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Degenerative Disk Disease

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https://www.readbyqxmd.com/read/27901415/burden-of-surgical-site-infections-associated-with-select-spine-operations-and-involvement-of-staphylococcus-aureus
#1
Harshila Patel, Hanane Khoury, Douglas Girgenti, Sharon Welner, Holly Yu
BACKGROUND: Spine operations may be indicated for treatment of diseases including vertebral injuries, degenerative spinal conditions, disk disease, spinal misalignments, or malformations. Surgical site infection (SSI) is a clinically important complication of spine surgery. Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA), is a leading cause of post-spinal SSIs. METHODS: PubMed and applicable infectious disease conference proceedings were searched to identify relevant published studies...
November 30, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27879511/c2-c3-anterior-cervical-fusion-technical-report
#2
Michael A Finn, Joel D MacDonald
STUDY DESIGN: Retrospective review of patients at a university hospital. OBJECTIVE: To describe the anterior approach for cervical discectomy and fusion (ACDF) at C2-C3 level and evaluate its suitability for treatment of instability and degenerative disease in this region. SUMMARY OF BACKGROUND DATA: The anterior approach is commonly used for ACDF in the lower cervical spine but is used less often in the high cervical spine. METHODS: We retrospectively reviewed a database of consecutive cervical spine surgeries performed at our institution to identify patients who underwent ACDF at the C2-C3 level during a 10-year period...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27807886/the-expression-of-cytokine-and-its-significance-for-the-intervertebral-disks-of-kazakhs
#3
Miao Xiaogang, Hou Quanshan, Zhang Liping, Habaxi Kaken
BACKGROUND: Proinflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 are expressed in herniated intervertebral disks of Kazakhs, but their significance is not yet understood. METHODS: Specimens of herniated lumbar disk were collected from 30 patients with single disk herniation during lumbar discectomy. As a control, 10 specimens were collected postmortem from the cadavers of individuals who did not die from spinal disease. The clinical symptoms in all cases were evaluated preoperation by the JOA index...
November 3, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27761804/the-presence-of-the-neuronal-nitric-oxide-synthase-isoform-in-the-intervertebral-disk
#4
Vitor Castania, Ana Carolina Issy, João Walter Silveira, Frederico Rogério Ferreira, Simoneide S Titze-de-Almeida, Fernando F B Resende, Nádia Rubia Ferreira, Ricardo Titze-de-Almeida, Helton L A Defino, Elaine Del Bel
Intervertebral disk degeneration is a progressive and debilitating disease with multifactorial causes. Nitric oxide (NO) might contribute to the cell death pathway. We evaluated the presence of the constitutive form of the neuronal NOS (nNOS) in both health and degenerated intervertebral disk through qPCR and immunohistochemistry. We also analyzed the potential role of nNOS modulation in the tail needle puncture model of intervertebral disk degeneration. Male Wistar rats were submitted to percutaneous disk puncture with a 21-gauge needle of coccygeal vertebras...
October 19, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27755643/neck-pain-preoperative-opioids-and-functionality-after-cervical-fusion
#5
Mhamad Faour, Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
The use of opioids among patients with workers' compensation claims is associated with tremendous costs, especially for patients who undergo spinal surgery. This study compared return-to-work rates after single-level cervical fusion for degenerative disk disease between patients who received opioids before surgery and patients who underwent fusion with no previous opioid use. All study subjects qualified for workers' compensation benefits for injuries sustained at work between 1993 and 2011. The study population included 281 subjects who underwent single-level cervical fusion for degenerative disk disease with International Classification of Diseases, Ninth Revision, and Current Procedural Terminology code algorithms...
October 18, 2016: Orthopedics
https://www.readbyqxmd.com/read/27718100/erratum-to-a-prospective-randomized-multicenter-phase-i-ii-clinical-trial-to-evaluate-safety-and-efficacy-of-novocart-disk-plus-autologous-disk-chondrocyte-transplantation-in-the-treatment-of-nucleotomized-and-degenerative-lumbar-disks-to-avoid-secondary-disease
#6
Anja Tschugg, Michael Diepers, Simone Steinert, Felix Michnacs, Sebastian Quirbach, Martin Strowitzki, Hans Jörg Meisel, Claudius Thomé
No abstract text is available yet for this article.
