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https://www.readbyqxmd.com/read/29036688/a-cell-penetrating-antibody-inhibits-human-rad51-via-direct-binding
#1
Audrey Turchick, Denise C Hegan, Ryan B Jensen, Peter M Glazer
RAD51, a key factor in homology-directed repair (HDR), has long been considered an attractive target for cancer therapy, but few specific inhibitors have been found. A cell-penetrating, anti-DNA, lupus autoantibody, 3E10, was previously shown to inhibit HDR, sensitize tumors to radiation, and mediate synthetic lethal killing of BRCA2-deficient cancer cells, effects that were initially attributed to its affinity for DNA. However, as the molecular basis for its ability to inhibit DNA repair, we report that 3E10 directly binds to the N-terminus of RAD51, sequesters RAD51 in the cytoplasm, and impedes RAD51 binding to DNA...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29026277/novel-splice-site-mutation-in-gata3-in-a-patient-with-hdr-syndrome
#2
Kumihiro Matsuo, Arisa Kobayashi, Yusuke Tanahashi, Satoko Maruyama, Yoshihiro Niitsu, Hidenori Katsuta, Akiko Furuya, Shigeru Suzuki, Mitsunobu Kawamura, Hiroshi Azuma
No abstract text is available yet for this article.
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29025280/effects-of-prenatal-ppar-%C3%AE-agonist-rosiglitazone-exposure-on-rat-hippocampus-development-in-a-time-dependent-manner-a-stereological-and-histopathological-study
#3
D Sağır, B Eren, B D Yılmaz, Z Eren, O N Keleş, A B Gökçe
Rosiglitazone is in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes mellitus. It works as an insulin sensitizer by binding to the peroxisome proliferator-activated receptor gamma. We investigated the effects of prenatally administered rosiglitazone on pyramidal cell numbers and morphologies in the hippocampus at postnatal period using histochemical and stereological techniques, congenital morphological properties and the number of offspring in rats. Eighteen female rats were grouped into control (C), low-dose rosiglitazone (LDR) and high-dose rosiglitazone (HDR)...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29025137/hypoparathyroidism-deafness-renal-dysplasia-hdr-syndrome-gata3
#4
Marisa Horta, Carlos Lino, Manuel C Lemos
No abstract text is available yet for this article.
September 4, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28993108/evaluation-of-interfractional-variation-of-organs-and-displacement-of-catheters-during-high-dose-rate-interstitial-brachytherapy-for-gynecologic-malignancies
#5
Soyoung Lee, Ellis Rodney, Bryan Traughber, Tithi Biswas, Valdir Colussi, Tarun Podder
PURPOSE: To investigate the dosimetric effects due to interfractional changes in catheter position and variation in patient's anatomy during the course of interstitial high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: A total of 15 patients with either cervical or vaginal cancer underwent interstitial HDR brachytherapy. Interstitial catheters and fiducials were placed under fluoroscopy and intraoperative 3T MRI to confirm the desired catheter placement for adequate target volume coverage...
October 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28985508/methods-and-applications-of-crispr-mediated-base-editing-in-eukaryotic-genomes
#6
REVIEW
Gaelen T Hess, Josh Tycko, David Yao, Michael C Bassik
The past several years have seen an explosion in development of applications for the CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to recruitment of a range of DNA and chromatin-modifying enzymes. While homology-directed repair (HDR) coupled with Cas9 nuclease cleavage has been used with great success to repair and re-write genomes, recently developed base-editing systems present a useful orthogonal strategy to engineer nucleotide substitutions. Base editing relies on recruitment of cytidine deaminases to introduce changes (rather than double-stranded breaks and donor templates) and offers potential improvements in efficiency while limiting damage and simplifying the delivery of editing machinery...
