-ababa-a-cross-sectional-study
#5
Melaku Adal, Rawleigh Howe, Desta Kassa, Abraham Aseffa, Beyene Petros
BACKGROUND: Both under- and over-nutrition may occur among human immunodeficiency virus (HIV)-infected individuals and impact on the course of the acquired immune deficiency syndrome (AIDS) and its management due to the close interaction between immunity and nutrition. We investigated occurrence of undernutrition, excess weight and lipid abnormalities among antiretroviral naïve HIV-infected adults in Addis Ababa, Ethiopia. METHODS: A cross-sectional study on 594 antiretroviral therapy (ART) naïve HIV-infected adults was conducted in four hospitals in Addis Ababa from February to September 2013...
2018: PloS One
https://www.readbyqxmd.com/read/29529066/type-2-diabetes-prevalence-and-its-risk-factors-in-hiv-a-cross-sectional-study
#6
Alastair D Duncan, Louise M Goff, Barry S Peters
BACKGROUND: Type 2 diabetes (T2D) has a reported greater prevalence and poorer treatment outcomes in people living with HIV (PLWH) than comparable HIV-uninfected cohorts. We conducted a cross-sectional study to delineate the factors driving T2D in PLWH in an ethnically diverse cohort, and additionally observed how these have changed over time. SETTING: We studied a diverse HIV cohort in London to determine the prevalence and risk factors for T2D, and compared them to a cohort studied 10 years previously...
2018: PloS One
https://www.readbyqxmd.com/read/29483948/prevalence-and-predictors-of-metabolic-syndrome-among-people-living-with-human-immunodeficiency-virus-plwhiv
#7
Dula Dessalegn Bosho, Lemessa Dube, Teshale Ayele Mega, Dawit Abera Adare, Mikyas Gashaw Tesfaye, Tesfahun Chanie Eshetie
Background: Use of combination antiretroviral therapy (cART) has led to significant reductions in morbidity and mortality. However, there is a growing concern about metabolic syndromes (MS), among patients receiving cART. Despite this fact, there is limited evidence for the prevalence of the MS among HIV-infected persons receiving cART in developing countries, particularly Ethiopia. Objective: To determine the prevalence and predictors of MS among people living with HIV/AIDS in Jimma health centre, Jimma Zone south west Ethiopia...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29482352/dolutegravir-plus-rilpivirine-as-a-switch-option-in-cart-experienced-patients-96-week-data
#8
Amedeo Ferdinando Capetti, Maria Vittoria Cossu, Gaetana Sterrantino, Giorgio Barbarini, Simona Di Giambenedetto, Giuseppe Vittorio De Socio, GianCarlo Orofino, Antonio Di Biagio, Benedetto M Celesia, Stefano Rusconi, Barbara Argenteri, Giuliano Rizzardini
BACKGROUND: Data from clinical studies confirm the efficacy of switching to dolutegravir (DTG) plus rilpivirine (RPV) in selected patients. OBJECTIVE: The primary objective is to report the 96-week virological suppression in our cohort, assessing the durability of this strategy in complicated situations. The secondary objective is to describe the safety and metabolic profile. METHODS: All patients who had switched to DTG plus RPV between October 1, 2014, and September 30, 2015, were analyzed using a retrospective-prospective design, approved by ethics committees...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29451987/association-of-adiponectin-leptin-ratio-with-carbohydrate-and-lipid-metabolism-parameters-in-hiv-infected-patients-during-antiretroviral-therapy
#9
Catalin Tiliscan, Victoria Arama, Raluca Mihailescu, Daniela Munteanu, Diana Gabriela Iacob, Cristina Popescu, Remulus Catana, Anca Negru, Alina Lobodan, Stefan Sorin Arama
BACKGROUND: Adiponectin and leptin are adipose tissue hormones that regulate important lipid and glucose metabolic pathways. Our objective was to evaluate the interplay of these hormones described by the adiponectin/leptin ratio (ALR) in correlation to lipid and carbohydrate metabolism parameters in nondiabetic HIV-infected patients during antiretroviral therapy (ART). MATERIALS AND METHODS: We enrolled consecutive nondiabetic patients with confirmed HIV infection, undergoing stable ART regimens for at least six months...
February 16, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29425211/effectiveness-of-a-bioactive-food-compound-in-anthropometric-measures-of-individuals-with-hiv-aids-a-nonrandomized-trial
#10
Rosângela Dos Santos Ferreira, Rita de Cássia Avellaneda Guimarães, Elenir Rose Jardim Cury Pontes, Lígia Aurélio Bezerra Maranhão Mendonça, Karine de Cássia Freitas, Priscila Aiko Hiane
BACKGROUND: Highly Active Antiretroviral therapy (HAART) promotes anthropometric changes in lipid metabolism and glucose in patients with Human Immunodeficiency Virus (HIV). Functional foods play an important role on metabolism. Bioactive Food Compound (BFC) has shown effective results in changes arising from decompensated lipid metabolism due to the effects of HAART on HIV patients. From this perspective, the objective of this study is to evaluate anthropometric indicators and the body composition of patients undergoing HAART before and after consumption of BFC...
