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Global longitudinal strain

Wojciech Kosmala, Aleksandra Rojek, Monika Przewlocka-Kosmala, Leah Wright, Andrzej Mysiak, Thomas H Marwick
BACKGROUND: Impaired functional capacity is a hallmark of patients with heart failure with preserved ejection fraction (HFpEF). Despite the association of HFpEF with reduced myocardial compliance attributed to fibrosis, spironolactone has not been shown to alter outcomes-perhaps reflecting the heterogeneity of underlying pathological mechanisms. OBJECTIVES: The authors sought to identify improvement in exercise capacity with spironolactone in the subset of patients with HFpEF with exercise-induced increase in ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/e') reflecting elevation of left ventricular (LV) filling pressure...
October 25, 2016: Journal of the American College of Cardiology
Peter Kruzliak, Alexander Berezin, Alexander Kremzer, Tatyana Samura, Roman Benacka, Ioana Mozos, Emmanuel Egom, Luis Rodrigo
BACKGROUND: Biomechanical stress and inflammatory biomarkers relate to global contractility dysfunction; however, adding these biomarkers into a risk model constructed on clinical data does not improve its prediction value in chronic heart failure (CHF). AIM: The aim of this study was to evaluate whether biomarkers predict declining of left ventricular global contractility function in diabetic patients with ischemia-induced CHF. PATIENTS AND METHODS: The study retrospectively evolved 54 diabetic patients who had systolic or diastolic ischemia-induced CHF that was defined as left-ventricular ejection fraction (LVEF) ≤45% or 46-55% respectively assessed by quantitative echocardiography and other conventional criteria according to current clinical guidelines...
September 1, 2016: Folia Medica
Kazunori Okada, Sanae Kaga, Taisei Mikami, Nobuo Masauzi, Ayumu Abe, Masahiro Nakabachi, Shinobu Yokoyama, Hisao Nishino, Ayako Ichikawa, Mutsumi Nishida, Daisuke Murai, Taichi Hayashi, Chikara Shimizu, Hiroyuki Iwano, Satoshi Yamada, Hiroyuki Tsutsui
We analyzed the waveform of systolic strain and strain-rate curves to find a characteristic left ventricular (LV) myocardial contraction pattern in patients with hypertrophic cardiomyopathy (HCM), and evaluated the utility of these parameters for the differentiation of HCM and LV hypertrophy secondary to hypertension (HT). From global strain and strain-rate curves in the longitudinal and circumferential directions, the time from mitral valve closure to the peak strains (T-LS and T-CS, respectively) and the peak systolic strain rates (T-LSSR and T-CSSR, respectively) were measured in 34 patients with HCM, 30 patients with HT, and 25 control subjects...
October 18, 2016: Heart and Vessels
Tingyan Xu, Jingping Sun, Alex Pui-Wai Lee, Yan Yang, Xingsheng Yang, Yan Li, Cheuk-Man Yu, Jiguang Wang
OBJECTIVE: Hypertension (HTN) leads to left ventricular (LV) remodeling, which results in diastolic dysfunction in the presence of preserved ejection fraction (EF). The goal of this study was to explore the subclinical left ventricular systolic dysfunction and mechanism of preserved EF using layer-specific quantification of myocardial deformation in patients with HTN. DESIGN AND METHOD: The routine 2D (frame rate >50 Hz) data sets were acquired using GE E9 system in 120 hypertensive patients (73 male, 54 ± 13years, blood pressure = 165 ± 20/ 96 ± 117 mmHg) and 120 age and gender matched normal subjects (124 ± 9/80 ± 8mmHg)...
September 2016: Journal of Hypertension
Darae Kim, Chi Young Shim, Geu-Ru Hong, In Jeong Cho, Hyuk-Jae Chang, Jong-Won Ha, Namsik Chung
OBJECTIVE: The aim of this study was to comprehensively assess mechanical adaptation of LV in subclinical patients with hypertension(HTN) using a layer specific speckle-tracking echocardiography. DESIGN AND METHOD: Conventional transthoracic echocardiography (TTE) with 2D-layer specific speckle-tracking echocardiography was performed on 218 HTN patients with preserved LV ejection fraction (EF > 50%). Endocardial, epicardial, and transmural global longitudinal strain (GLS), global circumferential strains (GCS), and peak LV torsion were measured...
September 2016: Journal of Hypertension
Krasimira Hristova, Vera Bogdanova, Rumen Marinov
OBJECTIVE: Arterial hypertension (HTN) causes left ventricular (LV) dysfunction even if ejection function (EF) remains preserved. The objective of this study was to assess whether complex LAFI (left atrium functional index) had additional value in definition and grading of diastolic dysfunction and compare with indices of atrial deformation - longitudinal strain. DESIGN AND METHOD: Peak atrial longitudinal strain (PALS) was evaluated in 82 patients with systemic HTN and preserved EF (> = 55%) divided in 41 with diastolic dysfunction but no hypertrophy (HTNdd), and 41 with no diastolic dysfunction or hypertrophy (eHTN)...
