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https://www.readbyqxmd.com/read/28749564/impact-of-sustained-virologic-response-with-direct-acting-antiviral-treatment-on-mortality-in-patients-with-advanced-liver-disease
#1
Lisa I Backus, Pamela S Belperio, Troy A Shahoumian, Larry A Mole
The impact of sustained virologic response (SVR) on mortality after direct-acting antiviral (DAA) treatment is not well documented. This study evaluated the impact of DAA-induced SVR on all-cause mortality and on incident hepatocellular carcinoma (HCC) in 15,059 HCV-infected patients with advanced liver disease defined by a FIB-4 >3.25. Overall, 1,067 patients did not achieve SVR (No SVR) and 13,992 patients achieved SVR. In a mean follow-up period of approximately 1.6 years, 195 No SVR patients and 598 SVR patients died...
July 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28749302/squamous-cell-carcinoma-in-two-snow-leopards-uncia-uncia-with-unusual-auricular-presentation
#2
Benoît Quintard, Eva Maria Greunz, Brice Lefaux, Karin Lemberger, Antoine Leclerc
Squamous cell carcinoma (SCC) is well documented in snow leopards ( Uncia uncia ) and most common locations are oral, facial, or pedal. These two cases illustrate an unusual auricular presentation, which is more often reported in white domestic cats. The animals were aged and presented clinical signs of otitis such as head shaking and ear scratching. Clinical examinations showed auricular canal masses with chronic purulent otitis. In both cases, clinical deterioration led to euthanasia and histology of the ear canal was consistent with SCC and showed numerous vascular emboli...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749282/oronasal-squamous-cell-carcinomas-in-fran%C3%A3-ois-langurs-trachypithecus-francoisi
#3
John A Flanders, Michelle E Thompson, Mitzi J Palazzolo, Michael M Garner, Matthew Reed, Donna M Ialeggio, Matti Kiupel, William H Westra, Kathryn C Gamble
Squamous cell carcinomas (SCCs) are common oronasal tumors in nonhuman primates. In this study, 11 cases of oronasal SCC in François' langurs ( Trachypithecus francoisi ) are described. Five initial cases were discovered on review of the North American François' langur studbook, with a potential familial pattern observed. The studbook was used to identify related individuals, and records were requested for review. Six additional cases were documented, and samples from all cases were submitted for microscopic review, as well as polymerase chain reaction (PCR), immunohistochemistry (IHC), and in situ hybridization (ISH), for generic papillomaviruses and PCR for herpesviruses because either virus may cause SCC in humans and other nonhuman primates...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749097/lymphoepithelioma-like-carcinoma-of-the-breast-mimicking-granulomatous-mastitis-case-report-and-review-of-the-literature
#4
Dalia M Abouelfad, Noha N Yassen, Hebat Allah A Amin, Marwa E Shabana
Lymphoepithelioma-like carcinoma (LELC) of the breast is an exceedingly rare variant of mammary cancer. To our knowledge, only twenty - one cases have been reported in the literature. Diagnosis of this type of mammary carcinoma may be challenging, owing to its rarity and the histopathological similarity to common inflammatory and malignant lesions of the breast mainly granulomatous mastitis, medullary carcinoma, pleomorphic lobular carcinoma, lymphoma and other hematological malignancies. Our case is the 22nd case of lymphoepithelioma-like carcinoma reported in the breast, presenting with a palpable tender mass in a post-menopausal female...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749000/-bone-metastases-of-a-gallbladder-carcinoma-detected-by-positron-emission-tomography-computed-tomography-case-report
#5
Pamela Humeres, Patricio González, Javiera González, Elizabeth Prado, Enrique Hiplan
