keyword
https://read.qxmd.com/read/38537180/perfluorobutane-sonazoid-contrast-enhanced-ultrasound-to-diagnose-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#1
REVIEW
Yujia Chen, Wenjun Zhu, Yunyun Yi, Huali Cao, Fan Chen, Qinling Zhu
AIM: This meta-analysis aimed to assess the precision of Sonazoid contrast-enhanced ultrasound (CEUS) to distinguish hepatocellular carcinoma (HCC) from focal liver lesions (FLLs). MATERIAL AND METHODS: The Cochrane Library, Embase, PubMed, and Web of Science databases were systematically searched and checked for studies using Sonazoid CEUS to characterize HCC. A comprehensive meta-analysis was conducted, involving data pooling, subgroup analyses, meta-regression, and investigation of publication bias...
February 25, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537149/urinary-bladder-involvement-in-igg4-related-disease-a-case-based-review
#2
JOURNAL ARTICLE
Parag Vijayvergia, Sayan Mukherjee, Lily Singh, Urmila Dhakad
Immunoglobulin G4-related disease (IgG4-RD) is an immune-driven fibroinflammatory disease that presents as tumefactive lesions that not only commonly affects the pancreas, lacrimal and salivary glands, lung, liver and kidney but can also affect any organs. However, involvement of the urinary bladder in IgG4-RD is rarely reported. We describe a case of IgG4-RD involving the urinary bladder mimicking carcinoma and review the published literature-a 39-year-old male presented with complaints of dysuria, urgency and hesitancy...
March 2, 2024: Modern rheumatology case reports
https://read.qxmd.com/read/38536633/the-significance-of-m6a-rna-methylation-regulators-in-diagnosis-and-subtype-classification-of-hbv-related-hepatocellular-carcinoma
#3
JOURNAL ARTICLE
Qijuan Zang, Yalin Ju, Siyi Liu, Shaobo Wu, Chengbin Zhu, Liangru Liu, Weicheng Xu, Yingli He
In recent years, abnormal m6A alteration in hepatocellular carcinoma (HCC) has been a focus on investigating the biological implications. In this study, our objective is to determine whether m6A modification contributes to the progression of HBV-related HCC. To achieve this, we employed a random forest model to screen top 8 characteristic m6A regulators from 19 candidate genes. Subsequently, we developed a nomogram model that utilizes these 8 characteristic m6A regulators to predict the prevalence of HBV-related HCC...
March 27, 2024: Human Cell
https://read.qxmd.com/read/38536464/automated-graded-prognostic-assessment-for-patients-with-hepatocellular-carcinoma-using-machine-learning
#4
JOURNAL ARTICLE
Moritz Gross, Stefan P Haider, Tal Ze'evi, Steffen Huber, Sandeep Arora, Ahmet S Kucukkaya, Simon Iseke, Bernhard Gebauer, Florian Fleckenstein, Marc Dewey, Ariel Jaffe, Mario Strazzabosco, Julius Chapiro, John A Onofrey
BACKGROUND: Accurate mortality risk quantification is crucial for the management of hepatocellular carcinoma (HCC); however, most scoring systems are subjective. PURPOSE: To develop and independently validate a machine learning mortality risk quantification method for HCC patients using standard-of-care clinical data and liver radiomics on baseline magnetic resonance imaging (MRI). METHODS: This retrospective study included all patients with multiphasic contrast-enhanced MRI at the time of diagnosis treated at our institution...
March 27, 2024: European Radiology
https://read.qxmd.com/read/38536204/the-impact-of-a-pandemic-on-a-military-oral-and-maxillofacial-pathology-biopsy-service
#5
JOURNAL ARTICLE
Trevor E Miller, Noel E Dickens, Matthew R Rehmel, Bradley E Jones, Nicholas J Hamlin, Quinn C Robbins
INTRODUCTION: Coronavirus disease 2019 (COVID-19) and the resulting societal reaction presented new challenges to the medical community by limiting patient access to care in 2020 and 2021. The Navy Postgraduate Dental School (NPDS) oral and maxillofacial pathology biopsy service is dependent on in-office physician or dentist appointments and patient biopsies. The purpose of this study was to understand the regulatory and societal impacts of COVID-19 restrictions on biopsy service submissions by assessing NPDS biopsy submission quantities and disease distribution...
