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Effectiveness of applied behavior analysis

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https://www.readbyqxmd.com/read/29331859/development-of-a-method-to-determine-axitinib-lapatinib-and-afatinib-in-plasma-by-micellar-liquid-chromatography-and-validation-by-the-european-medicines-agency-guidelines
#1
Jaume Albiol-Chiva, Josep Esteve-Romero, Juan Peris-Vicente
A method based on micellar liquid chromatography to quantify the tyrosine kinase inhibitors axitinib, lapatinib and afatinib in plasma is reported. The sample pretreatment was a simple 1/5-dilution in a pure micellar solution, filtration and direct injection, without requiring extraction or purification steps. The three drugs were resolved from the matrix in 17min, using an aqueous solution of 0.07M sodium dodecyl sulfate - 6.0% 1-pentanol, buffered at pH7 with 0.01M phosphate salt as mobile phase, running under isocratic mode at 1mL/min through a C18 column...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29331779/superior-peroxidase-mimetic-activity-of-tungsten-disulfide-nanosheets-silver-nanoclusters-composite-colorimetric-fluorometric-and-electrochemical-studies
#2
Alireza Khataee, Mahsa Haddad Irani-Nezhad, Javad Hassanzadeh, Sang Woo Joo
Developing a novel peroxidase nano-mimetic is a challenging research topic in biosensing field. Herein, WS2 nanosheets (WS2 NS) decorated with silver nanoclusters (AgNCs) was introduced as a new nanocomposite with improved peroxidase mimetic behavior. WS2 NS/AgNCs nanocomposite was synthesized by simple chemical reduction of silver cations in the presence of WS2 NS. The enhanced catalytic activity of nanocomposite in chemical and electrochemical reduction of H2O2 was studied using colorimetry, fluorometry and electrochemical techniques...
January 4, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29329214/analysis-of-emission-effects-related-to-drivers-compliance-rates-for-cooperative-vehicle-infrastructure-system-at-signalized-intersections
#3
Ruohua Liao, Xumei Chen, Lei Yu, Xiaofei Sun
Unknown remaining time of signal phase at a signalized intersection generally results in extra accelerations and decelerations that increase variations of operating conditions and thus emissions. A cooperative vehicle-infrastructure system can reduce unnecessary speed changes by establishing communications between vehicles and the signal infrastructure. However, the environmental benefits largely depend on drivers' compliance behaviors. To quantify the effects of drivers' compliance rates on emissions, this study applied VISSIM 5...
January 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29329098/effect-of-organic-amendments-on-cadmium-stress-to-pea-a-multivariate-comparison-of-germinating-vs-young-seedlings-and-younger-vs-older-leaves
#4
Saliha Shamshad, Muhammad Shahid, Marina Rafiq, Sana Khalid, Camille Dumat, Muhammad Sabir, Behzad Murtaza, Abu Bakr Umer Farooq, Noor S Shah
Despite significant recent advancement in research, biogeochemical behavior of heavy metals with respect to their applied form is still topical. Moreover, metal toxicity to plants may vary with their stage of development/maturity. Therefore, this study for the first time evaluated the influence of ethylenediaminetetraacetic acid (EDTA) and citric acid (CA) on cadmium (Cd) accumulation and toxicity to germinating and young pea seedlings as well as in younger and older leaves. The experimental setup of current study consisted of two separate studies...
January 9, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29327424/the-choreography-of-group-affiliation
#5
Jorina von Zimmermann, Staci Vicary, Matthias Sperling, Guido Orgs, Daniel C Richardson
When two people move in synchrony, they become more social. Yet it is not clear how this effect scales up to larger numbers of people. Does a group need to move in unison to affiliate, in what we term unitary synchrony; or does affiliation arise from distributed coordination, patterns of coupled movements between individual members of a group? We developed choreographic tasks that manipulated movement synchrony without explicitly instructing groups to move in unison. Wrist accelerometers measured group movement dynamics and we applied cross-recurrence analysis to distinguish the temporal features of emergent unitary synchrony (simultaneous movement) and distributed coordination (coupled movement)...
