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https://www.readbyqxmd.com/read/28919990/pharmacological-targeting-of-peptidylarginine-deiminase-4-prevents-cancer-associated-kidney-injury-in-mice
#1
Jessica Cedervall, Anca Dragomir, Falk Saupe, Yanyu Zhang, Johan Ärnlöv, Erik Larsson, Anna Dimberg, Anders Larsson, Anna-Karin Olsson
Renal insufficiency is a frequent cancer-associated problem affecting more than half of all cancer patients at the time of diagnosis. To minimize nephrotoxic effects the dosage of anticancer drugs are reduced in these patients, leading to sub-optimal treatment efficacy. Despite the severity of this cancer-associated pathology, the molecular mechanisms, as well as therapeutic options, are still largely lacking. We here show that formation of intravascular tumor-induced neutrophil extracellular traps (NETs) is a cause of kidney injury in tumor-bearing mice...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28919792/clinical-outcomes-and-nephrotoxicity-of-colistin-loading-dose-for-treatment-of-extensively-drug-resistant-acinetobacter-baumannii-in-cancer-patients
#2
Wasan Katip, Suriyon Uitrakul, Peninnah Oberdorfer
BACKGROUND: Colistin is a last-line defense therapy against extensively drug-resistant Acinetobacter baumannii (XDR-AB). Despite a loading dose of colistin being applied in many clinical practices, studies evaluating the effect of the loading dose of colistin in cancer patients remain limited. PATIENTS AND METHODS: A retrospective cohort study of cancer patients who received either a loading or non-loading dose of colistin for treatment of XDR-AB was conducted. For each group, the clinical response, bacteriological eradication and serum creatinine were recorded...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28913815/pharmacokinetic-pharmacodynamic-analysis-of-cisplatin-with-hydration-and-mannitol-diuresis-the-contribution-of-urine-cisplatin-concentration-to-nephrotoxicity
#3
Keizo Fukushima, Akira Okada, Hiroyuki Oe, Mika Hirasaki, Mami Hamori, Asako Nishimura, Nobuhito Shibata, Nobuyuki Sugioka
BACKGROUND AND OBJECTIVES: Forced diuresis, high-volume hydration with diuresis, is widely used as a prophylactic treatment against cisplatin nephrotoxicity. However, the details of the underlying mechanisms and the optimal protocol of forced diuresis remain unclear. The present study investigated the alterations in pharmacokinetics and pharmacodynamics (nephrotoxicity) of cisplatin with forced diuresis treatment. METHODS: Cisplatin (5 mg/kg) was intravenously injected to rats (5 rats/group, except for control group in pharmacodynamic study, n = 13) treated with or without forced diuresis 2-h pre- and post-hydration with 10% mannitol at different infusion rates (0...
September 14, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28911689/effect-of-oleuropein-against-chemotherapy-drug-induced-histological-changes-oxidative-stress-and-dna-damages-in-rat-kidney-injury
#4
Fatime Geyikoglu, Murat Emir, Suat Colak, Kubra Koc, Hasan Turkez, Murat Bakir, Mirkhalil Hosseinigouzdagani, Salim Cerig, Osman Nuri Keles, Nihal Simsek Ozek
Cisplatin-based chemotherapy is responsible for a large number of renal failures, and it is still associated with high rates of mortality today. Oleuropein (OLE) presents a plethora of pharmacological beneficial properties. In this study we investigated whether OLE could provide sufficient protection against cisplatin-induced nephrotoxicity. With this aim, Sprague-Dawley rats were divided into eight groups: control; 7 mg/kg/d cisplatin, 50 mg/kg, 100 mg/kg, and 200 mg/kg OLE; and treatment with OLE for 3 days starting at 24 hours following cisplatin injection...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904656/reversal-of-tenofovir-induced-nephrotoxicity-case-reports-of-two-patients
#5
Fatuma Some, Mathew Koech, Emily Chesire, Gabriel Kigen