October 8, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27684084/spondylolysis-and-end-plate-arthrosis-at-l5-s1-a-cadaveric-study
#7
Peter T McCunniff, Hojun Yoo, Charles Yu, Navkirat S Bajwa, Jason O Toy, Uri M Ahn, Nicholas Ahn
This study examined the effect of bilateral and unilateral L5 pars defects on the degree of disk degeneration at the L5-S1 level in cadaveric specimens. An observational study was performed of 690 cadaveric specimens selected at random. These specimens represent individuals who died between 1893 and 1938. The study included 558 male and 132 female cadavers. Of the 120 specimens with L5 spondylolysis, 95 cases were bilateral and 25 were unilateral. The remaining 544 specimens were used as the control cohort...
September 29, 2016: Orthopedics
https://www.readbyqxmd.com/read/27661661/intervertebral-disc-repair-by-allogeneic-mesenchymal-bone-marrow-cells-a-randomized-controlled-trial
#8
David C Noriega, Francisco Ardura, Ruben Hernández-Ramajo, Miguel Angel Martín-Ferrero, Israel Sánchez-Lite, Borja Toribio, Mercedes Alberca, Veronica García, José Maria Moraleda, Ana Sánchez, Javier García-Sancho
BACKGROUND: Degenerative disc disease often causes severe low-back pain, a public health problem with huge economic and life quality impact. Chronic cases often require surgery, which may lead to biomechanical problems and accelerated degeneration of the adjacent segments. Autologous mesenchymal stromal cells (MSC) treatments have shown feasibility, safety and strong indications of clinical efficacy. We present here a randomized, controlled trial using allogeneic MSC, which are logistically more convenient than autologous cells...
September 21, 2016: Transplantation
https://www.readbyqxmd.com/read/27630802/a-novel-minimally-invasive-approach-to-repair-degenerative-disk-disease-in-an-ovine-model-using-injectable-polymethyl-methacrylate-and-bovine-collagen-pmma-bc
#9
Reid Hoshide, Erica Feldman, Anisha Narayan, William Taylor
BACKGROUND: The natural, inflammatory repair processes of an injured intervertebral degenerative disc can propagate further injury and destruction. While there are many different treatment modalities of the pain related to degenerative disc disease, none are actually reparative in nature. Treatment strategies to repair a degenerative disc without inducing a destructive inflammatory milieu have been elusive.  PURPOSE: The purpose of this experiment is to discover the feasibility of reconstructing an injured intervertebral disc using an injected, inert polymer as the foundation for endogenous collagen growth...
2016: Curēus
https://www.readbyqxmd.com/read/27623300/degenerative-spondylolisthesis-in-the-fifth-lumbar-vertebra-and-radiographic-parameters-a-correlation-analysis
#10
Qian Chen, Lu Cao, Chong Bian, Hui-Ren Wang, Hong Lin, Xi-Lei Li, Yun-Qi Jiang, Jian Dong
STUDY DESIGN: A retrospective study. OBJECTIVE: This study aimed to analyze the relationships between degenerative spondylolisthesis in the fifth lumbar vertebra (L5-DS) and radiographic parameters and to further determine the radiographic predictors of the development of L5-DS. SUMMARY OF BACKGROUND DATA: Degenerative lumbar spondylolisthesis (DLS) is a common degenerative disease of the spine; however, the correlations between L5-DS and radiographic parameters remain controversial...
