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https://www.readbyqxmd.com/read/28918178/using-imaging-to-predict-treatment-response-in-genitourinary-malignancies
#1
REVIEW
Amir H Lebastchi, Matthew J Watson, Christopher M Russell, Arvin K George, Alon Z Weizer, Baris Turkbey
CONTEXT: Over the previous2 decades, there have been numerous advancements in the diagnostic evaluation, therapeutic management, and postoperative assessment of genitourinary malignancies. OBJECTIVE: To present a review of current and novel imaging modalities and their utility in the assessment of therapeutic response in the systemic management of renal, testicular, and prostate cancers. EVIDENCE ACQUISITION: A PubMed/Medline search of the current published literature inclusive of prospective and retrospective original research, systematic reviews, and meta-analyses was conducted evaluating imaging modalities for renal cell carcinoma, prostate cancer, and testicular cancer...
September 13, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28916862/monitoring-the-response-of-urothelial-precancerous-lesions-to-bacillus-calmette-guerin-at-the-proteome-level-in-an-in-vivo-rat-model
#2
Kerem Teke, Nil Guzel, Ali Kemal Uslubas, Murat Kasap, Hasan Yilmaz, Gurler Akpinar, Demir Kursat Yildiz, Ozdal Dillioglugil
Intravesical Bacillus Calmette-Guerin (BCG) is the best treatment modality for progression of non-muscle invasive bladder cancer. We aimed to monitor changes at the proteome level to identify putative protein biomarkers associated with the response of urothelial precancerous lesions to intravesical BCG treatment. The rats were divided into three groups (n = 10/group): control, non-treated, and BCG-treated groups. The non-treated and BCG-treated groups received N-methyl-N-nitrosourea intravesically. BCG Tice-strain was instilled into bladder in BCG-treated group...
September 15, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28916738/cold-atmospheric-helium-plasma-causes-synergistic-enhancement-in-cell-death-with-hyperthermia-and-an-additive-enhancement-with-radiation
#3
Rohan Moniruzzaman, Mati Ur Rehman, Qing-Li Zhao, Paras Jawaid, Keigo Takeda, Kenji Ishikawa, Masaru Hori, Kei Tomihara, Kyo Noguchi, Takashi Kondo, Makoto Noguchi
Cold atmospheric plasmas (CAPs) have been proposed as a novel therapeutic method for its anti-cancer potential. However, its biological effects in combination with other physical modalities remain elusive. Therefore, this study examined the effects of cold atmospheric helium plasma (He-CAP) in combination with hyperthermia (HT) 42 °C or radiation 5 Gy. Synergistic enhancement in the cell death with HT and an additive enhancement with radiation were observed following He-CAP treatment. The synergistic effects were accompanied by increased intracellular reactive oxygen species (ROS) production...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915710/insights-from-animal-models-of-bladder-cancer-recent-advances-challenges-and-opportunities
#4
REVIEW
Bincy Anu John, Neveen Said
Bladder cancer (urothelial cancer of the bladder) is the most common malignancy affecting the urinary system with increasing incidence and mortality. Treatment of bladder cancer has not advanced in the past 30 years. Therefore, there is a crucial unmet need for novel therapies, especially for high grade/stage disease that can only be achieved by preclinical model systems that faithfully recapitulate the human disease. Animal models are essential elements in bladder cancer research to comprehensively study the multistep cascades of carcinogenesis, progression and metastasis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915585/time-dependent-modulation-of-tumor-radiosensitivity-by-a-pan-hdac-inhibitor-abexinostat
#5
Sofia Rivera, Céline Leteur, Frédérique Mégnin, Frédéric Law, Isabelle Martins, Ioana Kloos, Stéphane Depil, Nazanine Modjtahedi, Jean Luc Perfettini, Christophe Hennequin, Eric Deutsch
Despite prominent role of radiotherapy in lung cancer management, there is an urgent need for strategies increasing therapeutic efficacy. Reversible epigenetic changes are promising targets for combination strategies using HDAC inhibitors (HDACi). Here we evaluated on two NSCLC cell lines, the antitumor effect of abexinostat, a novel pan HDACi combined with irradiation in vitro in normoxia and hypoxia, by clonogenic assays, demonstrating that abexinostat enhances radiosensitivity in a time dependent way with mean SER10 between 1...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915362/improved-efficacy-of-hyperthermia-by-auraptene-in-human-colon-adenocarcinoma-cells
#6
Mahdi Moussavi, Farhang Haddad, Matin Matin, Mehrdad Iranshahi, Fatemeh Rassouli
Colon adenocarcinoma is one of the most common cancers worldwide, and resistance to current therapeutic modalities is a serious drawback in its treatment. Auraptene is a natural coumarin with considerable anticancer effects. The goal of present study was to introduce a novel combinatorial approach against colon adenocarcinoma cells. To do so, HT29 cells were pretreated with non-toxic auraptene and then hyperthermia was applied. Afterwards, viability of cells was assessed, changes induced in the cell cycle were analyzed, and expression pattern of candidate genes was studied...