The use of the antiretroviral drug tenofovir has been associated with nephrotoxicity. However, the overall impact of this adverse effect has not comprehensively evaluated. Some researchers have reported that it is quite severe to warrant monitoring for renal toxicity, while others have concluded that the magnitude may not be that significant. We report two clinical cases seen in our renal clinic with high creatinine levels suggestive of nephrotoxicity who reverted back to normality upon withdrawal of tenofovir...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904297/sex-differences-in-the-excretion-levels-of-traditional-and-novel-urinary-biomarkers-of-nephrotoxicity-in-rats
#6
Satoshi Tsuji, Masayuki Sugiura, Shunsuke Tsutsumi, Hisaharu Yamada
Urinary biomarkers have been used widely in preclinical toxicity studies to detect dysfunctions and injuries of the kidney caused by drugs under development. While they have been well studied for evaluating nephrotoxicity, knowledge of sex differences in excretion levels of urinary biomarkers remains inadequate. We conducted experiments focused on effects of endogenous sex hormones on urinary biomarkers using intact and castrated male and female rats. Comparisons of the urinary biomarker excretion levels between intact male and female rats at 5, 7, 9 and 12 weeks of age revealed higher excretion levels of leucine aminopeptidase (LAP), γ-glutamyl transpeptidase (γGTP), total protein, liver-type fatty acid-binding protein (L-FABP), cystatin C (Cys-C) and β2-microglobulin (β2-MG), and lower excretion level of kidney injury molecule 1 (Kim-1), in male rats as compared to female rats...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28885000/multi-platform-approach-for-the-discovery-of-novel-drug-induced-kidney-injury-biomarkers
#7
Liuxi Chen, James D Smith, Jaromir Mikl, Ryan Fryer, Frank Pack, Brad J Williams, Jonathan Phillips, Vladimir Papov
Drug-induced kidney injury (DIKI) is a common toxicity observed in pharmaceutical development. We demonstrate the use of label-free liquid chromatography - mass spectrometry (LC-MS) and multiplex liquid chromatography-single reaction monitoring (LC-SRM) as practical extensions of standard immunoassay based safety biomarker assessments for identification of new toxicity marker candidates and for improved mechanistic understanding. Two different anti-cancer drugs doxorubicin (DOX) and cisplatin (cis-diamminedichloridoplatinum, CDDP) were chosen as the toxicants due to their different modes of nephrotoxicity...
September 8, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28881316/development-and-validation-of-a-sensitive-lc-ms-ms-method-without-derivatization-ion-pairing-agents-for-etimicin-quantification-in-rat-plasma-internal-ear-and-kidney
#8
Lan Yao, Fang Zhou, Mingmin Cai, Ying Peng, Jianguo Sun, Qianying Chen, Xiaoliang Jin, Guangji Wang, Jingwei Zhang
Etimicin (ETM), which belongs to the newest generation of aminoglycosides (AGs), has been proven to not only maintain but also strengthen the advantages of former AGs with relatively less toxicity. Now, it is widely applied for the treatment of bacterial infections in the clinic. Nevertheless, nephrotoxicity and ototoxicity are unavoidable issues for AGs, and while ETM is no exception, the seriousness of these issues is different. To explore the reason why ETM exhibits less toxicity and to better direct the optimization and development of new AGs, it is of great necessity and importance to monitor the pharmacokinetic behaviors of ETM in its potential toxicity target organs, the kidney and internal ear, as well as in plasma...
August 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28878864/use-of-everolimus-in-liver-transplantation
#9
REVIEW
Mei-Ling Yee, Hui-Hui Tan
In recent years, the use of mammalian target of rapamycin inhibitors has gained traction in their use as alternative or adjunct immunosuppressants in the post-liver transplantation (LT) setting. The efficacy of everolimus (EVR) in de novo LT is established and a reasonable time to initiate EVR is 30 d from LT surgery. Initiating EVR early post-LT allows for calcineurin inhibitor (CNI) reduction, thus reducing nephrotoxicity in LT recipients. However, data is inadequate on the appropriate timing for conversion from CNI to EVR maintenance in order to achieve optimal renoprotective effect without compromising drug efficacy...