March 25, 2024: Military Medicine
https://read.qxmd.com/read/38536193/-complications-of-intravesical-bcg-therapy
#6
JOURNAL ARTICLE
Aresh Farokhnia, Silvana K Rampini, Micha Gundelfinger
BCG instillations are considered to be the standard of care therapy for superficial urothelial bladder carcinoma. Although serious adverse events are uncommon, the presence of high fever for at least two days in conjunction with systemic and/or local organ manifestations (except for urogenital symptoms), with the exclusion of other causes, suffice for the diagnosis of a disseminated BCG infection. Microbiologic detection of the pathogen is not necessary for diagnosis, as the detection of granuloma is more often successful and sufficient...
February 2024: Praxis
https://read.qxmd.com/read/38535080/differences-in-histological-subtypes-of-invasive-lobular-breast-carcinoma-according-to-immunohistochemical-molecular-classification
#7
JOURNAL ARTICLE
Ivan Ilić, Jana Cvetković, Ratko Ilić, Ljubiša Cvetković, Aleksandar Milićević, Stefan Todorović, Pavle Ranđelović
UNLABELLED: The technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses. BACKGROUND AND OBJECTIVES: The aim of this study was to compare the differences between histological and molecular subtypes of invasive lobular carcinoma (ILC) of the breast, in order to be able to predict the behavior and prognosis of the disease, as well as to effectively determine therapy...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38535065/primary-adenosquamous-carcinoma-of-the-prostate
#8
JOURNAL ARTICLE
Roksolana Demianets, Dong Ren, Roozbeh Houshyar, Giovanna A Giannico, Cary Johnson
Prostate cancer accounts for 29% of malignant diagnoses among men in the United States and is the second leading cause of death from cancer. Effective screening methods and improved treatment have decreased the mortality rate significantly. This decreased mortality rate, however, does not apply to all histologic variants. Adenosquamous carcinoma of the prostate is an extremely aggressive neoplasm with no current known curative therapy. It is often diagnosed after chemotherapy, radiation, or androgen deprivation therapy for traditional prostatic adenocarcinomas...
March 19, 2024: Diagnostics
https://read.qxmd.com/read/38534935/ovarian-cancer-in-the-older-manitoban-population-treatment-tolerance-and-cancer-related-outcomes-a-manitoba-ovarian-cancer-outcomes-moco-group-study
#9
JOURNAL ARTICLE
Lesley F Roberts, Pascal Lambert, Mark W Nachtigal, Alon D Altman, Erin Dean
BACKGROUND: In Canada, individuals with gynecologic reproductive organs (ovaries, fallopian tubes, uterus) over the age of 70 comprise a large proportion of epithelial ovarian cancer patients. These patients often have co-morbidities, polypharmacy, or decreased functional status that may impact treatment initiation and tolerance. Despite this, there is limited evidence to guide treatment for older patients diagnosed with ovarian epithelial carcinoma. METHODS: This is a retrospective study with data from Manitoba, Canada...
March 5, 2024: Current Oncology
https://read.qxmd.com/read/38534931/real-world-analysis-of-the-clinical-and-economic-impact-of-the-21-gene-recurrence-score-rs-in-invasive-lobular-early-stage-breast-carcinoma-in-ireland
#10
JOURNAL ARTICLE
Lynda M McSorley, Mehala Tharmabala, Fathiya Al Rahbi, Fergus Keane, Denis Evoy, James G Geraghty, Jane Rothwell, Damian P McCartan, Megan Greally, Miriam O'Connor, Deirdre O'Mahony, Maccon Keane, Michael John Kennedy, Seamus O'Reilly, Steve J Millen, John P Crown, Catherine M Kelly, Ruth S Prichard, Cecily M Quinn, Janice M Walshe
Background: This study, using real-world data, assesses the impact of RS testing on treatment pathways and the associated economic consequences of such testing. This paper pertains to lobular breast cancer. Methods: A retrospective, observational study was undertaken between 2011 and 2019 on a cross-section of hormone receptor-positive (HR+), HER2-negative, lymph node-negative, early-stage breast cancer patients. All patients had ILC and had RS testing in Ireland. The patient population is representative of the national population...
