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JOURNAL ARTICLE
Ayana Yamagami, Shintaro Iwama, Tomoko Kobayashi, Xin Zhou, Yoshinori Yasuda, Takayuki Okuji, Masaaki Ito, Tetsushi Izuchi, Masahiko Ando, Takeshi Onoue, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Hiroshi Arima
Anti-thyroglobulin antibodies (TgAb) and/or anti-thyroid peroxidase antibodies (TPOAb) positivity at baseline is a risk marker for thyroid immune-related adverse events (thyroid-irAEs) in anti-programmed cell death-1 antibody (PD-1-Ab) treatment; however, it is unknown if TgAb and TPOAb titers are associated with clinical characteristics of thyroid-irAEs. Among 586 patients treated with PD-1-Ab at Nagoya University Hospital between 2 November 2015 and 30 September 2021, 57 patients developed thyroid-irAEs (thyrotoxicosis [n = 38]; hypothyroidism without prior thyrotoxicosis {isolated hypothyroidism} [n = 19]) in whom thyroid function, and TgAb and TPOAb titers were determined at baseline and at the onset...
April 11, 2024: Endocrine Journal
#22
JOURNAL ARTICLE
Yi Ruan, Xian-Pei Heng, Liu-Qing Yang, Wei-Dong He, Liang Li, Zhi-Ta Wang, Su-Ping Huang, Qi-Wei Chen, Zhuang Han
BACKGROUND: There is no doubt that both Hashimoto thyroiditis and Graves' disease are autoimmune thyroid diseases (AITDs), but the relationship between anti-nuclear antibody (ANA) and AITDs is poorly studied. The association between thyroid autoantibody levels and ANA positivity was evaluated to assess the role of ANA in AITDs. METHODS: We conducted an analysis using data from 1,149,893 patients registered at our hospital and 53,021 patients registered in the National Health and Nutrition Examination Survey databases...
2024: Frontiers in Endocrinology
#23
Ji-Yoon An, Soo-Im Jang, Seul-Gi Choi, Sae-Nal Lee, Eun-Ja Lee, Kwang-Ki Kim, Hang-Rai Kim
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune disorder with diverse clinical manifestations including myelitis, meningitis, encephalitis, and optic neuritis. MOGAD rarely presents with unilateral cerebral cortical encephalitis (CCE), rendering the diagnosis difficult in these cases. Furthermore, MOGAD is frequently accompanied by other autoimmune diseases such as thyroid disease or inflammatory bowel disease. Herein, we report a case of unilateral CCE with positive anti-myelin oligodendrocyte glycoprotein (MOG) antibodies...
April 2024: Encephalitis
#24
JOURNAL ARTICLE
Minghui Wang, Gongfei Li, Li Dong, Zhijia Hou, Ju Zhang, Dongmei Li
This study aims to establish a random forest model for detecting the severity of Graves Orbitopathy (GO) and identify significant classification factors. This is a hospital-based study of 199 patients with GO that were collected between December 2019 and February 2022. Clinical information was collected from medical records. The severity of GO can be categorized as mild, moderate-to-severe, and sight-threatening GO based on guidelines of the European Group on Graves' orbitopathy. A random forest model was constructed according to the risk factors of GO and the main ocular symptoms of patients to differentiate mild GO from severe GO and finally was compared with logistic regression analysis, Support Vector Machine (SVM), and Naive Bayes...
April 8, 2024: Hormone and Metabolic Research
#25
JOURNAL ARTICLE
Hemat Abdelsamea Mahmoud, Aya Abdel-Baset Ahmed Ali Alsanory, Hanan Gamal-Eldin Mostafa, Esraa Roshdy Hassan
BACKGROUND: This retrospective study analyzed factors influencing hypothyroidism development after radioactive iodine therapy for Graves' disease. PATIENTS AND METHODS: Three hundred and three patients with Graves' disease treated with radioactive iodine (RAI) from 2013 to 2022 at two Egyptian hospitals were included. Data collected included demographics, lab values, thyroid imaging, RAI doses, and outcomes. Patients were followed for ≥1 year to assess hypothyroidism onset...