January 12, 2018: Topics in Cognitive Science
https://www.readbyqxmd.com/read/29324567/electronic-health-record-implementation-findings-at-a-large-suburban-health-and-human-services-department
#6
Kenyon Crowley, Anubhuti Mishra, Raul Cruz-Cano, Robert Gold, Dushanka Kleinman, Ritu Agarwal
OBJECTIVE: Evaluate an electronic health record (EHR) implementation across a large public health department to better understand and improve implementation effectiveness of EHRs in public health departments. DESIGN: A survey based on Consolidated Framework for Implementation Research constructs was administered to staff before and after implementation of an EHR. SETTING: Large suburban county department of health and human services that provides clinical, behavioral, social, and oral health services...
January 10, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29319154/achieving-socially-significant-reductions-in-problem-behavior-following-the-interview-informed-synthesized-contingency-analysis-a-summary-of-25-outpatient-applications
#7
Joshua Jessel, Einar T Ingvarsson, Rachel Metras, Hillary Kirk, Ruth Whipple
Jessel, Hanley, and Ghaemmaghami (2016) reported the results of 30 interview-informed, synthesized contingency analyses (IISCAs) and found the IISCAs to be an effective tool for identifying the functions of problem behavior across a variety of topographies, participants, and settings. Jessel et al. did not, however, include data on the effectiveness of the corresponding treatments. In the current study, we collected and summarized 25 additional applications, from analysis to treatment, in which the IISCA was applied in an outpatient clinic...
January 10, 2018: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/29316911/the-standardized-withania-somnifera-dunal-root-extract-alters-basal-and-morphine-induced-opioid-receptor-gene-expression-changes-in-neuroblastoma-cells
#8
Francesca Felicia Caputi, Elio Acquas, Sanjay Kasture, Stefania Ruiu, Sanzio Candeletti, Patrizia Romualdi
BACKGROUND: Behavioral studies demonstrated that the administration of Withania somnifera Dunal roots extract (WSE), prolongs morphine-elicited analgesia and reduces the development of tolerance to the morphine's analgesic effect; however, little is known about the underpinning molecular mechanism(s). In order to shed light on this issue in the present paper we explored whether WSE promotes alterations of μ (MOP) and nociceptin (NOP) opioid receptors gene expression in neuroblastoma SH-SY5Y cells...
January 10, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29305628/dissecting-drug-effects-in-preclinical-models-of-impulsive-choice-emphasis-on-glutamatergic-compounds
#9
REVIEW
Justin R Yates
RATIONALE: Impulsive choice is often measured with delay discounting paradigms. Because there are multiple discounting procedures, as well as different statistical analyses that can be applied to data generated from these paradigms, there are some inconsistencies in the literature regarding drug effects on impulsive choice. OBJECTIVES: The goal of the current paper is to review the methodological and analytic approaches used to measure discounting and to discuss how these differences can account for differential drug effects observed across studies...
January 6, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29303838/experiences-related-to-urinary-incontinence-of-stroke-patients-a-qualitative-descriptive-study
#10
Gulcihan Arkan, Ayse Beser, Vesile Ozturk
INTRODUCTION: Poststroke urinary incontinence is a common problem, with a prevalence ranging from 32% to 79%. Urinary incontinence after stroke has negative physiological, psychological, and economic effects, which lead to lifestyle changes for both patients and caregivers. Nurses play an important role in preventing and improving incontinence, understanding the experiences of individuals experiencing incontinence, providing healthcare for them, and implementing behavioral therapy methods...