September 10, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27593792/a-rehabilitation-protocol-for-patients-with-lumbar-degenerative-disk-disease
#11
Nazan Canbulat, Tunc Oktenoglu, Yaprak Ataker, Mehdi Sasani, Omur Ercelen, Onder Cerezci, Tuncer Suzer, Ali Fahir Ozer
AIM: To evaluate the efficacy of the rehabilitation protocol on the patients with lumbar degenerative disk disease after posterior transpedicular dynamic stabilization (PTDS) surgery. MATERIAL AND METHODS: Patients (N:50) with single level lumbar degenerative disk disease were recruited for this study. Patients had PTDS surgery with hinged screws. A rehabilitation program was applied for all patients. Phase 1 was the preoperative evaluation phase. Phase 2 (active rest phase) was the first 6 weeks after surgery...
December 28, 2015: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27591062/feasibility-and-accuracy-of-new-insertion-technique-of-s1-transpedicular-screw-computed-tomography-based-morphometric-analysis
#12
Łukasz Kubaszewski, Grzegorz Miękisiak, Andrzej Nowakowski, Celina Pezowicz, Grzegorz Bajor, Zdzisław Kiełbowicz, Wojciech Kinda, Magdalena Wojtków, Jacek Kaczmarczyk
OBJECTIVE: To assess feasibility and accuracy of a new insertion technique of S1 transpedicular screw. SUMMARY OF BACKGROUND DATA: Transpedicular stabilization in the first sacral vertebra (S1) is a technically demanding surgical procedure with inherent risk of loosening of the implant. A modification of the technique was recently proposed, along with the analytical verification which was performed based on the available literature. In the study, we performed radiological assessment of screws inserted into the S1 using the classical and modified techniques...
2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27570718/minimally-invasive-direct-thoracic-interbody-fusion-mis-dtif-technical-notes-of-a-single-surgeon-study
#13
Hamid Abbasi, Ali Abbasi
BACKGROUND: Minimally invasive direct thoracic interbody fusion (MIS-DTIF) is a new single surgeon procedure for fusion of the thoracic vertebrae below the scapula (T6/7) to the thoracolumbar junction. In this proof of concept study, we describe the surgical technique for MIS-DTIF and report our experience and the perioperative outcomes of the first four patients who underwent this procedure. STUDY DESIGN/SETTING: In this study we attempt to establish the safety and efficacy of MIS-DTIF...
2016: Curēus
https://www.readbyqxmd.com/read/27567635/a-prospective-randomized-multicenter-phase-i-ii-clinical-trial-to-evaluate-safety-and-efficacy-of-novocart-disk-plus-autologous-disk-chondrocyte-transplantation-in-the-treatment-of-nucleotomized-and-degenerative-lumbar-disks-to-avoid-secondary-disease-safety
#14
Anja Tschugg, Michael Diepers, Steinert Simone, Felix Michnacs, Sebastian Quirbach, Martin Strowitzki, Hans Jörg Meisel, Claudius Thomé
NOVOCART(®) Disk plus, an autologous cell compound for autologous disk chondrocyte transplantation, was developed to reduce the degenerative sequel after lumbar disk surgery or to prophylactically avoid degeneration in adjacent disks, if present. The NDisc trial is an ongoing multi-center, randomized study with a sequential phase I study within the combined phase I/II trial with close monitoring of tolerability and safety. Twenty-four adult patients were randomized and treated with the investigational medicinal product NDisc plus or the carrier material only...