April 2, 2024: Nuclear Medicine Communications
#26
JOURNAL ARTICLE
Zheng-Xin Liu, Jin-Lin Lv, Yu-Luan Xiang, Wenbin Deng, Hong Huang, Yin-Hua Sun, Li-Hua Li
Objective This population-based cross-sectional study aimed to investigate the association between thyroid hormones and renal function in euthyroid Chinese individuals, as the relationship between thyroid hormones and renal function in this population remains unclear. Methods A total of 661 participants were included in the study after excluding individuals with thyroid diseases, incomplete clinical measurements, or those taking medications affecting thyroid function. Participants were categorized into three groups based on serum thyroid hormone and antibody levels...
March 2024: Curēus
#27
JOURNAL ARTICLE
Xue Meng, Ang Lv, Mulin Tang, Xue Liu, Xinhui Wang, Yuchen Li, Yuwei Chai, Qingqing Yang, Chunjia Kou, Li Zhang, Ming Li, Haiqing Zhang
OBJECTIVE: To identify risk factors for the development of non-thyroidal illness syndrome (NTIS) in patients with systemic lupus erythematosus (SLE). METHODS: A retrospective analysis of 517 SLE patients and 1034 age-and sex-matched healthy population was conducted to compare the prevalence of NTIS in these two groups, and to analyze the laboratory and clinical characteristics of SLE patients with NTIS. Finally Logistic regression analysis was used to determine the risk factors for NTIS in SLE patients...
April 5, 2024: Clinical Rheumatology
#28
REVIEW
Biki Kumar Sah, Zahra Fatima, Rajan Kumar Sah, Bushra Syed, Tulika Garg, Selia Chowdhury, Bikona Ghosh, Binita Kunwar, Anagha Shree, Vivek Kumar Sah, Anisha Raut
BACKGROUND AND OBJECTIVE: Guillain-Barre syndrome (GBS) has been found to have some interesting association with vaccinations. This paper mainly focuses on exploring different associations between COVID-19 vaccination and GBS. METHODS: Electronic databases such as PubMed, Google Scholar, Cochrane, and Embase were searched using MESH terms for case reports published till 1 August 2023 from which 70 case reports were documented involving 103 individuals from 23 different countries...
April 2024: Annals of Medicine and Surgery
#29
Alaa Baioumi, Alzbeta Kolenova, Hima Bindu Avatapalle
A 10-yr-old female was referred due to prolonged bleeding lasting for a week following tooth extraction. She had heavy periods since she was 9. Her height was < 0.4th centile. Tanner staging was breast stage B3-4, axillary hair A1, and pubic hair P1. Thyroid function tests showed elevated TSH, low free T4, and negative anti-TPO antibodies. Gonadotrophins showed high FSH and a prepubertal LH. Prolactin was high and ovarian cysts were found on ultrasound. Further investigations revealed low von Willebrand factor (vWF) antigen levels, leading to a diagnosis of acquired von Willebrand disease...
2024: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
#30
REVIEW
Jihed Anoun, Nourhen Guedri, Imen Ben Hassine, Wafa Baya, Anis Mzabi, Fatma Ben Fredj
INTRODUCTION: Autoimmune disorders often exhibit interconnectedness, although encountering multiple autoimmune conditions in a single patient is uncommon. Multiple autoimmune syndrome is characterized by the presence of at least three distinct autoimmune diseases in an individual. This report outlines the case of a middle-aged woman diagnosed with autoimmune thyroiditis, Sjögren's syndrome, scleroderma, autoimmune hepatitis, primary biliary cirrhosis, and antisynthetase syndrome...
February 5, 2024: La Tunisie Médicale
#31
Tamara Kufoof, Catherine Luxford, Kishani Kannangara, Roderick Clifton-Bligh, Kim C Donaghue
BACKGROUND: Familial non-autoimmune hyperthyroidism is a rare disorder characterized by the absence of thyroid autoimmunity, particularly TSH receptor antibody [TRAb]. OBJECTIVE: The aim of this study was to describe a novel TSHR mutation identified in a family of two siblings and their father. METHODS: Two siblings presented for endocrine assessment at ages 7 and 14 years with mild T3 toxicosis, and the father presented at 30 years of age with non-autoimmune thyrotoxicosis...
