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https://www.readbyqxmd.com/read/28531243/increased-postural-sway-during-quiet-stance-as-a-risk-factor-for-prospective-falls-in-community-dwelling-elderly-individuals
#1
Jonas Johansson, Anna Nordström, Yngve Gustafson, Göran Westling, Peter Nordström
Objective: fall-related injuries constitute major health risks in older individuals, and these risks are projected to increase in parallel with increasing human longevity. Impaired postural stability is a potential risk factor related to falls, although the evidence is inconclusive, partly due to the lack of prospective studies. This study aimed to investigate how objective measures of postural sway predict incident falls. Design, setting and participants: this prospectively observational study included 1,877 community-dwelling individuals aged 70 years who participated in the Healthy Ageing Initiative between June 2012 and December 2015...
May 22, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28529804/unilateral-discomfort-increases-the-use-of-contralateral-side-during-sit-to-stand-transfer
#2
Simisola O Oludare, Charlie C Ma, Alexander S Aruin
Individuals with unilateral impairment perform symmetrical movements asymmetrically. Restoring symmetry of movements is an important goal of rehabilitation. The aim of the study was to evaluate the effect of using discomfort-inducing devices on movement symmetry. Fifteen healthy individuals performed the sit-to-stand (STS) maneuver using devices inducing unilateral discomfort under the left sole and left thigh or right sole and right thigh and without them. 3D body kinematics, ground reaction forces, electrical activity of muscles, and the level of perceived discomfort were recorded...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28528575/characterization-of-a-cyclic-olefin-polymer-microcentrifuge-tube
#3
Lloyd Waxman, Rachel L Erwin, Vinod D Vilivalam
Here, we describe the properties of a prototype microcentrifuge tube made from the plastic cyclic olefin polymer (COP). This material has been used in the manufacture of primary containers including syringes and vials for the storage, shipment, and delivery of biotherapeutics, vaccines, and cell therapy products. Its low level of extractable substances and metals along with its glass-like clarity make COP an attractive material for the fabrication of microcentrifuge tubes and other consumable laboratory plasticware where contamination is an important consideration, such as in the storage and analysis of labile proteins, nucleic acids, and metabolites...
May 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28522225/genetic-screening-of-spinal-muscular-atrophy-using-a-real-time-modified-cop-pcr-technique-with-dried-blood-spot-dna
#4
Mawaddah Ar Rochmah, Nur Imma Fatimah Harahap, Emma Tabe Eko Niba, Kenta Nakanishi, Hiroyuki Awano, Ichiro Morioka, Kazumoto Iijima, Toshio Saito, Kayoko Saito, Poh San Lai, Yasuhiro Takeshima, Atsuko Takeuchi, Yoshihiro Bouike, Maya Okamoto, Hisahide Nishio, Masakazu Shinohara
BACKGROUND: Spinal muscular atrophy (SMA) is a common neuromuscular disorder caused by mutations in SMN1. More than 95% of SMA patients carry homozygous SMN1 deletion. SMA is the leading genetic cause of infant death, and has been considered an incurable disease. However, a recent clinical trial with an antisense oligonucleotide drug has shown encouraging clinical efficacy. Thus, early and accurate detection of SMN1 deletion may improve prognosis of many infantile SMA patients. METHODS: A total of 88 DNA samples (37 SMA patients, 12 carriers and 39 controls) from dried blood spots (DBS) on filter paper were analyzed...
May 15, 2017: Brain & Development
https://www.readbyqxmd.com/read/28521191/assessing-human-health-risks-from-pesticide-use-in-conventional-and-innovative-cropping-systems-with-the-browse-model
#5
Sabine-Karen Lammoglia, Marc C Kennedy, Enrique Barriuso, Lionel Alletto, Eric Justes, Nicolas Munier-Jolain, Laure Mamy
BACKGROUND: Reducing the risks and impacts of pesticide use on human health and on the environment is one of the objectives of the European Commission Directive 2009/128/EC in the quest for a sustainable use of pesticides. This Directive, developed through European national plans such as Ecophyto plan in France, promotes the introduction of innovative cropping systems relying, for example, on integrated pest management. Risk assessment for human health of the overall pesticide use in these innovative systems is required before the introduction of those systems to avoid that an innovation becomes a new problem...