Signet ring gallbladder carcinoma is a rare aggressive variant of mucinous adenocarcinoma with poor prognosis. Positron emission tomography/computed tomography (PET/CT) with Fluor18 deoxyglucose (F18-FDG) is a useful tool in the staging of gallbladder cancer. We report a 68 years old man with a surgically resected acute cholecystitis, whose biopsy was positive for signet ring cell gallbladder carcinoma. During surgery, locoregional lymph nodes, liver or peritoneal involvement were not detected. A PET/CT was performed for staging, finding multiple hypermetabolic lytic bone lesions...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748454/recurrence-with-pagetoid-spread-arising-17%C3%A2-years-after-surgery-for-intramucosal-rectal-cancer-a-case-report
#6
Taichi Matsubara, Yuta Kasagi, Kippei Ogaki, Yu Nakaji, Ryota Nakanishi, Yuichiro Nakashima, Masahiko Sugiyama, Hideto Sonoda, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara
BACKGROUND: Perianal Paget's disease (pPD) is uncommon, with only about 180 cases documented in the literature. Anorectal carcinoma with pagetoid spread is even rarer. CASE PRESENTATION: An 81-year-old woman underwent rectal cancer extirpation with a transanal approach 17 years prior. She has since undergone two reoperations for local rectal cancer recurrence. Then, warts frequently appeared on the vulva on several occasions. Warts appeared on the vulva 1 year ago, which were diagnosed as pPD by biopsy...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28748259/primary-nasopharyngeal-polyps-a-case-series-on-a-rare-clinical-entity
#7
De Hua Chen, Mu Qiong Mo, Chew Lip Ng, Zhi Bin Lin, Tian Ying Li, Wei Ping Wen, Chun Wei Li
Primary non-neoplastic polyps originating from the nasopharynx have not been reported in the English language literature. We present the clinical and histopathological features of three primary nasopharyngeal polyps. Clinical data of three patients with primary nasopharyngeal polyps treated at the Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University between 2005 and 2015 were analyzed and presented. Three male patients from 45 to 63 years presented with nasopharyngeal masses...
July 26, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28748250/-disseminated-osteolytic-lesions-in-a-28-year-old-refugee
#8
T Karrasch, H D Walmrath, M Kampschulte, D Steiner, W Seeger, W Padberg, U Sibelius, S Gattenlöhner, A Schäffler
A 28-year-old Syrian refugee presented with right-sided knee pain and progressive deterioration of the general condition over the past months. Laboratory diagnostics revealed severe hypercalcemia due to primary hyperparathyroidism, and computed tomography (CT) scanning demonstrated disseminated osteolytic lesions throughout the skeleton. Histologically, these lesions were characterized by multinuclear giant cells (defining these lesions as so-called brown tumors). Finally, surgical removal of a jugular mass allowed the histopathologic diagnosis of a sporadic parathyroid carcinoma...
July 26, 2017: Der Internist
https://www.readbyqxmd.com/read/28748094/metastatic-squamous-cell-carcinoma-of-the-lung-mimicking-multiple-bone-abscesses
#9
Yuki Haruta, Yuki Kataoka, Hiroshi Ito, Taro Mori, Masaki Matsuo
Squamous cell carcinoma of the lung is known to metastasize to the bones, but a presentation similar to bone abscess is rare. We encountered a case with bone metastases that mimicked bone abscess, which delayed the diagnosis of squamous cell lung carcinoma. A 67-year-old man presented with a left upper lung infiltrate and lytic lesions on the left first rib and right fifth rib. In consideration of a possible infectious process, cultures of the aspirate from the right fifth rib lesion and blood were taken; however, results were non-specific...
September 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28746917/cytological-features-of-the-large-cell-variant-of-small-cell-ovarian-carcinoma-in-young-patients-with-hypercalcemia-histological-findings-and-review-of-the-literature
#10
Helen J Trichia, Paraskevi Tziakou, Dimitrios C Papatheodorou, Joanna Lekka
OBJECTIVE: To present the cytological features of a very rare and lethal ovarian neoplasm occurring in the young. STUDY DESIGN: We reviewed the cytological findings as they presented in touch imprints obtained from an ovarian mass sent to our department for frozen section investigation. RESULTS: Smears were highly cellular. The cells were of intermediate size with a moderate amount of microvacuolated, pale, or eosinophilic cytoplasm with indistinct cell borders...