2024: Medical Archives
#32
JOURNAL ARTICLE
Ning Huang, Lixue Chen, Zhiqiang Yan, Hongbin Chi, Jie Qiao
BACKGROUND: Cumulative live birth rate (CLBR) is considered as the most important endpoint for assessing the probability of having a baby in a complete in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment cycle. Many previous studies have focused on the association between thyroid autoimmunity (TAI) and live birth rate after first embryo transfer cycle, however, evidence on whether the presence of TAI affects the CLBR is lacking. The purpose of this study is to investigate the impact of TAI on the CLBR in a complete IVF/ICSI cycle...
April 2, 2024: BMC Pregnancy and Childbirth
#33
JOURNAL ARTICLE
Oula Norman, Tuuli Vornanen, Hanna Franssila, Johanna Liinamaa, Elina Karvonen, Tommi Kotkavaara, Vesa-Matti Pohjanen, Ritva Ylikärppä, Taina Pihlajaniemi, Merja Hurskainen, Anne Heikkinen
PURPOSE: Antibodies against collagen XIII have previously been identified in patients with active thyroid-associated ophthalmopathy (TAO). Although collagen XIII expression has been described in extraocular muscles and orbital fat, its detailed localization in extraocular and thyroid tissues and the connection to autoimmunity for collagen XIII remain unclear. Our objective was to map the potential targets for these antibodies in the tissues of the orbit and thyroid. METHODS: We evaluated the expression of collagen XIII in human patient and mouse orbital and thyroid tissues with immunostainings and RT-qPCR using Col13a1-/- mice as negative controls...
April 1, 2024: Investigative Ophthalmology & Visual Science
#34
JOURNAL ARTICLE
Xinpan Wang, Tiantian Li, Yue Li, Qiuyi Wang, Yun Cai, Zhixiao Wang, Yun Shi, Tao Yang, Xuqin Zheng
BACKGROUND: A subset of Graves' disease (GD) patients develops refractory hyperthyroidism, posing challenges in treatment decisions. The predictive value of baseline characteristics and early therapy indicators in identifying high risk individuals is an area worth exploration. METHODS: A prospective cohort study (2018-2022) involved 597 newly diagnosed adult GD patients undergoing methimazole (MMI) treatment. Baseline characteristics and 3-month therapy parameters were utilized to develop predictive models for refractory GD, considering antithyroid drug (ATD) dosage regimens...
March 29, 2024: Journal of Translational Medicine
#35
JOURNAL ARTICLE
I Rami, D Zerrouki, I Assarrar, S Rouf, H Latrech
BACKGROUND: Plasmapheresis represent an alternative therapeutic option for hyperthyroidism with thyroid storm or refractory cases. It provides a rapid decrease in plasma thyroid hormones and anti-thyroid antibodies. The aim of this paper was to report our single center's experience in managing particular situations of hyperthyroidism using apheresis. CASES PRESENTATION: The following case series describes three young African patients (two females, one male) aged 29, 37, and 25 years old, respectively, with Graves' disease who presented with drug ineffectiveness, drug-induced agranulocytosis, and thyroid storm with multi-organ failure...
March 30, 2024: Journal of Medical Case Reports
#36
JOURNAL ARTICLE
Xiao-Shan Huang, Ning Dai, Jian-Xia Xu, Jun-Yi Xiang, Xiao-Zhong Zheng, Tian-Yu Ke, Lin-Ying Ma, Qi-Hao Shi, Shu-Feng Fan
OBJECTIVE: Hashimoto's thyroiditis is an inflammatory disease, and research suggests that a low-carbohydrate diet may have potential anti-inflammatory effects. This study aims to utilize Dixon-T2-weighted imaging (WI) sequence for semi-quantitative assessment of the impact of a low-carbohydrate diet on the degree of thyroid inflammation in patients with Hashimoto's thyroiditis. METHODS: Forty patients with Hashimoto's thyroiditis were recruited for this study and randomly divided into two groups: one with a normal diet and the other with a low-carbohydrate diet...