September 15, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28914772/the-heat-stable-enterotoxin-receptor-guanylyl-cyclase-c-as-a-pharmacological-target-in-colorectal-cancer-immunotherapy-a-bench-to-bedside-current-report
#7
REVIEW
Trevor R Baybutt, Allison A Aka, Adam E Snook
Cancer immunotherapy is becoming a routine treatment modality in the oncology clinic, in spite of the fact that it is a relatively nascent field. The challenge in developing effective immunotherapeutics is the identification of target molecules that promote anti-tumor efficacy across the patient population while sparing healthy tissue from damaging autoimmunity. The intestinally restricted receptor guanylyl cyclase C (GUCY2C) is a target that has been investigated for the treatment of colorectal cancer and numerous animal, and clinical studies have demonstrated both efficacy and safety...
September 15, 2017: Toxins
https://www.readbyqxmd.com/read/28914693/care-patterns-and-changes-in-treatment-for-nonmetastatic-breast-cancer-in-2013-2014-versus-2005-a-population-based-high-resolution-study
#8
Marcela Guevara, Rosana Burgui, Jorge Díaz-González, Esteban Salgado, Francisco Vicente, Conchi Moreno-Iribas, María J Urbina, Alicia Córdoba, Concepción de Miguel, Eva Ardanaz
Studies on recent trends in patterns of care for breast cancer patients are scarce. This study aims to examine the patterns and trends in the treatment of women with nonmetastatic breast cancer according to major recommended treatment options. A population-based study was carried out in Navarra, Spain, including all women with a primary invasive nonmetastasized breast cancer, diagnosed in 2005 and in 2013-2014. We compared patients' characteristics and treatment patterns between periods. Factors associated with receipt of recommended treatment were examined by multivariate logistic regression...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28914087/effect-of-myofascial-techniques-for-treatment-of-persistent-arm-pain-after-breast-cancer-treatment-randomized-controlled-trial
#9
An De Groef, Marijke Van Kampen, Nele Vervloesem, Evi Dieltjens, Marie-Rose Christiaens, Patrick Neven, Lore Vos, Tessa De Vrieze, Inge Geraerts, Nele Devoogdt
OBJECTIVE: To investigate the effect of myofascial therapy in addition to a standard physical therapy program for treatment of persistent arm pain after finishing breast cancer treatment. DESIGN: Double-blinded (patient and assessor) randomized controlled trial. SETTING: University Hospitals Leuven, Belgium. PATIENTS: A total of 50 patients with persistent arm pain and myofascial dysfunctions after breast cancer treatment...