May 15, 2017: Environment International
https://www.readbyqxmd.com/read/28521118/automated-cassette-based-production-of-high-specific-activity-203-212-pb-peptide-based-theranostic-radiopharmaceuticals-for-image-guided-radionuclide-therapy-for-cancer
#6
Mengshi Li, Xiuli Zhang, Thomas P Quinn, Dongyoul Lee, Dijie Liu, Falk Kunkel, Brian E Zimmerman, Daniel McAlister, Keith Olewein, Yusuf Menda, Saed Mirzadeh, Roy Copping, Frances L Johnson, Michael K Schultz
A method for preparation of Pb-212 and Pb-203 labeled chelator-modified peptide-based radiopharmaceuticals for cancer imaging and radionuclide therapy has been developed and adapted for automated clinical production. Pre-concentration and isolation of radioactive Pb2+ from interfering metals in dilute hydrochloric acid was optimized using a commercially-available Pb-specific chromatography resin packed in disposable plastic columns. The pre-concentrated radioactive Pb2+ is eluted in NaOAc buffer directly to the reaction vessel containing chelator-modified peptides...
May 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28515296/hepatitis-c-virus-lipoviroparticles-hcv-lvp-assemble-in-the-endoplasmic-reticulum-er-and-bud-off-from-the-er-to-golgi-in-copii-vesicles
#7
Gulam H Syed, Mohsin Khan, Song Yang, Aleem Siddiqui
Hepatitis C virus (HCV) exists as a lipoprotein-virus hybrid lipoviroparticle (LVP). In vitro studies have demonstrated the importance of apolipoproteins in HCV secretion and infectivity leading to the notion that HCV co-opts the secretion of very-low density lipoprotein (VLDL) for its egress. However, our understanding of the mechanisms involved in virus particle assembly and egress, are still elusive. Biogenesis of VLDL particle occurs in the ER followed by subsequent lipidation in the ER and Golgi. Secretion of mature VLDL particles occurs through the Golgi secretory pathway...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28512187/neutral-competition-for-drosophila-follicle-and-cyst-stem-cell-niches-requires-vesicle-trafficking-genes
#8
Matthew S Cook, Coralie Cazin, Marc Amoyel, Shinya Yamamoto, Erika Bach, Todd Nystul
The process of selecting for cellular fitness through competition plays a critical role in both development and disease. The germarium, a structure at the tip of the ovariole of a Drosophila ovary, contains two follicle stem cells (FSCs) that undergo neutral competition for the stem cell niche. Using the FSCs as a model, we performed a genetic screen through a collection of 126 mutants in essential genes on the X chromosome to identify candidates that increase or decrease competition for the FSC niche. We identified approximately 55% and 6% of the mutations screened as putative FSC hypo- or hypercompetitors, respectively...
May 16, 2017: Genetics
https://www.readbyqxmd.com/read/28504192/correlates-of-protection-for-enteric-vaccines
#9
Jan Holmgren, Umesh D Parashar, Stanley Plotkin, Jacques Louis, Su-Peing Ng, Eric Desauziers, Valentina Picot, Mitra Saadatian-Elahi
An immunological Correlate of Protection (CoP) is an immune response that is statistically interrelated with protection. Identification of CoPs for enteric vaccines would help design studies to improve vaccine performance of licensed vaccines in low income settings, and would facilitate the testing of future vaccines in development that might be more affordable. CoPs are lacking today for most existing and investigational enteric vaccines. In order to share the latest information on CoPs for enteric vaccines and to discuss novel approaches to correlate mucosal immune responses in humans with protection, the Foundation Mérieux organized an international conference of experts where potential CoPs for vaccines were examined using case-studies for both bacterial and viral enteric pathogens...