2018: PloS One
https://www.readbyqxmd.com/read/29406430/brief-report-abacavir-lamivudine-and-tenofovir-emtricitabine-in-pregnant-women-with-hiv-laboratory-and-clinical-outcomes-in-an-observational-national-study
#11
Marco Floridia, Carmela Pinnetti, Marina Ravizza, Giulia Masuelli, Carlo Personeni, Matilde Sansone, Anna Degli Antoni, Giovanni Guaraldi, Arsenio Spinillo, Beatrice Tassis, Serena Dalzero, Giuseppina Liuzzi, Enrica Tamburrini
BACKGROUND: Abacavir-lamivudine (ABC/3TC) and tenofovir-emtricitabine (TDF/FTC) represent in the guidelines of several countries, including Italy and United States, the preferred nucleoside/nucleotide backbones of antiretroviral regimens. We assessed their profile in pregnancy using data from a national observational study. METHODS: Laboratory measures (CD4, HIV-RNA, lipid profile, glucose, hemoglobin, and alanine transferase) and pregnancy outcomes (preterm delivery, low birthweight, nonelective cesarean section, birthweight Z-score, congenital defects, HIV transmission, maternal weight gain, and pregnancy complications) were compared after prenatal exposure to ABC/3TC or TDF/FTC...
May 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29389978/dendritic-cell-immunotherapy-followed-by-cart-interruption-during-hiv-1-infection-induces-plasma-protein-markers-of-cellular-immunity-and-neutrophil-recruitment
#12
Henk-Jan van den Ham, Jason D Cooper, Jakub Tomasik, Sabine Bahn, Joeri L Aerts, Albert D M E Osterhaus, Rob A Gruters, Arno C Andeweg
OBJECTIVES: To characterize the host response to dendritic cell-based immunotherapy and subsequent combined antiretroviral therapy (cART) interruption in HIV-1-infected individuals at the plasma protein level. DESIGN: An autologous dendritic cell (DC) therapeutic vaccine was administered to HIV-infected individuals, stable on cART. The effect of vaccination was evaluated at the plasma protein level during the period preceding cART interruption, during analytical therapy interruption and at viral reactivation...
2018: PloS One
https://www.readbyqxmd.com/read/29325542/visceral-adipose-tissue-and-carotid-intima-media-thickness-in-hiv-infected-patients-undergoing-cart-a-prospective-cohort-study
#13
Maria Teresa Beires, André Silva-Pinto, Ana Cristina Santos, António José Madureira, Jorge Pereira, Davide Carvalho, António Sarmento, Paula Freitas
BACKGROUND: Combined antiretroviral therapy (cART) in HIV-infected patients has been associated with lipodystrophy, metabolic abnormalities, and an increased risk of cardiovascular disease. Ultrasound measures of carotid artery intima-media thickness (cIMT) have been used as a valid measure of subclinical atherosclerosis and as a tool to predict the risk of cardiovascular events. Our aim was to evaluate the progression of cIMT in HIV-infected patients subjected to cART, with and without lipodystrophy, over a one-year period...
January 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29320547/dyslipidemia-chronic-inflammation-and-subclinical-atherosclerosis-in-children-and-adolescents-infected-with-hiv-the-posithive-health-study
#14
Luiz Rodrigo Augustemak de Lima, Edio Luiz Petroski, Yara Maria Franco Moreno, Diego Augusto Santos Silva, Erasmo Benício de Moraes Santos Trindade, Aroldo Prohmann de Carvalho, Isabela de Carlos Back
HIV-infected children and adolescents may be at risk for cardiovascular disease due to chronic inflammation and exacerbation of risk factors. The aim of this study was as follows: 1) compare cardiovascular risk factors, chronic inflammation, and carotid intima-media thickness (IMTc) between the HIV and control groups; 2) determine the association of HIV and antiretroviral (ART) regimens with cardiovascular risk factors, chronic inflammation, and IMTc; and 3) identify variables associated with elevated IMTc...