September 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28913301/concordant-surgical-treatment-non-melanocytic-skin-cancer-of-the-head-and-neck
#10
Wan Cheol Ryu, In Chang Koh, Yong Hae Lee, Jong Hyun Cha, Sang Il Kim, Chang Gyun Kim
BACKGROUND: Skin cancer is the most common type of cancer. Of the 4 million skin lesions excised annually worldwide, approximately 2 million are considered cancerous. In this study, we aimed to describe a regional experience with skin cancers treated by a single senior surgeon and to provide a treatment algorithm. METHODS: The medical records of 176 patients with head and neck non-melanocytic skin cancer (NMSC) who were treated by a single surgeon at our institution between January 2010 and May 2016 were retrospectively reviewed, and their data (age, sex, pathological type, tumor location/size, treatment modality) were analyzed...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28912824/prevalence-and-correlates-of-complementary-and-alternative-medicine-use-among-patients-with-lung-cancer-a-cross-sectional-study-in-beirut-lebanon
#11
Farah Naja, Bilal Anouti, Hibeh Shatila, Reem Akel, Yolla Haibe, Arafat Tfayli
Patients with lung cancer are increasingly seeking complementary and alternative medicine (CAM) to improve their physiological and psychological well-being. This study aimed to assess CAM use among lung cancer patients in Lebanon. Using a cross-sectional design, 150 lung cancer patients attending the Basile Cancer Institute at the American University of Beirut Medical Center were interviewed. Participants completed a questionnaire addressing sociodemographic characteristics, lung cancer condition, and use of CAM...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28911729/chemotherapy-and-tyrosine-kinase-inhibitors-for-medullary-thyroid-cancer
#12
REVIEW
Julien Hadoux, Martin Schlumberger
Medullary thyroid cancer (MTC) represents 3% of all clinical thyroid cancers and arises from thyroid C cells that produce calcitonin. Locally advanced or metastatic MTC requires a careful work-up including measurement of serum calcitonin and carcinoembryonic antigen, determination of their doubling time and comprehensive imaging to determine the extent of the disease, its aggressiveness, and the need for treatment. Cytotoxic chemotherapy can control tumor burden in some patients with response rates of around 20% in old series...
June 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28911724/radioactive-iodine-rai-therapy-for-metastatic-differentiated-thyroid-cancer
#13
REVIEW
Frederik A Verburg, Heribert Hänscheid, Markus Luster
Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. It usually has a comparatively benign course. If properly executed, radioiodine therapy can provide an effective treatment of even advanced, metastatic DTC. A major problem in determining the right RAI for a patient with metastatic disease is a comparative lack of evidence. There are no reports on randomized controlled trials in this patient group which can aid us in determining which way to treat which patient. Few non-randomized prospective observational studies have been performed...
June 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28911307/tumor-targeting-of-polymeric-nanoparticles-conjugated-with-peptides-saccharides-and-small-molecules-for-anticancer-drugs
#14
Banu Bayram, Aykut Özgür, Lütfi Tutar, Yusuf Tutar
Targeting drugs or pharmaceutical compounds to tumor site increases cancer treatment efficiency and therapeutic outcome. Nanoparticles are unique delivery systems for site-targeting within an organism. Many novel technologies have been established in drug research and development area. Nanotechnology now offers nanometer size polymeric nanoparticles and these particles direct drugs to their targets, protect drugs against degradation, and release the drug in a controlled manner. Modification of nanoparticle surface by molecules leads to prolonged retention and accumulation in the target area of the organism...
June 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28905009/living-donor-liver-transplantation-for-hepatocellular-cancer-an-almost-exclusive-eastern-procedure
#15
REVIEW
Rafael S Pinheiro, Daniel R Waisberg, Lucas S Nacif, Vinicius Rocha-Santos, Rubens M Arantes, Liliana Ducatti, Rodrigo B Martino, Quirino Lai, Wellington Andraus, Luiz A C D'Albuquerque
Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and it is linked with chronic liver disease. Liver transplantation (LT) is the best curative treatment modality, since it can cure simultaneously the underlying liver disease and HCC. Milan criteria (MC) are the benchmark for selecting patients with HCC for LT, achieving up to 91% 1-year survival post transplantation. However, when considering intention-to-treat (ITT) rates are substantially lower, mainly due dropout. Additionally, Milan criteria (MC) are too restrictive and more inclusive criteria have been reported with good outcomes...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28904890/biophysical-technologies-for-understanding-circulating-tumor-cell-biology-and-metastasis
#16
REVIEW
Derrick W Su, Jorge Nieva
An understanding of cancer evolution in lung cancer with its associated resistance to therapy can only be achieved with repeated sampling and analysis of the cancer. Given the high risks and costs associated with repeat physical biopsy, alternative technologies must be applied. Several modalities exist for analysis and re-analysis of cancer biology. Among them are the CellSearch platform, the CTC chip, and the high-definition CTC platform. While the former is primarily able to provide prognosticating information in the form of CTC enumeration, the latter two have the advantage of serving as a platform to study tumor biology...
