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intravenous fluid calculations

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https://www.readbyqxmd.com/read/29788919/prediction-of-fluid-responsiveness-in-mechanically-ventilated-cardiac-surgical-patients-the-performance-of-seven-different-functional-hemodynamic-parameters
#1
Michael T Ganter, Martin Geisen, Sonja Hartnack, Omer Dzemali, Christoph K Hofer
BACKGROUND: Functional hemodynamic parameters such as stroke volume and pulse pressure variation (SVV and PPV) have been shown to be reliable predictors of fluid responsiveness in mechanically ventilated patients. Today, different minimally- and non-invasive hemodynamic monitoring systems measure functional hemodynamic parameters. Although some of these parameters are described by the same name, they differ in their measurement technique and thus may provide different results. We aimed to test the performance of seven functional hemodynamic parameters simultaneously in the same clinical setting...
May 22, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29784852/plasma-and-intrapulmonary-concentrations-of-cefepime-and-zidebactam-following-intravenous-administration-of-wck-5222-to-healthy-adult-subjects
#2
Keith A Rodvold, Mark H Gotfried, Rakesh Chugh, Mugdha Gupta, Anasuya Patel, Rajesh Chavan, Ravindra Yeole, H David Friedland, Ashima Bhatia
WCK 5222 is a combination of cefepime and the novel beta-lactam enhancer zidebactam being developed for the treatment of serious Gram-negative infections. The objective of this study was to compare plasma (total), epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of cefepime and zidebactam in healthy adult subjects. The WCK 5222 dosing regimen was 2 grams cefepime/1 gram zidebactam administered as a 1-hour intravenous infusion every 8 hours for a total of 7 doses. Subjects were assigned to one bronchoalveolar lavage (BAL) sampling time at 0...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29698339/disparities-in-adherence-to-pediatric-diabetic-ketoacidosis-management-guidelines-across-a-spectrum-of-emergency-departments-in-the-state-of-indiana-an-observational-in-situ-simulation-based-study
#3
Kamal Abulebda, Samer Abu-Sultaneh, Erin E White, Michele L Kirby, Brian C Phillips, Courtney T Frye, Lee D Murphy, Riad Lutfi
BACKGROUND: Diabetic ketoacidosis (DKA) is a common presentation to an emergency department (ED), with the majority presenting to community EDs. Adherence to clinical guidelines in these EDs can reduce morbidity and mortality. Few methods to describe practice gaps for DKA management have been reported. OBJECTIVES: We hypothesized that high-fidelity in situ simulation can be used to measure and compare the quality of the care provided to pediatric patients with DKA presenting to community EDs in the state of Indiana...
April 24, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29622333/emergency-care-of-pediatric-burns
#4
REVIEW
Ashley M Strobel, Ryan Fey
Although the overall incidence of and mortality rate associated with burn injury have decreased in recent decades, burns remain a significant source of morbidity and mortality in children. Children with major burns require emergent resuscitation. Resuscitation is similar to that for adults, including pain control, airway management, and administration of intravenous fluid. However, in pediatrics, fluid resuscitation is needed for burns greater than or equal to 15% of total body surface area (TBSA) compared with burns greater than or equal to 20% TBSA for adults...
May 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29582421/the-enhanced-recovery-after-surgery-eras-greenie-board-a-navy-inspired-quality-improvement-tool
#5
A J Smirk, J J Nicholson, Y L Console, N J Hunt, A Herschtal, M N H H Nguyen, B Riedel
The United States Navy uses a visual feedback system for pilots, named 'the Greenie Board', to improve flight manoeuvres on aircraft carriers. Given that increased compliance with enhanced recovery after surgery protocols reduces postoperative complications, we decided to apply a similar feedback system to our institutional enhanced recovery programme. We undertook a prospective 12-month audit of 194 patients assigned to our enhanced recovery programme and evaluated adherence to the anaesthesia-related components of our protocol, before and after implementing a Greenie Board...
