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Degenerative Disk Disease

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https://www.readbyqxmd.com/read/29315121/cervical-total-disk-arthroplasty
#1
Timothy T Roberts, Ryan J Filler, Jason W Savage, Edward C Benzel
In the United States, cervical total disk arthroplasty (TDA) is US Federal Drug Administration (FDA) approved for use in both 1 and 2-level constructions for cervical disk disease resulting in myelopathy and/or radiculopathy. TDA designs vary in form, function, material composition, and even performance in vivo. However, the therapeutic goals are the same: to remove the painful degenerative/damaged elements of the intervertebral discoligamenous joint complex, to preserve or restore the natural range of spinal motion, and to mitigate stresses on adjacent spinal segments, thereby theoretically limiting adjacent segment disease (ASDis)...
January 8, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29284234/chemometric-evaluation-of-concentrations-of-trace-elements-in-intervertebral-disc-tissue-in-patient-with-degenerative-disc-disease
#2
Łukasz Kubaszewski, Anetta Zioła-Frankowska, Zuzanna Gasik, Marcin Frankowski, Mikołaj Dąbrowski, Bartłomiej Molisak, Jacek Kaczmarczyk, Robert Gasik
BACKGROUND: The work is designed to uncover the pattern of mutual relation among trace elements and epidemiological data in the degenerated intervertebral disk tissue in humans. Hitherto the reason of the degenerative process is not fully understood. Trace elements are the basic components of the biological compound related both its metabolism as well as environmental exposure. The relation pattern among elements occurs gives new perspective in solving the cause of the disease. MATERIAL AND METHODS: We have analysed trace elements content in the 30 intervertebral disc from 22 patients with degenerative disc disease...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29283093/anterior-cervical-disc-fusion-does-not-affect-the-presence-of-cervical-vestibular-evoked-myogenic-potential
#3
Ioannis Kastanioudakis, Panagiotis Saravakos, Andreas Zigouris, Vasileios Ragos, Oliver Reichel, Nafsika Ziavra
OBJECTIVE: Cervical spondylosis and cervical disk herniation are the most frequent forms of degenerative disease in the cervical spine. Surgical treatment mainly includes anterior cervical disk fusion. However, information concerning vestibular-evoked myogenic potential (VEMP) recording in patients undergoing cervical spine surgery is limited. The present prospective study aimed to investigate the effect of anterior disk fusion surgery on cervical VEMP (cVEMP) parameters. MATERIALS AND METHODS: Twenty-five patients were enrolled in this study, and 20 patients (10 men and 10 women) completed cVEMP testing...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29227558/rna-sequencing-identifies-gene-regulatory-networks-controlling-extracellular-matrix-synthesis-in-intervertebral-disk-tissues
#4
Scott M Riester, Yang Lin, Wei Wang, Lin Cong, Abdel-Moneim Mohamed Ali, Sun H Peck, Lachlan J Smith, Bradford L Currier, Michelle Clark, Paul Huddleston, William Krauss, Michael J Yaszemski, Mark E Morrey, Matthew P Abdel, Mohamad Bydon, Wenchun Qu, A Noelle Larson, Andre J van Wijnen, Ahmad Nassr
Degenerative disk disease of the spine is a major cause of back pain and disability. Optimization of regenerative medical therapies for degenerative disk disease requires a deep mechanistic understanding of the factors controlling the structural integrity of spinal tissues. In this investigation, we sought to identify candidate regulatory genes controlling extracellular matrix synthesis in spinal tissues. To achieve this goal we performed high throughput next generation RNA sequencing on 39 annulus fibrosus and 21 nucleus pulposus human tissue samples...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28948122/a-case-of-persistent-low-back-pain-in-a-young-female-caused-by-a-trauma-induced-schmorl-s-node-in-the-lumbar-spine-five-vertebra
#5
Kurt M Mohty, Divneet Mandair, Brent Munroe, Deborah Baldemor
Physicians are often faced with managing difficult conditions such as chronic lower back pain. Intervertebral disk herniation typically occurs horizontally, leading to impingement of the spinal cord which can potentially cause radicular symptoms or other spinal cord pathologies; however, disk herniations can also occur vertically and extend through the endplate of an adjacent cranial or caudal vertebra: a phenomenon known as a Schmorl's node. Although Schmorl's nodes can be seen in many asymptomatic individuals, they can be a cause of degenerative disk disease and low back pain...