October 5, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28984277/a-multicentre-audit-of-hdr-pdr-brachytherapy-absolute-dosimetry-in-association-with-the-interlace-trial-nct015662405
#7
Patricia Diez, Edwin G A Aird, Thorsten Sander, Clare A Gouldstone, Peter H G Sharpe, Christopher D Lee, Gerry Lowe, Russell A S Thomas, Tania Simnor, Peter Bownes, A Margaret Bidmead, Laura Gandon, David J Eaton, Antony L Palmer
A UK multicentre audit to evaluate HDR and PDR brachytherapy has been performed using alanine absolute dosimetry. This is the first national UK audit performing an absolute dose measurement at a clinically relevant distance (20 mm) from the source. It was performed in both INTERLACE (a phase III multicentre trial in cervical cancer) and non-INTERLACE brachytherapy centres treating gynaecological tumours. Forty-seven UK centres (including the National Physical Laboratory) were visited. A simulated line source was generated within each centre's treatment planning system and dwell times calculated to deliver 10 Gy at 20 mm from the midpoint of the central dwell (representative of Point A of the Manchester system)...
October 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28969957/reference-conditions-for-ion-chamber-based-hdr-brachytherapy-dosimetry-and-for-the-calibration-of-high-resolution-solid-detectors
#8
Andreas A Schoenfeld, Katrin Büsing, Björn Delfs, Ndimofor Chofor, Ping Jiang, Dietrich Harder, Björn Poppe, Kay C Willborn
The aim of this study has been to develop a two-step method of in-phantom dosimetry around a brachytherapy (192)Ir photon source. The first step is to measure the absorbed dose rate to water with a calibrated ionization chamber under reference conditions, the second to cross-calibrate, under these conditions, small solid-state detectors such as silicon diodes, synthetic diamond or scintillation detectors suited for spatially resolved dose rate measurements at other, particularly at smaller source axis distances in the water phantom...
September 29, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28967561/the-validity-of-acuros-bv-and-tg-43-for-high-dose-rate-brachytherapy-superficial-mold-treatments
#9
Eeva L Boman, Thomas W S Satherley, Nanette Schleich, Dean B Paterson, Lynne Greig, Rob J W Louwe
PURPOSE: The purpose of this work is to validate the Acuros BV dose calculation algorithm for high-dose-rate (HDR) brachytherapy superficial mold treatments in the absence of full scatter conditions and compare this with TG-43 dose calculations. We also investigate the impact of additional back scatter material (bolus) applied above surface molds to the dose distributions under the mold. METHODS AND MATERIALS: The absorbed dose at various depths was compared for simulations performed using either TG-43 or Acuros BV dose calculations...
September 26, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28964727/semiconductor-real-time-quality-assurance-dosimetry-in-brachytherapy
#10
REVIEW
Mauro Carrara, Dean Cutajar, Saree Alnaghy, Anthony Espinoza, Anna Romanyukha, Stefano Presilla, Chiara Tenconi, Annamaria Cerrotta, Carlo Fallai, Mitra Safavi-Naeini, Marco Petasecca, Alannah Kejda, Michael Lerch, Stéphanie Corde, Michael Jackson, Andrew Howie, Joseph Bucci, Anatoly B Rosenfeld
With the increase in complexity of brachytherapy treatments, there has been a demand for the development of sophisticated devices for delivery verification. The Centre for Medical Radiation Physics (CMRP), University of Wollongong, has demonstrated the applicability of semiconductor devices to provide cost-effective real-time quality assurance for a wide range of brachytherapy treatment modalities. Semiconductor devices have shown great promise to the future of pretreatment and in vivo quality assurance in a wide range of brachytherapy treatments, from high-dose-rate (HDR) prostate procedures to eye plaque treatments...
September 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28958736/image-guided-high-dose-rate-intracavitary-brachytherapy-in-the-treatment-of-medically-inoperable-early-stage-endometrioid-type-endometrial-adenocarcinoma
#11
Scott E Jordan, Ida Micaily, Enrique Hernandez, J Stuart Ferriss, Curtis T Miyamoto, Shidong Li, Bizhan Micaily
PURPOSE: The purpose of this case series is to describe the treatment and outcomes of a cohort of patients with inoperable early-stage endometrioid endometrial cancer with 3D image-guided high-dose-rate (HDR) intracavitary brachytherapy. MATERIALS AND METHODS: A review was performed of patients with early-stage endometrial cancer who underwent primary radiation treatment between 2010 and 2016. Staging and treatment planning were performed CT, pelvic ultrasound, and pelvic MRI...