May 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28503144/rigid-ankle-foot-orthosis-deteriorates-mediolateral-balance-control-and-vertical-braking-during-gait-initiation
#10
Arnaud Delafontaine, Olivier Gagey, Silvia Colnaghi, Manh-Cuong Do, Jean-Louis Honeine
Rigid ankle-foot orthoses (AFO) are commonly used for impeding foot drop during the swing phase of gait. They also reduce pain and improve gait kinematics in patients with weakness or loss of integrity of ankle-foot complex structures due to various pathological conditions. However, this comes at the price of constraining ankle joint mobility, which might affect propulsive force generation and balance control. The present study examined the effects of wearing an AFO on biomechanical variables and electromyographic activity of tibialis anterior (TA) and soleus muscles during gait initiation (GI)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28502934/a-cryptogenic-case-of-fulminant-fibrosing-organizing-pneumonia
#11
Takehiko Kobayashi, Masanori Kitaichi, Kazunobu Tachibana, Yutaro Kishimoto, Yasushi Inoue, Tomoko Kagawa, Toshiya Maekura, Chikatoshi Sugimoto, Toru Arai, Masanori Akira, Yoshikazu Inoue
Cryptogenic organizing pneumonia (COP) generally responds well to corticosteroids with a favorable outcome. Rare cases of organizing pneumonia are rapidly progressive. Yousem et al. studied pathologic predictors of idiopathic bronchiolitis obliterans organizing pneumonia/COP with an unfavorable prognosis. Beardsley and Rassl proposed the name fibrosing organizing pneumonia (FOP). A 74-year-old female non-smoker presented with a 2-week history of dry cough followed by dyspnea and a fever. The clinical course was fulminant, but we successfully performed bronchoscopy...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28501732/asymmetrical-stabilization-and-mobilization-exploited-during-static-single-leg-stance-and-goal-directed-kicking
#12
Adam C King, Zheng Wang
The motor control properties of the right and left legs are dependent on the stabilization and mobilization features of the motor tasks. The current investigation examined the right and left leg control differences - interlateral asymmetries - during static single leg stance and dynamic goal directed kicking with an emphasis of the asymmetrical stabilization and mobilization components of movements. Ten young, healthy, right-leg preferred individuals with minimal kicking experience completed both tests on each limb...
May 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28498442/prognostic-significance-of-altered-mirna-expression-in-whole-blood-of-oscc-patients
#13
Jutta Ries, Christoph Baran, Falk Wehrhan, Manuel Weber, Friedrich W Neukam, Andrea Krautheim-Zenk, Emeka Nkenke
Currently, there is a lack of blood markers for the detection of recurrent oral squamous cell carcinoma (OSCC). The present study aimed to investigate whether the aberrant expression of single microRNAs (miRNAs) in whole blood of patients could serve as a biomarker for persistent or recurrent OSCC. Whole blood of 2 groups of formerly treated OSCC patients was investigated by RT-qPCR for their circulating miRNA profiles. The R-OC group included patients with recurrence of OSCC (n=21) and the NR-OC group included patients without recurrence (n=21)...
May 11, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28495201/self-reported-balance-status-is-not-a-reliable-indicator-of-balance-performance-in-adolescents-at-one-month-post-concussion
#14
Coralie Rochefort, Coren Walters-Stewart, Mary Aglipay, Nick Barrowman, Roger Zemek, Heidi Sveistrup
OBJECTIVES: To determine if self-reported balance symptoms can be used as a proxy for measures of the center of pressure (COP) to identify balance deficits in a group of concussed adolescents. DESIGN: Case-control. METHODS: Thirteen adolescents 1-month post-concussion who reported ongoing balance problems (Balance+), 20 adolescent 1-month post-concussion who reported no balance problems (Balance-), and 30 non-injured adolescents (control) completed a series of balance tests...