August 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28875354/-life-after-acute-kidney-injury-long-term-consequences-%C3%AF-and-implications-for-clinical-practice
#10
REVIEW
S J Klein, A K Brandtner, M Peball, M Joannidis
Acute kidney injury (AKI) is a common complication in critically ill patients and is accompanied by significantly increased mortality and morbidity. Those complications are not limited to the acute phase of the illness, but may also affect a patient's risk profile long after AKI. Recovery of renal function is observed in the majority of patients although this rate significantly deteriorates with increasing severity of the AKI. After an AKI episode, the long-term risk for the development of chronic kidney disease (CKD) is considerably increased, as well as the risk for cardiovascular and neurological complications...
September 5, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28870684/isoliquiritigenin-pretreatment-attenuates-cisplatin-induced-proximal-tubular-cells-llc-pk1-death-and-enhances-the-toxicity-induced-by-this-drug-in-bladder-cancer-t24%C3%A2-cell-line
#11
Angela Patricia Moreno-Londoño, Claudia Bello-Alvarez, José Pedraza-Chaverri
Cisplatin is an effective antineoplastic agent widely used in the treatment of solid tumors, however, it induces nephrotoxicity. Cisplatin-induced nephrotoxicity is associated with increased reactive oxygen species (ROS) production and decreased antioxidant system defense in kidney. Isoliquiritigenin (IsoLQ) is a chalcone, which is characterized by its antioxidant and antiinflammatory properties. Herein, we investigated the protective effect of IsoLQ on LLC-PK1 proximal tubular cells against cisplatin-induced death and its effect on the antineoplastic activity of cisplatin on bladder cancer T24 cell line...
September 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28868009/good-tolerance-to-full-dose-crizotinib-in-a-patient-with-anaplastic-lymphoma-receptor-tyrosine-kinase-rearranged-lung-adenocarcinoma-and-preexisting-renal-impairment
#12
Adeline Rosoux, Fabrice Duplaquet, Sebahat Ocak
BACKGROUND: Crizotinib is an approved tyrosine kinase inhibitor in the treatment of advanced-stage non-small-cell lung cancer patients with anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangement. Renal dysfunction after crizotinib administration was recently reported, but the physiopathological explanation and the safety in patients with preexisting renal dysfunction are still not clear. CASE PRESENTATION: A 44-year-old female and current smoker was diagnosed with a stage IV lung adenocarcinoma and treated with five lines of chemotherapy during a 4-year period of time...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28866836/colistin-nephrotoxicity-in-the-icu-is-it-different-in-the-geriatric-patients
#13
Burcu Başarık Aydoğan, Fatma Yıldırım, Avşar Zerman, Kamil Gönderen, Melda Türkoğlu, Gülbin Aygencel
OBJECTIVE: Most significant side effect of colistin therapy which is used for the treatment of multi-drug resistant Gram-negative infections is nephrotoxicity. Our aim was to investigate the differences of colistin nephrotoxicity between the geriatric age group (≥65 years) and the younger age group (<65 years) in critically ill medical intensive care unit (ICU) patients. MATERIAL AND METHOD: The medical records of the 76 patients who were taken colistin therapy due to multi-resistant Gram-negative infections between January 2010 and June 2014 in the our medical ICU were retrospectively investigated...
September 2, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28851656/cholemic-nephropathy-historical-notes-and-novel-perspectives
#14
REVIEW
Elisabeth Krones, Marion J Pollheimer, Alexander R Rosenkranz, Peter Fickert
Acute kidney injury is common in patients with liver disease and associated with significant morbidity and mortality. Besides bacterial infections, fluid loss, and use of nephrotoxic drugs AKI in liver disease may be triggered by tubular toxicity of cholephiles. Cholemic nephropathy, also known as bile cast nephropathy, supposedly represents a widely underestimated but important cause of renal dysfunction in cholestasic or advanced liver diseases with jaundice. Cholemic nephropathy describes impaired renal function along with characteristic histomorphological changes consisting of intratubular cast formation and tubular epithelial cell injury directed towards distal nephron segments...