September 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28958735/an-integrated-system-for-clinical-treatment-verification-of-hdr-prostate-brachytherapy-combining-source-tracking-with-pretreatment-imaging
#12
Ryan L Smith, Max Hanlon, Vanessa Panettieri, Jeremy L Millar, Bronwyn Matheson, Annette Haworth, Rick D Franich
PURPOSE: High-dose-rate (HDR) prostate brachytherapy treatment is usually delivered in one or a few large dose fractions. Poor execution of a planned treatment could have significant clinical impact, as high doses are delivered in seconds, and mistakes in an individual fraction cannot be easily rectified. Given that most potential errors in HDR brachytherapy ultimately lead to a geographical miss, a more direct approach to verification of correct treatment delivery is to directly monitor the position of the source throughout the treatment...
September 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28951756/inflatable-multichannel-rectal-applicator-for-adaptive-image-guided-endoluminal-high-dose-rate-rectal-brachytherapy-design-dosimetric-characteristics-and-first-clinical-experiences
#13
Maximilian P Schmid, Daniel Berger, Martin Heilmann, Jessica Bör, Bernd Wisgrill, Ursula Azizi-Semrad, Nicole Nesvacil, Richard Pötter, Christian Kirisits, Rainer Schmid
PURPOSE: To investigate the dosimetric results and first clinical experiences with a new designed balloon applicator with adjustable catheters for endoluminal brachytherapy for patients with locally advanced rectal cancer not undergoing surgery. MATERIAL AND METHODS: The applicator consists of an inflatable rectal balloon with six attached Foley catheters used as guidance for the inserted brachytherapy plastic needles. The construction of the applicator and the dosimetric profile in terms of representative dose points in 0, 2, 5, 10 mm ipsilaterally and in 0 mm contralaterally are described...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28951755/automated-calculation-of-point-a-coordinates-for-ct-based-high-dose-rate-brachytherapy-of-cervical-cancer
#14
Hyejoo Kang, Laura Padilla, Yasmin Hasan, Hania Al-Hallaq
PURPOSE: The goal is to develop a stand-alone application, which automatically and consistently computes the coordinates of the dose calculation point recommended by the American Brachytherapy Society (i.e., point A) based solely on the implanted applicator geometry for cervical cancer brachytherapy. MATERIAL AND METHODS: The application calculates point A coordinates from the source dwell geometries in the computed tomography (CT) scans, and outputs the 3D coordinates in the left and right directions...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28951754/assessing-dose-contribution-to-pelvic-lymph-nodes-in-intracavitary-brachytherapy-for-cervical-cancer
#15
Gail Wan Ying Chua, Yong Wee Foo, Guan Heng Tay, David Boon Harn Tan
PURPOSE: In radical radiotherapy for cervical cancer, high-dose-rate (HDR) brachytherapy is commonly used after external beam radiation therapy (EBRT) to deliver a cumulative EQD2 of 80 to 90 Gy to the primary tumor. However, there is less certainty regarding brachytherapy dose contribution to the pelvic lymph nodes. This poses a challenge as to how high a preceding EBRT dose should be prescribed to gross nodal disease, in order to achieve a cumulative tumoricidal effect. Hence, this study aims to quantify brachytherapy dose contribution to individual pelvic nodal groups, using computed tomography (CT) planning with the Manchester system...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28951751/adjuvant-high-dose-rate-brachytherapy-in-the-management-of-oral-cavity-cancers-5-years-of-experience-in-iran
#16
Ali Kazemian, Mohammad Babaei, Marzieh Lashkari, Reza Ghalehtaki, Ata Garajei, Maziar Motiee-Langroudi, Ahmadreza Sebzari, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mahdi Aghili