2018: PloS One
https://www.readbyqxmd.com/read/29238337/the-role-of-type-2-diabetes-for-the-development-of-pathogen-associated-cancers-in-the-face-of-the-hiv-aids-epidemic
#15
REVIEW
Melissa J Blumenthal, Sylvia Ujma, Arieh A Katz, Georgia Schäfer
The contribution of HIV to the development of pathogen-associated cancers has long been recognized, as has the contribution of type 2 diabetes for the development of several types of cancer. While HIV/AIDS-associated immunosuppression reduces immunosurveillance and indirectly contributes favorably to cancerogenesis, diabetes directly increases cancer development due to chronic low-grade inflammation, dysregulated glucose metabolism, hyperactivation of insulin-responsive pathways, and anti-apoptotic signaling...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29197988/impact-of-circulating-bacterial-dna-in-long-term-glucose-homeostasis-in-non-diabetic-patients-with-hiv-infection-cohort-study
#16
Ó Moreno-Pérez, L Giner, S Reus, V Boix, R Alfayate, R Frances, E Merino, A Pico, J Portilla
In HIV-infected patients, the damage in the gut mucosal immune system is not completely restored after antiretroviral therapy (ART). It results in microbial translocation, which could influence the immune and inflammatory response. We aimed at investigating the long-term impact of bacterial-DNA translocation (bactDNA) on glucose homeostasis in an HIV population. This was a cohort study in HIV-infected patients whereby inclusion criteria were: patients with age >18 years, ART-naïve or on effective ART (<50 HIV-1 RNA copies/mL) and without diabetes or chronic hepatitis C...
February 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29189659/high-prevalence-of-lipid-abnormalities-and-insulin-resistance-among-antiretroviral-na%C3%A3-ve-hiv-infected-children-in-india
#17
C Padmapriyadarsini, Anita Shet, R Srinivasan, Geetha Ramachandran, G N Sanjeeva, Poornaganga Devi, K Ramesh, Perumal K Bhavani, Devaraj Reddy, E Suresh, C Chandrasekhar, Christine Wanke, Soumya Swaminathan
BACKGROUND: As large numbers of children are accessing antiretroviral therapy (ART) in India, we evaluated the dietary intake, growth pattern and risk of metabolic complications like dyslipidemia and insulin resistance among ART-naïve HIV-infected children (CLHIV). METHODS: CLHIV 2-12 years of age, at the time of initiating ART in Chennai and Bangalore, were assessed for their dietary intake, anthropometry, blood CD4 cell count, HIV-1 viral load, fasting serum lipids, glucose and insulin...
March 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29160443/body-fat-redistribution-and-changes-in-lipid-and-glucose-metabolism-in-people-living-with-hiv-aids
#18
Rebeca Antunes Beraldo, André Pereira Dos Santos, Mariana Palma Guimarães, Helena Siqueira Vassimon, Francisco José Albuquerque de Paula, Dalmo Roberto Lopes Machado, Maria Cristina Foss-Freitas, Anderson Marliere Navarro
INTRODUCTION: The HIV lipodystrophy syndrome is characterized by changes in metabolism, and body composition that increase cardiovascular risk of people living with HIV/AIDS (PLWHA) using highly active antiretroviral therapy (HAART). OBJECTIVE: To assess the prevalence of lipodystrophy and changes in lipid and glucose metabolism in PLWHA in use of HAART. METHODS: For the anthropometric evaluation we measured weight, height and abdominal circumference (AC)...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29121676/naringin-prevents-hiv-1-protease-inhibitors-induced-metabolic-complications-in-vivo
#19
Sanelisiwe Nzuza, Sindiswa Zondi, Peter M O Owira
BACKGROUND: Insulin resistance, glucose intolerance and overt diabetes are known metabolic complications associated with chronic use of HIV-Protease Inhibitors. Naringin is a grapefruit-derived flavonoid with anti-diabetic, anti-dyslipidemia, anti-inflammatory and anti-oxidant activities. OBJECTIVES: The study investigated the protective effects of naringin on glucose intolerance and impaired insulin secretion and signaling in vivo. METHODS: Male Wistar rats were divided into six groups (n = 6) and were daily orally treated with distilled water {3...
2017: PloS One
https://www.readbyqxmd.com/read/29121661/high-prevalence-of-non-communicable-diseases-and-associated-risk-factors-amongst-adults-living-with-hiv-in-cambodia
#20
Pheak Chhoun, Sovannary Tuot, Anthony D Harries, Nang Thu Thu Kyaw, Khuondyla Pal, Phalkun Mun, Carrine Brody, Gitau Mburu, Siyan Yi
BACKGROUND: With rapid expansion of antiretroviral therapy for HIV, there are rising life expectancies among people living with HIV. As a result, co-morbidity from non-communicable diseases in those living and aging with HIV is increasingly being reported. Published data on this issue have been limited in Cambodia. The aim of this study was to determine the prevalence of diabetes mellitus, hypertension and hypercholesterolemia and associated risk factors in adults living with HIV in Cambodia...
2017: PloS One
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