Rovina Ruslami, Federica Fregonese, Lika Apriani, Leila Barss, Nancy Bedingfield, Victor Chiang, Victoria J Cook, Dina Fisher, Eri Flores, Greg J Fox, James Johnston, Rachel K Lim, Richard Long, Catherine Paulsen, Thu Anh Nguyen, Nguyen Viet Nhung, Diana Gibson, Chantal Valiquette, Andrea Benedetti, Dick Menzies
BACKGROUND: Tuberculosis preventive treatment (TPT) is a key component of tuberculosis elimination. To improve completion and reduce the burden for people and health systems, short, safe, and effective TPT regimens are needed. We aimed to compare safety and treatment completion of various doses and durations of rifampicin in people who were recommended to receive TPT. METHODS: This partially blinded, parallel-arm, non-inferiority, randomised, controlled, phase 2b trial was done at seven university-affiliated clinics in Canada, Indonesia, and Viet Nam...
March 26, 2024: Lancet Respiratory Medicine