August 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28904173/impact-of-metastasectomy-in-the-multimodality-approach-for-braf-v600e-metastatic-colorectal-cancer-the-mayo-clinic-experience
#17
Benny Johnson, Zhaohui Jin, Mark J Truty, Rory L Smoot, David M Nagorney, Michael L Kendrick, Benjamin R Kipp, Axel Grothey
BACKGROUND: BRAF V600E mutations are present in 8%-10% of patients with metastatic colorectal cancer (mCRC) and portend poor prognosis. This study investigated the impact of metastasectomy for patients with BRAF V600E mCRC. Subjects, Materials, and Methods . Using prospective clinical and molecular data, patients with BRAF V600E mCRC were analyzed for clinical characteristics and survival. Statistical analyses utilized the Kaplan-Meier method, log-rank test, and Cox proportional hazard models...
September 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28903837/impact-of-different-treatment-modalities-on-the-outcome-of-pancreatic-cancer
#18
Misbah Khan, Muhammad Ijaz Ashraf, Aamir Ali Syed, Faisal Hanif
OBJECTIVE: To analyze overall survival patterns of our pancreatic cancer patient population managed with a curative or palliative intent. STUDY DESIGN: Analytical study. PLACE AND DURATION OF STUDY: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from January 2000 till February 2015. METHODOLOGY: Aretrospective review of the data of all of our pancreatic cancer patients was performed, using the hospital information system...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28901637/pet-ct-versus-bone-marrow-biopsy-in-the-initial-evaluation-of-bone-marrow-infiltration-in-various-pediatric-malignancies
#19
Claudia P Zapata, Branko Cuglievan, Catalina M Zapata, Raquel Olavarrieta, Scott Raskin, Kavita Desai, Guillermo De Angulo
Accurate staging is essential in the prognosis and management of pediatric malignancies. Current protocols require screening for marrow infiltration with bone marrow biopsy (BMB) as the gold standard. Positron emission tomography-computed tomography (PET-CT) is commonly used to complete the staging process and can also be used to evaluate marrow infiltration. OBJECTIVE: To compare PET-CT and BMB in the initial evaluation of bone marrow infiltration in pediatric cancers. DESIGN/METHOD: We retrospectively reviewed new cases of EWS, rhabdomyosarcoma, neuroblastoma, and lymphoma diagnosed between January 2009 and October 2014...
September 13, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28901301/expert-consensus-workshop-report-guideline-for-three-dimensional-printing-template-assisted-computed-tomography-guided-125-i-seeds-interstitial-implantation-brachytherapy
#20
REVIEW
Junjie Wang, Fujun Zhang, Jinhe Guo, Shude Chai, Guangjun Zheng, Kaixian Zhang, Anyan Liao, Ping Jiang, Yuliang Jiang, Zhe Ji
Radioactive 125I seeds (RIS) interstitial implantation brachytherapy has been a first-line treatment for early-stage cancer of the prostate gland. However, its poor accuracy and homogeneity has limited its indication and hampered its popularization for a long time. Intriguingly, scholars based in China introduced computed tomography (CT)-guided technology to improve the accuracy and homogeneity of RIS implantation and broadened the indications. Then, they creatively designed and introduced three-dimensional printing coplanar template (3D-PCT) and 3D printing noncoplanar template (3D-PNCT) into the practice of RIS implantation...
2017: Journal of Cancer Research and Therapeutics
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