September 2016: Journal of Hypertension
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
Yang Li, You-Bin Deng, Xiao-Jun Bi, Ya-Ni Liu, Jun Zhang, Li Li, Bin Chen
This study evaluated the myocardial strain and aortic elasticity in patients with bicuspid aortic valve (BAV) and then investigated the relation between them. Thirty-nine patients (30 males; mean age 44±19 years; range 6 to 75 years) with BAV were recruited as BAV group, and 29 age- and sex-matched healthy controls (21 males; mean age 42±11 years; range 20 to 71 years) served as control group. Aortic strain, distensibility and stiffness index were derived using M-mode echocardiography. Left ventricular global myocardial strain was acquired with speckle-tracking echocardiography...
October 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
Patricia Reant, Alexandre Metras, Dominique Detaille, Annabel Reynaud, Philippe Diolez, Beatrice Jaspard-Vinassa, Raymond Roudaut, Alexandre Ouattara, Laurent Barandon, Pierre Dos Santos, Stephane Lafitte
BACKGROUND: Left ventricular (LV) afterload could be associated with reduced myocardial contractility. The aim of this study was to evaluate the relative impact of increased afterload on LV myocardial deformation indices in chronic aortic constriction, with regard to hypertrophy, myocardial fibrosis, and mitochondrial function, and to differentiate acute versus chronic afterload effect. METHODS: Young pigs underwent aortic banding (n = 11) or sham (n = 7) operations...
October 14, 2016: Journal of the American Society of Echocardiography
Blazej Michalski, Przemyslaw Trzcinski, Karolina Kupczynska, Dawid Miskowiec, Lukasz Peczek, Barbara Nawrot, Piotr Lipiec, Jaroslaw D Kasprzak
BACKGROUND: The aim of the study was to assess the correlation of the selected biomarkers and collagen turn-over indices with advanced echocardiographic parameters among patients with preserved and reduced ejection fraction (EF). METHODS: We included 62 patients with the symptomatic heart failure. The patients were divided in to two groups according to the evaluated ejection fraction (EF - Simpson method): heart failure with reduced ejection fraction (HFrEF) group - 30 patients with low EF - 35-50% (16 male, mean age 54...
October 17, 2016: Cardiology Journal
E D'Elia, P Ferrero, C Vittori, A Calabrese, V Duino, S Perlini, M Senni
Athletes may have electrocardiogram (ECG) repolarization abnormalities during stress test suggestive for ischemia in the absence of ischemic coronary artery disease, often in a setting of myocardial septum hypertrophy. Global longitudinal strain (GLS) might be altered in these athletes compared to hypertensive patients with the same degree of septal thickness. About 735 consecutive athletes were screened for mandatory assessment of fitness to participate in competitive sports. At the stress test, 23 (19 M, 4 F) were found to have ECG repolarization abnormalities suggestive for ischemia in the presence of normal coronary vessels...
October 17, 2016: Scandinavian Journal of Medicine & Science in Sports
Tomoko Negishi, Kazuaki Negishi, Paaladinesh Thavendiranathan, Goo-Yeong Cho, Bogdan A Popescu, Dragos Vinereanu, Koji Kurosawa, Martin Penicka, Thomas H Marwick
OBJECTIVES: This study sought to show the degree to which experience and training affect the precision and validity of global longitudinal strain (GLS) measurement and to evaluate the variability of strain measurement after feedback. BACKGROUND: The application of GLS for the detection of subclinical dysfunction has been recommended in an expert consensus document and is being used with increasing frequency. The role of experience in the precision and validity of GLS measurement is unknown, as is the efficacy of training...
October 6, 2016: JACC. Cardiovascular Imaging
Sabha Bhatti, Srikanth Vallurupalli, Stephanie Ambach, Adam Magier, Evan Watts, Vien Truong, Abdul Hakeem, Wojciech Mazur
Cardiac MRI is frequently used in the diagnosis of cardiac amyloidosis. Feature tracking is a novel method of analyzing myocardial strain at the myocardial borders. We investigated myocardial deformation mechanics of both the right and left ventricles in patients with multiple myeloma with suspected cardiac amyloidosis. Comprehensive strain analysis was performed in 43 patients with multiple myeloma and suspected cardiac amyloidosis. MRI strain by feature tracking was measured using 2D cardiac performance analysis MR software (Tomtec, Germany)...