March 26, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29527575/-take-ten-improving-the-surgical-post-take-ward-round-a-quality-improvement-project
#6
Danielle Alice Banfield, Carly Adamson, Amy Tomsett, James Povey, Tony Fordham, Sarah Kathryn Richards
Background: The surgical post-take ward round is a complex multidisciplinary interaction in which new surgical patients are reviewed and management plans formulated. Its fast-paced nature can lead to poor communication and inaccurate or incomplete documentation with potential detriment to patient safety. Junior team members often do not fully understand the diagnosis and management plan. Aims: The aims of this project were to improve both communication and documentation on the surgical post-take ward round, influencing patient safety...
2018: BMJ open quality
https://www.readbyqxmd.com/read/29509322/epidemiology-clinical-management-and-outcomes-of-dogs-involved-in-road-traffic-accidents-in-the-united-kingdom-2009-2014
#7
Georgina L Harris, David Brodbelt, David Church, Karen Humm, Paul D McGreevy, Peter C Thomson, Dan O'Neill
OBJECTIVE: To estimate the prevalence and risk factors for road traffic accidents (RTA) in dogs and describe the management and outcome of these dogs attending primary-care veterinary practices in the United Kingdom. DESIGN: Retrospective cross-sectional study. SETTING: Primary-care veterinary practices in the United Kingdom. ANIMALS: The study population included 199,464 dogs attending 115 primary-care clinics across the United Kingdom...
March 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29506859/comparison-of-acid-base-and-electrolyte-changes-following-administration-of-6-hydroxyethyl-starch-130-0-42-in-a-saline-and-a-polyionic-solution-in-anaesthetized-dogs
#8
Katja N Adamik, Rafael Obrador, Judith Howard
OBJECTIVE: To evaluate the effects of a 6% hydroxyethyl starch (130/0.42) in either a buffered, electrolyte-balanced (HES-BAL) or saline (HES-SAL) carrier solution on electrolyte concentrations and acid-base parameters in healthy anaesthetized dogs. STUDY DESIGN: Prospective randomised clinical study. ANIMALS: A group of 40 client-owned dogs undergoing general anaesthesia for elective surgical procedures or diagnostic imaging. METHODS: During anaesthesia, dogs were intravenously administered 15 mL kg-1 of either HES-SAL (n = 20) or HES-BAL (n = 20) over 30-40 minutes...
May 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29356561/using-24-hour-weight-as-reference-for-weight-loss-calculation-reduces-supplementation-and-promotes-exclusive-breastfeeding-in-infants-born-by-cesarean-section
#9
Xiaomeng Deng, Margaret McLaren
BACKGROUND AND OBJECTIVES: To promote exclusive breastfeeding, supplements are not recommended without medical indications such as clinical evidence of dehydration. Loss of ≥10% of birth weight (BW) often triggers supplementation due to nursery staff's concern for dehydration. Studies have demonstrated that transplacental passage of maternal intrapartum intravenous fluids for anesthesia may inflate BW. Researchers have proposed using newborn's 24-hour weight (24HW), after fluid diuresis, as preferred reference for weight loss calculation...
March 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29343658/differences-in-signal-intensity-and-enhancement-on-mr-images-of-the-perivascular-spaces-in-the-basal-ganglia-versus-those-in-white-matter
#10
Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka
PURPOSE: To elucidate differences between the perivascular space (PVS) in the basal ganglia (BG) versus that found in white matter (WM) using heavily T2-weighted FLAIR (hT2-FL) in terms of 1) signal intensity on non-contrast enhanced images, and 2) the degree of contrast enhancement by intravenous single dose administration of gadolinium based contrast agent (IV-SD-GBCA). MATERIALS AND METHODS: Eight healthy men and 13 patients with suspected endolymphatic hydrops were included...