July 21, 2017: Curēus
https://www.readbyqxmd.com/read/28945642/clinical-and-radiologic-comparison-of-minimally-invasive-surgery-with-traditional-open-transforaminal-lumbar-interbody-fusion-a-review-of-452-patients-from-a-single-center
#6
Julian P Price, John M Dawson, James D Schwender, Kurt P Schellhas
STUDY DESIGN: Retrospective analysis of prospective data for parallel, consecutive series of patients (Level III). OBJECTIVE: Compare clinical results and radiographic outcomes of minimally invasive surgery (MIS) versus open techniques for transforaminal lumbar interbody fusion (TLIF). SUMMARY OF BACKGROUND DATA: Minimally invasive techniques allow transforaminal exposure with decreased soft tissue disruption, but the question remains whether surgical and functional outcomes are equivalent to open techniques...
September 22, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28846710/apparent-diffusion-coefficient-maps-in-the-assessment-of-surgical-patients-with-lumbar-spine-degeneration
#7
Evgenii Belykh, Andrey A Kalinin, Arpan A Patel, Eric J Miller, Michael A Bohl, Ivan A Stepanov, Liudmila A Bardonova, Talgat Kerimbaev, Anton O Asantsev, Morgan B Giers, Mark C Preul, Vadim A Byvaltsev
PURPOSE: To assess the utility of apparent diffusion coefficient (ADC) maps for the assessment of patients with advanced degenerative lumbar spine disease and describe characteristic features of ADC maps in various degenerative lumbar spinal conditions. METHODS: T1-weighted, T2-weighted and diffusion weighted (DWI) MR images of 100 consecutive patients admitted to the spinal surgery service were assessed. ADC maps were generated from DWI images using Osyrix software...
2017: PloS One
https://www.readbyqxmd.com/read/28750870/-impact-of-obesity-in-the-pathophysiology-of-degenerative-disk-disease-and-in-the-morbidity-and-outcome-of-lumbar-spine-surgery
#8
Pedro David Delgado-López, José Manuel Castilla-Díez
Obesity (BMI>30Kg/m(2)) is a pandemic with severe medical and financial implications. There is growing evidence that relates certain metabolic processes within the adipose tissue, preferentially abdominal fat, with a low-intensity chronic inflammatory state mediated by adipokines and other substances that favor disk disease and chronic low back pain. Obesity greatly conditions both the preoperative evaluation and the spinal surgical technique itself. Some meta-analyses have confirmed an increase of complications following lumbar spine surgery (mainly infections and venous thrombosis) in obese subjects...
July 24, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28746177/correlation-between-high-intensity-zone-on-mri-and-discography-in-patients-with-low-back-pain
#9
Huadong Wang, Zhonghai Li, Chunli Zhang, Weisheng Zhang, Li Li, Jidong Guo, Wenwen Wu, Shuxun Hou
The aim of this study was to analyze the correlation between high-intensity zone (HIZ) on magnetic resonance imaging (MRI) of a lumbar disc and positive pain response assessed by discography for the diagnosis and treatment of discogenic low back pain (LBP). Thirty-seven patients aged 21 to 59 years with chronic LBP but without any neurological symptoms or lumbar disc herniation who underwent MRI and subsequent discography were included in this study. During discography, concordant pain was regarded as positive, whereas discordant pain and no pain were regarded as negative...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28706805/arthroscopic-intra-articular-disk-excision-of-the-sternoclavicular-joint
#10
Graham Tytherleigh-Strong, Abbas Rashid, Christopher Lawrence, David Morrissey
The sternoclavicular joint (SCJ) has a complete intra-articular disk that can be damaged either as a result of trauma or as part of ongoing degenerative joint disease. Although often asymptomatic, SCJ disk tears may lead to mechanical symptoms and pain. Previously, isolated symptomatic SCJ disk tears have only occasionally been mentioned in the literature with a few associated case reports of diskectomy by open arthrotomy. With improved imaging and availability of magnetic resonance imaging scans and the advent of SCJ arthroscopy it is now possible to treat symptomatic SCJ disk tears by arthroscopic excision...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28670416/correlation-among-inflammatory-cytokine-expression-levels-degree-of-disk-degeneration-and-predominant-clinical-symptoms-in-patients-with-degenerated-intervertebral-discs
#11
Takeshi Sainoh, Kazuhide Inage, Sumihisa Orita, Masao Koda, Takeo Furuya, Kazuyo Yamauchi, Miyako Suzuki, Yoshihiro Sakuma, Go Kubota, Yasuhiro Oikawa, Jun Sato, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Kazuhisa Takahashi, Seiji Ohtori
STUDY DESIGN: Observational study. PURPOSE: To assess the correlation among inflammatory cytokine expression levels, degree of intervertebral disk (IVD) degeneration, and predominant clinical symptoms observed in degenerative disk disease (DDD). OVERVIEW OF LITERATURE: Low back pain (LBP) is associated with inflammatory cytokine expression levels, including those of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and nerve growth factor (NGF)...