October 14, 2016: International Journal of Cardiovascular Imaging
Suma P Goudar, G Hamilton Baker, Shahryar M Chowdhury, Kimberly J Reid, Girish Shirali, Mark A Scheurer
BACKGROUND: Adult studies demonstrate that echocardiographic measurements of cardiac function using speckle tracking correlate with invasive measurements, but such data in the pediatric population are sparse. Our aim was to compare speckle-derived measures of cardiac function to measurements routinely obtained by cardiac catheterization in children. METHODS: Echocardiograms were performed on the day of cardiac catheterization. Using Tomtec 2D Cardiac Performance Analysis, longitudinal strain (LS), longitudinal strain rate (LSR), early diastolic LSR, and ejection fraction (EF) for the right and left ventricle (RV and LV) were calculated via speckle tracking...
October 14, 2016: Echocardiography
Daisuke Murai, Satoshi Yamada, Taichi Hayashi, Kazunori Okada, Hisao Nishino, Masahiro Nakabachi, Shinobu Yokoyama, Ayumu Abe, Ayako Ichikawa, Kota Ono, Sanae Kaga, Hiroyuki Iwano, Taisei Mikami, Hiroyuki Tsutsui
Whether and how left ventricular (LV) strain and strain rate correlate with wall stress is not known. Furthermore, it is not determined whether strain or strain rate is less dependent on the afterload. In 41 healthy young adults, LV global peak strain and systolic peak strain rate in the longitudinal direction (LS and LSR, respectively) and circumferential direction (CS and CSR, respectively) were measured layer-specifically using speckle tracking echocardiography (STE) before and during a handgrip exercise...
October 12, 2016: Heart and Vessels
Wilson Nadruz, Dalane Kitzman, Beverly Gwen Windham, Anna Kucharska-Newton, Kenneth Butler, Priya Palta, Michael E Griswold, Lynne E Wagenknecht, Gerardo Heiss, Scott D Solomon, Hicham Skali, Amil M Shah
BACKGROUND: The contribution of cardiovascular dysfunction to frailty in older adults is uncertain. This study aimed to define the relationship between frailty and cardiovascular structure and function, and determine whether these associations are independent of coexisting abnormalities in other organ systems. METHODS: We studied 3,991 older adults (mean age 75.6±5.0 years; 59% female) from the Atherosclerosis Risk in Communities (ARIC) Study in whom the following six organ systems were uniformly assessed: cardiac (by echocardiography), vascular (by ankle-brachial-index and pulse-wave-velocity), pulmonary (by spirometry), renal (by estimated glomerular filtration rate), hematologic (by hemoglobin), and adipose (by body mass index and bioimpedance)...
October 12, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Kuniko Yoshida, Masaru Obokata, Koji Kurosawa, Hidemi Sorimachi, Masahiko Kurabayashi, Kazuaki Negishi
BACKGROUND: Embolic stroke in atrial fibrillation is more prevalent in women than in men, yet the basis for this difference remains unclear. This study seeks to elucidate whether there are any sex differences in the relationships between stroke risk (CHADS2 score, CHA2DS2-VASc score without a sex category, and estimated stroke rate) and left atrial (LA) anatomy or mechanics in patients with atrial fibrillation. METHODS AND RESULTS: LA emptying fraction and global peak atrial longitudinal strain were assessed in 414 subjects with paroxysmal or persistent atrial fibrillation (156 women and 258 men)...
October 2016: Circulation. Cardiovascular Imaging
C Guruchaithanya Kumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Arnold C T Ng, Shi Yi Goo, Nicole Roche, Rob J van der Geest, William Y S Wang
BACKGROUND: Although epicardial adipose tissue (EAT) volume is associated with increased incidence of coronary artery disease (CAD), its role in myocardial systolic dysfunction is unclear. The present study aimed to identify independent determinants of EAT volume in patients without obstructive CAD, and to evaluate the association between EAT volume (vs other measures of obesity) and myocardial systolic strain analysis. METHODS: We prospectively recruited 130 patients without obstructive CAD on contrast-enhanced cardiac computed tomography imaging and normal left ventricular ejection fraction on 3-dimensional (3D) echocardiography...
June 23, 2016: Canadian Journal of Cardiology
Agnieszka Krystyna Lech, Piotr Paweł Dobrowolski, Anna Klisiewicz, Piotr Hoffman
BACKGROUND: The management of patients with asymptomatic severe aortic stenosis (ASAS) is still under discussion. Therefore, it is advisable to search for the parameters of early damage to left ventricular function. AIM: The aim of the study was to assess exercise-induced changes in left ventricular global longitudinal strain (GLS) in ASAS. METHODS: The ASAS group consisted of 50 patients (26W/24M, aged 38.4±18.1) meeting the echocardiographic criteria of severe aortic stenosis (AVA<1cm², AVAI<0...
October 7, 2016: Kardiologia Polska
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