March 1, 2024: Endocrine Connections
#37
JOURNAL ARTICLE
Ines Šiško Markoš, Maja Franceschi, Valentina Vidranski, Pave Markoš, Tomislav Jukić, Ana Fröbe, Vanja Bašić Kes
The concentration of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in the blood is higher in patients with active multiple sclerosis (MS) compared to those with inactive disease. The concentration of IL-6 and TNF-α in the blood is higher in patients with Hashimoto's thyroiditis (HT) compared to those with a healthy thyroid. The aim of the study was to assess whether serum IL-6 and TNF-α levels correlated with saliva in patients with inactive MS and whether there was a difference in these groups of patients depending of thyroid status...
August 2023: Acta Clinica Croatica
#38
JOURNAL ARTICLE
Joris A J Osinga, Yindi Liu, Tuija Männistö, Marina Vafeiadi, Fang-Biao Tao, Bijay Vaidya, Tanja G M Vrijkotte, Lorena Mosso, Judit Bassols, Abel López-Bermejo, Laura Boucai, Ashraf Aminorroaya, Ulla Feldt-Rasmussen, Aya Hisada, Jun Yoshinaga, Maarten A C Broeren, Sachiko Itoh, Reiko Kishi, Ghalia Ashoor, Liangmiao Chen, Flora Veltri, Xuemian Lu, Peter N Taylor, Suzanne J Brown, Leda Chatzi, Polina V Popova, Elena N Grineva, Farkhanda Ghafoor, Amna Pirzada, Maryam Kianpour, Emily Oken, Eila Suvanto, Andrew Hattersley, Marisa Rebagliato, Isolina Riaño-Galán, Amaia Irizar, Martine Vrijheid, Juana Maria Delgado-Saborit, Ana Fernández-Somoano, Loreto Santa-Marina, Kristien Boelaert, Gabriela Brenta, Rima Dhillon-Smith, Chrysoula Dosiou, Jennifer L Eaton, Haixia Guan, Sun Y Lee, Spyridoula Maraka, Lilah F Morris-Wiseman, Caroline T Nguyen, Zhongyan Shan, Mònica Guxens, Victor J M Pop, John P Walsh, Kypros H Nicolaides, Mary E D'Alton, W Edward Visser, David M Carty, Christian Delles, Scott M Nelson, Erik K Alexander, Layal Chaker, Glenn E Palomaki, Robin P Peeters, Sofie Bliddal, Kun Huang, Kris G Poppe, Elizabeth N Pearce, Arash Derakhshan, Tim I M Korevaar
Background: International guidelines recommend targeted screening to identify gestational thyroid dysfunction. However, currently used risk factors have questionable discriminative ability. We quantified the risk for thyroid function test abnormalities for a subset of risk factors currently used in international guidelines. Methods: We included prospective cohort studies with data on gestational maternal thyroid function and potential risk factors (maternal age, body mass index [BMI], parity, smoking status, pregnancy through in vitro fertilization, twin pregnancy, gestational age, maternal education, and thyroid peroxidase antibody [TPOAb] or thyroglobulin antibody [TgAb] positivity)...
March 28, 2024: Thyroid: Official Journal of the American Thyroid Association
#39
REVIEW
Andrey Valerievich Ushakov
For different thyroid diseases and hormonal metabolism, ultrasound (US) of the thyroid gland reveals hypoechogenicity. Despite the direct correlation of hypoechogenicity with the levels of thyroid-stimulating hormone and antibodies of thyroid peroxidase and thyroglobulin, ~20% of this correlation is inconsistent, thus restricting the comprehensive utilisation of this valuable diagnostic sign. Thus, it is necessary to investigate the additional circumstances affecting the extent and features of the US hypoechogenicity of the thyroid gland...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
#40
REVIEW
Teodoro Durá-Travé, Fidel Gallinas-Victoriano
Hashimoto's thyroiditis (HT) is marked by self-tissue destruction as a consequence of an alteration in the adaptive immune response that entails the evasion of immune regulation. Vitamin D carries out an immunomodulatory role that appears to promote immune tolerance. The aim of this study is to elaborate a narrative review of the relationship between vitamin D status and HT and the role of vitamin D supplementation in reducing HT risk by modulating the immune system. There is extensive literature confirming that vitamin D levels are significantly lower in HT patients compared to healthy people...
March 9, 2024: International Journal of Molecular Sciences
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