PURPOSE: Brachytherapy is a cost-effective method for the management of oral cavity cancers in low to middle income countries. We aimed to evaluate the clinical outcomes of high-dose-rate interstitial brachytherapy (HDR-IBT) in patients with oral cavity cancer. MATERIAL AND METHODS: From 2009 to 2013, 78 patients (49 combined external beam radiotherapy [EBRT] plus IBT and 29 IBT monotherapy) with oral cavity cancers had been treated in our center. Slightly more than half the patients were male, and the median age was 54 years...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28940520/direction-modulated-brachytherapy-dmbt-for-treatment-of-cervical-cancer-a-planning-study-with-192ir-60co-and-169yb-hdr-sources
#17
Habib Safigholi, Dae Yup Han, Shahram Mashouf, Abraam Soliman, Ali S Meigooni, Amir Owrangi, William Y Song
PURPOSE: To evaluate plan quality of a novel MRI-compatible direction modulated brachytherapy (DMBT) tandem applicator using 192Ir, 60Co, and 169Yb HDR brachytherapy sources, for various cervical cancer high-risk clinical target volumes (CTVHR ). MATERIALS AND METHODS: The novel DMBT tandem applicator has six peripheral grooves of 1.3-mm diameter along a 5.4-mm thick nonmagnetic tungsten alloy rod. Monte Carlo (MC) simulations were used to benchmark the dosimetric parameters of the 192Ir, 60Co, and 169Yb HDR sources in a water phantom against the literature data...
September 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28935450/needle-migration-and-dosimetric-impact-in-high-dose-rate-brachytherapy-for-prostate-cancer-evaluated-by-repeated-mri
#18
Simon Buus, Maria Lizondo, Steffen Hokland, Susanne Rylander, Erik M Pedersen, Kari Tanderup, Lise Bentzen
PURPOSE: To quantify needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer and propose a threshold for needle migration. METHODS AND MATERIALS: Twenty-four high-risk prostate cancer patients treated with an HDR boost of 2 × 8.5 Gy were included. Patients received an MRI for planning (MRI1), before (MRI2), and after treatment (MRI3). Time from needle insertion to MRI3 was ∼3 hours. Needle migration was evaluated from coregistered images: MRI1-MRI2 and MRI1-MRI3...
September 18, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28934238/a-tool-to-automatically-analyze-electromagnetic-tracking-data-from-high-dose-rate-brachytherapy-of-breast-cancer-patients
#19
Th I Götz, G Lahmer, V Strnad, Ch Bert, B Hensel, A M Tomé, E W Lang
During High Dose Rate Brachytherapy (HDR-BT) the spatial position of the radiation source inside catheters implanted into a female breast is determined via electromagnetic tracking (EMT). Dwell positions and dwell times of the radiation source are established, relative to the patient's anatomy, from an initial X-ray-CT-image. During the irradiation treatment, catheter displacements can occur due to patient movements. The current study develops an automatic analysis tool of EMT data sets recorded with a solenoid sensor to assure concordance of the source movement with the treatment plan...
2017: PloS One
https://www.readbyqxmd.com/read/28933084/-cloning-and-bioinformatics-analysis-of-1-hydroxy-2-methyl-2-e-butenyl-4-diphosphate-reductase%C3%AF-pchdr1%C3%AF-gene-in-phlegmarirus-carinatus
#20
Zhi-Li Zhang, Hai-Zhou Lv, Xu Guo, Liu He, Jing-Yuan Song, Chao Sun, Hong-Mei Luo
The open reading frame of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (HDR) was cloned from Phlegmarirus carinatus by RT-PCR method and the sequence was analyzed by bioinformatics tools. After searching the transcriptome dataset of P. carinatus, one unique sequence encoding 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase was discovered. The primers were designed according to the cDNA sequence of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase from the dataset. And then, the open reading frame (ORF) of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, named as PcHDR1 (GenBank Accession number:JQ957845), was cloned by RT-PCR strategy with the template of mixed RNA extracted from roots, stem and leaf of P...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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