January 18, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29317968/b-type-natriuretic-peptide-a-predictor-for-mortality-intensive-care-unit-length-of-stay-and-hospital-length-of-stay-in-patients-with-resolving-sepsis
#11
Harsimar Singh, Daryl Ramai, Harshil Patel, Marina Iskandir, Sarina Sachdev, Rabjot Rai, Jay Patolia, Getaw Worku Hassen
Background: B-type natriuretic peptide (BNP) is a hormone secreted by cardiomyocytes in response to myocardial ischemia, increased ventricular wall tension, and overload. BNP is utilized as a diagnostic and prognostic marker in congested heart failure (CHF). Its prognostic value in sepsis is unknown. The aim of this study is to determine if BNP correlates with increased in-hospital mortality for septic patients. Methods: This was a retrospective study of 505 patients admitted for sepsis or severe sepsis or septic shock during the period of January 2013 and August 2014...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29310984/comparison-of-sonographic-inferior-vena-cava-and-aorta-indexes-during-fluid-administered-in-children
#12
Yun Ang Choi, Hyuksool Kwon, Jin Hee Lee, Jae Yun Jung, Yoo Jin Choi
OBJECTIVES: This prospective, observational study evaluated changes in ultrasound measurements of the inferior vena caval index (IVCI), the aorta diameter/IVC diameter index (Ao/IVCD), and the aorta area/IVC area index (Ao/IVCA) during fluid administration in children requiring intravenous fluid administration. METHODS: Children who presented to the pediatric emergency department with symptoms of dehydration were enrolled between May 2015 and February 2016. The maximum diameter of the aorta, from inner wall to inner wall, and the long and short axis diameters of IVC were measured using a convex array transducer in the transverse view...
January 4, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29171669/volume-responsiveness-assessed-by-passive-leg-raising-and-a-fluid-challenge-a-critical-review-focused-on-mean-systemic-filling-pressure
#13
K Cooke, R Sharvill, S Sondergaard, A Aneman
This review applied cardiovascular principles relevant to the physiology of venous return in interpreting studies on the utility of a passive leg-raising manoeuvre to identify patients who do (responders) or do not respond to a subsequent intravenous volume challenge with an increase in cardiac output. Values for cardiac output, mean arterial and central venous pressure, and the calculated cardiovascular variables mean systemic filling pressure analogue, heart efficiency, cardiac power indexed by volume state and volume efficiency, before and after passive leg raising as well as before and after fluid volume challenge, were extracted from published studies...
March 2018: Anaesthesia
https://www.readbyqxmd.com/read/29142152/indirect-proton-mr-imaging-and-kinetic-analysis-of-17-o-labeled-water-tracer-in-the-brain
#14
Kohsuke Kudo, Taisuke Harada, Hiroyuki Kameda, Ikuko Uwano, Fumio Yamashita, Satomi Higuchi, Kunihiro Yoshioka, Makoto Sasaki
PURPOSE: The feasibility of steady-state sequences for (17)O imaging was evaluated based on a kinetic analysis of the brain parenchyma and cerebrospinal fluid (CSF). MATERIALS AND METHODS: The institutional review board approved this prospective study with written informed consent. Dynamic 2D or 3D steady-state sequences were performed in five and nine participants, respectively, with different parameters using a 3T scanner. During two consecutive dynamic scans, saline was intravenously administered for control purposes in the first scan, and 20% (17)O-labeled water (1 mL/Kg) was administered in the second scan...
November 16, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29112650/maternal-pulse-pressure-and-the-risk-of-postepidural-complications-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Justin R Lappen, Stephen A Myers, Norman Bolen, Brian M Mercer, Edward K S Chien
OBJECTIVE: To test the hypothesis that increasing the intravenous fluid bolus volume at the time of epidural placement in women with narrow pulse pressure would reduce postepidural fetal heart rate (FHR) abnormalities, hypotension, and resuscitative obstetric interventions. METHODS: We performed a single-center randomized controlled trial. Eligible participants were normotensive with a nonanomalous singleton gestation at or after 35 weeks and with a narrow pulse pressure (less than 45 mm Hg) on admission...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29108091/effects-of-low-dose-epinephrine-on-perioperative-hemostasis-and-inflammatory-reaction-in-major-surgical-operations-a-randomized-clinical-trial
#16
J L Liu, W N Zeng, F Y Wang, C Chen, X Y Gong, H Yang, Z J Tan, X L Jia, L Yang
Essentials Blood loss and immune reaction are closely related to morbidity and recovery after surgery. We studied the effect of epinephrine plus tranexamic acid on blood loss and immune reaction. Epinephrine plus tranexamic acid reduced postoperative total blood loss and immune reaction. Epinephrine plus tranexamic acid did not increase the incidence of complications. SUMMARY: Background Hemostasis, thrombosis and surgical stress-induced immune reactions are important for perioperative morbidity and recovery after major surgical operations...