February 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29303552/correlating-itinerant-magnetism-in-rco2pn2-pnictides-r-la-ce-pr-nd-eu-ca-pn-p-as-to-their-crystal-and-electronic-structures
#11
Xiaoyan Tan, Zachary P Tener, Michael Shatruk
Rare-earth cobalt pnictides, RCo2Pn2 (Pn = P, As), belong to the ThCr2Si2 structure type, which is ubiquitous among intermetallic compounds. The structural and magnetic properties of simple ternary RCo2P2 phosphides, which combine partially delocalized (itinerant) 3d magnetic moments of cobalt and localized 4f magnetic moments of lanthanides, were investigated extensively in 1980-1990s, predominantly by the Jeitschko group. Those studies established that LaCo2P2 shows ferromagnetic (FM) ordering of Co moments, while the other members of the series, with R = Ce, Pr, Nd, or Sm, exhibit antiferromagnetic (AFM) ordering in both R and Co magnetic sublattices...
January 5, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29296563/single-repeated-dose-toxicity-and-genotoxicity-assessment-of-herb-formula-kiom2012h
#12
Hwayong Park, Youn-Hwan Hwang, Jin Yeul Ma
Background: Traditional medicine and herbal prescriptions are becoming more popular, and they account for a large share of the world's healthcare research studies, developments, and market demands. Increasing scientific evidence of the substantive efficacies such as preventive health keeping pharmaceutical materials and dietary supplements can be found elsewhere. Above all, safety should be the critical premise for considering developmental materials such as pharmaceuticals without side effects and toxicity...
December 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/29296084/development-and-characterization-of-p1025-loaded-bioadhesive-liquid-crystalline-system-for-the-prevention-of-streptococcus-mutans-biofilms
#13
Giovana Maria Fioramonti Calixto, Cristiane Duque, Kelly Limi Aida, Vanessa Rodrigues Dos Santos, Loiane Massunari, Marlus Chorilli
Formation of a dental biofilm by Streptococcus mutans can cause dental caries, and remains a costly health problem worldwide. Recently, there has been a growing interest in the use of peptidic drugs, such as peptide p1025, analogous to the fragments 1025-1044 of S. mutans cellular adhesin, responsible for the adhesion and formation of dental biofilm. However, peptides have physicochemical characteristics that may affect their biological action, limiting their clinical performance. Therefore, drug-delivery systems, such as a bioadhesive liquid-crystalline system (LCS), may be attractive strategies for peptide delivery...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29295494/gtso-global-trace-synchronization-and-ordering-mechanism-for-wireless-sensor-network-monitoring-platforms
#14
Marlon Navia, José Carlos Campelo, Alberto Bonastre, Rafael Ors
Monitoring is one of the best ways to evaluate the behavior of computer systems. When the monitored system is a distributed system-such as a wireless sensor network (WSN)-the monitoring operation must also be distributed, providing a distributed trace for further analysis. The temporal sequence of occurrence of the events registered by the distributed monitoring platform (DMP) must be correctly established to provide cause-effect relationships between them, so the logs obtained in different monitor nodes must be synchronized...
December 23, 2017: Sensors
https://www.readbyqxmd.com/read/29291454/nanoscale-determination-of-antiviral-drug-acyclovir-engaging-bifunctionality-of-single-walled-carbon-nanotubes-nafion-film
#15
Pravin Tarlekar, Afsan Khan, Sanghamitra Chatterjee
An elementary and exemplary approach is proposed for the accurate monitoring of antiviral drug acyclovir (ACV) utilizing glassy carbon electrode (GCE) fabricated with single-walled carbon nanotubes and nafion composite film employing square wave voltammetry for the first time. The developed sensor exhibits effective and sustained electron mediating behavior displaying higher peak currents at lower potential than those obtained at bare GCE. At optimal experimental conditions, oxidation current showed a wide linear response for ACV in the concentration range from 10 nM to 30 μM...