August 27, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27536737/rate-of-lumbar-paravertebral-muscle-fat-infiltration-versus-spinal-degeneration-in-asymptomatic-populations-an-age-aggregated-cross-sectional-simulation-study
#15
Rebecca J Crawford, Thomas Volken, Stephanie Valentin, Markus Melloh, James M Elliott
BACKGROUND: The spinal column including its vertebrae and disks has been well examined and extensively reported in relation to age-aggregated degeneration. In contrast, paravertebral muscles are poorly represented in describing normative degeneration. Increasing evidence points to the importance of paravertebral muscle quality in low back health, and their potential as a modifiable factor in low back pain (LBP). Studies examining normative decline of paravertebral muscles are needed to advance the field's etiological understanding...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27433434/biological-treatment-approaches-for-degenerative-disk-disease-a-literature-review-of-in-vivo-animal-and-clinical-data
#16
REVIEW
Yu Moriguchi, Marjan Alimi, Thamina Khair, George Manolarakis, Connor Berlin, Lawrence J Bonassar, Roger Härtl
STUDY DESIGN: Literature review. OBJECTIVE: Degenerative disk disease (DDD) has a negative impact on quality of life and is a major cause of morbidity worldwide. There has been a growing interest in the biological repair of DDD by both researchers and clinicians alike. To generate an overview of the recent progress in reparative strategies for the treatment of DDD highlighting their promises and limitations, a comprehensive review of the current literature was performed elucidating data from in vivo animal and clinical studies...
August 2016: Global Spine Journal
https://www.readbyqxmd.com/read/27433432/choice-of-approach-does-not-affect-clinical-and-radiologic-outcomes-a-comparative-cohort-of-patients-having-anterior-lumbar-interbody-fusion-and-patients-having-lateral-lumbar-interbody-fusion-at-24-months
#17
Gregory M Malham, Rhiannon M Parker, Carl M Blecher, Fiona Y Chow, Kevin A Seex
STUDY DESIGN: Retrospective analysis of prospectively collected registry data. OBJECTIVE: This study aimed to compare the clinical and radiologic outcomes between comparative cohorts of patients having anterior lumbar interbody fusion (ALIF) and patients having lateral lumbar interbody fusion (LLIF). METHODS: Ninety consecutive patients were treated by a single surgeon with either ALIF (n = 50) or LLIF (n = 40). Inclusion criteria were patients age 45 to 70 years with degenerative disk disease or grade 1 to 2 spondylolisthesis and single-level pathology from L1 to S1...
August 2016: Global Spine Journal
https://www.readbyqxmd.com/read/27415595/epidural-fibrosis-seen-from-a-different-angle-extraforaminal-lumbar-interbody-fusion
#18
Arthur Robert Kurzbuch, Didier Recoules-Arche
Background Postoperative epidural fibrosis (PEF) localized around the exposed dura and nerve roots is a known radiologic entity seen after lumbar surgery. Although excessive PEF is associated with residual and new lumbar pain and radiculopathy, its role as the generator of the pain is still discussed. Various materials acting as an adhesion barrier have been tested. There is no undebated class I evidence that any one of them is suitable to reduce or avoid PEF and provide a better clinical outcome. In revision surgery, the dissection of epidural scar tissue is time consuming and related to an elevated risk of dural tear and nerve damage...
July 14, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27404851/failure-to-launch-what-the-rejection-of-lumbar-total-disk-replacement-tells-us-about-american-spine-surgery
#19
Robert A Hart, J Mason DePasse, Alan H Daniels
STUDY DESIGN: Spine surgeon survey. OBJECTIVE: The objective was to investigate the failure of widespread adoption of lumbar total disk replacement (L-TDR) in the United States. SUMMARY OF BACKGROUND DATA: L-TDR has been available for use in the United States since 2005. L-TDR has not gained wide acceptance as a treatment for degenerative disk disease despite substantial investments in product development and positive results in randomized controlled trials...
July 11, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27399438/159%C3%A2-neurological-outcomes-of-two-level-total-disk-replacement-versus-anterior-discectomy-and-fusion-7-year-results-from-a-prospective-randomized-multicenter-trial
#20
Robert Jackson, Darin Eric Johnson
INTRODUCTION: Studies suggest significant biomechanical and clinical differences exist between total disk replacement (TDR) and anterior cervical discectomy and fusion (ACDF) patients treated at multiple cervical levels. However, long-term results for treatment of multilevel cervical degenerative disc disease are lacking. Here we evaluate 7-year neurological and clinical outcomes of patients treated at 2 contiguous levels with TDR or ACDF. METHODS: Prospective, randomized, multicenter, controlled clinical trial...
August 2016: Neurosurgery
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