June 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28632548/are-modic-changes-able-to-help-us-in-our-clinical-practice-a-study-of-the-modic-changes-in-young-adults-during-working-age
#12
José V Martínez-Quiñones, José Aso-Escario, Laura González-García, Fabián Consolini, Ricardo Arregui-Calvo
STUDY DESIGN: Modic changes [vertebral endplate spinal changes (VESC)] have been related to degenerative disk disease, and in past decades it was thought that their presence justified the surgical treatment, in particular spinal fusion. OBJECTIVE: The aim of the present study is to investigate its prevalence and features in a population of young workers suffering from low back pain, and explore the eventual relationship with the treatment applied in each case. BACKGROUND DATA: We conducted a retrospectively review of 450 magnetic resonance images from our hospital, in patients with low back pain or sciatica and age below 40...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28604508/symptomatic-adjacent-segment-disease-after-anterior-cervical-discectomy-for-single-level-degenerative-disk-disease
#13
Roland D Donk, Wim I M Verhagen, Allard J F Hosman, Andre Verbeek, Ronald H M A Bartels
STUDY DESIGN: A prospective cohort of 142 patients underwent either anterior cervical discectomy alone, anterior cervical discectomy with fusion by cage stand-alone, or anterior cervical discectomy with arthroplasty. We then followed up on their condition for a mean of 9.1±1.9 years (5.6-12.2 y) later. OBJECTIVE: We aimed to evaluate the annual rate of clinically symptomatic adjacent segment disease (ASD) and to analyze predictive factors. SUMMARY OF BACKGROUND DATA: Until recent, ASD has been predominantly evaluated radiologically...
June 9, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28574940/management-of-lumbar-conditions-in-the-elite-athlete
#14
Wellington K Hsu, Tyler James Jenkins
Lumbar disk herniation, degenerative disk disease, and spondylolysis are the most prevalent lumbar conditions that result in missed playing time. Lumbar disk herniation has a good prognosis. After recovery from injury, professional athletes return to play 82% of the time. Surgical management of lumbar disk herniation has been shown to be a viable option in athletes in whom nonsurgical measures have failed. Degenerative disk disease is predominately genetic but may be accelerated in athletes secondary to increased physiologic loading...