December 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29283590/tutorial-the-practical-application-of-longitudinal-structural-equation-mediation-models-in-clinical-trials
#16
Kimberley A Goldsmith, David P MacKinnon, Trudie Chalder, Peter D White, Michael Sharpe, Andrew Pickles
The study of mediation of treatment effects, or how treatments work, is important to understanding and improving psychological and behavioral treatments, but applications often focus on mediators and outcomes measured at a single time point. Such cross-sectional analyses do not respect the implied temporal ordering that mediation suggests. Clinical trials of treatments often provide repeated measures of outcomes and, increasingly, of mediators as well. Repeated measurements allow the application of various types of longitudinal structural equation mediation models...
December 28, 2017: Psychological Methods
https://www.readbyqxmd.com/read/29282463/prevalence-of-work-related-musculoskeletal-disorders-among-surgeons-and-interventionalists-a-systematic-review-and-meta-analysis
#17
Sherise Epstein, Emily H Sparer, Bao N Tran, Qing Z Ruan, Jack T Dennerlein, Dhruv Singhal, Bernard T Lee
Importance: Physicians in procedural specialties are at high risk for work-related musculoskeletal disorders (MSDs). This has been called "an impending epidemic" in the context of the looming workforce shortage; however, prevalence estimates vary by study. Objectives: To estimate the prevalence of work-related MSDs among at-risk physicians and to evaluate the scope of preventive efforts. Data Sources and Study Selection: Systematic search in MEDLINE (Ovid), Embase (Elsevier), Web of Science, PubMed (National Center for Biotechnology Information), and 2 clinical trial registries, without language restriction, for studies reporting on the prevalence and prevention of work-related MSDs among at-risk physicians published until December 2016...
December 27, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29280183/semiparametric-bayesian-models-for-evaluating-time-variant-driving-risk-factors-using-naturalistic-driving-data-and-case-crossover-approach
#18
Feng Guo, Inyong Kim, Sheila G Klauer
Driver behavior is a major contributing factor for traffic crashes, a leading cause of death and injury in the United States. The naturalistic driving study (NDS) revolutionizes driver behavior research by using sophisticated nonintrusive in-vehicle instrumentation to continuously record driving data. This paper uses a case-crossover approach to evaluate driver-behavior risk. To properly model the unbalanced and clustered binary outcomes, we propose a semiparametric hierarchical mixed-effect model to accommodate both among-strata and within-stratum variations...
December 26, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29275615/-changes-of-platelet-rheological-behavior-and-the-interventional-effects-of-ulinastatin-in-rats-with-high-voltage-electrical-burns
#19
Q F Zhang, Y Li, J K Feng, Y F Xu, L L Tu
Objective: To explore the influence of high-voltage electrical burns on the number of platelet aggregation, β-thromboglobulin (β-TG) and platelet factor 4 (PF-4) and the interventional effects of ulinastatin in rats with high-voltage electrical burns. Methods: A total of 240 Sprague-Dawley rats were divided into sham injury (SI) group, simple electrical burn (SEB) group, normal saline (NS) group, and ulinastatin (UTI) group according to the random number table, with 60 rats in each group. The electrical current was applied to the outside proximal part of left forelimb of rats and exited from the outside proximal part of right hind limb of rats...
December 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29258808/incomplete-evidence-that-increasing-current-intensity-of-tdcs-boosts-outcomes
#20
Zeinab Esmaeilpour, Paola Marangolo, Benjamin M Hampstead, Sven Bestmann, Elisabeth Galletta, Helena Knotkova, Marom Bikson
BACKGROUND: Transcranial direct current stimulation (tDCS) is investigated to modulate neuronal function by applying a fixed low-intensity direct current to scalp. OBJECTIVES: We critically discuss evidence for a monotonic response in effect size with increasing current intensity, with a specific focus on a question if increasing applied current enhance the efficacy of tDCS. METHODS: We analyzed tDCS intensity does-response from different perspectives including biophysical modeling, animal modeling, human neurophysiology, neuroimaging and behavioral/clinical measures...
December 13, 2017: Brain Stimulation
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