April 22, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28491029/sample-entropy-univariate-and-multivariate-multi-scale-entropy-in-comparison-with-classical-postural-sway-parameters-in-young-healthy-adults
#15
Clint Hansen, Qin Wei, Jiann-Shing Shieh, Paul Fourcade, Brice Isableu, Lina Majed
The present study aimed to compare various entropy measures to assess the dynamics and complexity of center of pressure (COP) displacements. Perturbing balance tests are often used in healthy subjects to imitate either pathological conditions or to test the sensitivity of postural analysis techniques. Eleven healthy adult subjects were asked to stand in normal stance in three experimental conditions while the visuo-kinesthetic input was altered. COP displacement was recorded using a force plate. Three entropy measures [Sample Entropy (SE), Multi-Scale Entropy (MSE), and Multivariate Multi Scale Entropy (MMSE)] describing COP regularity at different scales were compared to traditional measures of COP variability...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28487917/integrating-natural-biomass-electro-oxidation-and-hydrogen-evolution-using-a-porous-fe-doped-cop-nanosheet-array-as-a-bifunctional-catalyst
#16
Shuai Hao, Libin Yang, Danni Liu, Rongmei Kong, Gu Du, Abdullah M Asiri, Yingchun Yang, Xuping Sun
Electrochemical water splitting has been considered as a promising strategy for hydrogen production, but the sluggish anodic oxygen evolution reaction (OER) limits the efficiency of overall water splitting. In this communication, we report a facile strategy to realize energy-saving hydrogen generation by replacing OER with a thermodynamically more favorable aloe extract (AE) oxidation reaction (AOR). An Fe-doped CoP nanosheet array (Fe-CoP/CC) is used as a bifunctional catalyst for both AOR and hydrogen evolution reaction (HER)...
May 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28486165/dynamical-structure-of-center-of-pressure-trajectories-with-and-without-functional-taping-in-children-with-cerebral-palsy-level-i-and-ii-of-gmfcs
#17
Silvia Leticia Pavão, Annick Ledebt, Geert J P Savelsbergh, Nelci Adriana C F Rocha
Postural control during quiet standing was examined in typical children (TD) and children with cerebral palsy (CP) level I and II of GMFCS. The immediate effect on postural control of functional taping on the thighs was analyzed. We evaluated 43 TD, 17 CP children level I, and 10 CP children level II. Participants were evaluated in two conditions (with and without taping). The trajectories of the center of pressure (COP) were analyzed by means of conventional posturography (sway amplitude, sway-path-length) and dynamic posturography (degree of twisting-and-turning, sway regularity)...
May 6, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28484411/age-related-interference-between-the-selection-of-input-output-modality-mappings-and-postural-control-a-pilot-study
#18
Christine Stelzel, Gesche Schauenburg, Michael A Rapp, Stephan Heinzel, Urs Granacher
Age-related decline in executive functions and postural control due to degenerative processes in the central nervous system have been related to increased fall-risk in old age. Many studies have shown cognitive-postural dual-task interference in old adults, but research on the role of specific executive functions in this context has just begun. In this study, we addressed the question whether postural control is impaired depending on the coordination of concurrent response-selection processes related to the compatibility of input and output modality mappings as compared to impairments related to working-memory load in the comparison of cognitive dual and single tasks...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28482769/men-s-health-and-communities-of-practice-in-australia
#19
Maree Henwood, Amie Shaw, Jillian Cavanagh, Timothy Bartram, Timothy Marjoribanks, Madeleine Kendrick
Purpose The purpose of this paper is to examine the social opportunities for Aboriginal and Torres Strait Islander men created through Men's Groups/Sheds across urban, regional and remote areas of Australia. Men's Sheds are a safe space, resembling a work-shop setting or backyard shed, where men are encouraged to socialise and participate in health promotion, informal learning and engage in meaningful tasks both individually and at the community level. Design/methodology/approach Explore five case study sites through Wenger's (1998) active communities of practice (CoP)...
April 10, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28477042/unintentional-drifts-during-quiet-stance-and-voluntary-body-sway
#20
Omid Rasouli, Stanisław Solnik, Mariusz P Furmanek, Daniele Piscitelli, Ali Falaki, Mark L Latash
We explored unintentional drifts in voluntary whole-body sway tasks following the removal of visual feedback. The main hypothesis was that the unintentional drifts were produced by drifts of referent coordinates for salient performance variables. Young healthy subjects stood quietly on a force platform and also performed voluntary body sway at 0.5 Hz both in the anterio-posterior and medio-lateral directions. Visual feedback on the center of pressure (COP) coordinate was provided and then turned off. During quiet stance trials, the subjects matched the initial COP coordinate with a target shifted by 3 cm anterior, posterior, left, or right from the coordinate during natural standing and activated the right tibialis anterior to 30% of its maximal voluntary contraction...
May 5, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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