July 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28531995/scavenging-free-radicals-and-soaring-osteoinduction-by-extra-cellular-matrix-protein-based-nanocomposites-on-degenerative-bone-treatments
#15
Kavitha Kandiah, Navaneethan Duraisamy, Vinoth Amirthalingam, Balagurunathan Ramasamy
A number of materials are now available to alleviate the ever-growing bone disruption. However, these are inadequate and inappropriate for addressing issues associated natural process of aging and degeneration of bone due to diseases. This study advances the existing material and offers more privileged and synergistically active remedy for these conditions. Here, they are three different nano-composites prepared such as nano-TiO2 with chitosan (TC), nano-TiO2 with chondroitin 4-sulfate (TG), and nano-TiO2 with chitosan and chondroitin 4-sulfate (TCG), whereas nano-TiO2 act as a control...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28525492/degenerative-cervical-disc-disease-long-term-changes-in-sagittal-alignment-and-their-clinical-implications-after-cervical-interbody-fusion-cage-subsidence-a-prospective-study-with-standalone-lordotic-tantalum-cages
#16
Félix Tomé-Bermejo, Julián A Morales-Valencia, Javier Moreno-Pérez, Juan Marfil-Pérez, Elena Díaz-Dominguez, Angel R Piñera, Luis Alvarez
STUDY DESIGN: A retrospective, observational study of prospectively collected outcomes. OBJECTIVE: To investigate the long-term clinical course of anterior cervical discectomy and fusion with interbody fusion cages (ACDF-IFC) with lordotic tantalum implants and to correlate the radiologic findings with the clinical outcomes, with special emphasis on the significance and the influence of implant subsidence. SUMMARY OF BACKGROUND DATA: Cage subsidence is the most frequently reported complication after ACDF-IFC...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525488/artificial-disk-replacement-combined-with-fusion-versus-2-level-fusion-in-cervical-2-level-disk-disease-with-a-5-year-follow-up
#17
Gyu Yeul Ji, Chang Hyun Oh, Dong Ah Shin, Yoon Ha, Seong Yi, Keung Nyun Kim, Hyun Cheol Shin, Do Heum Yoon
STUDY DESIGN: Prospective study. OBJECTIVE: The purpose of this study was to compare the long-term clinical and radiologic outcomes of hybrid surgery (HS) and 2-level anterior cervical discectomy and fusion (2-ACDF) in patients with 2-level cervical disk disease. SUMMARY OF BACKGROUND DATA: In a previous study with a 2-year follow-up, HS was shown to be superior to 2-ACDF, with a better Neck Disability Index (NDI) score, less postoperative neck pain, faster C2-C7 range of motion (ROM) recovery, and less adjacent ROM increase...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525482/artificial-cervical-disk-replacement-for-the-treatment-of-adjacent-segment-disease-after-anterior-cervical-decompression-and-fusion
#18
Sheng Bin, Huang Xiangwang, Xiao Sheng, Xiang Tiecheng, Liu Xiangyang, Zhang Yi, Liu Bin
STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the outcome of artificial cervical disk replacement (ACDR) for the treatment of adjacent segment disease (ASD) after anterior cervical decompression and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is the useful procedure for degenerative cervical diseases. However, studies have reported accelerated degeneration of functional spinal units adjacent to the fusion site after ACDF. MATERIALS AND METHODS: Between January 2004 and January 2011, 32 inpatients (18 male, 14 female; age, 38-61 y; mean, 48 y) underwent ACDR for the treatment of ASD after previous ACDF (single-level: n=12; 2-level: n=15; 3-level: n=5)...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525473/is-total-disk-replacement-a-cost-effective-treatment-for-cervical-degenerative-disk-disease
#19
Bernd Wiedenhöfer, Joachim Nacke, Mike Stephan, Wiltrud Richter, Claus Carstens, Markus Eichler
STUDY DESIGN: A retrospective study. OBJECTIVE: The objective of this study was to assess the cost-effectiveness and clinical outcome of motion-preserving versus fusion procedures in cervical spine surgery. SUMMARY OF BACKGROUND DATA: During the last decade there has been a huge growth in spine surgery with a concurrent increase in the economic burden. Currently, there appear to be no differences in clinical outcome between cervical total disk replacement (TDR) and spinal fusion (SF)...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525471/cervical-disk-replacement-with-discover-versus-fusion-in-a-single-level-cervical-disk-disease-a-prospective-single-center-randomized-trial-with-a-minimum-2-year-follow-up
#20
Marjan Rožanković, Sergej M Marasanov, Miroslav Vukić
STUDY DESIGN: Prospective randomized study. OBJECTIVE: To compare the clinical outcome after Discover arthroplasty versus anterior cervical discectomy and fusion (ACDF) in patients treated for symptomatic single-level cervical disk disease. SUMMARY OF BACKGROUND DATA: ACDF is still the gold standard for surgical treatment of cervical spine degenerative disk disease. However, results of many studies suggest that it may cause degenerative changes at levels immediately above and below the fusion, known as adjacent segment degenerative disease...
June 2017: Clinical Spine Surgery
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