July 27, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28746753/letter-to-the-editor-reply-to-ultrasonography-and-cytology-as-predictors-of-noninvasive-follicular-thyroid-niftp-neoplasm-with-papillary-like-nuclear-features-importance-of-the-differential-diagnosis-with-the-invasive-encapsulated-follicular-variant-of-papillary
#11
Jung Hee Shin
As Dr. Rosario pointed out, it might be more useful to differentiate NIFTP from invasive encapsulated follicular variant of papillary thyroid carcinoma (iE-FVPTC), not from infiltrative FVPTC (I-FVPTC) in clinical setting since infiltrative FVPTCs show overt malignant US features more frequently. However, in the previous study, we attempted to describe the characteristic ultrasound (US) features and diagnostic method of NIFTP specifically. This article is protected by copyright. All rights reserved.
July 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28746315/colorectal-cancer-in-different-age-groups-in-a-tertiary-hospital-in-nepal
#12
N S Poudyal, S Chaudhary, B K Basnet, B N Paudel, B Shrestha, A K Mandal, M S Paudel
INTRODUCTION: Some studies have suggested that colorectal cancer at a younger age had distinct biological characteristics: different clinical presentations, more advanced stage at time of diagnosis and poorly differentiated carcinoma. The aim of the study is to analyze clinical and histopathological differences between younger (≤40 years of age) and older (>40 years of age) colorectal cancer patients. METHODS: A cross-sectional analysis was conducted amongst the colorectal cancer patients who visited Bir Hospital between July 2015 and April 2017...
April 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28746218/localized-nasopharyngeal-amyloidosis-mimicking-malignancy-a-case-report
#13
Jong Seung Kim, Sam Hyun Kwon
RATIONALE: Nasopharyngeal amyloidosis is a benign, slowly progressive disease that is characterized by extracellular eosinophilic deposition. PATIENT CONCERNS: We report a rare case of localized nasopharyngeal amyloidosis. DIAGNOSES: The initial chief complaint of this patient was frequent epistaxis and right aural fullness. The initial diagnosis was nasopharyngeal tumor. INTERVENTIONS: There is no universally effective medical treatment for nasopharyngeal amyloidosis but surgery can be an option...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745797/expressions-and-significances-of-ttf-1-and-pten-in-early-endometrial-cancer
#14
H-M Zhang, T-T Fan, W Li, X-X Li
OBJECTIVE: To analyze the expressions and significances of TTF-1 (Thyroid transcription factor-1) and PTEN (Phosphatase and tensin homolog) in early endometrial cancer. PATIENTS AND METHODS: 41 patients with endometrial cancer, 38 patients with proliferative endometrium and 13 patients with normal endometrium, were selected. The fluorescence quantitative PCR (polymerase chain reaction) was used to detect the expression levels of TFF-1 and PTEN mRNAs (Messenger ribonucleic acids) in the above three endometria, and their relations with clinical pathological characteristics were analyzed...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28744752/radiotherapy-for-ductal-carcinoma-in-situ-and-risk-of-second-non-breast-cancers
#15
Diana R Withrow, Lindsay M Morton, Rochelle E Curtis, Sara J Schonfeld, Amy Berrington de González
PURPOSE: Radiotherapy for ductal carcinoma (DCIS) is increasing, but the risks and benefits of the treatment remain uncertain. We aimed to investigate the relationship between radiotherapy for DCIS and risk of second non-breast cancers in a large US cohort. METHODS: We conducted a retrospective cohort study of 52,556 women in 12 U.S. population-based cancer registries diagnosed with first primary DCIS during 1992-2008 at age 25-79 years. We estimated relative risks (RRs), attributable risks (AR), and excess absolute risks (EAR) of second non-breast cancers associated with radiotherapy using Poisson regression adjusted for age at year of diagnosis, grade, hormonal therapy (yes/no or unknown), and time since diagnosis...
July 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28743857/the-clinical-signification-of-claudin-11-promoter-hypermethylation-for-laryngeal-squamous-cell-carcinoma
#16
Zhisen Shen, Bing Cao, Lexi Lin, Chongchang Zhou, Dong Ye, Shijie Qiu, Qun Li, Xiang Cui
BACKGROUND Claudin-11 (CLDN11) is frequently silenced by its promoter hypermethylation. Previous studies have shown that CLDN11 promoter hypermethylation is a potential biomarker for diagnosing various cancers. The aim of this study was to investigate CLDN11 promoter methylation and its potential relevance to clinicopathologic features and prognosis of patients with laryngeal squamous cell carcinoma (LSCC). MATERIAL AND METHODS Using the quantitative methylation-specific polymerase chain reaction (qMSP), CLDN11 promoter methylation was measured in 91 tumor tissues and their paired adjacent normal tissues, and the relationship between CLDN11 methylation and clinicopathologic features was evaluated...