August 26, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28845130/anaesthetic-challenges-in-cancer-patients-current-therapies-and-pain-management
#15
Jūratė Gudaitytė, Dominykas Dvylys, Indrė Šimeliūnaitė
THE OBJECTIVE: The aim is to present the major effects of cancer treatment (chemotherapy, radiotherapy, surgery) that the anaesthesiologist should consider preoperatively, and to review techniques of the analgesic management of the disease. MATERIALS AND METHODS: To summarize the major challenges that cancer patients present for the anaesthesiologists, a literature review was conducted. Articles presenting evidence or reviewing the possible effects of anaesthetics on cancer cells were also included...
2017: Acta medica Lituanica
https://www.readbyqxmd.com/read/28834230/renal-impairment-hampers-bisphosphonate-treatment-in-a-quarter-of-lung-cancer-patients-with-bone-metastasis
#16
Katalin Fábián, Rita Puskás, Tímea Kakuk, László Prés, Dorottya Fejes, Zsolt Szegedi, Lívia Rojkó, Zoltán Szállási, Balázs Döme, Orsolya Pipek, Judit Moldvay
Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function parameters. Co-morbidities included hypertension (50%), COPD (33%) and diabetes mellitus (15%). Statistical analysis was performed with Fisher's exact tests and a Cox proportional hazards model...
August 21, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28828381/paracetamol-in-patent-ductus-arteriosus-treatment-efficacious-and-safe
#17
REVIEW
Flaminia Bardanzellu, Paola Neroni, Angelica Dessì, Vassilios Fanos
In preterm infants, failure or delay in spontaneous closure of Ductus Arteriosus (DA), resulting in the condition of Patent Ductus Arteriosus (PDA), represents a significant issue. A prolonged situation of PDA can be associated with several short- and long-term complications. Despite years of researches and clinical experience on PDA management, unresolved questions about the treatment and heterogeneity of clinical practices in different centers still remain, in particular regarding timing and modality of intervention...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28828347/the-role-of-gamma-amino-butyric-acid-in-cisplatin-induced-nephrotoxicity-in-streptozotocin-induced-diabetic-rats
#18
Masoomeh Nasiri, Nepton Soltani, Safoora Mazaheri, Maryam Maleki, Ardeshir Talebi, Fatemah Gharibi, Mehdi Nematbakhsh
BACKGROUND: Diabetes mellitus can change the risk of developing cancer. Cisplatin (CP) is a common antineoplastic drug. The major side effect of CP is nephrotoxicity. Gamma amino butyric acid (GABA) is an antioxidant agent that may have a protective role against CP-induced nephrotoxicity. The aim of the present study was to investigate the role of GABA in CP-induced nephrotoxicity in hyperglycemic male and female rats. MATERIALS AND METHODS: Sixty male and female Wistar diabetic rats were used in ten experimental groups...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28823018/prevalence-and-nature-of-potential-drug-drug-interactions-among-kidney-transplant-patients-in-a-german-intensive-care-unit
#19
Julia Amkreutz, Alexander Koch, Lukas Buendgens, Anja Muehlfeld, Christian Trautwein, Albrecht Eisert
Background Complex polypharmacotherapy makes kidney transplant patients vulnerable to drug-drug interactions (DDIs). Objective To study prevalence and nature of potential DDIs (pDDIs) in kidney transplant patients. Setting Internal medicine ICU, University Hospital RWTH Aachen. Method In this retrospective observational study, pDDIs were identified in the first week after transplant from 1999 to 2010. Patients aged at least 18 years with prescription of at least two drugs were included. Patients with incomplete data were excluded...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28821388/a-case-control-analysis-investigating-risk-factors-and-outcomes-for-nephrocalcinosis-and-renal-calculi-in-neonates
#20
Melissa Huynh, Roderick Clark, Jenny Li, Guido Filler, Sumit Dave
INTRODUCTION: Studies on outcomes and risk factors for neonatal nephrocalcinosis (NC) and renal calculi (RC) are limited, and often do not include controls for comparison. We conducted a case-control analysis to identify risk factors associated with NC and/or RC in neonates and studied the natural course of these anomalies. STUDY DESIGN: Infants diagnosed with NC/RC on ultrasound within the first year of life and corresponding gestational age- and gender-matched controls were identified from the neonatal intensive care unit database at our institution over a 10-year period...
July 27, 2017: Journal of Pediatric Urology
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