March 1, 2024: Current Oncology
https://read.qxmd.com/read/38534502/state-of-the-art-in-the-diagnosis-and-assessment-of-oral-malignant-and-potentially-malignant-disorders-present-insights-and-future-outlook-an-overview
#11
REVIEW
Dardo Menditti, Mario Santagata, David Guida, Roberta Magliulo, Giovanni Maria D'Antonio, Samuel Staglianò, Ciro Emiliano Boschetti
Oral Potentially Malignant Disorder (OPMD) is a significant concern for clinicians due to the risk of malignant transformation. Oral Squamous Cell Carcinoma (OSCC) is a common type of cancer with a low survival rate, causing over 200,000 new cases globally each year. Despite advancements in diagnosis and treatment, the five-year survival rate for OSCC patients remains under 50%. Early diagnosis can greatly improve the chances of survival. Therefore, understanding the development and transformation of OSCC and developing new diagnostic methods is crucial...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38534035/adverse-jaw-outcomes-from-immune-checkpoint-inhibitors-for-head-and-neck-cancer-case-reports
#12
JOURNAL ARTICLE
Gayathri Subramanian, Vincent Yeung, Soly Baredes, Sung Kim, Tessa Bergsbaken, Samuel Quek
Radiation treatment plays a mainstream role in the management of head and neck squamous cell carcinomas (HNSCCs). Adverse effects from radiation therapy include osteoradionecrosis of the jaw, and rarely, pathologic fracture. Immune checkpoint inhibitors (ICI) such as pembrolizumab are of growing relevance to the management of metastatic and recurrent HNSCCs. Adverse impacts on bone secondary to medications such as pembrolizumab and nivolumab have been sporadically documented in the literature. The objective of this manuscript is to raise awareness of possible increase in risk for adverse jaw outcomes in patients with HNSCCs exposed to both radiation treatment to the jaws and ICI therapy...
March 27, 2024: Quintessence International
https://read.qxmd.com/read/38533984/cytomorphological-features-of-sebaceous-carcinoma-of-the-breast
#13
JOURNAL ARTICLE
Ken Misawa, Mikiko Kobayashi, Tomoko Yamamoto, Atsushi Sato
Sebaceous carcinoma of the breast is an extremely rare histological subtype of breast cancer, with fewer than 30 cases reported to date. Because of its extremely rare histological presentation, there are few case reports that highlight its cytological findings. In this case report, the cytomorphological features of a sebaceous carcinoma of the breast are described in detail. Cytomorphological analysis revealed atypical cells presenting predominantly as loose clusters. No tubular or papillary structures were evident in the clusters and no mucin production was observed...
March 27, 2024: Diagnostic Cytopathology
https://read.qxmd.com/read/38532511/a-hierarchical-fusion-strategy-of-deep-learning-networks-for-detection-and-segmentation-of-hepatocellular-carcinoma-from-computed-tomography-images
#14
JOURNAL ARTICLE
I-Cheng Lee, Yung-Ping Tsai, Yen-Cheng Lin, Ting-Chun Chen, Chia-Heng Yen, Nai-Chi Chiu, Hsuen-En Hwang, Chien-An Liu, Jia-Guan Huang, Rheun-Chuan Lee, Yee Chao, Shinn-Ying Ho, Yi-Hsiang Huang
BACKGROUND: Automatic segmentation of hepatocellular carcinoma (HCC) on computed tomography (CT) scans is in urgent need to assist diagnosis and radiomics analysis. The aim of this study is to develop a deep learning based network to detect HCC from dynamic CT images. METHODS: Dynamic CT images of 595 patients with HCC were used. Tumors in dynamic CT images were labeled by radiologists. Patients were randomly divided into training, validation and test sets in a ratio of 5:2:3, respectively...
March 26, 2024: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://read.qxmd.com/read/38532506/sonographic-characteristics-of-diffuse-sclerosing-variant-of-papillary-thyroid-carcinoma-with-histopathological-correlation-a-preliminary-study
#15
JOURNAL ARTICLE
Wanying Li, Ying Wang, Luying Gao, Ruie Feng, Ke Lv, Xining Wu, Xiao Yang, Sheng Cai, Hongyan Wang, Jianchu Li
BACKGROUND: Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) is a rare but high invasive subtype of papillary thyroid carcinoma, which mandates an aggressive clinical strategy. Few studies have focused on the sonographic characteristics of DSVPTC and the role of ultrasound in diagnosis and treatment of this variant remains unknown. This study aimed to identify and understand DSVPTC more accurately under ultrasound in correlation with pathology. METHODS: The ultrasound characteristics and histopathologic sections of 10 lesions in 10 DSVPTC patients who underwent thyroid surgery at our center between 2014 and 2020 were reviewed and compared with 184 lesions in 168 classic variant of papillary thyroid carcinoma (cPTC) patients...