January 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29091212/penetration-of-linezolid-into-synovial-fluid-and-muscle-tissue-after-elective-arthroscopy
#17
R Schwameis, S Syré, K Sarahrudi, A Appelt, D Marhofer, D Burau, C Kloft, M Zeitlinger
Objectives: Penetration of antibiotics into synovial fluid is crucial to combat septic arthritis efficiently. Since linezolid may be used for treatment of septic arthritis when methicillin-resistant bacterial strains are suspected, we investigated its target-site concentrations in synovial fluid. Patients and methods: Ten patients undergoing elective knee arthroscopy were included in this study. Subjects received a single dose of 600 mg of linezolid intravenously and linezolid concentrations were measured in plasma and by using microdialysis in muscle tissue and synovial fluid...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29089037/revisiting-atenolol-as-a-low-passive-permeability-marker
#18
Xiaomei Chen, Tim Slättengren, Elizabeth C M de Lange, David E Smith, Margareta Hammarlund-Udenaes
BACKGROUND: Atenolol, a hydrophilic beta blocker, has been used as a model drug for studying passive permeability of biological membranes such as the blood-brain barrier (BBB) and the intestinal epithelium. However, the extent of S-atenolol (the active enantiomer) distribution in brain has never been evaluated, at equilibrium, to confirm that no transporters are involved in its transport at the BBB. METHODS: To assess whether S-atenolol, in fact, depicts the characteristics of a low passive permeable drug at the BBB, a microdialysis study was performed in rats to monitor the unbound concentrations of S-atenolol in brain extracellular fluid (ECF) and plasma during and after intravenous infusion...
October 31, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29067696/pharmacokinetics-and-antinociceptive-effects-of-the-soluble-epoxide-hydrolase-inhibitor-t-tucb-in-horses-with-experimentally-induced-radiocarpal-synovitis
#19
A G P Guedes, F Aristizabal, A Sole, A Adedeji, R Brosnan, H Knych, J Yang, S-H Hwang, C Morisseau, B D Hammock
This study determined the pharmacokinetics, antinociceptive, and anti-inflammatory effects of the soluble epoxide hydrolase (sEH) inhibitor t-TUCB (trans-4-{4-[3-(4-Trifluoromethoxy-phenyl)-ureido]-cyclohexyloxy}-benzoic acid) in horses with lipopolysaccharide (LPS)-induced radiocarpal synovitis. A total of seven adult healthy mares (n = 4-6/treatment) were administered 3 μg LPS into one radiocarpal joint and t-TUCB intravenously (i.v.) at 0 (control), 0.03, 0.1, 0.3, and 1 mg/kg in a blinded, randomized, crossover design with at least 3 weeks washout between...
April 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28948373/evaluation-of-endolymphatic-hydrops-using-3-t-mri-after-intravenous-gadolinium-injection
#20
Takao Imai, Atsuhiko Uno, Tadashi Kitahara, Tomoko Okumura, Arata Horii, Yumi Ohta, Takashi Sato, Suzuyo Okazaki, Takefumi Kamakura, Yoshiyuki Ozono, Yoshiyuki Watanabe, Yukiko Hanada, Ryusuke Imai, Kazuya Ohata, Hidenori Inohara
Aim of this work is to establish evaluation criteria for identifying endolymphatic hydrops in the vestibule and cochlea using a magnetic resonance imaging (MRI) scanner. This is a retrospective diagnostic study. We evaluated 70 ears of 35 unilateral Ménière's disease patients. We performed 3-T MRI 4 h after intravenous gadolinium injection. Otologists manually traced the outline of vestibule, cochlea, and endolymphatic space of the vestibule and cochlea on two-dimensional fluid-attenuated inversion-recovery (2D-FLAIR) images...
December 2017: European Archives of Oto-rhino-laryngology
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