July 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28743666/biological-significance-of-5-hydroxymethylcytosine-in-oral-epithelial-dysplasia-and-oral-squamous-cell-carcinoma
#17
Maria Carolina Cuevas-Nunez, Camilla Borges F Gomes, Sook-Bin Woo, Matthew R Ramsey, Xiaoxin L Chen, Shuyun Xu, Ting Xu, Qian Zhan, George F Murphy, Christine G Lian
OBJECTIVES: The aim of this study was to determine the levels of 5-hydroxylmethylcytosine (5-hmC) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) compared with those in benign, reactive inflammatory lesions and to explore whether DNA hydroxymethylation may serve as a novel biomarker for early diagnosis and prognosis of OSCC. STUDY DESIGN: The study included normal mucosa from uninvolved margins of 9 fibromas, 10 oral lichen planus, 15 OED, and 23 OSCC...
June 16, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28743206/outpatient-photodynamic-guided-diagnosis-of-carcinoma-in-situ-with-flexible-cystoscopy-an-alternative-to-conventional-inpatient-photodynamic-guided-bladder-biopsies-in-the-operating-theatre
#18
Karin Mogensen, Anders Glenthøj, Birgitte Grønkær Toft, Thomas Scheike, Gregers Gautier Hermann
OBJECTIVE: The aim of this prospective open comparative study was to establish whether conventional photodynamic-guided bladder biopsies using general anaesthesia and rigid resectoscopes (inpatient) can be replaced with less traumatic flexible cystoscopy in non-sedated patients (outpatient), without compromising the diagnosis of carcinoma in situ (CIS). MATERIALS AND METHODS: Thirty-one patients were included. After BCG instillation for CIS, bladder biopsies were obtained using photodynamic-guided flexible cystoscopy...
July 26, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28742983/should-adults-with-diabetes-mellitus-be-vaccinated-against-hepatitis-b-virus-a-systematic-review-of-diabetes-mellitus-and-the-progression-of-hepatitis-b-disease
#19
Zobair Younossi, Katrin Kochems, Marc de Ridder, Desmond Curran, Eveline M Bunge, Laurence de Moerlooze
Despite the burden of diabetes mellitus (DM), little is known about the role of this and other metabolic syndromes on the severity of hepatitis B virus (HBV) chronicity and liver disease progression. The value of hepatitis B vaccination and its impact on liver diseases and HCC has been largely demonstrated (ref), adult vaccination coverage is however suboptimal and DM diagnosis represents an opportunity for the HCP to discuss hepatitis B and other adult vaccinations. We performed a systematic literature search to identify studies (2000 to January 2017) describing liver disease progression among patients with HBV by DM status...
July 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28742698/survival-benefit-of-neoadjuvant-treatment-in-clinical-t3n0m0-esophageal-cancer-results-from-a-retrospective-multicenter-european-study
#20
Styliani Mantziari, Caroline Gronnier, Florence Renaud, Alain Duhamel, Jérémie Théreaux, Cécile Brigand, Nicolas Carrère, Jérémie H Lefevre, Arnaud Pasquer, Nicolas Demartines, Denis Collet, Bernard Meunier, Christophe Mariette
BACKGROUND: Based on current guidelines, clinical T3N0M0 esophageal tumors may or may not receive neoadjuvant treatment, according to their perception as locally advanced (cT3) or early-stage tumors (stage II). The study aim was to assess the impact of neoadjuvant treatment upon survival for cT3N0M0 esophageal cancer patients, with subgroup analyses by histological type (squamous cell carcinoma vs adenocarcinoma) and type of neoadjuvant treatment (chemotherapy vs radiochemotherapy). METHODS: Data from patients operated on for esophageal cancer in 30 European centers were collected...
July 24, 2017: Annals of Surgery
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