March 26, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38532363/quantitative-differentiation-of-non-invasive-bladder-urothelial-carcinoma-and-inverted-papilloma-based-on-ct-urography
#16
JOURNAL ARTICLE
Pengfei Jin, Liqin Yang, Yitao Liu, Jiehui Huang, Xu Wang
PURPOSE: To investigate the value of CT urography (CTU) indicators in the quantitative differential diagnosis of bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB). MATERIAL AND METHODS: The clinical and preoperative CTU imaging data of continuous 103 patients with histologically confirmed BUC or IPB were retrospectively analyzed. The imaging data included 6 qualitative indicators and 7 quantitative measures. The recorded clinical information and imaging features were subjected to univariate and multivariate logistic regression analysis to find independent risk factors for BUC, and a combined multi-indicator prediction model was constructed, and the prediction model was visualized using nomogram...
March 26, 2024: BMC Urology
https://read.qxmd.com/read/38531788/rare-but-still-there-a-scoping-review-on-endometriosis-associated-ovarian-cancer
#17
JOURNAL ARTICLE
Karl Livori, Jean Calleja-Agius
Endometriosis is a medical condition affecting at least up to 10% of women of reproductive age. This condition occurs when ectopic endometrial glands and stroma implant outside the uterus and there are several theories regarding the underlying origins of the disease. Endometriosis is one of the major causes of severe dysmenorrhoea, chronic pelvic pain and infertility. While endometriosis is generally a non-malignant condition, it rarely may transform into an invasive cancer, and increase the risk for epithelial ovarian cancer, notably endometrioid or clear cell ovarian cancer...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38530538/the-impact-of-transcriptional-profiling-cadherin-family-and-therapeutic-approaches-of-gastric-cancer-a-translational-outlook-on-multi-omics-data-analysis
#18
JOURNAL ARTICLE
Huan Wang, Baomin Zhang
The classical cadherin gene has been linked to a variety of human malignancies, including gastric cancer. However, the link between cadherin genes and gastric cancer outcome is still unclear. This study used multi-omics data to examine the cadherin genes that were differentially regulated in gastric cancer. Differential expression of genes, epigenetic, molecular alterations, and protein expression analyses was conducted. Male SD rats were given N-methyl-N-nitrosourea (MNU) to induce stomach carcinoma in order to verify the activation of cadherin genes...
March 26, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38530498/predicting-microvascular-invasion-in-small-%C3%A2-%C3%A2-5%C3%A2-cm-hepatocellular-carcinomas-using-radiomics-based-peritumoral-analysis
#19
JOURNAL ARTICLE
Fang Wang, Ming Cheng, Binbin Du, Jing Li, Liming Li, Wenpeng Huang, Jianbo Gao
OBJECTIVE: We assessed the predictive capacity of computed tomography (CT)-enhanced radiomics models in determining microvascular invasion (MVI) for isolated hepatocellular carcinoma (HCC) ≤ 5 cm within peritumoral margins of 5 and 10 mm. METHODS: Radiomics software was used for feature extraction. We used the least absolute shrinkage and selection operator (LASSO) algorithm to establish an effective model to predict patients' preoperative MVI status...
March 26, 2024: Insights Into Imaging
https://read.qxmd.com/read/38529394/ultrasound-guided-fine-needle-aspiration-thyroglobulin-in-the-diagnosis-of-lymph-node-metastasis-of-differentiated-papillary-thyroid-carcinoma-and-its-influencing-factors
#20
JOURNAL ARTICLE
Xuejiao Su, Lei Shang, Can Yue, Buyun Ma
BACKGROUND: Ultrasound-guided fine needle aspiration thyroglobulin (FNA-Tg) is recommended for the diagnosis of lymph node metastasis (LNM) in differentiated thyroid cancer (DTC), but its optimal cutoff value remains controversial, and the effect of potential influencing factors on FNA-Tg levels is unclear. METHOD: In this study, a retrospective analysis was conducted on 281 patients diagnosed with DTC, encompassing 333 lymph nodes. We analyze the optimal cutoff value and diagnostic efficacy of FNA-Tg, while also evaluating the potential influence of various factors on FNA-Tg...
2024: Frontiers in Endocrinology
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